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Clinical and radiographic features of Hutchinson-Gilford progeria syndrome: A case report

World Journal of Clinical Cases 2014年第3期2卷 67-71页

作者： Daniel Berretta Alves juliana melo silva Tatiany Oliveira Menezes Rosely Santos Cavaleiro Fabrício Mesquita Tuji Marcio Ajudarte Lopes Alexandre Augusto Zaia Ricardo Della Coletta Department of Radiology Esperanca Institute of Higher Learning Santarém-Pará 68040-100 Brazil Department of Endodontics Federal University of Pará Belém-Pará 66055-240 Brazil Department of Dentistry for Patients with Special Needs Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral and Maxillofacial Pathology Federal University of Pará Belém-Pará 66055-240 Brazil Department of Oral Diagnosis School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil Department of Restorative Dentistry School of Dentistry State University of Campinas Piracicaba-Sao Paulo 13083-970 Brazil

Hutchinson-Gilford progeria syndrome(HGPS) is a rare dysmorphic syndrome characterized by several features of premature aging with clinical involvement of the skin, bones, and cardiovascular system. HGPS has an estimated incidence of one in four million to one in eight million births. The main clinical features of HGPS include short stature, craniofacial dimorphism, alopecia, bone fragility, and cardiovascular disorders. The most frequent cause of death is myocardial infarction at a mean age of 13 years old. Dental manifestations include delayed development and eruption of teeth, discoloration, crowding and rotation of teeth, and displaced teeth. Cone beam computed tomography images revealed the absence of the sphenoid, frontal, and maxillary sinus, flattening of the condyles and glenoid fossa, and bilateral hypoplasia of the mandibular condyles. The disease is caused by mutations in lamin A/C(LMNA). Here, we present a case report of an 11-year-old boy with classical features of HGPS, which was caused by a de novo germ-line mutation(C1824T, G608G) in exon 11 of the LMNA gene. Some uncommon HGPS-associated features in our patient, such as alterations in the facial sinuses and hypoplasia of the condyles, contributed to the expansion of the phenotypic spectrum of this syndrome from a dentomaxillofacial perspective.

关键词： Cone beam computed tomography LMNA mutation Craniofacial anomalies Temporomandibular joint

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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla S.Sousa Andreia Monteiro António J.Salgado Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

Spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

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Secretome of polarized macrophages:potential for targeting inflammatory dynamics in spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro Susana Monteiro Nuno A.silva Life and Health Sciences Research Institute(ICVS) School of MedicineUniversity of MinhoBragaPortugal ICVS/3B’s Associate Lab PT Government Associated LabBraga/GuimaraesPortugal

Spinal cord injury(SCI)involves an initial traumatic phase,followed by secondary events such as ischemia,increased blood-spinal cord barrier permeability,ionic disruption,glutamate excitotoxicity,and metabolic alterations.A pe rsistent and exagge rated inflammato ry response within the spinal cord accompanies these events(Lima et al.,2022).The complexity and interplay of these mechanisms exacerbate the initial injury,leading to a degenerative process at the injury *** the initial trauma is unavoidable,the secondary injury begins within minutes and can last for months,creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

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t-SNE:A study on reducing the dimensionality of hyperspectral data for the regression problem of estimating oenological parameters

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Artificial Intelligence in Agriculture 2023年第1期7卷 58-68页

作者： Rui silva Pedro melo-Pinto CITAB-Centre for the Research and Technology of Agro-Environmental and Biological Sciences Inov4Agro-Institute for InnovationCapacity Building and Sustainability of Agri-Food ProductionUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal Departamento de Engenharias Escola de Ciências e TecnologiaUniversidade de Trás-os-Montes e Alto DouroQuinta dos PradosVila Real 5000-801Portugal

