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Traps and trumps from adjacent-to-tumor samples in gastric cancer research

Chinese Journal of Cancer Research 2018年第5期30卷 564-567页

作者： Paulo Pimentel de Assumpcao Andre Salim Khayat Taissa Maira Thomaz Araujo Williams fernandes Barra Geraldo Ishak Mine Maria Pereira Cruz Ramos Sidney Emanuel Batista dos santos Andrea Kely Campos Ribeiro dos santos Samia Demachki Paula Barauna de Assumpcao Danielle Queiroz Calcagno Ney Pereira Carneiro dos santos Monica Barauna de Assumpcao Fabiano Cordeiro Moreira Andre Mauricio Ribeiro dos santos Carolina Barauna de Assumpcao Gregory Joseph Riggins Rommel Mario Rodriguez Burbano Oncology Research Center Federal University of Para Belem 66075-110 Brazil PhD Program in Genetics and Molecular Biology Federal University of Para Belem 66075-110 Brazil Gastrointestinal Endoscopy Service Joao de Barros Barreto University Hospital Belem 66073-000 Brazil Department of Surgical Oncology Oswaldo Cruz Germany Hospital Sao Paulo 01327-001 Brazil Department of Neurosurgery Johns Hopkins University Baltimore 21287 USA Laboratory of Molecular Biology Ophir Loyola Hospital Belem 66060-281 Brazil

The search for cancer biomarkers is frequently based on comparisons between tumors and adjacent-to-tumor samples. However, even after histological confirmation of been free of cancer cells, these adjacent-to-tumor samples might harbor molecular alterations which are not sufficient to cause them to look like cancer, but can differentiate these cells from normal cells. When comparing them, potential biomarkers are missed, and mainly the opportunity of finding initial aberrations presents in both tumors and adjacent samples, but not in true normal samples from non-cancer patients, resulting in misinterpretations about the carcinogenic process. Nevertheless, collecting adjacent-to-tumor samples brings trumps to be explored. The addition of samples from non-cancer patients opens an opportunity to increase the finds of the molecular cascade of events in the carcinogenic process. Differences between normal samples and adjacent samples might represent the first steps of the carcinogenic process. Adding samples of non-cancer patients to the analysis of molecular alterations relevant to the carcinogenic process opens a new window of opporttmides to the discovery of cancer biomarkers and molecular targets.

关键词： Adjacent-to-tumor trumps traps

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Mercury in aquatic fauna contamination:A systematic review on its dynamics and potential health risks

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Journal of Environmental Sciences 2019年第10期31卷 205-218页

作者： Paloma de Almeida Rodrigues Rafaela Gomes Ferrari Luciano Neves dos santos Carlos Adam Conte Junior Molecular and Analytical Laboratory Center Department of Food TechnologyFaculty of VeterinaryUniversidade Federal FluminenseNiteróiBrazil Chemistry Institute Food Science ProgramUniversidade Federal do Rio de JaneiroRio de JaneiroBrazil National Institute of Health Quality Control Fundacaeo Oswaldo CruzRio de JaneiroBrazil Laboratory of Theoretical and Applied Ichthyology Department of Ecology and Marine ResourcesUniversidade Federal do Estado do Rio de JaneiroRio de JaneiroBrazil

Mercury is an important pollutant,released into aquatic ecosystems both naturally and by anthropogenic *** element is transferred to aquatic organisms in different ways,causing potential health *** addition,mercury can be accumulated by humans,especially through the consumption of contaminated *** systematic review aims to present mercury pathways,the major routes through which this element reaches the aquatic environment and its transformations until becoming available to living animals,leading to bioaccumulation and biomagnification *** key biotic and abiotic factors affecting such processes,the impact of mercury on animal and human health and the issue of seafood consumption as a source of chronic mercury contamination are also addressed.A total of 101 articles were retrieved from a standardized search on three databases(PubMed,Emabse,and Web of Science),in addition to 28 other studies not found on these databases but considered fundamental to this review(totaling 129 articles).Both biotic and abiotic factors display fundamental importance in mediating mercurial dynamics,i.e.,muscle tropism,and salinity,***,mercurial contamination in aquatic environments affects animal health,especially the risk of extinction species and also on human health,with methylmercury the main mercury species responsible for acute and chronic symptomatology.

