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Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch pilar perez‑Garcia Laura Morales‑Fernandez Javier Garcia‑Bella Jose Manuel Benitez‑del‑Castillo julian Garcia‑Feijoo David p.pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain Department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain Department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IpL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IpL treatment using the Optima IpL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IpL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SpEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(ppp=0.012),as well as in tear film osmolarity(p=0.001).A significant reduction was also found in meibomian gland expressibility(p=0.003),changing the percentage of grade 3 eyes from 44.4%before IpL to 17.2%after ***:IpL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

Development of an active-site titrant for SARS-CoV-2 main protease as an indispensable tool for evaluating enzyme kinetics

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Acta pharmaceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget julian Breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa E.Müller Michael Gütschow pharmaceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chemistry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Department of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 main protease(M^(pro))was developed that enables,for the first time,the exact determination of the concentration of the enzymatically active M^(pro) by active-site *** covalent binding mode of the tetrapeptidic titrant was elucidated by the determination of the crystal structure of the enzyme–titrant *** fluorogenic substrates of M^(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were compared in terms of solubility under typical assay *** exploiting the new titrant,key kinetic parameters for the M^(pro)-catalyzed cleavage of these substrates were determined.

关键词： COVID-19 SARS-CoV-2 Main protease peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis development

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ramin Alimy Miriam E.A.Tschaffon-Müller Shan Jiang Tobias Malte Ballhause Anke Baranowsky Simon von Kroge julian Delsmann Eva pawlus Kian Eghbalian Klaus püschel Astrid Schoppa Melanie Haffner-Luntzer David J.Beech Frank Timo Beil Michael Amling Johannes Keller Anita Ignatius Timur A.Yorgan Tim Rolvien Thorsten Schinke Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Department of Trauma and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biomechanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Department Legal Medicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and Metabolic Medicine School of MedicineUniversity of LeedsLS29JT LeedsUK

piezo proteins are mechanically activated ion channels,which are required for mechanosensing functions in a variety of cell *** we and others have previously demonstrated that the expression of piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of piezo1 and/or piezo2 in *** we addressed the question if and how chondrocyte expression of the mechanosensitive proteins piezo1 or piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of piezo1(piezo1^(Col2a1Cre)),but not of piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all piezo1^(Col2a1Cre) animals displayed multiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only mildly affected in these mice,OA pathologies were markedly less pronounced compared to littermate controls at 60 weeks of ***,when OA was induced by anterior cruciate ligament transection,only the chondrocyte inactivation of piezo1,not of piezo2,resulted in attenuated articular cartilage ***,osteophyte formation and maturation were also reduced in piezo1^(Col2a1Cre) *** further observed increased piezo1 protein abundance in cartilaginous zones of human ***,we identified ptgs2 and Ccn2 as potentially relevant piezo1 downstream genes in ***,our data do not only demonstrate that piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that piezo1 antagonists may be established as a novel approach to limit osteophyte formation in OA.

关键词： piezo1 markedly ossification

Accretion in strong field gravity with eXTp

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Science China(physics,Mechanics & Astronomy) 2019年第2期62卷 45-73页

