检索结果-南通市图书馆

From oral formulations to drug-eluting implants:using 3D and 4D printing to develop drug delivery systems and personalized medicine

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2022年第1期5卷 85-106页

作者： Niels G.A.Willemen Margaretha A.J.Morsink Devin Veerman Classius F.da Silva juliana C.Cardoso Eliana B.Souto Patrícia Severino Center for Biomedical Engineering Department of MedicineBrigham and Women&HospitalHarvard Medical School65 Landsdowne StreetMA 02139 CambridgeUSA Department of Developmental BioEngineering Faculty of Science and TechnologyTechnical Medical CentreUniversity of TwenteEnschedeThe Netherlands Translational Liver Research Department of Medical Cell BioPhysicsTechnical Medical CentreFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Targeted Therapeutics Department of Biomaterials Science and TechnologyFaculty of Science and TechnologyUniversity of TwenteEnschedeThe Netherlands Department of Chemical Engineering Institute of EnvironmentalChemical and Pharmaceutical SciencesFederal University of São PauloRua São Nicolau210Diadema 09913‑030Brazil University of Tiradentes(Unit) and Institute of Technology and Research(ITP)Av.Murilo Dantas300Aracaju 49010‑390Brazil Faculty of Pharmacy University of CoimbraPólo das Ciências da SaúdeAzinhaga de Santa Comba3000‑548 CoimbraPortugal CEB‑Centre of Biological Engineering University of MinhoCampus de Gualtar4710‑057 BragaPortugal Tiradentes Institute 150 Mt Vernon StDorchesterMA 02125USA

Since the start of the Precision Medicine Initiative by the United States of America in 2015,interest in personalized medicine has grown *** short,personalized medicine is a term that describes medical treatment that is tuned to the *** possible way to realize personalized medicine is 3D *** using materials that can be tuned upon stimulation,4D printing is *** recent years,many studies have been exploring a new field that combines 3D and 4D printing with *** has resulted in many concepts of pharmaceutical devices and formulations that can be printed and,possibly,tailored to an ***,the first 3D printed drug,Spritam®,has already found its way to the *** review gives an overview of various 3D and 4D printing techniques and their applications in the pharmaceutical field as drug delivery systems and personalized medicine.

关键词： Drug delivery systems 3D/4D printing Drug-eluting implants Microneedles Oral formulations

Ergatoid reproductives in the Neotropical termite Nasutitermes aquilinus (Holmgren) (Blattaria: Isoptera: Termitidae): developmental origin, fecundity, and genetics

在线全文

学校读者我要写书评

暂无评论

Insect Science 2020年第6期27卷 1322-1333页

作者： Iago Bueno da Silva Ives Haifig Edward LVargo Fabiana Elaine Casarin Marcelo Luiz da Mota juliana Toledo Lima Ana Maria Costa-Leonardo Laboratorio de Cupins Departamento de BiologiaInstituto de BiocienciasUniversidade Estadual Paulista-UN ESPRio ClaroSPBrazil Centro de Ciencias Naturais e Humanas Universidade Federal do ABCSao Bernardo do CampoSPBrazil Department of Entomology Texas A&M UniversityCollege StationTexasUSA Departamento de Ciencias Biologicas Universidade Federal de Sao Paulo-UNIFESPDiademaSPBrazil Instituto de Ciencias Agrarias Universidade Federal de Uberlandia—UFUMonte CarmeloMGBrazil Centro de Estudos em Recursos Naturais Universidade Estadual de Mato Grosso do SulDouradosMSBrazil

Termite colonies are usully headed by primary reproductives,which estab-listh nests during the swar ming ***,secondary reproductives may develop in some specics and become supplementary or replacement breeders,extending colony *** we investigate the developmental origin,fecundity and genetic characterizaion of ergatoid reproductives in the Neotropical termite Nasuitermes aquilinus(Holmgren),using morphometrical and histological techniques,five micosiallitle loci and the COI mitochondrial *** measurements performed on 208 apterous individuals of Nuauidius revealed 10 groups,including ergatoid females,which developed from major workers through two successive *** were characterized by the presence of imaginal features such as eyes andl wing *** difentiation of these features was correlated to physogastric development in these ergatoids,Histology revealed ooeytes in all matu-ration sages in worker-derived reproductives of N aquidinus,presence of nonflagellate spermatozoa inside the spermatheea,and royal fa ***,ergatoid reproduwetives were reproductively *** to the genotypes of 221 individuals from 11 nests,and mitochondrial haplotypes of 43 ergatoids,73%of the colomies were simple families,whereas 27%were extendbed *** the oecurenee of related reproductives,low inbreeding rates were detected within and among *** values could be explained given that sib mating itself cannot result in a higher inbreeding rate but depend on several factors discussed in *** is the first study to investigate the genetic structure of termite colonies influenced by the development of ergatoids and further investigations are encouraged 10 understand the inflwence of these reproductives on colony lifespan.