关键词： Mercury levels Seafood Methylmercury Public health Aquatic environment

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Hybrid Triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting:A Review

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Nano-Micro Letters 2021年第12期13卷 163-220页

作者： Joao V.Vidal Vladislav Slabov Andrei L.Kholkin Marco P.Soares dos santos Department of Physics and CICECO-Aveiro Institute of Materials University of Aveiro3810-193 AveiroPortugal Department of Physics and I3N University of Aveiro3810-193 AveiroPortugal Laboratory of Functional Low-Dimensional Structures National University of Science and Technology MISISMoscowRussia Department of Mechanical Engineering Centre for Mechanical Technology and Automation(TEMA)University of Aveiro3810-193 AveiroPortugal

Motion-driven electromagnetictriboelectric energy generators(E-TENGs) hold a Hybrid triboelectric-electromagnetic generators C A Bgreat potential to provide higher voltages,higher currents and wider operating bandwidths than Cantilever generators1 μm both electromagnetic and triboelectric generators Rotating generatorsSliding generators standing alone. Therefore,they are promising solutions to autonomously supply a broad range of Flexible blade generators Magnetoelectric highly sophisticated devices. This paper provides generators a thorough review focused on major recent breakLinear generators Multidimensional generators throughs in the area of electromagnetic-triboelectric vibrational energy harvesting. A detailed Pendulum generators analysis was conducted on various architectures including rotational,pendulum,linear,sliding,cantilever,flexible blade,multidimensional and 1 cm magnetoelectric,and the following hybrid technologies. They enable highly e cient ways to harvest electric energy from many forms of vibrational,rotational,biomechanical,wave,wind and thermal sources,among others. Open-circuit voltages up to 75 V,short-circuit currents up to 60 mA and instantaneous power up to 144 mW were already achieved by these nanogenerators. Their transduction mechanisms,including proposed models to make intelligible the involved physical phenomena,are also overviewed here. A comprehensive analysis was performed to compare their respective construction designs,external excitations and electric outputs. The results highlight the potential of hybrid E-TENGs to convert unused mechanical motion into electric energy for both large-and small-scale ***,this paper proposes future research directions toward optimization of energy conversion e ciency,power management,durability and stability,packaging,energy storage,operation input,research of transduction mechanisms,quantitative standardization,system integration,miniaturization and multi-energy hybrid cells.

关键词： E-TENG Hybrid triboelectric-electromagnetic Nanogenerators Energy harvesting

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Autophagy, apoptosis and organelle features during cell exposure to cadmiumč

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BIOCELL 2013年第2期37卷 45-54页

作者： CRISTIANE dos santos VERGILIO EDÉSIO JOSÉTENÓRIO DE MELO Universidade Estadual do Norte Fluminense Centro de Biociências e BiotecnologiaLaboratório de Biologia Celular e TecidualCampos dos GoytacazesRJBrasil28013-602.

Cadmium(Cd)induces several effects in different tissues,but our knowledge of the toxic effects on organelles is insuffi *** observe the progression of Cd effects on organelle structure and function,HuH-7 cells(human hepatic carcinoma cell line)were exposed to CdCl2 in increasing concentrations(1μM–20μM)and exposure times(2 h–24 h).During Cd treatment,the cells exhibited a progressive decrease in viability that was both time-and *** treated cells displayed progressive morphological changes that included cytoplasm retraction and nuclear condensation preceding a total loss of cell *** with 10μM for 12 h led to irreversible *** these drastic and irreparable damages,treated cells(5μM for 12 h)presented a progressive loss of mitochondrial function and cytoplasm acidifi cation as well as dysfunction and disorganization of microfi laments and endoplasmic *** damages led to the induction of apoptotic events and an increase in autophagic bodies in the *** results revealed that Cd affects multiple intra-cellular targets that induce alterations in the mitochondria,cytoskeleton,endoplasmic reticulum and acidic compartments,ultimately culminating in cell death via apoptotic and autophagic pathways.

关键词： Cd cell death hepatocyte HuH-7 cells mitochondria

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Bioactive extracts of red seaweeds Pterocladiella capillacea and Osmundaria obtusiloba(Floridophyceae:Rhodophyta) with antioxidant and bacterial agglutination potential

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 363-370页

作者： Daniel Barroso de Alencar Fátima Cristiane Teles de Carvalho Rosa Helena Rebouas Daniel Rodrigues dos santos Kelma Maria dos santos Pires-Cavalcante Rebeca Larangeira de Lima Bárbara Mendes Baracho Rayssa Mendes Bezerra Francisco Arnaldo Viana Regine Helena Silva dos fernandes Vieira Alexandre Holanda Sampaio Oscarina Viana de Sousa Silvana Saker-Sampaio Laboratrio de Produtos Naturais Marinhos.Departamento de Engenharia de Pesca Universidade Federal do Ceará.Campus do Pici.Ar.Mister Hull.s/nCaixa Postal 6043 Laboratrio de Microbiologia Ambiental e do Pescado.Instituto de Ciências do Mar.Universidade Federal do Ceará.Av.da Abolicao 3207 Laboratrio de Microbiologia Ambiental e do Pescado.Instituto de Ciências do Mar.Universidade Federal do Ceará Laboratrio de Produtos Naturais Marinhos.Departamento de Engenharia de Pesca Universidade Federal do Ceará Laboratrio de Cromatografia Departamento de QuimicaUniversidade do Estado do Rio Grande do NorteCampus Universitário Central