In recent years there is a growing importance in using machine learning techniques to improve procedures in precision agriculture:in this work we perform a study on models capable of predicting oenological parameters from hyperspectral images of wine grape berries,a specially relevant topic to boost production tasks for ***,we explore the capabilities of a novel technique mostly used for visualization,t-Distributed Stochastic Neighbor Embedding(t-SNE),for reducing the dimensionality of the highly complex hyperspectral data and compare its performance with Principal Component Analysis(PCA)method,which despite the introduction of many nonlinear dimensionality reduction techniques over the years,had achieved the best results for real-world data across several studies in *** we explore the potential of Kernel t-SNE,an extension to the t-SNE method that allows for the usage of the technique in streaming data or online *** results show that,in a direct comparison,t-SNE achieves better metrics than PCA for most of the data sets in this work and that the regressor(Support Vector Regression,SVR)performs better with the t-SNE reduced features as inputs,accomplishing better predictions with lower error *** the results with current literature,our shallow learning model paired with t-SNE achieves either better or on par results than those reported,even competing with more advanced models that use deep learning techniques,which should propel the introduction of t-SNE in more studies that require dimensionality reduction.

关键词： Hyperspectral images Dimensionality reduction Regression T-SNE Support vector machines Wine grape berries

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Innate and adaptive immune responses that control lymph-borne viruses in the draining lymph node

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Cellular & Molecular Immunology 2024年第9期21卷 999-1007页

作者： Carolina R.melo-silva Luis J.Sigal Department of Microbiology and Immunology Thomas Jefferson UniversityBluemle Life Sciences Building Room 709233 South 10th StreetPhiladelphiaPA19107USA

The interstitial fluids in tissues are constantly drained into the lymph nodes(LNs)as lymph through afferent lymphatic vessels and from LNs into the blood through efferent *** are strategically positioned and have the appropriate cellular composition to serve as sites of adaptive immune initiation against invading ***,for lymph-borne viruses,which disseminate from the entry site to other tissues through the lymphatic system,immune cells in the draining LN(dLN)also play critical roles in curbing systemic viral dissemination during primary and secondary ***-borne viruses in tissues can be transported to dLNs as free virions in the lymph or within infected *** of the entry mechanism,infected myeloid antigen-presenting cells,including various subtypes of dendritic cells,inflammatory monocytes,and macrophages,play a critical role in initiating the innate immune response within the *** innate immune response involves cellular crosstalk between infected and bystander innate immune cells that ultimately produce type I interferons(IFN-Is)and other cytokines and recruit inflammatory monocytes and natural killer(NK)***-I and NK cell cytotoxicity can restrict systemic viral spread during primary infections and prevent serious ***,the memory CD8+T-cells that reside or rapidly migrate to the dLN can contribute to disease prevention during secondary viral *** review explores the intricate innate immune responses orchestrated within dLNs that contain primary viral infections and the role of memory CD8+T-cells following secondary infection or CD8+T-cell vaccination.

关键词： Virus infection lymph borne virus lymph node virus control innate immunity adaptive immunity dendritic cells Langerhans cells macrophages inflammatory monocytes natural killer cells CD8+T-cells

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Mechanical stimulation devices formechanobiology studies:a market,literature,and patents review

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Bio-Design and Manufacturing 2023年第3期6卷 340-371页

作者： F.melo-Fonseca O.Carvalho M.Gasik G.Miranda F.S.silva Center for MicroElectroMechanical Systems University of Minho(CMEMS-UMinho)Campus de Azurém4800-058 GuimarãesPortugal LABBELS–Associate Laboratory BragaGuimarãesPortugal International Iberian Nanotechnology Laboratory(INL) 4715-330 BragaPortugal School of Chemical Engineering Aalto University Foundation00076 EspooFinland Seqvera Ltd. HelsinkiFinland Department of Materials and Ceramic Engineering CICECOAveiro Institute of MaterialsUniversity of Aveiro3810-193 AveiroPortugal

Significant advancements in various research and technological fields have contributed to remarkable findings on the physiological dynamics of the human *** closely mimic the complex physiological environment,research has moved from two-dimensional(2D)culture systems to more sophisticated three-dimensional(3D)dynamic *** bioreactors or microfluidic-based culture models,cells are typically seeded on polymeric substrates or incorporated into 3D constructs which are mechanically stimulated to investigate cell response to mechanical stresses,such as tensile or *** review focuses on the working principles of mechanical stimulation devices currently available on the market or custom-built by research groups or protected by patents and highlights the main features still open to *** are the features which could be focused on to perform,in the future,more reliable and accurate mechanobiology studies.

