检索结果-南通市图书馆

Social relationship satisfaction and accumulation of chronic conditions and multimorbidity:a national cohort of Australian women

引用

General Psychiatry 2023年第1期36卷 9-18页

作者： Xiaolin Xu Gita D Mishra julianne Holt-Lunstad Mark Jones School of Public Health The University of QueenslandBrisbaneQueenslandAustralia Departments of Psychology and Neuroscience Brigham Young UniversityProvoUtahUSA

Background Social relationships are associated with mortality and chronic ***,little is known about the effects of social relationship satisfaction on multiple chronic conditions(multimorbidity).Aims To examine whether social relationship satisfaction is associated with the accumulation of *** Data from 7694 Australian women who were free from 11 chronic conditions at 45–50 years of age in 1996 were *** types of social relationship satisfaction(partner,family members,friends,work and social activities)were measured approximately every 3 years and scored from 0(very dissatisfied)to 3(very satisfied).Scores from each relationship type were summed to provide an overall satisfaction score(range:≤5–15).The outcome of interest was the accumulation of multimorbidity in 11 chronic *** Over a 20-year period,4484(58.3%)women reported ***,the level of social relationship satisfaction had a dose–response relationship with the accumulation of *** with women reporting the highest satisfaction(score 15),women with the lowest satisfaction(score≤5)had the highest odds of accumulating multimorbidity(odds ratio(OR)=2.35,95%confidence interval(CI):1.94 to 2.83)in the adjusted *** results were observed for each social relationship *** risk factors,such as socioeconomic,behavioural and menopausal status,together explained 22.72%of the *** Social relationship satisfaction is associated with the accumulation of multimorbidity,and the relationship is only partly explained by socioeconomic,behavioural and reproductive *** connections(eg,satisfaction with social relationships)should be considered a public health priority in chronic disease prevention and intervention.

关键词： morbidity prevention behaviour

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Convenient synthesis of nucleoside 5'-(α-P-thio)triphosphates and phosphorothioate nucleic acids(DNA and RNA)

引用

中国科学：化学 2012年第2期42卷 215-218页

作者： CATON-WILLIAMS julianne FIAZ Bilal HOXHAJ Rudiona SMITH Matthew Department of Chemistry Georgia State UniversityAtlantaGA 30303USA

Modified deoxy-and ribo-nucleoside triphosphates are chemically synthesized in multiple steps due to the protection and deprotection of the nucleoside *** conveniently synthesize the S-modified triphosphates for enzymatically preparing phosphorothioate DNAs and RNAs(PS-DNA and PS-RNA) as potential therapeutics,herein we report a one-pot strategy to synthesize the deoxy-and ribo-nucleoside 5'-(α-P-thio)triphosphates(dNTPαS and NTPαS) without protecting any nucleoside *** facile synthesis is achieved by treating the nucleosides with a mild phosphitylating reagent,reacting selectively with the 5'-hydroxyl group of each unprotected nucleoside,followed by sulfurization and hydrolysis to afford the crude dNTPαS and NTPαS analogs(mixtures of Sp and Rp diastereomers).We also demonstrated that after just simple precipitation(without HPLC and ion-exchange purification),the quality of the synthesized dNTPαS and NTPαS analogs is excellent for direct DNA polymerization and RNA transcription,*** Klenow DNA polymerase and T7 RNA polymerase accept the Sp diastereomers of dNTPαS and NTPαS analogs,respectively,while the Rp diastereomers are neither substrates nor inhibitors,the diastereomerically-pure PS-DNAs and PS-RNAs can be conveniently synthesized enzymatically.

关键词： DNA聚合酶 RNA聚合酶核糖核苷化学合成三磷酸硫代 dNTP浓度高效液相色谱法

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

引用

Journal of Sport and Health Science 2018年第2期7卷 191-196页

作者： Malcolm Eaton Cesare Granata julianne Barry Adeel Safdar David Bishop Jonathan P.Little School of Health and Exercise Science University of British Columbia Okanagan Institute of Sport Exercise and Active Living (ISEAL)College of Sport and Exercise ScienceVictoria University Department of Pediatrics Mc Master University