关键词： breeding syslem caste ifrentiation COI genotyping micosallites reproduction

Blue LED as a new treatment to vaginal stenosis due pelvic radiotherapy:Two case reports

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第23期9卷 6839-6845页

作者： Daniela Barros Cecília Alvares Teresa Alencar Priscila Baqueiro Augusto Marianno Rafael Alves juliana Lenzi Laura Ferreira Rezende Patricia Lordelo Oncology Department Hospital Santa IzabelSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP)and Postgraduate Bahiana School of Medicine and Public HealthSalvador 40290-000Brazil Oncology Department NOB/Grupo OncoclinicasSalvador 40290-000Brazil Pelvic Floor Care Center(CAAP) University Center of the Associated Teaching FacultiesCampinas 40000000Brazil Physiotherapy Instituto Patrícia Lordelo-IPLSalvador 40290-000Brazil

BACKGROUND Currently,the advancement cancer treatment technology improves overall survival,however,adverse events are still a challenge for health *** syndrome of menopause and vaginal stenosis are conditions that impact the quality of life of patients undergoing *** present two such cases in patients with previous cervical and endometrial *** conditions were handled with an innovative method using an energy-based device with blue light emitting diode for concomitant vaginal and vulvar *** impact in clinical findings,cytologic changes,and referred symptoms were *** SUMMARY One patient diagnosed with vaginal severe vaginal stenosis with previous cervix cancer treatment and other patient diagnosed with mild stenosis with severe dyspareunia and recent endometrium cancer treatment were considered for vulvovaginal treatment with weekly blue led device and closely evaluated with repeated validated questionnaires and cytological *** This innovative technique showed an improvement in all areas of the examiner's criteria,the cytological criteria,and most bothered symptoms.

关键词： Radiotherapy Atrophic vaginitis Vaginal diseases Laser therapy Semiconductor diode lasers Nonhormonal vaginal therapy Case report

Using Response Surface Methodology and High-Intensity Sweeteners’ Positive Synergy to Optimize Peach Nectar Acceptability

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food and Nutrition Sciences 2013年第5期4卷 503-509页

作者： Lauro Melo juliana Maria Porto Cardoso juliana Rosa Battochio Helena Maria André Bolini Department of Biochemical Engineering School of Chemistry Federal University of Rio de Janeiro Rio de Janeiro Brazil Department of Food and Nutrition University of Campinas Campinas Brazil

Combining the high-intensity sweeteners’ positive synergy with response surface methodology (RSM), it is possible to optimize food and beverage products liking, masking undesired sensory attributes and reducing costs and consumers’ additives intake (up to 50%). A RSM based on a five-level, two variable central composite rotatable designs (CCRD) was applied, varying aspartame and acesulfame-K concentrations in order to optimize consumers’ sensory liking (n = 118) for peach nectar in terms of appearance, aroma, flavor, and overall liking. Statistically valid models were found for flavor and overall liking attributes and highest liking values were found for samples combining the two sweeteners (therefore overcoming acesulfame-K’s sensory limitations) in lower concentrations, confirming the synergetic effect and allowing cost reduction and less additives intake, without losing sensory quality.

关键词： Sweetener Blends Aspartame Acesulfame-K CCRD RSM Sensory Evaluation

Development and characterization of 3CaO·P_(2)O_(5)-SiO_(2)-MgO glass-ceramics with different crystallization degree

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Advanced Ceramics 2013年第4期2卷 378-388页

作者： juliana Kelmy M.F.DAGUANO Paulo A.SUZUKI Kurt STRECKER JoséMartinho Marques de OLIVEIRA Maria Helena Figueira Vaz FERNANDES Claudinei SANTOS Universidade de São Paulo-Escola de Engenharia de Lorena USP-EEL-Pólo Urbo-Industrials/nGleba AI-6Lorena-SPCEP 12600-000Brazil Universidade Federal de São João del-Rei -UFSJ-CENENCampus S^(to)Antônio-Praça Frei Orlando 170-CentroS.J.del-Rei-MG.CEP 36307-352Brazil Escola Superior Aveiro Norte Edifício Rainha3720-232 O.AzeméisPortugal Universidade de Aveiro Campus Universitário de Santiago 3810-193 AveiroPortugal Universidade do Estado do Rio de Janeiro-Faculdade de Tecnologia de Resende-ueRJ-FAT-Rod.Presidente Dutra km298Resende-RJCEP 27537-000Brazil

