检索结果-南通市图书馆

data-driven analysis of chemicals,proteins and pathways associated with peanut allergy:from molecular networking to biological interpretation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年第3期13卷 1322-1335页

作者： Emmanuel Kemmler julian Braun Florent Fauchère Sabine dölle-Bierke Kirsten Beyer robert Preissner margitta Worm Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany member of the KFO339 FOOD@Berlin 10115Germany Si-m/“der Simulierte mensch”a science framework of Technische Universität Berlin and Charité-Universitätsmedizin Berlin Berlin 10115Germany Charité-Universitätsmedizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany division of Allergy and Immunology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is majorly related to severe food induced allergic *** food including cow's milk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,almonds,cashews,pecans and pistachios),fish and shellfish are responsible for more than 90%of food ***,we provide promising insights using a large-scale data-driven analysis,comparing the mechanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,almonds,cashews,pecans and pistachios)and ***,we have analysed the chemical compositions of peanuts in different processed form raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisome proliferator-activated receptors(PPARs)and its isoform and their interaction with dietary lipids may have significant effect on allergic *** results obtained from this study will direct future experimeantal and clinical studies to understand the role of dietary lipids and PPARisoforms to exert pro-inflammatory or anti-inflammatory functions on cells of the innate immunity and influence antigen presentation to the cells of the adaptive immunity.

关键词： Allergy informatics Knowledge-graph data analysis Food allergy Peroxisome proliferator-activated receptors Fatty acids

Single-shot 3d incoherent imaging with diffuser endoscopy

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Light(Advanced manufacturing) 2024年第2期5卷 64-74页

作者： julian Lich Tom Glosemeyer Jürgen Czarske robert Kuschmierz Laboratory of measurement and Sensor System Technique TU DresdenGermany Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenGermany Else Kroner Fresenius Center for digital Health(EKFZ) TU DresdenGermany Cluster of Excellence Physics of Life TU DresdenGermany

minimally invasive endoscopy offers a high potential for biomedical imaging ***,conventional fiberoptic endoscopes require lens systems which are not suitable for real-time 3d ***,a diffuser is utilized for passively encoding incoherent 3d objects into 2d speckle *** networks are employed for fast computational image reconstruction beyond the optical memory *** this paper,we demonstrate single-shot 3d incoherent fiber imaging with keyhole access at video *** the diffuser fiber endoscope for fluorescence imaging is promising for in vivo deep brain diagnostics with cellular resolution.

关键词： Endoscopy diffuser deep learning Coherent fiber bundle multicore fiber Neural networks Fiber optics Speckle patterns Fluorescence imaging

Prospective cohort study on facial profile changes in infants with robin sequence and healthy controls

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers julian Sowula Karen Kreutzer Christoph E.Schwarz Christina Weismann michael Krimmel Christian F.Poets Bernd Koos department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft Lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany department of Orthodontics Tuebingen University HospitalTuebingenGermany department of Oral and maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between may 2018 and Nov *** with RS received 3d-photographs during clinically indicated *** controls were recruited from dec 2018 to Sep 2019 and received 3d-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(L),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073d images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3d images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant mandibular catch-up growth Pre-epiglottic Baton Plate robin sequence Three-dimensional photography

Effect of operational parameters on the performance of an anaerobic sequencing batch reactor(AnSBR)treating protein-rich wastewater

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Environmental Science and Ecotechnology 2024年第1期17卷 89-99页

作者： Zhe deng julian muñoz Sierra Ana Lucia morgado Ferreira daniel Cerqueda-Garcia Henri Spanjers Jules B.van Lier delft University of Technology Faculty of Civil Engineering and GeosciencesStevinweg 12628 CNDelftthe Netherlands Veolia Water Technologies Techno Center Netherlands B.V.-Biothane Tanthofdreef 212623 EWDelftthe Netherlands KWR Water Research Institute Groningenhaven 7P.O.Box 10723430 BBNieuwegeinthe Netherlands Institute of Ecology.A.C Cluster Cientifico y Tecnologico BioMimic®Carretera Antigua a Coatepec 351El Haya91073XalapaVeracruzMexico