Objective:To evaluate the antioxidant,antibacterial and bacterial cell agglutination activities of the hexane(Hex) and 70%ethanol(70%EtOH) extracts of two species of red seaweeds Pterocladiella capillacea(***) and Osmundaria ***:In vitro antioxidant activity was determined by DPPH radical scavenging assay,ferric-reducing antioxidant power assay,ferrous ion chelating assay,β-carotene bleaching assay and total phenolic content *** activity was tested using the method of disc diffusion on Mueller-Hinton *** ability of algal extracts to agglutinate bacterial cells was also ***:The 70%EtOH extract of the two algae showed the highest values of total phenolic content compared to the Hex *** results of DPPH for both extracts(Hex,70%EtOH) of Osmundaria obtusiloba(43.46%and 99.47%) were higher than those of ***(33.04%and 40.81%) at a concentration of 1 000 μg/*** for the ferrous ion chelating,there was an opposite behavior,extracts of *** had a higher *** extracts showed a low ferric-reducing antioxidant power,with optical density ranging from0.054 to *** activities of all extracts evaluated for β-carotene bleaching were above 40%.There was no antibacterial activity against bacterial strains ***,the extracts of both species were able to agglutinate bacterial Gram positive cells of Staphylococcus aureus and Gram negative cells of Escherichia coli,multidrug-resistant Salmonella and Vibrio *** This is the first report of the interaction between these algal extracts,rich in natural compounds with antioxidant potential,and Gram positive and Gram negative bacterial cells.

关键词： Bioactive compounds Antioxidant Bacterial agglutination Rhodophyta

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Inosine: a novel treatment for sciatic nerve injury

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Neural Regeneration Research 2021年第1期16卷 127-128页

作者： Fellipe Soares dos santos Cardoso Ana Maria Blanco Martinez Fernanda Martins de Almeida Laboratório de Neurodegeneração e Reparo–Departamento de Anatomia Patológica–Hospital Universitário Clementino Fraga Filho HUCFF/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil Instituto de Ciências Biomédicas–ICB/Universidade Federal do Rio de Janeiro Rio de JaneiroBrazil

Trauma to the peripheral nervous system often results in loss of motor and sensory functions of the affected area of the body,leading to a series of functional impairments(Allodi et al.,2012).Injuries to peripheral nerves initiate a series of complex events,known as Wallerian degeneration,which allows the injured axons to regenerate and reinnervate their targets(Allodi et al.,2012).Damage to a nerve induces multiple alterations,which include:axonal degeneration,breakdown of myelin sheath,Schwann cells(SC)proliferation and conversion to a repair phenotype which express cytokines and chemokines that allow the infiltration and activation of macrophages(Mietto et al.,2015;Jessen and Mirsky,2016).

关键词： al. degeneration alterations

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Recovery of polyphenols from camu-camu(Myrciaria dubia ***)depulping residue by cloud point extraction

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Chinese Journal of Chemical Engineering 2018年第12期26卷 2471-2476页

作者： Carlos Eduardo de Araujo Padilha juliana Chris Silva de Azevedo Francisco Caninde de Sousa Junior Sergio Dantas de Oliveira Junior Domingos Fabiano de Santana Souza Jackson Araujo de Oliveira Gorete Ribeiro de Macedo Everaldo Silvino dos santos Laboratory of Biochemical Engineering Chemical Engineering Department Federal University of Rio Grande do Notre(UFRN)NatalRNBrazil Laboratory of Food Bioactive Compounds and Dairy Technology Chemical Engineering DepartmentFederal University of Rio Grande do Notre(UFRN)NatalRNBrazil

In this study the potential of cloud point extraction formed by a non-ionic surfactant was used in order to separate polyphenols from industrial residues of camu-camu. The effects of operational conditions of the cloud point extraction(CPE) on the polyphenol recovery and volumetric ratio were investigated. The results showed a maximum recovery of 95.71% that was obtained using 7.0 wt% Triton X-114, native pH(3.25), and 80 wt%polyphenol extract at 30 °C. The use of cloud point extraction was successful to recover the polyphenols from agroindustrial residue since it is a simple as well as of low-cost technique.