关键词： Biomaterials Polymers Actuators Mechanical stress Mechanotransduction

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China as a Responsible Power Amid the COVID-19 Crisis:Perceptions of Partners and Adversaries on Twitter

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Fudan Journal of the Humanities and Social Sciences 2022年第2期15卷 159-188页

作者： Maria Papageorgiou Daniella da silva Nogueira de melo Department of Political Science and International Relations University of MinhoBragaPortugal

The challenging COVID-19 context has questioned China’s role as a responsible power but also tested its relationship with other *** study seeks to investigate‘How other actors have perceived China’s role as a responsible power amid the COVID-19 crisis’.To do so,we opt for a qualitative approach examining the official Twitter accounts of seven actors that hold different types of relationships with China,namely Brazil,EU,Japan,Iran,Pakistan,Russia,and the *** aim to identify the perceptions of these actors towards China as unfolding from January to June 2020,emphasising the empirical applicability of Twitter’s *** adopting the concept of responsible power approached from a Role Theory perspective,this paper contributes to a more nuanced understanding of interstate relations and role *** findings indicate that there have been variations in the responses and perceptions other states have expressed towards China while its framing as a responsible power differs significantly during the crisis and its landmark events.

关键词： China COVID-19 Twitter Role theory Responsible power

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Retention of eucalyptus harvest residues reduces soil compaction caused by deep subsoiling

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Journal of Forestry Research 2022年第2期33卷 643-651页

作者： Raphael Oliveira de melo AymbiréAngeletti da Fonseca Nairam Félix de Barros Raphael Bragança Alves Fernandes Rafael da silva Teixeira Iago Nery melo Ricardo Previdente Martins Soil Science Department Universidade Federal de ViçosaViçosaMinas GeraisBrazil BRACELL Company AlagoinhasBahiaBrazil

Eucalyptus harvesting,forwarding and soil tillage operations are among the main causes for compaction of forest soils,with potential impacts on *** concern is especially important in areas with soils that are naturally compacted(fragipans and duripans).In these soils,tillage operations include the use of subsoilers that can reach depths of more than one meter and require heavy tractors that exert high pressure on the *** of the ways to try to minimize the effect of this compaction is by retaining harvest *** objective of this study was to evaluate the impacts of eucalyptus harvesting on soil physical attributes,as well as to determine the potential of different types of residue management to reduce compaction from the soil tillage *** experiments were conducted in the same area with a Yellow *** the first experiment,compaction caused by mechanized harvesting with harvester+forwarder was *** the second experiment,different managements of harvest residues were examined as potential modifiers of soil compaction during tillage for new *** this,three managements systems were tested:(1)retention of all harvest residues and litter from the previous rotation(HR+L),(2)retention of litter from the previous rotation(L),and(3)removal of harvest residues and litter from the previous rotation(WR).Before and after harvest,sampling was carried out in the planting rows and inter-rows,and after tillage,samples were collected in the traffic line of the subsoiler-tractor *** both experiments,undisturbed soil samples were collected from the center of the 0-10,10-20,20-40,40-60,and 60-100 cm layers to determine soil density and total *** each period and site of evaluation,mechanical resistance to penetration up to the 60-cm depth was also *** harvesting operation increased soil density at 0-10 and 60-100 cm depths only in the *** of harvest residues and litter(HR+L)after harvesting avoi

关键词： Soil penetration resistance Harvester+forwarder Soil tillage Soil density Cohesive soils

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Pathogenesis and clinical management of arboviral diseases

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World Journal of Virology 2025年第1期14卷 9-50页

作者： Victoria Cenci Dietrich Juan Marcos Caram Costa Marina Maria Gomes Leite Oliveira Carlos Eduardo Oliveira Aguiar Luis Guilherme de Oliveira silva Marcel silva Luz Fabian Fellipe Bueno Lemos Fabrício Freire de melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

