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A tribute to George Polgar, M.D.

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Pediatric Investigation 2019年第4期3卷 197-198页

作者： julian lewis allen Division of Pulmonary Medicine The Children's Hospital of Philadelphiathe Perelman School of Medicine at the University of PennsylvaniaPhiladelphiaPAUSA

George Polgar,a world renowned pediatric pulmonologist and physiologist,and founding editor of the journal Pediatric Pulmonology,was born in Gy(o)ngy(o)s,Hungary and earned his medical degree at the University of Szeg... 详细信息

关键词： George Polgar renowned pediatric pulmonologist founding

"Reactance inversion" at low frequencies in a child undergoing treatment of a cystic fibrosis exacerbation

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Pediatric Investigation 2019年第4期3卷 257-260页

作者： julian lewis allen Clement L.Ren Joseph McDonough Charles C.Clem Division of Pulmonary Medicine The Children's Hospital of PhiladelphiaPhiladelphiaPAUSA Riley Hospital for Children Indiana University School of MedicineIndianapolisIndianaUSA

Introduction:Impulse oscillometry(IOS)employs high frequency sinusoidal or impulse pressure and flow waveforms to interrogate the mechanical properties of the respiratory *** has special applications to preschool and younger children who may have difficulty performing the repetitive forced expiratory maneuvers required for *** presentation:We present a case illustrating improvements of respiratory system mechanics measured by IOS in a 6-year-old child with cystic fibrosis(CF)who demonstrated clinical and radiological improvement after a course of therapy with hospitalization and intravenous antibiotics,and initiation of a cystic fibrosis transmembrane regulator(CFTR)protein corrector/potentiator *** also report a new finding:observed lower than expected reactance at low compared to high frequencies("reactance inversion").Conclusion:Reactance inversion may reflect parallel pathway inhomogeneities in resistance and elastance or intrabreath airway inertance changes in young children with *** study is needed in children with airway obstruction due to asthma,cystic fibrosis,and chronic lung disease of infancy to demonstrate the prevalence of this finding and whether it is specific to a measurement device.

关键词： Cystic fibrosis Exacerbation Impulse oscillometry Reactance Reactance inversion

Advanced bioactive glue tethering Lubricin/PRG4 to promote integrated healing of avascular meniscus tears

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Bioactive Materials 2023年第10期28卷 61-73页

作者： Solaiman Tarafder Jaskirti Ghataure David Langford Rachel Brooke Ryunhyung Kim Samantha lewis Eyen julian Bensadoun Jeffrey T.Felix James L.Cook Chang H.Lee Regenerative Engineering Laboratory Columbia University Medical Center630 W.168 St.-VC12-212New YorkNY10032USA Thompson Laboratory for Regenerative Orthopaedics Missouri Orthopedic InstituteUniversity of Missouri1100 Virginia AvenueColumbi1MO65212USA

Meniscus injuries are extremely common with approximately one million patients undergoing surgical treatment annually in the U.S. alone, but no regenerative therapy exist. Previously, we showed that controlled applications of connective tissue growth factor (CTGF) and transforming growth factor beta 3 (TGFβ3) via fibrin-based bio-glue facilitate meniscus healing by inducing recruitment and stepwise differentiation of synovial mesenchymal stem/progenitor cells. Here, we first explored the potential of genipin, a natural crosslinker, to enhance fibrin-based glue’s mechanical and degradation properties. In parallel, we identified the harmful effects of lubricin on meniscus healing and investigated the mechanism of lubricin deposition on the injured meniscus surface. We found that the pre-deposition of hyaluronic acid (HA) on the torn meniscus surface mediates lubricin deposition. Then we implemented chemical modifications with heparin conjugation and CD44 on our bioactive glue to achieve strong initial bonding and integration of lubricin pre-coated meniscal tissues. Our data suggested that heparin conjugation significantly enhances lubricin-coated meniscal tissues. Similarly, CD44, exhibiting a strong binding affinity to lubricin and hyaluronic acid (HA), further improved the integrated healing of HA/lubricin pre-coated meniscus injuries. These findings may represent an important foundation for developing a translational bio-active glue guiding the regenerative healing of meniscus injuries.

关键词： Knee meniscus Bioactive glue Stem cell recruitment Lubricin

Molecular Biology of the Cell, Fourth Edition 4th ed.

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Molecular Biology of the Cell 5th ed.

