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World Journal of Traditional Chinese Medicine 2016年第2期 81-81页

作者： Grace Gar-lee Yue julia kin-ming lee Hin-Fai Kwok Da-Rong Wu Shao-Hua Liu Wei-Lie Xiao Clara Bik-San Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Chengdu No.1 Pharmaceutical Group Co. Ltd. State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Introduction:Heteronone B(HB)is a labdane diterpene isolated from Leonurus heterophyllus Sweet which is known as Yimucao in Chinese medicines and is traditionally used for the treatment of gynaecological *** was first... 详细信息

关键词： HB ANTI-ANGIOGENIC AND IMMUNOMODULATORY ACTIVITIES OF A LABDANE DITERPENE FROM LEONURUS HETEROPHYLLUS RNA

A Study on a Snowband Associated with a Coastal Front and Cold-Air Damming Event of 3-4 February 1998 along the Eastern Coast of the Korean Peninsula

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Advances in Atmospheric Sciences 2013年第2期30卷 263-279页

作者： Jae-Gyoo lee ming XUE Department of Atmospheric Environmental Sciences Kangnung National University Center for Analysis and Prediction of Storms Norman OKUSA School of Meteorology University of OklahomaNorman OKUSA

A 24-h simulation with the Advanced Regional Prediction System （ARPS） nonhydrostatic model is performed for the heavy snowfall event of 3-4 February 1998 along the eastern coast of Korean Peninsula; the results are used to understand the snowfall process, including why the precipitation maxima formed along the Yeongdong coastal region rather than over the mountain slope and ridge top during. The numerical simulation with a 4-kin horizontal grid spacing and 43 levels reproduces very well the narrow snowband located off the eastern Korean coast, away from, instead of over, the Yeongdong coastal mountain range. The general evolution of the snowband agrees quite well with radar observations, while the water-equivalent precipitation amount agrees reasonably well with radar precipitation estimate. The simulation results clearly show that the snow band developed due to the lifting by a coastal front that developed because of the damming of cold air against the eastern slope of the coastal mountain range. The damming was enhanced by the advection of cold air by a tow-level mountain-parallel jet from the north, formed due to geostrophic adjustment as the on-shore upslope air was decelerated by the mountain blocking. As the onshore flow weakened later due to synoptic-scale flow pattern change, the cold front propagated off shore and the precipitation dissipated.

关键词： coastal snowfall cold air damming orographic precipitation

Charge balance materials for homojunction and heterojunction OLED applications

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Frontiers of Optoelectronics 2009年第4期2卷 435-441页

作者： Louis M.LEUNG Yik-Chung LAW Michael Y.WONG Tik-Ho lee kin ming LAI Lok-Yee TANG Department of Chemistry and Centre for Advanced Luminescence Materials Hong Kong Baptist University

In a homojunction device, a single organic layer assumes the multiple roles of hole, electron transportation, and emitter. Its ease in processing is highly desirable from the manufacturing point of view. In this paper, we shall describe the synthesis of a range of bipolar small molecules and conductive vinyl polymers for application in homojunction and heterojunction organic light emitting diodes（OLEDs）. The bipolar materials, in general, consist of three basic building blocks: an arylamine, a 1,3,4-oxadiazole, and a polycyclic aromatic moiety. The achievement of charge balance can be validated either by direct measurement of electron/hole mobility or indirectly via optimization of device properties.A series of conductive vinyl copolymers containing hole transporting N-（4-methoxyphenyl）-N-（4-vinylphenyl）naphthalen-1-amine（4MeONPA） and electron transporting 2-phenyl-5-（4-vinylphenyl）-1,3,4-oxadiazole（OXA）at different compositions was applied for heterojunction and homojunction OLEDs. For heterojunction devices employed the copolymers as the hole transporting layer and Alq3as the electron transporting and emitting layer,a maximum luminance and current efficiency of over 23000 cd/m2and 4.2 cd/A（PL of Alq3）, respectively, were achieved at the charge balance composition. Homojunction devices for the copolymers were demonstrated by the addition of rubrene as a dopant. The single layer devices at the optimal copolymer composition has ca 1500 cd/m2and 0.74 cd/A.

