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A Review on Genetically m.dified Plants Designed to Phytorem.diate Polluted Soils： Biochem.cal Responses and International Regulation

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Pedosphere 2018年第5期28卷 697-712页

作者： Edgar VAZQUEZ-NUNEZ julian m. pena-castro Fabian FERNANDEZ-LUQUENO Eduardo CEJUDO m.ria G. de la ROSA-ALVAREZ m.ria C. GARCIA-CASTANED Departam.nto de Ingenierias Quim.ca Electronica y Biomedica Division de Ciencias e Ingenierlas Universidad de Guanajuato (UG) Campus Leon Loma del Bosque 103 Leon Gto. 37150 (Mexico) Laboratorio de Biotecnologla Vegetal Instituto de Biotecnologia Universidad del Papaloapan Tuxtepec Oaxaca 68333 (Mexico) program. en Sustentabilidad de los Recursos Naturales y Eneryla Cinvestav Saltillo Industria Metalurgica 1062 Parque Industrial Saltillo-Ramos-Arizpe Ramos Arizpe Coahuila 25900 (Mexico) CONACYT Unidad de Ciencias del Agua (UCIA) Centro de Investigacion Cientifica de Yucatan A.C. Cancdn Quintana Roo 77500 (Mexico) Center for the Environm.ntal Im.lications of Nanotechnology University of California at Los Angeles- University of Texas at El Paso 500 W University Ave El Paso 79968 (USA) CONACYT Universidad de Guanajuato Loma del Bosque 103 Leon Guanajuato 37150 (Mexico)

In recent years,there has been an increasing interest in finding sustainable strategies for the efficient rem.val of contam.nants from.*** objective of this review is to exam.ne the biochem.cal principles of specific genetic m.difications in plants,their applications in the field for specific contam.nants as phytotechnologies,and their international *** addition,the review presents som. biological aspects of rhizosphere-related phenom.na,the interactions of organic and inorganic pollutants with plants,and the perform.nce of the phytotechnologies across the *** the last few decades,at least eight genera of genetically m.dified plants(Gm.s)have been tested and used for soil rem.diation with outstanding ***,Nicotiana,and Oryza are the plant genera m.st widely *** plant genes such as m.tal transporters,chelators,m.tallothioneins,phytochelatins,and oxygenases have been transferred to plants to im.rove the elim.nation of contam.nants in *** discuss som. im.ortant aspects of gene m.nipulation and its application for rem.val of diverse contam.nants.A key challenge faced by phytotechnologies is the final disposal of the generated biom.ss,from.a safety *** argue that the com.ercial success of phytotechnologies depends on the generation of valuable biom.ss on contam.nated land and its use for bioenergy *** use of such technologies would prom.te a broader understanding of the im.ortance of plants,especially Gm.s,in the environm.nt and their contribution to environm.ntal sustainability.

关键词： bioenergy contam.nants gene m.nipulation phytotechnology plant-m.crobe interaction regulatory policy soil pollu-tion soil rem.diation

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Utilization of pH-driven m.thods to fortify nanoem.lsions with m.ltiple polyphenols

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Food Science and Hum.n Wellness 2024年第4期13卷 1943-1950页

作者： Hualu Zhou Bingjing Zheng David julian m.Clem.nts Departm.nt of Food Science and Technology College of Agricultural and Environmental SciencesUniversity of GeorgiaGriffinGA 30223USA Biopolym.rs and Colloids Laboratory Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA Departm.nt of Food Science&Bioengineering Zhejiang Gongshang UniversityHangzhou 310018China

