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Protein synthesis,degradation,and energy metabolism in T cell immunity

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Cellular & Molecular Immunology 2022年第3期19卷 303-315页

作者： julia M.Marchingo Doreen A.Cantrell Cell Signalling and Immunology Division School of Life SciencesUniversity of DundeeDundeeDD15EHUK

T cell activation,proliferation,and differentiation into effector and memory states involve massive remodeling of T cell size and molecular content and create a massive increase in demand for energy and amino *** synthesis is an energy-and resource-demanding process;as such,changes in T cell energy production are intrinsically linked to proteome *** this review,we discuss how protein synthesis and degradation change over the course of a T cell immune response and the crosstalk between these processes and T cell energy *** highlight how the use of high-resolution mass spectrometry to analyze T cell proteomes can improve our understanding of how these processes are regulated.

关键词： T lymphocyte Protein Translation Proteomics Immunometabolism Protein degradation

Approaches for handling high-dimensional cluster expansions of ionic systems

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npj Computational Materials 2022年第1期8卷 1254-1264页

作者： julia H.Yang Tina Chen Luis Barroso-Luque zinab Jadidi Gerbrand Ceder Department of Materials Science and Engineering BerkeleyCA94720USA Materials Sciences Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Disordered multicomponent systems attract great interest due to their engineering design flexibility and subsequent rich space of ***,detailed characterization of the structure and atomic correlations remains challenging and hinders full navigation of these complex spaces.A lattice cluster expansion is one tool to obtain configurational and energetic *** in theory a cluster expansion can be applied to any system of any dimensionality,the method has primarily been used in binary systems or ternary *** we apply cluster expansions in high-component ionic systems,setting up the largest cluster expansion ever attempted to our *** doing so,we address and discuss challenges specific to high-component ionic systems,namely charge state assignments,structural relaxations,and rank-deficient *** introduce practical procedures to make the fitting and analysis of complex systems tractable,providing guidance for future computational studies of disordered ionic systems.

关键词： properties cluster ionic

Novel self-assembled two-dimensional layered oxide structure incorporated with Au nanoinclusions towards multifunctionalities

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Nano Research 2023年第1期16卷 1465-1472页

作者： Di zhang Xingyao Gao Juanjuan Lu Ping Lu julia Deitz Jianan Shen Hongyi Dou zihao He zhongxia Shang C.Austin Wade Xinghang zhang Aiping Chen Haiyan Wang School of Materials Engineering Purdue UniversityWest LafayetteIN 47907USA Center for Integrated Nanotechnologies(CINT) Los Alamos National LaboratoryLos AlamosNM 87545USA Sandia National Laboratories AlbuquerqueNM 87185USA School of Electrical and Computer Engineering Purdue UniversityWest LafayetteIN 47907USA Thermo Fisher Scientific HillsboroOR 97124USA

Two-dimensional(2D)layered oxides have recently attracted wide attention owing to the strong coupling among charges,spins,lattice,and strain,which allows great flexibility and opportunities in structure designs as well as multifunctionality *** parallel,plasmonic hybrid nanostructures exhibit exotic localized surface plasmon resonance(LSPR)providing a broad range of applications in nanophotonic devices and sensors.A hybrid material platform combining the unique multifunctional 2D layered oxides and plasmonic nanostructures brings optical tuning into the new *** this work,a novel self-assembled Bi2MoO6(BMO)2D layered oxide incorporated with plasmonic Au nanoinclusions has been demonstrated via one-step pulsed laser deposition(PLD)*** microstructural characterizations,including scanning transmission electron microscopy(STEM),differential phase contrast imaging(DPC),and STEM tomography,have demonstrated the high epitaxial quality and particle-in-matrix morphology of the BMO-Au nanocomposite ***-STEM imaging clarifies the magnetic domain structures of BMO *** different BMO structures including layered supercell(LSC)and superlattices have been revealed which is attributed to the variable strain states throughout the BMO-Au *** to the combination of plasmonic Au and layered structure of BMO,the nanocomposite film exhibits a typical LSPR in visible wavelength region and strong anisotropy in terms of its optical and ferromagnetic *** study opens a new avenue for developing novel 2D layered complex oxides incorporated with plasmonic metal or semiconductor phases showing great potential for applications in multifunctional nanoelectronics devices.

关键词： layered oxides plasmonic strain anisotropy multifunctionality

Nicotinamide mononucleotide:a potential effective natural compound against insulin resistance

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Signal Transduction and Targeted Therapy 2021年第9期6卷 2609-2610页

作者： julian Roos julia zinngrebe Pamela Fischer-Posovszky Department of Pediatrics and Adolescent Medicine Ulm University Medical CenterUlmGermany

Recently,a study published in Science by Yoshino et al.1 reported on a randomized,placebo-controlled,double-blind clinical trial to examine the effects of a 10-week nicotinamide mononucleotide(NMN)administration on human metabolism in 25 postmenopausal overweight or obese women with *** revealed positive effects of NMN on insulin sensitivity,insulin signalling,and tissue remodelling in skeletal muscle.