Background: Exercise promotes numerous phenotypic adaptations in skeletal muscle that contribute to improved function and metabolic capacity. An emerging body of evidence suggests that skeletal muscle also releases a myriad of factors during exercise, termed "myokines". The purpose of this study was to examine the effects of high-intensity interval training(HIIT) on the acute regulation of the mRNA expression of several myokines, including the prototypical myokine interleukin-6(IL-6), and recently identified myokines fibronectin type III domain-containing protein 5(FNDC5)(irisin) and meteorin-like protein(METRNL).Methods: Both before and after a 20-day period of twice-daily high-volume HIIT, 9 healthy males(20.5 ± 1.5 years performed a standardized bout of high-intensity interval exercise(HIIE; 5 × 4 min at ~80% pretraining peak power output) with skeletal muscle biopsy samples(vastus lateralis) obtained at rest, immediately following exercise, and at 3 h ***: Before training, a single bout of HIIE increased IL-6(p < 0.05) and METRNL(p < 0.05) mRNA expression measured at 3 h recovery when compared to rest. Following 20 days of HIIT, IL-6 and FNDC5 mRNA were increased at 3 h recovery from the standardized HIIE bout when compared to rest(both p < 0.05). Resting METRNL and FNDC5 mRNA expression were higher following training(p < 0.05), and there was an overall increase in FNDC5 mRNA post-training(main effect of training, p < 0.05).Conclusion: In human skeletal muscle(1) an acute bout of HIIE can induce upregulation of skeletal muscle IL-6 mRNA both before and after a period of intensified HIIT;(2) Resting and overall FNDC5 mRNA expression is increased by 20 days of HIIT; and(3) METRNL mRNA expression is responsive to both acute HIIE and short-term intense HIIT. Future studies are needed to confirm these findings at the protein and secretion level in humans.

关键词： Brown adipose tissue Exerkines High-intensity interval training Intermittent exercise Myokine Obesity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Slowed driving-reaction time following concussion-symptom resolution

引用

Journal of Sport and Health Science 2021年第2期10卷 145-153页

作者： Landon B.Lempke Robert C.Lynall Nicole L.Hoffman Hannes Devos julianne D.Schmidt UGA Concussion Research Laboratory Department of KinesiologyUniversity of GeorgiaAthensGA 30602USA School of Kinesiology and Recreation Illinois State UniversityNormalIL 61790USA Laboratory for Advanced Rehabilitation Research in Simulation Department of Physical Therapy and Rehabilitation ScienceUniversity of Kansas Medical CenterKansas CityKS 66160USA

Background:Concussed patients have impaired reaction time(RT)and cognition following injury that may linger and impair driving *** research has used direct methods to assess driving-RT *** study compared driving RT during simulated scenarios between concussed and control individuals and examined driving-RT’s relationship with traditional computerized neurocognitive testing(CNT)***:We employed a cross-sectional study among 14 concussed(15.9±9.8 days post-concussion,mean±SD)individuals and 14 healthy controls matched for age,sex,and driving *** completed a driving simulator and CNT(CNS Vital Signs)assessment within 48 h of symptom resolution.A driving-RT composite(ms)was derived from 3 simulated driving scenarios:stoplight(green to yellow),evasion(avoiding approaching vehicle),and pedestrian(person running in front of vehicle).The CNT domains included verbal and visual memory;CNT-RT(simple-,complex-,Stroop-RT individually);simple and complex attention;motor,psychomotor,and processing speed;executive function;and cognitive *** t tests and Hedge d effect sizes assessed driving-RT differences between groups,Pearson correlations(r)examined driving RT and CNT domain relationships among cohorts separately,and p values were controlled for false discovery rate via Benjamini-Hochberg procedures(a=0.05).Results:Concussed participants demonstrated slower driving-RT composite scores than controls(mean difference=292.86 ms;95%confidence interval(95%CI):70.18515.54;p=0.023;d=0.992).Evasion-RT(p=0.054;d=0.806),pedestrian-RT(p=0.258;d=0.312),and stoplight-RT(p=0.292;d=0.585)outcomes were not statistically significant after false-discovery rate corrections but demonstrated medium to large effect sizes for concussed *** concussed individuals,driving-RT outcomes did not significantly correlate with CNT domains(r-range:0.51 to 0.55;p>0.05).No correlations existed between driving-RT outcomes a

关键词： Mild traumatic brain injury Motor vehicle Neurocognitive function Response time Return to driving

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Incidental Finding of Isolated Rosai-Dorfman Disease in the Tonsils of a 4-Year-Old Girl: A Case Report and a Brief Review of Current Practice in Tonsillectomy Specimen Handling

引用

Open Journal of Pathology 2013年第1期3卷 7-9页

作者： julianne Qualtieri Samir B. Kahwash Department of Pathology and Laboratory Medicine Nationwide Children’s Hospital Columbus USA Department of Pathology The Ohio State University Columbus USA

We report herein a case of isolated Rosai-Dorfman disease (Sinus Histiocytosis with Massive Lymphadenopathy) diagnosed upon routine microscopic examination of tonsils in a child. The patient is a 4 year old girl who had a history of sleep apnea, but no other significant medical history or other findings on physical examination. In this report, we discuss the various approaches to handling of tonsillectomy specimens. We also discuss the value of routine microscopic examination, providing a list of case examples of incidental, clinically important, findings that can be missed if a microscopic examination of tonsils was not performed. We finally discuss the clinical significance of finding histologic evidence of Rosai-Dorfman disease in a child.