关键词： homojunction devices charge balance bipolar small molecules conductive vinyl copolymers

Association between MDM2-SNP309 and hepatocellular carcinoma in Taiwan Residents population

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World Journal of Gastroenterology 2009年第44期15卷 5592-5597页

作者： Jyh-Der Leu I-Feng kin Ying-Fang Sun Su-Mei Chen Chih-Chao Liu Yi-Jang lee Division of Radiation Oncology Taipei City Hospital Ran Ai Branch 10629 Taipei Taiwan China Department of Public Health National Yang-Ming University 112 Taipei Taiwan China Department of Biomedical Imaging and Radiological Sciences National Yang-Ming University 112 Taipei Taiwan China Division of Nuclear Medicine Taipei City Hospital Ren Ai Branch 10629 Taipei Taiwan China Institute of Environmental and Occupational Healthy Sciences National Yang-Ming University 112 Taipei Taiwan China

AIM:To investigate the risk association and compare the onset age of hepatocellular carcinoma(HCC) patients in Taiwan with different genotypes of MDM2- SNP309. METHODS:We analyzed MDM2-SNP309 genotypes from 58 patients with HCC and 138 cancer-free healthy controls *** of MDM2-SNP309 was conducted by restriction fragment length polymor- phism assay. RESULTS:The proportion of homozygous MDM2- SNP309 genotype(G/G)in cases and cancer-free healthy controls was similar(17.2%vs 16.7%).Multi-variate analysis showed that the risk of G/G genotypeof MDM2-SNP309 vs wild-type T/T genotype in patients with HCC was not significant(OR=1.265,95% CI=0.074-21.77)after adjustment for sex,hepatitis B or C virus infection,age,and cardiovascular disease/ ***,there was a trend that GG genotype of MDM2-SNP309 might increase the risk in HCC patients infected with hepatitis virus(OR=2.568, 95%CI=0.054-121.69).Besides,the homozygous MDM2-SNP309 genotype did not exhibit a significantly earlier age of onset for HCC. CONCLUSION:Current data suggest that the asso- ciation between MDM2-SNP309 GG genotype and HCC is not significant,while the risk may be enhanced in patients infected by hepatitis virus in Taiwan.

关键词： MDM2 protein Hepatocellular carcinoma Taiwan Tumor suppressor protein p53

A truncated hepatitis E virus ORF2 protein expressed in tobacco plastids is immunogenic in mice

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World Journal of Gastroenterology 2006年第2期12卷 306-312页

作者： Yuan-Xiang Zhou Maggie Yuk-Ting lee James ming-Him Ng Mee-Len Chye Wing-kin Yip Sze-Yong Zee Eric Lam Department of Botany The University of Hong Kong PokfulamRoad Hong Kong China Biotech Center Rutgers University 59 Dudley RoadNew Brunswick NJ 08901-8520 United States

AIM： To cost-effectively express the 23-ku pE2, the most promising subunit vaccine encoded by the E2 fragment comprising of the 3＇-portion of hepatitis E virus （HEV） open reading frame 2 （ORF2） in plastids of tobacco （Nicotiana tabacum cv. SR1）, to investigate the transgene expression and pE2 accumulation in plastids, and to evaluate the antigenic effect of the plastid-derived pE2 in mice. METHODS： Plastid-targeting vector pRB94-E2 containing the E2 fragment driven by rice psbA promoter was constructed. Upon delivery into tobacco plastids, this construct could initiate homologous recombination in psaB-trnfM and trnG-psbC fragments in plastid genome, and result in transgene inserted between the two fragments. The pRB94-E2 was delivered with a biolistic particle bombardment method, and the plastid-transformed plants were obtained following the regeneration of the bombarded leaf tissues on a spectinomycin-supplemented medium. Transplastomic status of the regenerated plants was confirmed by PCR and Southern blot analysis, transgene expression was investigated by Northern blot analysis, and accumulation of pE2 was measured by ELISA. Furthermore, protein extracts were used to immunize mice, and the presence of the pE2-reactive antibodies in serum samples of the immunized mice was studied by ELISA. RESULTS： Transplastomic lines confirmed by PCR and Southern blot analysis could actively transcribe the E2 mRNA. The pE2 polypeptide was accumulated to a level as high as 13.27 μg/g fresh leaves. The pE2 could stimulate the immunized mice to generate pE2-specific antibodies. CONCLUSION： HEV-E2 fragment can be inserted into the plastid genome and the recombinant pE2 antigen derived is antigenic in mice. Hence, plastids may be a novel source for cost-effective production of HEV vaccines.