Arboviral diseases are viral infections transmitted to humans through the bites of arthropods,such as mosquitoes,often causing a variety of pathologies associated with high levels of morbidity and *** the past decades,these infections have proven to be a significant challenge to health systems worldwide,particularly following the considerable geographic expansion of the dengue virus(DENV)and its most recent outbreak in Latin America as well as the difficult-tocontrol outbreaks of yellow fever virus(YFV),chikungunya virus(CHIKV),and Zika virus(ZIKV),leaving behind a substantial portion of the population with complications related to these ***,the world is experiencing a period of intense globalization,which,combined with global warming,directly contributes to wider dissemination of arbovirus vectors across the ***,all continents remain on high alert for potential new ***,this review aims to provide a comprehensive understanding of the pathogenesis of the four main arboviruses today(DENV,ZIKV,YFV,and CHIKV)discussing their viral characteristics,immune responses,and mechanisms of viral evasion,as well as important clinical aspects for patient *** includes associated symptoms,laboratory tests,treatments,existing or developing vaccines and the main associated complications,thus integrating a broad historical,scientific and clinical approach.

关键词： Arboviruses Arbovirus infections Dengue Zika virus Yellow fever Chikungunya virus Clinical diagnosis Pathogenesis Flavivirus Togaviridae infections

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Neoarchean atmospheric chemistry and the preservation of S-MIF in sediments from the São Francisco Craton

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Geoscience Frontiers 2022年第5期13卷 207-226页

作者： Alice Bosco-Santos William Patrick Gilhooly Ⅲ Paola de melo-silva Fotios Fouskas Amaury Bouyon João Gabriel Motta Mauricio Rigoni Baldim Wendell Fabricio-silva Pascal Philippot Elson Paiva Oliveira Department of Geology and Natural Resources University of CampinasCampinasSP 13083855Brazil Department of Earth Sciences Indiana University-Purdue University IndianapolisIndianapolisINUSA Institut de Physique du Globe de Paris Universitéde ParisCNRS-UMR 715475005 Paris Cedex 05France Vizlab-X-Reality and GeoInformatics Lab UNISINOSSão LeopoldoRS 93022-750Brazil Geosciences Department Federal University of Mato GrossoCuiabáMTBrazil Geosciences Institute University of BrasiliaBrasíliaDistrito Federal 70910-900Brazil Institute of Geography and Geology University of Würzburg97074 WürzburgGermany Géosciences Montpellier Universitéde MontpellierCNRSUniversitédes AntillesMontpellierFrance Institute of Astronomy Geophysicsand Atmospheric SciencesUniversity of São PauloRua do Matão 1226São PauloBrazil

Sulfur mass-independent fractionation(S-MIF)preserved in Archean sedimentary pyrite is interpreted to reflect atmospheric *** ranges in Δ^(33)S that expanded into larger fractionations leading up to the Great Oxygenation Event(GOE;2.45–2.2 Ga)are disproportionately represented by sequences from the Kaapvaal and Pilbara *** patterns of S-MIF attenuation and enhancement may differ from the timing and magnitude of minor sulfur isotope fractionations reported from other cratons,thus obscuring local for global sulfur cycling *** expanding the Δ^(33)S record to include the relatively underrepresented São Francisco Craton in Brazil,we suggest that marine biogeochemistry affected S-MIF preservation prior to the *** an early Neoarchean sequence(2763–2730 Ma)from the Rio das Velhas Greenstone Belt,we propose that low δ^(13)Corg(<-30‰)and dampened Δ^(33)S(-0.4‰to-0.7‰)in banded iron formation reflect the marine diagenetic process of anaerobic methane *** overlying black shale(TOC up to 7.8%)with higher δ^(13)Corg(-33.4‰to-19.2‰)and expanded Δ^(33)S(2.3‰±0.8‰),recorded oxidative sulfur cycling that resulted in enhance preservation of S-MIF input from atmospheric sources of elemental *** sequence culminates in a metasandstone,where concomitant changes to more uniform δCorg(-30‰to--25‰),potentially associated with the RuBisCO I enzyme,and near-zero Δ^(33)S(-0.04‰to 0.38‰)is mainly interpreted as evidence for local oxygen *** placed in the context of other sequences worldwide,the Rio das Velhas helps differentiate the influences of global atmospheric chemistry and local marine diagenesis in Archean biogeochemical *** data suggest that prokaryotic sulfur,iron,and methane cycles might have an underestimated role in pre-GOE sulfur minor isotope records.

关键词： S-MIF preservation Archean atmospheric chemistry GOE São Francisco Craton

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