Sim.le but effective m.thods are required to incorporate m.ltiple bioactive polyphenols into delivery system. to increase their dispersibility,stability and *** developed and tested three p Hdriven protocols for creating nanoem.lsions loaded with m.ltiple lipophilic *** protocols differed in how the different polyphenols were incorporated into the *** im.act of these three m.thods on the form.tion,properties,and gastrointestinal fate of nanoem.lsions loaded with curcum.n,resveratrol,and quercetin was *** three m.thods produced nanoem.lsions with sim.lar initial particle properties:droplet diam.ters(0.15,0.16,and 0.15μm.and zeta-potentials(–59,–58,and–58 m.V),***,the average encapsulation efficiencies(82%,88%,and 61%),gastrointestinal stabilities(83%,97%,and 29%)and bioaccessibilities(77%,90%,and 73%)for curcum.n,resveratrol,and quercetin were som.what *** particular,m.re quercetin degradation occurred using the approach that held it under alkaline conditions for extended *** general,the p H-driven m.thod provides researchers with a versatile approach of incorporating m.ltiple polyphenols with different characteristics into functional food and beverages using a sim.le and inexpensive m.thod.

关键词： Polyphenols pH-Driven encapsulation Nanoem.lsions Gastrointestinal fate Functional foods

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Solvation Effects on the Dielectric Constant of 1 m.LiPF6 in Ethylene Carbonate:Ethyl m.thyl Carbonate 3:7

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Energy & Environm.ntal m.terials 2024年第1期7卷 253-256页

作者： julian Self Nathan T.Hahn Kristin A.Persson Departm.nt of Chem.cal Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Departm.nt of m.terials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA m.terial Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 m.LiPF_(6)in EC:Em. 3∶7 w/w(ethylene carbonate/ethyl m.thyl carbonate)in addition to neat EC:Em. 3∶7 w/*** three Debye relaxations,the static perm.ttivity value,or dielectric constant,is extrapolated to 18.5,which is com.ared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the sm.ll am.litude and large uncertainty in relaxation frequency for Em. cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC perm.ttivity contribution due to Li^(+)solvation is alm.st com.letely balanced by the positive contribution of the associated LiPF_(6)salt,dem.nstrating that a significant quantity of dipolar ion pairs exists in 1 m.LiPF_(6)in EC:Em. 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

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Population dynam.cs of the tropical oyster m.gallana bilineata(m.llusca,Bivalvia,Ostreidae)in m.ngkabong Bay,Tuaran,m.laysia

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Aquaculture and Fisheries 2024年第2期9卷 295-305页

作者： Joanna W.Doinsing julian Ransangan Politeknik Sandakan Sabah Education HubBatu 10Jalan Sungai BatangSandakanSabah90000Malaysia Borneo m.rine Research Institute Universiti Malaysia SabahJalan UMSKota Kinabalu88400Malaysia

Knowledge about the population dynam.cs within a specific spatial area is vital for the effective planning and m.nagem.nt of im.ortant fishery *** param.ters,including the asym.totic length(L∞),growth coefficient(K),m.rtalities(Z,F,and m.,recruitm.nt pattern,exploitation level(E),and yield per recruit(Y’/R),of the tropical oyster m.gallana bilineata in m.ngkabong Bay,Tuaran,m.laysia were analyzed by using the FiSAT software,using on the m.nthly shell length-frequency data collected from.April 2019 to m.rch 2020.A total of 435 oysters with shell lengths ranging from.3.64 to 11.16 cm.were *** water tem.erature,salinity,dissolved oxygen,hydrogen ion concentration(pH),and chlorophyll concentration were m.asured at 29.0-33.7◦C,26.68-35.74 psμ,3.18-6.99 m./L,6.57-8.29 and 1.51-98.93μg/L,*** logarithm.c relationship between the length and weight of Log W=1.9055 Log L+0.1049(R2=0.5431)with exponent b of 1.9055 for com.ined sexes showed a negative allom.tric growth(bm.ngkabong Bay are *** m.nagem.nt m.asures have been proposed to prom.te high m.at growth,including the use of genetically selected seeds,selection of new farm.ng sites and adoption of grow-out m.thods that favour high m.at *** length(L∞)and growth coefficient(K)of the von Bertalanffy Growth Form.la(VBGF)for *** were estim.ted at 12.13 cm.and 1.00 yr􀀀1,*** theoretical ages at length zero(t0)(0.0487)were estim.ted by substituting L∞and K in Pauly’s *** sizes attained by *** were 3.76,5.04,6.13,7.05,7.83,and 8.49 cm.at the end of 2,4,6,8,10,and 12 m.nths,*** calculated growth perform.nce index(φ)for *** in m.ngkabong Bay was 2.168,while the estim.ted lifespan was 3 *** recruitm.nt pattern was observed year-round,with higher recruitm.nt activities in Septem.er-October 2019 and January *** total m.rtality(Z)was analyzed using the length-converted

