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challenges and improvements in testosterone and estradiol testing

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Asian Journal of Andrology 2014年第2期16卷 178-184,I0006,I0007页

作者： Hubert W vesper julianne c Botelho Yuesong Wang clinical chemistry Branch Division of Laboratory Sciences Centers for Disease Control and Prevention Atlanta Georgia USA.

Assays that measure steroid hormones in patient care, public health, and research need to be both accurate and precise, as these criteria help to ensure comparability across all clinical and research applications. This review addresses major issues relevant to assay variability and describes recent activities by the US centers for Disease control and Prevention （cDc） to improve assay performance. currently, high degrees of accuracy and precision are not always met for testosterone and estradiol measurements; although technologies for steroid hormone measurement have advanced significantly, measurement variability within and across laboratories has not improved accordingly. Differences in calibration and specificity are discussed as sources of variability in measurement accuracy. Ultimately, a combination of factors appears to cause inaccuracy of steroid hormone measurements, with nonuniform assay calibration and lack of specificity being two major contributors to assay variability. Within-assay variability for current assays is generally high, especially at low analyte concentrations. The cDc Hormone Standardization （HoSt） Program is improving clinical assays, as evidenced by a 50% decline in mean absolute bias between mass spectrometry assays and the cDc reference method from 2007 to 2011. This program provides the measurement traceability to cDc reference methods and helps to minimize factors affecting measurement variability.

关键词： cDc hormone standardization cDc HoSt estradiol steroid hormone testing testosterone

Slowed driving-reaction time following concussion-symptom resolution

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Journal of Sport and Health Science 2021年第2期10卷 145-153页

作者： Landon B.Lempke Robert c.Lynall Nicole L.Hoffman Hannes Devos julianne D.Schmidt UGA concussion Research Laboratory Department of KinesiologyUniversity of GeorgiaAthensGA 30602USA School of Kinesiology and Recreation Illinois State UniversityNormalIL 61790USA Laboratory for Advanced Rehabilitation Research in Simulation Department of Physical Therapy and Rehabilitation ScienceUniversity of Kansas Medical CenterKansas CityKS 66160USA

Background:concussed patients have impaired reaction time(RT)and cognition following injury that may linger and impair driving *** research has used direct methods to assess driving-RT *** study compared driving RT during simulated scenarios between concussed and control individuals and examined driving-RT’s relationship with traditional computerized neurocognitive testing(cNT)***:We employed a cross-sectional study among 14 concussed(15.9±9.8 days post-concussion,mean±SD)individuals and 14 healthy controls matched for age,sex,and driving *** completed a driving simulator and cNT(cNS vital Signs)assessment within 48 h of symptom resolution.A driving-RT composite(ms)was derived from 3 simulated driving scenarios:stoplight(green to yellow),evasion(avoiding approaching vehicle),and pedestrian(person running in front of vehicle).The cNT domains included verbal and visual memory;cNT-RT(simple-,complex-,Stroop-RT individually);simple and complex attention;motor,psychomotor,and processing speed;executive function;and cognitive *** t tests and Hedge d effect sizes assessed driving-RT differences between groups,Pearson correlations(r)examined driving RT and cNT domain relationships among cohorts separately,and p values were controlled for false discovery rate via Benjamini-Hochberg procedures(a=0.05).Results:concussed participants demonstrated slower driving-RT composite scores than controls(mean difference=292.86 ms;95%confidence interval(95%cI):70.18515.54;p=0.023;d=0.992).Evasion-RT(p=0.054;d=0.806),pedestrian-RT(p=0.258;d=0.312),and stoplight-RT(p=0.292;d=0.585)outcomes were not statistically significant after false-discovery rate corrections but demonstrated medium to large effect sizes for concussed *** concussed individuals,driving-RT outcomes did not significantly correlate with cNT domains(r-range:0.51 to 0.55;p>0.05).No correlations existed between driving-RT outcomes a

关键词： Mild traumatic brain injury Motor vehicle Neurocognitive function Response time Return to driving

Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

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World Journal of cardiology 2023年第5期15卷 262-272页

作者： julianne Theresa Nelson Longjian Liu Department of Epidemiology and Biostatistics Dornsife School of Public HealthDrexel UniversityPhiladelphiaPA 19104United States