2002年

作者： Bruce Alberts Alexander Johnson julian lewis Martin Raff Keith Roberts Peter Walter

ISBN: (纸本)9780815332183

Molecular Biology of the Cell is the classic in-depth text reference in cell biology. By extracting the fundamental concepts from this enormous and ever-growing field, the authors tell the story of cell biology, and create a coherent framework through which non-expert readers may approach the subject. Written in clear and concise language, and beautifully illustrated, the book is enjoyable to read, and it provides a clear sense of the excitement of modern biology. Molecular Biology of the Cell sets forth the current understanding of cell biology (completely updated as of Autumn 2001), and it explores the intriguing implications and possibilities of the great deal that remains *** hallmark features of previous editions continue in the Fourth Edition. The book is designed with a clean and open, single-column layout. The art program maintains a completely consistent format and style, and includes over 1,600 photographs, electron micrographs, and original drawings by the authors. Clear and concise concept headings introduce each section. Every chapter contains extensive references. Most important, every chapter has been subjected to a rigorous, collaborative revision process where, in addition to incorporating comments from expert reviewers, each co-author reads and reviews the other authors' prose. The result is a truly integrated work with a single authorial voice.

关键词： Cytology.

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Essential Cell Biology, 2nd ed.

2008年

作者： Bruce Alberts Alexander Johnson julian lewis Martin Raff Keith Roberts Peter Walter

ISBN: (纸本)9780815341055

For nearly a quarter century, "Molecular Biology of the Cell" has been the leading cell biology textbook. This tradition continues with the new Fifth Edition, which has been completely revised and updated to describe our current, rapidly advancing understanding of cell biology. To list but a few examples, a large amount of new material is presented on epigenetics; stem cells; RNAi; comparative genomics; the latest cancer therapies; apoptosis (now its own separate chapter); and cell cycle control and the mechanics of M phase (now integrated into one chapter). The hallmark features of "Molecular Biology of the Cell" have been retained, such as its consistent and comprehensive art program, clear concept headings, and succinct section summaries. Additionally, in response to extensive feedback from readers, the Fifth Edition now includes several new features. It is now more portable. Chapters 1-20 are printed and Chapters 21-25, covering multicellular systems, are provided as PDF files on the free Media DVD-ROM which accompanies the book. And for the first time, "Molecular Biology of the Cell" now contains end-of-chapter questions. These problems, written by John Wilson and Tim Hunt, emphasize a quantitative approach and the art of reasoning from experiments, and they will help students review and extend their knowledge derived from reading the textbook. The Media DVD-ROM, which is packaged with every copy of the book, contains PowerPoint[registered] presentations with all of the figures, tables and micrographs from the text (available as JPEGs too). Also included is the Media Player, which plays over 125 movies - animations, videos, and molecular models - all with voice-over narration. A new reader-friendly feature is the integration of media codes throughout the text that link directly to relevant videos and animations. The Media DVD-ROM holds the multicellular systems chapters (21-25) of the text as well. By skillfully extracting the fundamental concepts from this eno

关键词： Cell.

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星际探索卓瑞尔天文台“第一道光”射电天文馆

2004年

作者： Bruce Alberts Dennis Bray Karen Hopkin Alexander Johnson julian lewis Martin Raff Keith Roberts Peter Walter

Includes index.

ISBN: (纸本)9780815334804;081533480X

Includes index.

关键词： Cytology.

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室内设计与装修 2023年第6期 70-73页

作者： julian Gitsham Gary Collins Adam Atraktzi Oliver Kampshoff Sarah Willats Clive lewis Kaja Swiezewska Trang Dao David Brown(摄影) Hassell 不详

“第一道光”射电天文馆由建筑事务所Hassell设计。该项目建成开放后,世界各地的访客在著名的卓瑞尔天文台的参观体验得到很大提升,他们将射电天文学理论,转化成了迷人的星际探索。作为这块场地上最大的公共建筑,展馆的设计以捕捉太空... 详细信息

“第一道光”射电天文馆由建筑事务所Hassell设计。该项目建成开放后,世界各地的访客在著名的卓瑞尔天文台的参观体验得到很大提升,他们将射电天文学理论,转化成了迷人的星际探索。作为这块场地上最大的公共建筑,展馆的设计以捕捉太空爱好者的好奇心为主旨,引发人们科学探索的欲望,在广袤无垠太空收获天文学的发现。

关键词：建筑事务所射电天文学公共建筑广袤无垠瑞尔天文馆天文台好奇心