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The Global Role of Kidney Transplantation

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肾脏病与透析肾移植杂志 2012年第1期21卷 1-7页

作者： Guillermo garcia garcia Paul Harden Jeremy Chapman Nephrology Service Hospital Civil de GuadalajaraUniversity of Guadalajara Health Sciences Center (CUCS)Hospital 278GuadalajaraJal.44280MEXICO Oxford Kidney Unit and Oxford Transplant Centre Churchill HospitalOxfordUnited Kingdom Centre for Transplant and Renal Research Westmead Millennium InstituteSydney UniversityWestmead HospitalSydneyNSW2145Australia

World Kidney Day on March 8th 2012 provides a chance to reflect on the success of kidney transplantation as a therapy for end stage kidney disease that surpasses dialysis treatments both for the quality and quantity of life that it provides and for its cost *** that is both cheaper and better,but is not actually the dominant therapy,must have other drawbacks that prevent replacement of all dialysis treatment by *** barriers to universal transplantation as the therapy for end stage kidney disease include the economic limitations which,in some countries place transplantation,appropriately,at a lower priority than public health fundamentals such as clean water,sanitation and *** in high income countries the technical challenges of surgery and the consequences of immunosuppression restrict the number of suitable recipients,but the major finite restrictions on kidney transplantation rates are the shortage of donated organs and the limited medical,surgical and nursing workforces with the required *** problems have solutions which involve the full range of societal,professional,governmental and political *** Kidney Day is a call to deliver transplantation therapy to the one million people a year who have a right to benefit.

关键词：肾脏病肾移植症状临床研究

Understanding the immune response and the current landscape of immunotherapy in pancreatic cancer

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World Journal of Gastroenterology 2021年第40期27卷 6775-6793页

作者： Lorena Ostios-garcia Julia Villamayor Esther garcia-Lorenzo David Vinal Jaime Feliu Department of Oncology La Paz University HospitalIDIPAZCIBERONCCátedra UAMAMGENMadrid 28046Spain

Pancreatic ductal adenocarcinoma(PDAC)is an aggressive tumor with high *** with surgery,radiotherapy,chemotherapy,and other locoregional or systemic therapies,the survival rates for PDAC are low and have not significantly changed in the past *** special characteristics of the PDAC’s microenvironment and its complex immune escape mechanism need to be considered when designing novel therapeutic approaches in this *** is characterized by chronic inflammation with a high rate of tumor-associated macrophages and myeloid-derived suppressor cells and a low rate of natural killer and effector T *** pancreatic microenvironment is a fibrotic,microvascularized stroma that isolates the tumor from systemic ***,a novel approach that has demonstrated effectiveness in certain solid tumors,has failed to show any practice-changing results in pancreatic cancer,with the exception of PDACs with mismatch repair deficiency and high tumor mutational burden,which show prolonged survival rates with ***,numerous clinical trials are attempting to assess the efficacy of immunotherapeutic strategies in PDAC,including immune checkpoint inhibitors,cancer vaccines,and adoptive cell transfer,alone or in combination with other immunotherapeutic agents,chemoradiotherapy,and other targeted therapies.A deep understanding of the immune response will help in the development of new therapeutic strategies leading to improved clinical outcomes for patients with PDAC.

关键词： Pancreatic cancer Immunity Immune evasion Tumor microenvironment Immunotherapy Cancer vaccines

A SHORT NOTE ABOUT EXPOSED POINTS IN REAL BANACH SPACES

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Acta Mathematica Scientia 2008年第4期28卷 797-800页

作者： Antonio Aizpuru Francisco J garcia-Pacheco Departamento de Matemá ticas Universidad de Cá diz Department of Mathematical Sciences Kent State University

We express the set of exposed points in terms of rotund points and non-smooth *** long as we have Banach spaces each time＂bigger＂,we consider sets of non-smooth points each time＂smaller＂.

关键词： Exposed point exposed face rotund point smooth point

Can plasticity make spatial structure irrelevant in individual-tree models?