BAcKGROUND A limited number of studies have been conducted to test the magnitudes of the association between apparent treatment resistant hypertension(aTRH)and risk of cardiovascular disease(cvD).AIM To investigate the association between aTRH and risk of cvD and examine whether sex and age modify this *** We applied an observational analysis study design using data from the United States Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial(ALLHAT).ALLHAT recruited participants(n=25516)from 625 primary care settings throughout the United States,canada,Puerto Rico,and United States virgin Islands,aged 55 and older with hypertension and at least one additional risk factor for heart *** was assessed from the year 2 *** event was defined as one of the following from the year 2 follow-up visit:Fatal or non-fatal myocardial infarction,coronary revascularization,angina,stroke,heart failure,or peripheral artery *** proportional hazards regression was used to examine the effect of aTRH on cvD *** modifications of sex and age on this association were examined on the multiplicative scale by interaction term and additive scale by joint effects and relative excess risk for *** Of the total study participants(n=25516),5030 experienced a cvD event during a mean of 4.7 years *** was associated with a 30%increase in risk of cvD compared to non-aTRH[hazards ratio(HR)=1.3,95%cI:1.19-1.42].Sex and age modified this relationship on both multiplicative and additive scales *** by sex,aTRH was associated with a 64%increase in risk of cvD(HR=1.64,95%cI:1.43–1.88)in women,and a 13%increase in risk of cvD(HR=1.13,95%cI:1.01–1.27)in *** by age,aTRH had a stronger impact on the risk of cvD in participants agedcI:1.32–1.77)than it did in those aged≥65(HR=1.18,95%cI:1.05–1.32).Significant two-way interactions of sex and aTRH,and age and aTRH on risk of

关键词： Apparent treatment resistant hypertension cardiovascular disease outcomes chronic kidney disease Sex Age

Gut microbiome and pancreatic cancer cachexia:An evolving relationship

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World Journal of Gastrointestinal Oncology 2022年第7期14卷 1218-1226页

作者： Andrew Hendifar Rasaq Akinsola Hayato Muranaka Arsen Osipov Shant Thomassian Natalie Moshayedi julianne Yang Jonathan Jacobs Suzanne Devkota Neil Bhowmick Jun Gong Department of Medicine Division of Hematology and OncologyCedars-Sinai Medical CenterLos AngelesCA 90048United States The vatche and Tamar Manoukian Division of Digestive Diseases Department of MedicineUniversity of CaliforniaLos AngelesCA 90095United States Department of Medicine David Geffen School of Medicine at UCLAUniversity of CaliforniaLos AngelesLos AngelesCA 90095United States cedars-Sinai Medical center Department of MedicineInflammatory Bowel and Immunobiology Research InstituteUniversity of CaliforniaLos AngelesCA 90048United States

Nearly 80% of patients with pancreatic ductal adenocarcinoma(PDAc)develop cachexia along their disease *** is characterized by progressive weight loss,muscle wasting,and systemic inflammation and has been linked to poorer outcomes and impairments in quality of *** of PDAc cachexia has historically involved a multidisciplinary effort comprised of nutritional support,pancreatic enzyme replacement therapy,and/or pharmacologic *** current interventions to mitigate PDAc cachexia,a significant proportion of patients continue to die from complications associated with cachexia underscoring the need for novel insights and treatments for this *** highlight the feasibility and effectiveness of a recent enteral feeding prospective trial at our institution to improve cachexia outcomes in patients with advanced ***,we were among the first to characterize the stool microbiome composition in patients with advanced PDAc receiving enteral feeding for the treatment of *** insights into the relationship between enteral nutritional support,cachexia,and the gut microbiome are *** promising results are discussed in the context of a potential ability to modulate the stool microbiome as a new interventional strategy to mitigate PDAc cachexia.

关键词： Gut microbiome Pancreatic cancer Stool cachexia Inflammation Weight

comparison of Two Protocols of Agar Gel Immunodiffusion(AGID)Used to Diagnose of Equine Infectious Anemia(EIA)

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Open Journal of veterinary Medicine 2015年第7期5卷 169-174页

作者： Maria do Rosario Oliveira da cunha Beltrao cid Aristoteles de Siqueira Alencar Adriana Soares Leite Leonardo Tavares Freitas julianne cortizo Gonzalez vania Lucia de Assis santana Helio cordeiro Manso-Filho Department of veterinary Medicine Federal Rural University of PernambucoRecifeBrazil National Animal and Plant Laboratory Ministry of AgricultureLivestock and Food SupplyRecifeBrazil

The aim of the present study was to compare two protocols of Agar Gel Immunodiffusion (AGID) that can be used to diagnose Equine Infectious Anemia (EIA). Different volumes of reagents and support for agar gel were used, as recommended by the Ministry of Agriculture, Livestock and Food Supply (MAPA) and the World Organization for Animal Health (OIE). Equidae sera samples (n = 1000) were tested using a national commercial kit and different volumes (i.e. 25 μL—MAPA and 50 μL—OIE) of reagents and standard sera. Antigen was used as recommended by MAPA. The results were assessed by two operators, 48 hours after beginning the test. At the end of the experiment, a Kappa index of 1 was obtained by the operators, for the interpretation of the results and for the different volumes of reagents used. Similar results of agreement (Kappa index = 1) were obtained when using slides or Petri dishes as support for the agar gel. In both cases, an almost perfect agreement was achieved, suggesting that the use of different supports does not affect the results. These findings indicate that both protocols (MAPA and OIE) can be used to diagnose EIA.

关键词： Horses Equids EIA Diagnosis AGID Serology