作者： Alessandra De Rosa phil Uttley LiJun Gou Yuan Liu Cosimo Bambi Didier Barret Tomaso Belloni Emanuele Berti Stefano Bianchi Ilaria Caiazzo piergiorgio Casella Marco Feroci Valeria Ferrari Leonardo Gualtieri Jeremy Heyl Adam Ingram Vladimir Karas FangJun Lu Bin Luo Giorgio Matt Sara Motta Joseph Neilsen paolo pani Andrea Santangelo XinWen Shu JunFeng Wang Jian-Min Wang YongQuan Xue Yupeng Xu WeiMin Yuan YeFei Yuan Shuang-Nan Zhang Shu Zhang Ivan Agudo Lorenzo Amati Nils Andersson Cristina Baglio pavel Bakala Altan Baykal Sudip Bhattacharyya Ignazio Bombaci NiccolóBucciantini Fiamma Capitanio Riccardo Ciolfi Wei K.Cui Filippo D'Ammando Thomas Dauser Melania Del Santo Barbara De Marco Tiziana Di Salvo Chris Done Michal Dovciak Andrew C.Fabian Maurizio Falanga Angelo Francesco Gambino Bruce Gendre Victoria Grinberg Alexander Heger Jeroen Homan Rosario Iaria JiaChen Jiang ChiChuan Jin Elmar Koerding Manu Linares Zhu Liu Thomas J.Maccarone Julien Malzac Antonios Manousakis Frédéric Marin Andea Marinucci Missagh Mehdipour Mariano Méndez Simone Migliari Cole Miller Giovanni Miniutti Emanuele Nardini paul T.O'Brien julian p.osborne pierre Olivier petrucci Andrea possenti Alessandro Riggio Jerome Rodriguez Andrea Sanna LiJing Shao Malgosia Sobolewska Eva Sramkova Abigail L.Stevens Holger Stiele Giulia Stratta Zdenek Stuchlik Jiri Svoboda Fabrizio Tamburini Thomas M.Tauris Francesco Tombesi Gabriel Torok Martin Urbanec Frederic Vincent QingWen Wu Feng Yuan Jean J.M.in't Zand Andrzej A.Zdziarski XinLin Zhou INAF-Istituto di Astrofisica e planetologie Spaziali Via Fosso del Cavaliere Anton pannekoek Institute for Astronomy University of Amsterdam National Astronomical Observatories Chinese Academy of Science Institute of High Energy physics Chinese Academy of Science Center for Field Theory and particle physics and Department of physics Fudan University IRAp Universitéde ToulouseCNRSUPSCNES INAF-Osservatorio Astronomico di Brera Department of physics and Astronomy The University of MississippiUniversity Dipartimento di Matematica e Fisica Universitàdegli studi Roma Tre University of British Columbia INAF-Osservatorio Astronomico di Roma INFN-Roma 2 c/o Dipartimento di Fisica II Universit?di Roma"Tor Vergata" Dipartimento di Fisica Universitàdegli Studi di Roma"La Sapienza"&Sezione INFN Roma1 Department of physics University of OxfordClarendon Laboratory Astronomical Institute Academy of Sciences School of Astronomy and Space Science Nanjing University MIT Kavli Institute for Astrophysics and Space Research Institut für Astronomie und Astrophysik Eberhard Karls Universität Department of physics Anhui Normal University Department of Astronomy and Institute of Theoretical physics and Astrophysics Xiamen University CAS Key Laboratory for Research in Galaxies and Cosmology Department of AstronomyUniversity of Science and Technology of China Instituto de Astrofísica de Andalucia(CSIC) Glorieta de la Astronomía s/n INAF-Istituto di Astrofisica Spaziale e Fisica cosmica di Bologna Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Institute of physics and Research Centre for Computational physics and Data processing Faculty of Philosophy&ScienceSilesian University in OpavaíBezru?ovo nám. Department of physics Middle East Technical University Department of Astronomy and Astrophysics Tata Institute of Fundamental Research Dipartimento di Fisica Universit?di Pisa&INFN INAF-Osservatorio Astrofisico di Arcetri INAF-Osservatorio Astronomico di padova INFN-TIFpA Trento Ins

In this paper we describe the potential of the enhanced X-ray Timing and polarimetry(eXTp) mission for studies related to accretion flows in the strong field gravity regime around both stellar-mass and supermassive black-holes. eXTp has the unique capability of using advanced "spectral-timing-polarimetry" techniques to analyze the rapid variations with three orthogonal diagnostics of the flow and its geometry, yielding unprecedented insight into the inner accreting regions, the effects of strong field gravity on the material within them and the powerful outflows which are driven by the accretion process.