关键词： Cloud point extraction Recovery Polyphenols Camu-camu Depulping residue

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Challenges in Implementing DVI Best Practice Guidelines Due to the Brumadinho Disaster

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Forensic Medicine and Anatomy Research 2024年第1期12卷 1-12页

作者： Reinaldo Moreira Silva Bruno Diniz Sander Morais Carlos Danilo Ruas Silva Elza Cristina Lopes de Oliveira Fernando Pereira Macedo Giovanni Vitral Pinto Guadalupe Dell’Arret Coutinho Higgor Gonçalves Dornelas João Luiz Silva Moreira Laila Evangelista de Almeida fernandes Marcia Lobão Iannini Patrícia Siqueira Valéria Rosalina Dias e santos Sordaini Maria Caligiorne Instituto de Criminalística Polícia Civil de Minas Gerais Belo Horizonte Brazil

The broke of a tailings dam from Vale S.A. destroyed a gigantic area killing 270 persons in Brumadinho/Brazil. Organizing activities after a mass disaster is a complex process that requires the involvement of many people and resources in the laboratory. To DNA identification of the victims, a daunting work had to be made by DNA laboratory staff in a collaborative effort with many partners. Efforts to implement good practice guidelines in Disaster Victim Identification (DVI) have revealed several important aspects that need to change in the forensic DNA laboratory. This article highlights the challenges of implementing DVI best practice guidelines in resource-poor settings, but with professionals from different sectors engaged in the same goal of briefly identifying victims and helping families and society.

关键词： Disaster Victim Identification DNA Brumadinho

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Study about Top-Down and Bottom-Up Controls in Regulating the Phytoplankton Biomass in a Eutrophic Reservoir in Northeastern Brazil

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Journal of Water Resource and Protection 2012年第8期4卷 616-621页

作者： juliana dos santos Severiano Ariadne do Nascimento Moura Enaide Marinho de Melo Magalhaes Viviane Lucia dos santos Almeida Graduating Program on Botany Rural and Federal University of PernambucoRecifeBrasil Federal University of Alagoas Institute of Biological Sciences and Health—IBSHMaceioBrasil Department of the Environment Prefecture of RecifeOlindaBrasil

This study aims to analyze the effects of nutrients and predation by zooplankton on phytoplankton biomass (chlorophyll a) in a eutrophic reservoir in Brazil (Apipucos Reservoir, State of Pernambuco), through experiments in microcosms. For this, samples of water were placed in 1 L Erlenmeyer flasks and kept for seven days. Treatments included the addition of nutrients (nitrogen combined with phosphorus and isolated additions of nitrogen and phosphorus), with presence and absence of zooplankton and a control which contained the reservoir water without any manipulation. The addition of nutrients did not stimulate phytoplankton growth. However, zooplankton significantly decreased phytoplankton biomass in the treatments it was added to (p < 0.05). The results of this study showed that for the reservoir studied, predation by zooplankton is the most significant factor in the regulation of phytoplankton, contradicting several studies which show that phytoplankton biomass is more strongly controlled by nutrients (bottom-up control) than by predation (top-down control).

关键词： Chlorophyll α Nutrients Zooplankton Tropical Regions

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Thermal Behavior of Sr（ll） and Ba（ll）-Diclofenac Complexes in Solid State： Study of the Dehydration and Thermal Decomposition

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Chinese Journal of Chemistry 2011年第11期29卷 2271-2277页

作者： Kobelnik, Marcelo Cassimiro, Douglas Lopes santos, Diogenesdos dos Ribeiro, Clovis Augusto Crespi, Marisa Spirandelic Centro Universitdrio do Norte Paulista-UNORP Rua Ipiranga 3460 Sao Jose do Rio Preto SP Brazil Instituto de Quimica Sao Paulo State University C.P. 355 14800-900 Araraquara SP Brazil

Solid state compounds of general formula Sr（Diclof）2 ·5.7H2O and Ba（Diclof）2·4.8H2O were obtained. Thermo- gravimetry （TG）, differential scanning calorimetry （DSC）, X-ray diffraction powder patterns and microscopy analysis were used to characterize these compounds. Details concerning the dehydration and thermal decomposition as well as data of kinetic parameters have been described here. The kinetic behaviors of these stages were evaluated from several heating rates with samples masses of 2 and 5 mg in open crucibles under a nitrogen atmosphere. The results of the present study improve the knowledge on these compounds including their dehydration and thermal stability. The obtained data depend on the mass of the sample which results in two kinetic behavior patterns.

关键词： diclofenac divalent metal ions thermal behavior kinetic parameters

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