Treating protein-rich wastewater using cost-effective and simple-structured single-stage reactors presents several *** this study,we applied an anaerobic sequencing batch reactor(AnSBR)to treat protein-rich wastewater from a *** focused on identifying the key factors influencing the removal of chemical oxygen demand(COd)and the settling performance of the *** AnSBR achieved a maximum total COd removal of 90%,a protein degradation efficiency exceeding 80%,and a COd to methane conversion efficiency of over 70%at organic loading rates of up to 6.2 g COd L^(-1)d^(-1).We found that the variations in both the organic loading rate within the reactor and the hydraulic retention time in the buffer tank had a significant effect on COd *** hydraulic retention time in the buffer tank and the reactor,which determined the ammonification efficiencies and the residual carbohydrate concentrations in the reactor liquid,affected the sludge ***,the genus Clostridium sensu stricto 1,known as protein-and lipids-degraders,was predominant in the *** analysis showed a significant correlation between the core microbiome and ammonification efficiency,highlighting the importance of protein degradation as the governing process in the *** results will provide valuable insights to optimise the design and operation of AnSBR for efficient treatment of protein-rich wastewater.

关键词： Anaerobic digestion Anaerobic sequencing batch reactor (AnSBR) Protein microbial community Slaughterhouse wastewater

multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa maria Jose Curras-Tuala Sara Pischedda miriam Cebey-Lopez Jose Gomez-Rial Irene Rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande julian montoto-Louzao Alba Camino-mera Isabel Ferreiros-Vidal maximo Fraga Jose RAntunez Rodolfo Gomez Federico martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

Predictive modelling of ferroelectric tunnel junctions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

npj Computational materials 2016年第1期2卷 150-162页

作者： julian P Velev John d Burton mikhail Ye Zhuravlev Evgeny Y Tsymbal department of Physics and Astronomy University of NebraskaLincolnNEUSA department of Physics and Astronomy University of Puerto RicoSan JuanPuerto RicoUSA Nebraska Center for materials and Nanoscience University of NebraskaLincolnNEUSA Kurnakov Institute for General and Inorganic Chemistry Russian Academy of SciencesMoscowRussia Faculty of Liberal Arts and Sciences St Petersburg State UniversitySt PetersburgRussia

Ferroelectric tunnel junctions combine the phenomena of quantum-mechanical tunnelling and switchable spontaneous polarisation of a nanometre-thick ferroelectric film into novel device *** the ferroelectric barrier polarisation direction produces a sizable change in resistance of the junction—a phenomenon known as the tunnelling electroresistance *** a fundamental perspective,ferroelectric tunnel junctions and their version with ferromagnetic electrodes,i.e.,multiferroic tunnel junctions,are testbeds for studying the underlying mechanisms of tunnelling electroresistance as well as the interplay between electric and magnetic degrees of freedom and their effect on *** a practical perspective,ferroelectric tunnel junctions hold promise for disruptive device *** a very short time,they have traversed the path from basic model predictions to prototypes for novel non-volatile ferroelectric random access memories with non-destructive *** remarkable progress is to a large extent driven by a productive cycle of predictive modelling and innovative experimental *** this review article,we outline the development of the ferroelectric tunnel junction concept and the role of theoretical modelling in guiding experimental *** discuss a wide range of physical phenomena that control the functional properties of ferroelectric tunnel junctions and summarise the state-of-the-art achievements in the field.

关键词： ferroelectric tunnel resistance

Variant selection in laser powder bed fusion of non-spherical Ti-6Al-4V powder

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of materials Science & Technology 2023年第16期147卷 56-67页

作者： mohammadreza Asherloo Ziheng Wu julian E.C.Sabisch Iman Ghamarian Anthony d.Rollett Amir mostafaei department of mechanical Materials and Aerospace EngineeringIllinois Institute of Technology10 W 32nd StreetChicagoIL 60616United States materials Engineering division Lawrence Livermore National Laboratory7000 East AveLivermoreCA 94550United States Samuel roberts Noble microscopy Laboratory University of OklahomaNormanOK 73019United States School of Aerospace and mechanical Engineering University of OklahomaNormanOK 73019United States department of materials Science and Engineering Carnegie Mellon UniversityPittsburghPA 15213United States