关键词： X-ray black holes physics accretion

Exploring the Dynamic X-ray Universe:Scientific Opportunities for the Einstein probe Mission

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空间科学学报 2016年第2期36卷 117-138页

作者： YUAN Weimin osborne julian p ZHANG Chen WILLINGALE Richard Key Laboratory for Space Astronomy and Technology National Astronomical ObservatoriesChinese Academy of Sciences School of Astronomy and Space Science University of Chinese Academy of Sciences Department of physics and Astronomy University of Leicester University

Time-domain astrophysics will enter a golden era towards the end of this decade with the advent of major facilities across the electromagnetic spectrum and in the multi-messenger realms of gravitational wave and *** the soft X-ray regime,the novel micro-pore lobster-eye optics provides a promising technology to realise,for the first time,focusing X-ray optics for wide-angle monitors to achieve a good combination of sensitivity and wide field of *** this context Einstein probe,a soft X-ray all-sky monitor mission,was proposed and selected as a candidate mission of priority in the space science programme of the Chinese Academy of *** paper reviews the most important science developments and key questions in this field towards 2020 and beyond,and how to achieve them *** also introduces the Einstein probe mission,including its key science goals and mission definition,as well as some of the key technological issues.

关键词： Time-domain astronomy High-energy astrophysics X-rays Transients Instruments

重复荷载作用后海工高性能混凝土梁刚度退化试验研究

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土木与环境工程学报（中英文） 2024年第3期46卷 171-179页

作者：陆春华吴小龙蔡启明张菊连江苏大学土木工程与力学学院江苏镇江212013 上海宏信建筑科技有限公司上海201800

在荷载长期作用下,钢筋混凝土受弯构件的变形是一个重要的评价指标,也是构件正常使用极限状态的验算内容之一。为了研究经历重复荷载后海工高性能混凝土梁的变形发展规律,设计制作了10根试验梁,分别进行了重复荷载试验、氯盐干湿试验以... 详细信息

在荷载长期作用下,钢筋混凝土受弯构件的变形是一个重要的评价指标,也是构件正常使用极限状态的验算内容之一。为了研究经历重复荷载后海工高性能混凝土梁的变形发展规律,设计制作了10根试验梁,分别进行了重复荷载试验、氯盐干湿试验以及两者的共同作用试验;通过四点受弯试验对梁的跨中挠度及刚度退化进行评价,提出了梁短期刚度规范计算公式的修正方法。研究结果表明:荷载水平按梁纯弯段弯矩等于0.4M_(u)确定时,施加30次重复荷载后混凝土的损伤度接近15%;对于仅进行氯盐干湿循环的试验梁,其跨中挠度发展要慢于参照梁;施加重复荷载后,试验梁的跨中挠度发展要快于参照梁;对施加重复荷载后的试验梁再进行氯盐干湿循环,梁的刚度退化更为显著。结合试验结果,采用损伤效应折减系数对梁短期刚度计算公式进行修正,并验证了修正公式的合理性和有效性。

关键词：重复荷载海工混凝土梁损伤度氯盐环境弯曲刚度

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Carbon pool trends and dynamics within a subtropical peatland during long-term restoration

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Ecological processes 2017年第1期6卷 449-462页

作者： paul julian II Stefan Gerber Alan L.Wright Binhe Gu Todd Z.osborne University of Florida Soil and Water Sciences DepartmentFt.PierceFL 34945USA. University of Florida Soil and Water Sciences DepartmentGainesvilleFL 32611USA. South Florida Water Management District Water Quality BureauWest Palm BeachFL 33406USA. University of Florida Whitney Laboratory for Marine BioscienceSt AugustineFL 32080USA.