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Forestry Studies in China 2014年第3期16卷 134-146页

作者： Oscar garcia University of Northern British Columbia 3333 University WayV2N 4Z9 Prince GeorgeBCCanada

Background： Distance-dependent individual-tree models have commonly been found to add little predictive power to that of distance-independent ones. One possible reason is plasticity, the ability of trees to lean and to alter crown and root development to better occupy available growing space. Being able to redeploy foliage （and roots） into canopy gaps and less contested areas can diminish the importance of stem ground locations. Methods： Plasticity was simulated for 3 intensively measured forest stands, to see to what extent and under what conditions the allocation of resources （e.g., light） to the individual trees depended on their ground coordinates. The data came from 50 x 60 m stem-mapped plots in natural monospecific stands of jack pine, trembling aspen and black spruce from central Canada. Explicit perfect-plasticity equations were derived for tessellation-type models. Results： Qualitatively similar simulation results were obtained under a variety of modelling assumptions. The effects of plasticity varied somewhat with stand uniformity and with assumed plasticity limits and other factors. Stand-level implications for canopy depth, distribution modelling and total productivity were examined. Conclusions： Generally, under what seem like conservative maximum plasticity constraints, spatial structure accounted for less than 10% of the variance in resource allocation. The perfect-plasticity equations approximated well the simulation results from tessellation models, but not those from models with less extreme competition asymmetry Whole-stand perfect plasticity approximations seem an attractive alternative to individual-tree models.

关键词： Growth and yield Competition Perfect plasticity approximation (PPA) siplab

Normozoospermic versus teratozoospermic domestic cats： differential testicular volume, sperm morphometry, and subpopulation structure during epididymal maturation

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Asian Journal of Andrology 2016年第6期18卷 871-878页

作者： Miguel Angel Gutierrez-Reinoso Manuel garcia-Herreros National Secretariat of Higher Education Science Technology and Innovation (SENESCYT) Quito Ecuador

Teratozoospermia （〈40% morphologically normal spermatozoa/ejaculate） is a frequent phenomenon in feline species. This research was carried out to study the possible differences in testicular volume, differential sperm morphometric traits, and potential differences regarding the sperm subpopulational structure during epididymal sperm maturation in teratozoospermic feline donors. Epididymal sperm samples were collected from the caput （R1）, corpus （R2）, and cauda （R3） epididymidis in two donor groups （N： normozoospermic; T： teratozoospermic）. Aliquots were assessed for concentration, viability, motility, and acrosomal integrity. Sperm morphometric descriptors from CASA-Morph analysis were analyzed by the Principal Component Analysis （PCA） and clustering analyses. Irrespective of the group analyzed, PCA revealed two Principal Components （PCs） for each epididymal region explaining more than the 93% of the variance. Surprisingly, the number of subpopulations remained constant in regions R1-R2-R3 irrespective of the donor group analyzed. However, the distribution of these subpopulations was found to be structurally different and strongly influenced by the epididymal region and the donor group. In conclusion, testicular morphometry and the sperm subpopulation structure were different in N and T donors. The alterations in subpopulations during epididymal maturation could be used as a potential clinical indicator of teratozoospermic individuals since an important influence of teratozoospermia on sperm subpopulation structure has been demonstrated.

关键词： epididymis feline sperm morphometry sperm subpopulations teratozoospermia testicular volume

A simulation approach: Miscible carbon dioxide injection in a carbonate reservoir

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Petroleum Science 2010年第2期7卷 257-262页

作者： Ehsan Heidaryan Jamshid Moghadasi Marylena garcia Quijada Faculty of Energy Kermanshah University of Technology Petroleum Engineering Department Petroleum University of Technology Texas A&M University College Station Texas USA

The purpose of this study is to optimize the existing carbon dioxide （CO2） flood in deep dolomite formations by improving oil sweep efficiency of miscible CO2 floods and enhancing the conformance control. A full compositional simulation model using a detailed geologic characterization was built to optimize the injection pattern. The model is a quarter of an inverted nine-spot and covers 20 acres of field formation. Geologic description was used to construct the simulation grids. The simulation layers represent actual flow units and resemble the large variation of reservoir properties. History match was performed to validate the model. Several sensitivity runs were made to improve the CO2 sweep efficiency and increase the oil recovery. Finally, the optimum CO2 injection rate for dolomite formations was determined approximately. Simulation results also indicate that a water-alternating-gas （WAG） ratio of 1：1 along with an ultimate CO2 slug of 100% hydrocarbon pore volume （HCPV） will allow an incremental oil recovery of 18%. The additional recovery increases to 34% if a polymer is injected as a conformance control agent during the course of the WAG process at a ratio of 1：1. According to the results, a pattern reconfiguration change from the nine spot to staggered line drive would represent an incremental oil recovery of 26%.