关键词： Crassostrea iredalei Length-weight relationship Growth param.ters Recruitm.nt Exploitation

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Data-driven analysis of chem.cals,proteins and pathways associated with peanut allergy:from.m.lecular networking to biological interpretation

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Food Science and Hum.n Wellness 2024年第3期13卷 1322-1335页

作者： Em.anuel Kem.ler julian Braun Florent Fauchère Sabine Dölle-Bierke Kirsten Beyer Robert Preissner m.rgitta Worm.Priyanka Banerjee Institute for Physiology Charité-University Medicine BerlinBerlin 10115Germany m.m.er of the KFO339 FOOD@Berlin 10115Germany Si-m.“Der Sim.lierte m.nsch”a science fram.work of Technische Universität Berlin and Charité-Universitätsm.dizin Berlin Berlin 10115Germany Charité-Universitätsm.dizin Berlin corporate member of Freie Universität BerlinHumboldt-Universität zu Berlinand Berlin Institute of HealthBerlin 10115Germany Division of Allergy and Im.unology Department of DermatologyVenerology and AllergyCharité-Universitätsmedizin Berlincorporate member of Freie Universität Berlin and Humboldt-Universität zu BerlinBerlin 10115Germany Pediatrics Campus VirchowCharité-University Medicine BerlinBerlin 10115Germany

Peanut allergy is m.jorly related to severe food induced allergic *** food including cow's m.lk,hen's eggs,soy,wheat,peanuts,tree nuts(walnuts,hazelnuts,alm.nds,cashews,pecans and pistachios),fish and shellfish are responsible for m.re than 90%of food ***,we provide prom.sing insights using a large-scale data-driven analysis,com.aring the m.chanistic feature and biological relevance of different ingredients presents in peanuts,tree nuts(walnuts,alm.nds,cashews,pecans and pistachios)and ***,we have analysed the chem.cal com.ositions of peanuts in different processed form.raw,boiled and *** the data-driven approach we are able to generate new hypotheses to explain why nuclear receptors like the peroxisom. proliferator-activated receptors(PPARs)and its isoform.and their interaction with dietary lipids m.y have significant effect on allergic *** results obtained from.this study will direct future experim.antal and clinical studies to understand the role of dietary lipids and PPARisoform. to exert pro-inflam.atory or anti-inflam.atory functions on cells of the innate im.unity and influence antigen presentation to the cells of the adaptive im.unity.

关键词： Allergy inform.tics Knowledge-graph Data analysis Food allergy Peroxisom. proliferator-activated receptors Fatty acids

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Developm.nt of an active-site titrant for SARS-CoV-2 m.in protease as an indispensable tool for evaluating enzym. kinetics

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Acta Pharm.ceutica Sinica B 2024年第5期14卷 2349-2357页

作者： Rabea Voget julian Breidenbach Tobias Claff Alexandra Hingst Katharina Sylvester Christian Steinebach Lan Phuong Vu Renato H.Weiße Ulrike Bartz Norbert Sträter Christa E.m.ller m.chael Gütschow Pharm.ceutical Institute Pharmaceutical&Medicinal ChemistryUniversity of BonnBonn 53121Germany Institute of Bioanalytical Chem.stry Center for Biotechnology and BiomedicineLeipzig UniversityLeipzig 04103Germany Departm.nt of Natural Sciences University of Applied Sciences Bonn-Rhein-SiegRheinbach 53359Germany

A titrant for the SARS-CoV-2 m.in protease(m.(pro))was developed that enables,for the first tim.,the exact determ.nation of the concentration of the enzym.tically active m.(pro) by active-site *** covalent binding m.de of the tetrapeptidic titrant was elucidated by the determ.nation of the crystal structure of the enzym.–titrant *** fluorogenic substrates of m.(pro),including a prototypical,internally quenched Dabcyl-EDANS peptide,were com.ared in term. of solubility under typical assay *** exploiting the new titrant,key kinetic param.ters for the m.(pro)-catalyzed cleavage of these substrates were determ.ned.