Introduction:The Florida Everglades has undergone significant ecological change spanning the continuum of disturbance to *** the restoration effort is not complete and the ecosystem continues to experience short duration perturbations,a better understanding of long-term C dynamics of the Everglades is needed to facilitate new restoration *** study evaluated temporal trends of different aquatic carbon(C)pools of the northern Everglades protection Area over a 20-year period to gauge historic C cycling *** inorganic C(DIC),dissolved organic C(DOC),particulate organic C(pOC),and surface water carbon dioxide(pCO2(aq))were investigated between May 1,1994 and April 30,***:Annual mean concentrations of DIC,DOC,pOC,and pCO2(aq)significantly decreased through time or remained constant across the Water Conservation Areas(WCAs).Overall,the magnitude of the different C pools in the water column significantly differed between *** of CO2 was dynamic across the Everglades ranging from 420 to 2001 kg CO2 year−***,the historic trend in CO2 flux from the marsh declined across our study area while pCO2(aq)largely remained somewhat constant with the exception of Water Conservation Area 2 which experienced significant declines in pCO2(aq).particulate OC concentrations were consistent between WCAs,but a significantly decreasing trend in annual pOC concentrations was ***:Hydrologic condition and nutrient inputs significantly influenced the balance,speciation,and flux of C pools across WCAs suggesting a subsidy-stress response in C dynamics relative to landscape scale responses in nutrient *** interplay between nutrient inputs and hydrologic condition exert a driving force on the balance between DIC and DOC production via the metabolism of organic matter which forms the base of the aquatic food *** the restoration trajectory as water quality and hydrology continues to improve,it is expect

关键词： Inorganic carbon Organic carbon Carbon dioxide particulate carbon Hydrology Nutrients

Hierarchical Mean-Field Type Control of price Dynamics for Electricity in Smart Grid

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Journal of Systems Science & Complexity 2022年第1期35卷 1-17页

作者： FRIHI Zahrate El Oula CHOUTRI Salah Eddine BARREIRO-GOMEZ julian TEMBINE Hamidou Laboratory of probability and Statistics(La pS) Department of MathematicsBadji-Mokhtar UniversityB.P.12Annaba 23000Algeria. NYUAD Research Institute New York University Abu DhabiUAE Learning&Game Theory Laboratory New York University Abu DhabiSaadiyat Campus PO Box 129188UAE

This paper solves a mean-field type hierarchical optimal control problem in electricity *** authors consider n-1 prosumers and one *** ith prosumer,for 1prosumer and is a follower of the(i+1)th *** first player(agent)is the follower at the bottom whereas the nth is the leader at the *** problem is described by a linear jump-diffusion system of conditional mean-field type,where the conditioning is with respect to common noise,and a quadratic cost functional involving,the square of the conditional expectation of the controls of the *** authors provide a semi-explicit solution of the corresponding meanfield-type hierarchical control problem with common ***,the authors illustrate the obtained result via a numerical example with two different scenarios.

关键词： Electricity price dynamics hierarchical control mean-field-type control smart grids

Observatory science with eXTp

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Science China(physics,Mechanics & Astronomy) 2019年第2期62卷 97-138页