关键词： Tonsils Rosai-Dorfman Disease Microscopic Examination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A gender comparison of impaired endothelial function in mesenteric arteries from insulin-resistant obese Zucker rats

A gender comparison of impaired endothelial function in mese...

引用

11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia, Shanghai-Suzhou 2006

作者： julianne Reid Elisa Young School of Medical Sciences RMIT University School of Medical Sciences RMIT University

Background/Aims: The objective of this study was to compare the effect of insulin resistance on mesenteric endothelial function between males and females using 25-week insulin-resistant obese Zucker rats (OZR) and their corresponding lean littermate control rats (LZR). Methods: Third-order mesenteric arteries were mounted on a pressure myograph, and the internal diameter was recorded by video microscopy in the presence of 10 μM indomethacin to inhibit prostanoid production. Results: Blood glucose levels in male OZR (12.6±1.6 mM) were

关键词： A gender comparison of impaired endothelial function in mesenteric arteries from insulin-resistant obese Zucker rats

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

每个人心中都有一把椅子

引用

服装设计师 2018年第11期 96-101页

作者： julianne

在每一个热爱设计的人心中，必然有一个位置是留给北欧设计的，尤其是北欧的家居设计。可以丝毫不夸张地说，北欧椅子的没计史就是一部近现代设计史。在我们的印象中，北欧是那个常年冰封，被森林覆盖之境，他们的家居或是椅子都是温暖... 详细信息

在每一个热爱设计的人心中，必然有一个位置是留给北欧设计的，尤其是北欧的家居设计。可以丝毫不夸张地说，北欧椅子的没计史就是一部近现代设计史。在我们的印象中，北欧是那个常年冰封，被森林覆盖之境，他们的家居或是椅子都是温暖的木头色，而说到金属，大多数的人的第一反应都是冰冷，别说是北欧人，大概绝大多数人在选择家具的时候也不会选择这种材质。

关键词：椅子家居设计现代设计史森林覆盖北欧家具

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ache Studios,来自北欧的销售神话

引用

服装设计师 2018年第4期 96-101页

作者： julianne

北欧，对我们来说是遥远的、小众的，但也是一个我们永远也绕不开的话题，尤其是北欧设计和品牌，不仅有无人不知的乐高，还有家居设计领域无数的大师：Poul Henningsen、Alvar Aalto、Arne Jacobsen、Finn Juhl、***……每一个都是如... 详细信息

北欧，对我们来说是遥远的、小众的，但也是一个我们永远也绕不开的话题，尤其是北欧设计和品牌，不仅有无人不知的乐高，还有家居设计领域无数的大师：Poul Henningsen、Alvar Aalto、Arne Jacobsen、Finn Juhl、***……每一个都是如雷贯耳、改变世界的名字，当然还有符合我们国人审美的宜家家居。

关键词： Ache 北欧神话销售家居设计 Hans

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nucleic Acid Chemistry and Structural Biology for Disease Mechanism Study and Drug Discovery

Nucleic Acid Chemistry and Structural Biology for Disease Me...

引用

中国化学会第27届学术年会

作者： Jozef Salon julianne Caton-Williams Abdalla Hassan Department of Chemistry ＆ Department of Biology Georgia State University

＜正＞3D structure determination and study of nucleic acids and protein-nucleic acid complexes have enormous importance for disease molecular mechanism research and drug discovery.X-ray crystallography is one of the m... 详细信息

关键词： selenium- and tellurium-derivatization nucleic acids X-ray crystal structure and function studies.

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

来自北欧最冷静的首饰品牌

引用

服装设计师 2018年第7期 84-89页

作者： julianne

买不到自己喜欢的东西，这是很多设计师为何开始做自己的品牌最直接也是最任性的原因。近年来迅速蹿红的瑞典奢华首饰品牌All Blues的诞生正是因为这样的初衷。

关键词：品牌首饰北欧设计师

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：