The presence ofα/αon priorβ/βgrain boundaries directly impacts the final mechanical properties of the titanium ***β/βgrain boundary variant selection of titanium alloys has been assumed to be unlikely owing to the high cooling rates in laser powder bed fusion(L-PBF).However,we hypothesize that powder characteristics such as morphology(non-spherical)and particle size(50–120μm)could affect the initial variant selection in L-PBF processed Ti-6Al-4V alloy by locally altering the cooling *** the high cooling rate found in L-PBF,results showed the presence ofβ/βgrain boundaryαlath growth inside two adjacent priorβ*** backscatter diffraction micrographs confirmed the presence ofβ/βgrain boundary variant selection,and synchrotron X-ray high-speed imaging observation revealed the role of the“shadowing effect”on the locally decreased cooling rate because of keyhole depth reduction and the consequentβ/βgrain boundaryαlath *** self-accommodation mechanism was the main variant selection driving force,and the most abundantα/αboundary variant was type 4(63.26°//[10553¯]).The dominance of Category IIαlath clusters associated with the type 4α/αboundary variant was validated using the phenomenological theory of martensite transformations and analytical calculations,from which the stress needed for theβ→αtransformation was calculated.

关键词： Variant selection Phase formation Additive manufacturing Hydride-dehydride powder Texture analysis Electron backscattered diffraction

Seroconversion of HBsAG coincides with hepatitis A superinfection: A case report

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2020年第9期8卷 1651-1655页

作者： Claudia Beisel marylyn m Addo julian Schulze zur Wiesch department of Internal medicine Division of Infectious DiseaseUniversity Medical Center Hamburg-EppendorfHamburg 20251Germany German Center for Infection Research Hamburg 20251Germany

BACKGROUNd Hepatitis B virus(HBV)is a hepatotropic virus that can cause acute and chronic liver *** to the world health organization 257 million people are infected with chronic HBV infection ***-infection with other hepadnaviruses,including hepatitis A virus(HAV),hepatitis C virus,hepatitis d virus,and hepatitis E virus is associated with increased risk of acute liver failure in patients with chronic *** SUmmARY Here,we report a case of a 47-year old male patient with HBV-related compensated Child A cirrhosis,who presented with general fatigue,malaise and laboratory signs of acute *** the patient was regularly seen at a specialized university liver unit,the HAV vaccination status was *** HAV super-infection was diagnosed by positive serological and polymerase chain reaction *** acute HAV super-infection,spontaneous HBsAg elimination and development of an anti-HBs titer were *** This case illustrates the importance of carefully checking the vaccination *** our patient,unspecific immunological responses to HAV led to functional cure of HBV.

关键词： Chronic hepatitis B infection Liver cirrhosis Acute hepatitis A infection HBsAg clearance Functional cure Case report

monitoring spatiotemporal soil moisture changes in the subsurface of forest sites using electrical resistivity tomography (ERT)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Forestry Research 2022年第5期33卷 1649-1662页

作者： julian Fäth Julius Kunz Christof Kneisel Institute of Geography and Geology University of WürzburgAm Hubland97074 WürzburgGermany

The effects of drought on tree mortality at forest stands are not completely understood. For assessing their water supply, knowledge of the small-scale distribution of soil moisture as well as its temporal changes is a key issue in an era of climate change. However, traditional methods like taking soil samples or installing data loggers solely collect parameters of a single point or of a small soil volume. Electrical resistivity tomography (ERT) is a suitable method for monitoring soil moisture changes and has rarely been used in forests. This method was applied at two forest sites in Bavaria, Germany to obtain high-resolution data of temporal soil moisture variations. Geoelectrical measurements (2d and 3d) were conducted at both sites over several years (2015-2018/2020) and compared with soil moisture data (matric potential or volumetric water content) for the monitoring plots. The greatest variations in resistivity values that highly correlate with soil moisture data were found in the main rooting zone. Using the ERT data, temporal trends could be tracked in several dimensions, such as the interannual increase in the depth of influence from drought events and their duration, as well as rising resistivity values going along with decreasing soil moisture. The results reveal that resistivity changes are a good proxy for seasonal and interannual soil moisture variations. Therefore, 2d- and 3d-ERT are recommended as comparatively non-laborious methods for small-spatial scale monitoring of soil moisture changes in the main rooting zone and the underlying subsurface of forested sites. Higher spatial and temporal resolution allows a better understanding of the water supply for trees, especially in times of drought.

关键词： Geoelectrical monitoring Forest ecology Hydrology Soil water content