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The Action of p-Synephrine on Lipid Metabolism in the Perfused Rat Liver

Journal of Biosciences and Medicines 2017年第5期5卷 8-21页

作者： juliany fontoura da silva-pereira Andrea Luiza de Oliveira Valoto Livia Bracht Geferson de Almeida Goncalves Rosane Marina Peralta Adelar Bracht Department of Biochemistry University of MaringaMaringaBrazil Faculdade Integrado Campo MouraoBrazil

p-synephrine and p-octopamine were found to increase lipolysis in adipocytes. The present study approaches the question if these compounds, natural products of the bitter orange (Citrus aurantium fruit), increase lipolysis and fatty acid oxidation in the liver. Experiments were done in the perfused rat liver. Non-recirculating hemoglobin-free perfusion was done using the Krebs/ Henseleit-bicarbonate buffer (pH 7.4) as perfusion fluid. Both p-synephrine and p-octopamine, at the concentrations of 100 μM, were found to stimulate the hepatic triacylglycerol lipase by 40% and 51%, respectively. These seem to be the maximal stimulations possible in the liver. In the perfused liver, p-synephrine, when present at an initial concentration of 500 μM, was able to increase the non-esterified fatty acid release after one hour of recirculating perfusion. The effects of p-synephrine on the oxidation of exogenously supplied [1-14C]octanoate and [1-14C]oleate were minimal. Only oxygen uptake, already stimulated by octanoate or oleate, was additionally increased by the infusion of p-synephrine. These results contrast with those obtained in a previous study with p-octopamine, which increased the production of 14CO2 from both [1-14C]octanoate and [1-14C]oleate. Apparently only the oxidation of endogenous fatty acids is stimulated by p-synephrine. On the other hand, both p-synephrine and p-octopamine stimulate the hepatic triacylglycerol lipase to a much lesser extent than the adipocyte lipase. It can be concluded that p-synephrine affects much more carbohydrate metabolism in the liver than lipid metabolism.

关键词： Hepatic Lipid Metabolism Lipolysis Fatty Acid Release Fatty Acid Oxidation

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Preemptive endoluminal vacuum therapy after pancreaticoduodenectomy: A case report

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World Journal of Gastrointestinal Endoscopy 2020年第11期12卷 493-499页

作者： Flaubert Sena de Medeiros Epifanio Silvino do Monte Junior Romero de Lima França Heli Clóvis de Medeiros Neto juliany Medeiros Santos Eligio Alves Almeida Júnior Samuel Oliveira da silva Júnior Mario Herman Santos Moura Pedreira Tavares Eduardo Guimarães Hourneaux de Moura Department of Surgery Federal University of Rio Grande do NorteNatal 59012-300Rio Grande do NorteBrazil Gastrointestinal Endoscopy Unit Hospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 05403-000Brazil Department of Surgery Hospital do CoraçãoNatal 59075-050Rio Grande do NorteBrazil Gastrointestinal Endoscopy Unit Faculty of Medicine of ABCSão Paulo 09190-615Brazil Department of Surgery Instituto Juarez AlmeidaBacabal 65700-000MaranhãoBrazil Department of Surgery Hospital Naval Marcílio DiasRio de Janeiro 20725-090Rio de JaneiroBrazil

BACKGROUND Pancreaticoduodenectomy is a technically demanding operation,with reported morbidity rates of approximately 40%-50%.A novel idea is to use endoscopic vacuum therapy(EVT)in a preemptive setting to prevent anastomotic leakage and pancreatic *** a recent case series,EVT was proven to be effective in preventing leaks in patients with anastomotic *** have been no previous reports on preemptive EVT after *** SUMMARY We describe the case of a 71-year-old woman with hypertension and diabetes who was admitted to the emergency room with jaundice,choluria,fecal acholia,abdominal pain,and *** examinations revealed leukocytosis and hyperbilirubinemia(total:13 mg/dL;conjugated:12.1 mg/dL).Abdominal ultrasound showed cholelithiasis and dilation of the common bile *** resonance imaging demonstrated a stenotic area,and a biopsy confirmed cholangiocarcinoma. Considering the high risk of leaks after pancreaticoduodenectomy,preemptive endoluminal vacuum therapy was *** system comprised a nasogastric tube,gauze,and an antimicrobial incise *** negative pressure was 125 mmHg,and no adverse events *** patient was discharged on postoperative day 5 without any *** Preemptive endoluminal vacuum therapy may be a safe and feasible technique to reduce leaks after pancreaticoduodenectomy.

关键词： Preemptive Endoluminal Vacuum Pancreaticoduodenectomy Case report

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