The CaO-P_(2)O_(5)-SiO_(2)-MgO system presents several compounds used as biomaterials such as hydroxyapatite(HA),tricalcium phosphate(TCP)and TCP with magnesium substituting partial calcium(TCMP).Theβ-TCMP phase with whitlockite structure has interesting biological features and mechanical properties,meeting the requirements of a bioactive material for bone *** this work,the production of Mg-doped TCP,β-TCMP,has been investigated by crystallization from a glass composed of 52.75 wt%3CaO·P_(2)O_(5),30 wt%SiO_(2)and 17.25 wt%MgO(i.e.,31.7 mol%CaO,10.6 mol%P_(2)O_(5),26.6 mol%MgO and 31.1 mol%SiO_(2))using heat treatments between 775℃and 1100℃for up to 8 *** devitrification process of the glass has been accompanied by differential scanning calorimetry(DSC),high-resolution X-ray diffraction(HRXRD),relative density and bending strength *** characterization by HRXRD and DSC revealed the occurrence of whitlockite soon after the bulk glass preparation,a transient non-cataloged silicate between 800℃and 1100℃,and the formation of diopside in samples treated at 1100℃as crystalline *** overall crystalline fraction varied from 26%to 70%depending on the heat ***,contraction of the a-axis lattice parameter and expansion of the c-axis lattice parameter of the whitlockite structure have been observed during the heat treatments,which were attributed to theβ-TCMP formation with the partial substitution of Ca^(2+)by Mg^(2+).Relative densities near 99%and 97%for the glass and glass-ceramics respectively indicated a discrete reduction as a function of the devitrification *** strengths of 70 MPa and 120 MPa were determined for the glass and glass-ceramic material crystallized at 975℃for 4 h,respectively.

关键词： glass-ceramics heat treatment high-resolution X-ray diffraction(HRXRD) bending strength

SF分子基态及低激发态势能函数与光谱常数的研究

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

物理学报 2013年第16期62卷 96-101页

作者：朱遵略郎建华乔浩河南师范大学物理与电子工程学院新乡453007

采用含Davidson修正的内收缩多参考组态相互作用的方法和考虑相对论修正,在价态范围内的最大相关一致基aug-cc-pV6Z的条件下,对SF分子的基态2Π及几个低激发态4Σ-,2Σ-,2△进行了势能扫描计算.对SF分子的势能曲线进行拟合,得到了该分... 详细信息

采用含Davidson修正的内收缩多参考组态相互作用的方法和考虑相对论修正,在价态范围内的最大相关一致基aug-cc-pV6Z的条件下,对SF分子的基态2Π及几个低激发态4Σ-,2Σ-,2△进行了势能扫描计算.对SF分子的势能曲线进行拟合,得到了该分子的光谱常数Re,ωe,ωeχe,D0,De,Be和αe,通过比较发现它们与已有的实验结果较为一致.利用SF分子的势能曲线,通过求解双原子分子核运动的径向Schrdinger方程得到J=0时SF分子所计算各电子态的多个振动态.对于每一振动态,分别计算了振动能级、惯性转动常数和离心畸变常数.

关键词： SF 势能曲线光谱常数分子常数

In vitro establishment of shoot meristems of Ilex paraguariensis and identification of endophytic bacteria

在线全文

学校读者我要写书评

暂无评论

Journal of Forestry Research 2019年第5期30卷 1765-1777页

作者： Jessica de Cassia Tomasi juliana Degenhardt-Goldbach Renata Lucia Grunennvaldt Germana Davila dos Santos Vania Aparecida Vicente Luziane Franciscon Cleusa Bona Marguerite Quoirin Department of Crop Production and Protection Federal University of Parana1540 Rua dos Funciona′riosCuritibaPR 80035-060Brazil Brazilian Agricultural Research Corporation(EMBRAPA)Forestry ColomboPRBrazil Department of Basic Pathology Federal University of ParanaCuritibaBrazil Department of Botany Federal University of ParanaCuritibaBrazil

Yerba mate(Ilex paraguariensis ***.-Hil.)is a species of great economic,social and environmental importance for the southern regions of Brazil,Uruguay and *** the most diverse products are obtained from mate leaves,including mate *** objective of this study was to establish shoot meristem cultures(meristematic dome and a few primordia)of elite clones and identify the endophytic bacteria present in the *** tested the effect of clones(F1,F2,A03 and A07),culture media(MS,1/2MS,1/4MS and WPM),cytokinins(kinetin,BA and 2iP),activated charcoal(1,2 and 3 g L^-1),and disinfecting agent(sodium hypochlorite and mercuric chloride)on in vitro establishment.F1 and F2 clones were the most responsive for shoot meristem in vitro *** medium supplemented with 8.8 lM 2iP,0.2 lM NAA and 3 g L^-1 activated charcoal was the most suitable for the in vitro establishment of the F1 *** phytotoxic effect of the disinfectant was observed and some meristems *** isolated endophytic bacterium was identified for the first time in yerba mate as Agrobacterium *** conclude,we were able to establish in vitro culture of yerba mate using meristems as explants but the tissues were not free of endophytic microorganisms which could interfere with explant response.

