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Alendronate disturbs femoral growth due to changes during immunolocalization of transforming growth factor-β1 and bone morphogenetic protein-2 in epiphyseal plate

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World Journal of Experimental Medicine 2020年第1期10卷 1-9页

作者： juliana souza Vieira Emanuelle juliana Cunha juliana feltrin de souza Luis Henrique Koeler Chaves Jessica Lakes de souza Allan Fernando Giovanini Clinical dentistry University PositivoCuritibaPR 81280330Brazil Stomatology department University Federal of ParanáCuritibaPR 80210-170Brazil

BACKGROUND The epiphyseal growth plate is an important anatomical segment localized on the ends of a long *** the abovementioned atractive reasons for alendronate’s use,few data on the effect of alendronate during epiphyseal growth *** Verify the effect of alendronate on the growth epiphyseal plate,and compare its effect with the size of the femur during the double-staining of the immunolocalization of transforming growth factor-β1(TGF-β1)and bone morphogenetic protein-2(BMP2)in endochondral ossifing in specimens that have received *** Forty newborn rats were randomly divided into two groups:a control group(were given applications of 1 mg/kg physiologic saline)and a group that received Alendronate(a dose of 2.5 mg/kg).These groups were then divided into two subgroups for euthanasia in two and 12 d of *** euthanasia,the femurs were removed,and the femoral bones were measured linearly between the apex of the greater trochanter until the lower intercondylar midlle face to verify the probable bone growth between 3 and 12 d in control and alednroanto treated ***,the surgical pieces were also sent to the histopathology laboratory to produce histological *** obtained slides were stained with hematoxylin and eosin to measure each of the cartilage zones in endochondral *** other slides were immunohistochemically tested for anti-TGF-β1 and BMP-2 antibodies to investigate the immunolocalization of these proteins in the epiphyseal plaque *** On the third day,some diferences between the control group and specimens treated with alendronate were ***,we found similarities in size between the femoral bones when we compared the control group with the specimens that received *** the 12^th day,the bone size of the mice receiving the drug was significantly smaller than those of the control *** results coincide with changes in the TGF-β1 and BMP-2 *** the speci

关键词： Alendronate Bone development Epiphyseal plate Bone morphogentic protein-2 Transforming growth factor-β1

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