作者： Jean J.M.in 't Zand Enrico Bozzo JinLu Qu Xiang-Dong Li Lorenzo Amati Yang Chen Immacolata Donnarumma Victor Doroshenko Stephen A.Drake Margarita Hernanz peter A.Jenke Thomas J.Maccarone Simin Mahmoodifar Domitilla de Martino Alessandra De Rosa Elena M.Rossi Antonia Rowlinson Gloria Sala Giulia Stratta Thomas M.Tauris Joern Wilms XueFeng Wu ping Zhou Iván Agudo Diego Altamirano Jean-Luc Atteia Nils A.andersson M.Cristina Baglio David R.Ballantyne Altan Baykal Ehud Behar Tomaso Belloni Sudip Bhattacharyya Stefano Bianchi Anna Bilous pere Blay Joao Braga Sφren Brandt Edward F.Brown Niccolo Bucciantini Luciano Burderi Edward M.Cackett Riccardo Campana Sergio Campana piergiorgio Casella Yuri Cavecchi Frank Chambers Liang Chen Yu-peng Chen Jér?me Chenevez Maria Chernyakova ChiChuan Jin Riccardo Ciolfi Elisa Costantini Andrew Cumming Antonino D'Aì Zi-Gao Dai Filippo D'Ammando Massimiliano De pasquale Nathalie Degenaar Melania Del Santo Valerio D'Elia Tiziana Di Salvo Gerry Doyle Maurizio Falanga XiLong Fan Robert D.Ferdman Marco Feroci Federico Fraschetti Duncan K.Galloway Angelo F.Gambino poshak Gandhi MingYu Ge Bruce Gendre Ramandeep Gill Diego G?tz Christian Gouiffès paola Grandi Jonathan Granot Manuel Güdel Alexander Heger Craig O.Heinke Jeroen Homan Rosario Iaria Kazushi Iwasawa Luca Izzo Long Ji peter G.Jonker Jordi José Jelle S.Kaastra Emrah Kalemci Oleg Kargaltsev Nobuyuki Kawai Laurens Keek Stefanie Komossa Ingo Kreykenbohm Lucien Kuiper Devaky Kunneriath Gang Li En-Wei Liang Manuel Linares Francesco Longo FangJun Lu Alexander A.Lutovinov Denys Malyshev Julien Malzac Antonios Manousakis Ian McHardy Missagh Mehdipour Yunpeng Men Mariano Méndez Roberto p.Mignani Romana Mikusincova M.Coleman Miller Giovanni Miniutti Christian Motch Joonas Nättilä Emanuele Nardini Torsten Neubert paul T.O'Brien Mauro Orlandini julian p.osborne Luigi pacciani Stéphane paltani Maurizio paolillo Iossif E.papadakis Biswajit paul Alberto pellizzoni Uria peretz Miguel A.pérez Torres Emanuele perinati Chanda prescod-Weinstein pablo Reig SRON Netherlands Institute for Space Research Department of Astronomy University of Geneva Key Laboratory for particle Astrophysics Institute of High Energy PhysicsChinese Academy of Sciences School of Astronomy and Space Science Nanjing University INAF-IASF Bologna ASI Via del Politecnico snc INAF-Istituto di Astrofisica e planetologie Spaziali Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen NASA Goddard Space Flight Center ICREA&Institute of Space Sciences(IEEC-CSIC) Campus UABCarrer de Can Magrans CSpAR SPA University of Alabama in Huntsville Department of physics Texas Tech University INAF Osservatorio Astronomico di Capodimonte Leiden Observatory Leiden University Anton pannekoek Institute University of Amsterdam ASTRON Netherlands Institute for Radio Astronomy Universitat politecnica de Catalunya(UpC-IEEC) Universitádegli Studi di Urbino‘Carlo Bo’ Max-planck-Institut für Radioastronomie Dr.Karl-Remeis-Sternwarte and Erlangen Centre for Astroparticle physics(ECAp) Friedrich Alexander Universit?t Erlangen-Nurnberg purple Mountain Observatory Chinese Academy of Sciences Instituto de Astrofysíca de Andalucia-CSIC Department of physics and Astronomy University of Southampton IRAp Universitéde ToulouseCNRSUPSCNES Mathematical Sciences and STAG Research Centre University of Southampton New York University Abu Dhabi Center for Relativistic Astrophysics School of PhysicsGeorgia Institute of Technology physics Department Middle East Technical University Department of physics Technion-Israel Institute of Technology INAF Osservatorio Astronomico di Brera Tata Institute of Fundamental Research Dipartimento di Matematica e Fisica Universitàdegli Studi Roma Tre Instituto de Astrofísica de Canarias Instituto Nacional de pesquisas Espaciais-INpE National Space Institute Technical University of Denmark(DTU Space) Department of physics and Astronomy Michigan State University INAF Osservatorio Astrofisico di Arcetri Dipartimento di Fisica Universitádegli Studi di Cagliari Department of physics and A

In this White paper we present the potential of the enhanced X-ray Timing and polarimetry(eXTp) mission for studies related to Observatory Science targets. These include flaring stars, supernova remnants, accreting white dwarfs, low and high mass X-ray binaries, radio quiet and radio loud active galactic nuclei, tidal disruption events, and gamma-ray bursts. eXTp will be excellently suited to study one common aspect of these objects: their often transient nature. Developed by an international Consortium led by the Institute of High Energy physics of the Chinese Academy of Science, the eXTp mission is expected to be launched in the mid 2020s.

关键词： space research in struments nuclear astrophysics flare stars accretion and accretion disks mass loss and stellar winds cataclysmic binaries X-ray binaries supernova remnants active galactic nuclei X-ray bursts gamma-ray bursts gravitational waves