关键词： Miscible injection carbon dioxide dolomite formation water-alternating-gas

Phenotypic variation in food utilization in an outbreak insect herbivore

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Insect Science 2018年第3期25卷 467-474页

作者： Roberto Quezada-garcia Alvaro Fuentealba Eric Bauce Faculté de Foresterie Géographie et Géomafique Département des Sciences du Bois et de la Forêt Centre d'Etude de la Forêt (CEF) Universite Laval Quebec City Quebec Canada

The effects of nutrition may have subtantial impact on insect evolution by shaping different components of phenotypes. The key to undestanding this evolutionary process is to know how nutritional condition affects additive and nonadditive components of the phenotype. However, this is poorly understood in outbreaking insects. We investigated the additive and nonadditive variation present in food utilization traits in spruce budworm individuals subjected to chronic nutritional stress. A total of 160 full-sib families of spruce budworm （Choristoneurafumiferana Clem.） were raised under laboratory condi- tions, feeding on 2 diets （high and low energy） during 3 generations. Variables tested were pupal mass, consumption rate （RCR）, growth rate （RGR）, approximate digestibility （AD）, the efficiency of conversion of digested food （ECD） and the efficiency of conversion of ingested food （ECI）. Our results show that all traits tested presented a high percentage of nonadditive effects that modulate phenotype expression. We found a significant impact of family × diet interaction on pupal mass, RGR and ECD. Furthermore, these traits exhib- ited the greatest heritability. There was no evidence of presence of maternal effects. The results revealed that food utilization traits may evolve through epigenetics effects, such as phenotypic plasticity. This information can be used by modellers to improve forecast of spruce budworm population dynamics.

关键词： food utilization nutritional stress phenotypic plasticity spruce budworm

Human condition monitoring in hazardous locations using pervasive RFID sensor tags and energy-efficient wireless networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 674-688页

作者： Javier G.ESCRIBANO Andrés garcia Autolog Group Industrial Engineering SchoolUniversity of Castilla-La ManchaAvda.Camilo José Cela s/n13071 Ciudad RealSpain

Tracking persons in dangerous situations as well as monitoring their physical condition, is often crucial for their safety. The systems commonly used for this purpose do not include individual monitoring or are too expensive and intrusive to be deployed in common situations. In this project, a mobile system based on energy-efficient wireless sensor networks (WSNs) and active radio frequency identification (RFID) has been developed to achieve ubiquitous positioning and monitoring of people in hazardous situations. The system designed can identify each individual, locate him/her, send data regarding their physical situation, and ascertain whether they are located in a confined space. A new algorithm called time division double beacon scheduling (TDDBS) has been implemented to increase operation time and data transmission rate of the nodes in the system. The results show that the use of this system allows us to find the location and state of a person, as well as to provide an analysis of the potential risks at each moment, in real time and in an energy-efficient way. In an emergency, the system also allows for quicker intervention, as it not only provides the location and causes of the event, but also informs about the physical condition of the individual at that moment.

关键词： Active RFID Wireless sensor networks (WSNs) ZigBee Human monitoring Time division double beacon sched-uling (TDDBS)

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Current Zoology 2014年第3期60卷 373-380页

作者： Noelle FABRFE Eduardo garcia-GALEA Dolors VINYOLES Department of Animal Biology Faculty of Biology University of Barcelona Avda. Diagonal 643 08028 Barcelona CataloniaSpain

Boldness is defined as the tendency of an individual to take risks when exposed to novel objects or situations. The main aim of this work was to dilucidate if boldness was related to the development of the secondary sexual traits （SSTs） in the male of the fiver blenny Salariafluviatilis, a freshwater fish which takes care of eggs. As a second objective SSTs effect on pa rental status adoption was also be explored. Wild young fish were caught in the Segre River （Ebro basin） in November 2010. Fish were kept in five aquaria in groups of eight males and eight females with artificial nests. Boldness （boldness score and hesitancy） of males （initially with little SSTs development） was tested as the time required to exit a refuge when exposed to a new environ ment. Fish were mantained in the same aquaria for several months, and males＇ SSTs development and reproductive behaviour were monitored. Boldness score was negatively associated to cephalic crest development. Hesitancy was negatively related to male length and was also influenced by the interaction between male length and cephalic crest. Parental status acquisition was positively related to the male＇s length, marginally related to anal gland development, and nonrelated to cephalic crest. These re sults suggest an intrasexual role of the crest as an informative trait of boldness （honest signal） which might not necessarily be chosen by the females. It is also discussed that correlational selection could be responsible for linking boldness and growth rate in this species. Sexual selection, in addition to having directed the evolution of secondary sexual traits, might have favored certain personality traits （e.g. boldness） associated with the achievement of a larger body length .

关键词： Animal personality Behavioural syndromes Freshwater blenny Male reproductive success Shyness