关键词： Hepatitis E virus E2 Plastid transformation Vaccine Tobacco

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據上博楚簡訂補楊伯峻《春秋左傳注》十則

人文中国学报 2019年第2期 -页

作者：李詠健香港大學中文學院

楊伯峻(1909—1992)《春秋左傳注》是近代重要的《左傳》注本。該書總結前人的研究,爲《左傳》全書作了通盤注釋。惟是書出版至今有年,期間有不少楚簡文獻出土,當中部分內容更可與《左傳》記載相互印證,對校訂《左傳》甚有裨益,亟待加... 详细信息

楊伯峻(1909—1992)《春秋左傳注》是近代重要的《左傳》注本。該書總結前人的研究,爲《左傳》全書作了通盤注釋。惟是書出版至今有年,期間有不少楚簡文獻出土,當中部分內容更可與《左傳》記載相互印證,對校訂《左傳》甚有裨益,亟待加以利用。本文即以2001至2012年間出版的《上海博物館藏戰國楚竹書(一至九)》所録文獻爲依據,就簡文與《左傳》相關之十處內容作比較分析,以訂正或補苴楊注。

关键词：楊伯峻《春秋左傳注》上博楚簡注釋訂補

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釋《上博七·吳命》簡9之“■日”

人文中国学报 2014年第1期 15-34页

作者：李詠健香港理工大學專業及持續教育學院

《上博七·吳命》簡9有'■日'一詞,整理者隸作'■日',讀爲'望日'。復旦讀書會將'■'改釋爲'暑';郭永秉改讀爲'曙';陳偉、沈培釋爲'是';王連成釋爲'堤'。馮勝君將字形改隸作'■',但在釋讀上仍從整理者說,釋爲'望'。本文綜考各家說法,認... 详细信息

《上博七·吳命》簡9有'■日'一詞,整理者隸作'■日',讀爲'望日'。復旦讀書會將'■'改釋爲'暑';郭永秉改讀爲'曙';陳偉、沈培釋爲'是';王連成釋爲'堤'。馮勝君將字形改隸作'■',但在釋讀上仍從整理者說,釋爲'望'。本文綜考各家說法,認爲馮氏釋'■'爲'■(望)'最爲可信,惟'望'應讀爲'明'。'望'、'明'古音同屬明紐陽部,音近可通,二字於古籍中亦有相通例證。從文義上看,簡文'明日',正相當於《左傅》中的'詰朝'都是指交戰之期。要之,簡文'自明日以往,比五六日',即'自明天開始,連續五六天'之意。

关键词：《上博七》楚簡《吳命》明日通假

教师“职业高原期”的成因与迈向卓越教师的策略

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当代教育与文化 2021年第1期13卷 1-10+125页

作者：李子建蒲永明梁霞香港教育大学成都大学师范学院成都市泡桐树小学西区分校

从学者提出的卓越教师的特质结构与教师的"职业高原期"的成因与表现进行分析对比来看,二者有内在的相关性,即具备迎接挑战、适应变化的环境、具有抗逆能力、持续自我的反思的素质等,这是决定一个教师避免进入"职业高原期"或者面临"职业... 详细信息

从学者提出的卓越教师的特质结构与教师的"职业高原期"的成因与表现进行分析对比来看,二者有内在的相关性,即具备迎接挑战、适应变化的环境、具有抗逆能力、持续自我的反思的素质等,这是决定一个教师避免进入"职业高原期"或者面临"职业高原期"时在身心和正向发展方面积极努力并且迈向卓越的关键。

关键词：教师专业发展职业高原期卓越教师

NOVEL ANTI-ANGIOGENIC ACTIVITIES OF A TRITERPENOID DEOXYACTEIN FROM CIMICIFUGA FOETIDA

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World Journal of Traditional Chinese Medicine 2015年第4期1卷 95-95页

作者： GraceGL Yue julia KM lee Hin-Fai Kwok Yin Nian ming-Hua Qiu Clara BS Lau Institute of Chinese Medicine State Key Laboratory of Phytochemistry and Plant Resources in West China The Chinese University of Hong Kong Institute of Chinese Medicine The Chinese University of Hong Kong State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of Sciences

Deoxyactein(DA)is a triterpenoid isolated from the root of Cimicifuga foetida which is a source of traditional Chinese herb'shengma'and is traditionally used as an antipyretic and analgesic *** studies showed that DA ... 详细信息

关键词： NOVEL ANTI-ANGIOGENIC ACTIVITIES OF A TRITERPENOID DEOXYACTEIN FROM CIMICIFUGA FOETIDA