关键词： Yerba mate Tissue culture 2iP Activated charcoal Endophytic bacteria Agrobacterium larrymoorei Oxidation

Gangliosides in nervous system development,regeneration,and pathologies

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第1期18卷 81-86页

作者： juliana F.Vasques Renata Guedes de Jesus Gonçalves Almir Jordão da Silva-Junior Robertta Silva Martins Fernanda Gubert Rosalia Mendez-Otero Instituto de Ciências Biomédicas Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Instituto de Biofísica Carlos Chagas Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Programa Redes de Pesquisa em Saúde no Estado do Rio de Janeiro Rio de JaneiroBrazil Programa Rede NanoSaúde do Estado do Rio de Janeiro Rio de JaneiroBrazil Instituto Nacional de Ciência e Tecnologia em Medicina Regenerativa Rio de JaneiroBrazil

Gangliosides,sialic acid-containing sphingolipids,are major constituents of neuronal *** to the number of sialic acids and the structure of the oligosaccharide chain,gangliosides can be classified as simple or complex and grouped in different *** of gangliosides have been identified in vertebrate cells,with different expression patterns during development and related to several physiological processes,especially in the nervous *** GD3 and its O-acetylated form,9acGD3,are highly expressed in early developmental stages,GM1,GD1a,GD1b,and GT1b are the most abundant ganglioside species in the mature nervous *** in enzymes involved in ganglioside metabolism can lead to the accumulation of specific species,a condition termed gangliosidosis and usually marked by severe neurological *** in ganglioside levels have also been described in several neurodegenerative diseases,such as Alzheimer’s and Parkinson’*** this review,we summarized recent information about the roles of GD3,9acGD3,GM1,GD1a,GD1b,GT1b,and other ganglioside species in nervous system development and regeneration,as well as clinical trials evaluating possible therapeutic applications of these molecules.

关键词： 9acGD3 gangliosides GD1a GD1b GD3 glycolipids GM1 GM2 GM3 GM4 GT1b

Gastrointestinal tuberculosis:An autopsy-based study

在线全文

学校读者我要写书评

暂无评论

Infectious Medicine 2023年第2期2卷 122-127页

作者： Julio Cesar Mantilla Juan JoséChaves Ferney Africano-Lopez Néstor Blanco-Barrera Marta juliana Mantilla Department of Pathology Universidad Industrial de SantanderBucaramanga 680002Colombia Department of Pathology Hospital Universitario de SantanderBucaramanga 680002Colombia Department of Pathology Fundación Universitaria de Ciencias de la SaludBogotá111411Colombia Department of Gastroenterology Gastrocenter and Medical SpecialitiesIpiales 524061Colombia Department of Gastroenterology Universidad Militar Nueva GranadaBogotá250240Colombia Department of Rheumatology Universidad de la SabanaChía 250001Colombia

Background:Tuberculosis is a disease of great relevance since it is one of the leading causes of morbidity and mortality *** tuberculosis is an unusual *** is defined as the involvement of any segment of the digestive tract,associated viscera,and *** study’s main objective is to collect information from autopsies of patients diagnosed with gastrointestinal tuberculosis in a Pathology reference center in ***:This is a retrospective and descriptive study of autopsy reports.A total of 4,500 autopsies were performed between January 2004 and December *** inclusion criteria were authorization of a family member following local law regulations and a final autopsy diagnosis of gastrointestinal tuberculosis using microscopic ***:Forty-eight patients with gastrointestinal tuberculosis autopsies were included in our *** of the patients were male(n=35,72.9%)with a median age of 40.5 years *** immunodeficiency virus infection history was reported in 28 cases(58.33%).The most affected gastrointestinal tract site was the terminal *** and thickened epithelium were common autopsies macroscopic *** multiorgan compromise was a relevant finding in patients with gastrointestinal ***:Gastrointestinal tuberculosis is a disease of great importance,being its diagnosis a clinical *** can be reported in a high percentage of cases,so autopsy diagnosis can help reveal more accurate data about this condition.

关键词： Gastrointestinal tuberculosis Autopsy Forensic pathology Infections Colombia