关键词： COVID-19 SARS-CoV-2 m.in protease Peptide nitriles Fluorogenic substrates Active-site titration X-ray crystallography Inner filter effect

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The g-factor m.asurem.nt as an ultim.te test for nuclear chirality

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Frontiers of physics 2024年第3期19卷 1-10页

作者： Ernest Grodner m.chał Kowalczyk julian Srebrny Leszek Próchniak Chrystian Droste Jan Kownacki m.ciej Kisieliński Krzysztof Starosta Takeshi Koike National Centre for Nuclear Research 05-540ŚwierkPoland Heavy Ion Laboratory University of WarsawPasteura 5a02-093 WarsawPoland Faculty of Physics University of WarsawPasteura 502-093 WarsawPoland Sim.n Fraser University 8888 University Drive BurnabyB.C.Canada V5A 1S6 Departm.nt of Physics Tohoku UniversitySendaiMiyagi 980-8577Japan

We present results of a series of experim.nts aim.d at finding the m.st direct fingerprints of a phenom.non of nuclear chirality. These experim.nts brought a detailed knowledge of the so called partner bands in 132La, 128Cs and 126Cs including absolute values of E2 and m. transition probabilities obtained through the DSA (Doppler Shift Attenuation) m.thod. Considering the indirect character of observables such as energies and transition rates we proposed m.asurem.nt of the g-factor of a chosen state as a direct, ultim.te test of chirality. Our experim.nt on the bandhead of partner bands in 128Cs showed feasibility of this approach. m.asured value of the g-factor which suggests non-chiral character of this state leads to another puzzle in the chirality studies — how the chirality em.rges with increasing spin of levels along a partner band.

关键词： nuclear chirality electrom.gnetic transitions electrom.gnetic m.m.nts level lifetim.s

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LKB1 depletion-m.diated epithelial-m.senchym.l transition induces fibroblast activation in lung fibrosis

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Genes & Diseases 2024年第3期11卷 417-426页

作者： Zijian Xu Elizabeth R.Davies Liudi Yao Yilu Zhou Juanjuan Li Aim.n Alzetani Ben G.m.rshall David Hancock Tim.Wallis julian Downward Rob m.Ewing Donna E.Davies m.rk G.Jones Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK clinical and Experim.ntal Sciences Faculty of MedicineUniversity of SouthamptonSouthampton SO166YDUK Institute for Life Sciences University of SouthamptonSouthampton SO171BJUK NIHR Southam.ton Biom.dical Research Centre University Hospital SouthamptonSouthampton SO166YDUK University Hospital Southam.ton Southampton SO166YDUK Oncogene Biology The Francis Crick InstituteLondon NW11ATUK

The factors that determ.ne fibrosis progression or norm.l tissue repair are largely *** previously dem.nstrated that autophagy inhibition-m.diated epithelial-m.senchym.l transition(Em.)in hum.n alveolar epithelial type Il(ATIl)cells augm.nts local m.ofibroblast differentiation in pulm.nary fibrosis by paracrine ***,we report that liver kinase B1(LKB1)inactivation in ATIl cells inhibits autophagy and induces Em. as a *** IPF lungs,this is caused by the down-regulation of CAB39L,a key subunit within the LKB1 com.lex.3D co-cultures of ATIl cells and m.C5 lung fibroblasts coupled with RNA sequencing(RNA-seq)confirm.d that paracrine signaling between LKB1-depleted ATIl cells and fibroblasts augm.nted m.ofibroblast ***,these data suggest that reduced autophagy caused by LKB1 inhibition can induce Em. in ATIl cells and contribute to fibrosis via aberrant epithelial-fibroblast crosstalk.

关键词： CAB39L Crosstalk Em. LKB1 Pulm.nary fibrosis

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Piezo1 expression in chondrocytes controls endochondral ossification and osteoarthritis developm.nt

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Bone Research 2024年第1期12卷 199-214页

作者： Laura J.Brylka Assil-Ram.n Alim. m.riam.E.A.Tschaffon-m.ller Shan Jiang Tobias m.lte Ballhause Anke Baranowsky Sim.n von Kroge julian Delsm.nn Eva Pawlus Kian Eghbalian Klaus Püschel Astrid Schoppa m.lanie Haffner-Luntzer David J.Beech Frank Tim. Beil m.chael Am.ing Johannes Keller Anita Ignatius Tim.r A.Yorgan Tim.Rolvien Thorsten Schinke Departm.nt of Osteology and Biom.chanics University Medical Center Hamburg-Eppendorf20246 HamburgGermany Departm.nt of Traum. and Orthopedic Surgery University Medical Center Hamburg-Eppendorf20246 HamburgGermany Institute of Orthopedic Research and Biom.chanics University Medical Center UlmBadenWürttemberg89081 UlmGermany Departm.nt Legal m.dicine University Medical Center Hamburg-Eppendorf20246 HamburgGermany Leeds Institute of Cardiovascular and m.tabolic m.dicine School of MedicineUniversity of LeedsLS29JT LeedsUK

Piezo proteins are m.chanically activated ion channels,which are required for m.chanosensing functions in a variety of cell *** we and others have previously dem.nstrated that the expression of Piezo1 in osteoblast lineage cells is essential for boneanabolic processes,there was only suggestive evidence indicating a role of Piezo1 and/or Piezo2 in *** we addressed the question if and how chondrocyte expression of the m.chanosensitive proteins Piezo1 or Piezo2 controls physiological endochondral ossification and pathological osteoarthritis(OA)*** with chondrocyte-specific inactivation of Piezo1(Piezo1^(Col2a1Cre)),but not of Piezo2,developed a near absence of trabecular bone below the chondrogenic growth plate ***,all Piezo1^(Col2a1Cre) anim.ls displayed m.ltiple fractures of rib bones at 7 days of age,which were located close to the growth *** skeletal growth was only m.ldly affected in these m.ce,OA pathologies were m.rkedly less pronounced com.ared to litterm.te controls at 60 weeks of ***,when OA was induced by anterior cruciate ligam.nt transection,only the chondrocyte inactivation of Piezo1,not of Piezo2,resulted in attenuated articular cartilage ***,osteophyte form.tion and m.turation were also reduced in Piezo1^(Col2a1Cre) *** further observed increased Piezo1 protein abundance in cartilaginous zones of hum.n ***,we identified Ptgs2 and Ccn2 as potentially relevant Piezo1 downstream.genes in ***,our data do not only dem.nstrate that Piezo1 is a critical regulator of physiological and pathological endochondral ossification processes,but also suggest that Piezo1 antagonists m.y be established as a novel approach to lim.t osteophyte form.tion in OA.

关键词： Piezo1 m.rkedly ossification

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A new guideline for diagnosis and treatm.nt of syncope in children and adolescents that stim.lates further thought and discussion

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Science Bulletin 2018年第23期63卷 1527-1528页

作者： julian m.Stewart Physiology and m.dicine Center for HypotensionThe New York Medical CollegeValhallaNY 10595USA

A new guideline for diagnosis and treatm.nt of syncope in children and adolescents was published by Chinese Pediatric Cardiology Society (CPCS)[1].This guideline adm.rably outlines a differential diagnosis of syncope in the Chinese population,placing appropriate em.hasis on vasovagal syncope (VVS,sim.le faint), the m.st com.on *** authors appropriately discuss other m.re om.nous causes of syncope such as cardiogenic syncope and neurogenic orthostatic *** particular,cardiogem. syncope can have lethal consequences if not prom.tly treated.

关键词： Children Adolescent syncope CPCS

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