关键词： metabolism clinical

The differences and similarities between two-sample t-test and paired t-test

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上海精神医学 2017年第3期29卷 184-188页

作者：徐曼菲 Drew FRALICK julia z.zHENG Bokai Wang Xin M.TU Changyong FENG Shanghai Mental Health Center Shanghai Jiao Tong University School of Medicine Department of Immunology and Microbiology McG ill University Departments of Biostatistics & Computational Biology University of Rochester Department of Family Medicine and Public Health University of California San Diego School of Medicine Departments of Anesthesiology University of Rochester

临床研究中经常遇到比较实验组和对照组之间的结果。双样本t检验(又称为独立样本t检验)和配对t检验可能是运用于比较两个样本之间均值的最广泛的统计方法。然而,这两种方法的运用会产生混淆,从而导致使用不当。本文中,我们讨论了这两种... 详细信息

临床研究中经常遇到比较实验组和对照组之间的结果。双样本t检验(又称为独立样本t检验)和配对t检验可能是运用于比较两个样本之间均值的最广泛的统计方法。然而,这两种方法的运用会产生混淆,从而导致使用不当。本文中,我们讨论了这两种t检验之间的异同性,并运用三个范例来阐述双样本t检验和配对t检验的计算过程。

关键词：样本均值 t检验配对异同独立样本测试方法使用不当计算过程

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比较两组连续性结果的样本计算

上海精神医学 2017年第4期29卷 250-256页

作者： julia z. zHENG Yangyi LI Tuo LIN Angelica ESTRADA Xiang LU Changyong FENG Department of Immunology and Microbiology McGill University Montreal Canada Department of Mathematics State University of New York in Stony Brook Stony Brook NY USA Department of Mathematics University of California in San Diego San Diego CA USA Department of Physics University of California in San Diego San Diego CA USA Department of Biostatistics and Computational Biology University of Rochester Rochester NY USA

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意... 详细信息

概述:所有的临床研究都需要对样本量进行辨证。然而,对于众多生物医学和临床研究人员来说,把握度和样本量看起来就像一个统计学家的魔术。在本文中,我们讨论了把握度和样本量的计算,并说明生物医学和临床研究人员在该分析的可行性和意义中具有重要作用。因此,把握度分析的确是一个互动的过程,并且科学研究人员和统计人员在研究团队中是平等合作的伙伴。

关键词：样本量连续性结果临床研究把握度

Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

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Journal of Geriatric Cardiology 2021年第1期18卷 20-29页

作者： Juan Martínez-Milla Marcelino Cortés García julia Anna Palfy Mikel Taibo Urquía Marta López Castillo Ana Devesa Arbiol Ana Lucía Rivero Monteagudo María Luisa Martín Mariscal Inés Jiménez-Varas Sem Briongos Figuero Juan Antonio Franco-Pelaéz JoséTuñón Department of Cardiology Hospital Universitario Fundación Jiménez Díaz-Quirónsalud Centro Nacional de Investigaciones Cardiovasculares MadridSpain Department of Cardiology Hospital Central de Asturias Department of Cardiology Hospital Universitario Ruber-Quirónsalud Department of Cardiology Hospital Universitario Infanta Leonor Department of Endocrinology Hospital Clínico San Carlos Universidad Autónoma de Madrid CIBERCV MadridSpain

OBJECTIVE To assess the role of beta-blockers(BB)in patients with chronic kidney disease(CKD)aged≥75 *** AND RESULTS From January 2008 to July 2014,we included 390 consecutive patients≥75 years of age with ejection fraction≤35%and glomerular filtration rate(GFR)≤60 m L/min per 1.73 m^*** analyzed the relationship between treatment with BB and mortality or cardiovascular *** mean age of our population was 82.6±4.1 *** ejection fraction was 27.9%±6.5%.GFR was 60-45 m L/min per 1.73 m^2 in 50.3%of patients,45-30 m L/min per 1.73 m^2 in 37.4%,andzation for heart failure).BB use was significantly associated with a reduced risk of death(HR=0.51,95%CI:0.35-0.74;P<0.001).Patients receiving BB consistently showed a reduced risk of death across the different stages of CKD:stage IIIa(GFR=30-45 m L/min per 1.73 m^2;HR=0.47,95%CI:0.26-0.86,P<0.0001),stage IIIb(GFR 30-45 m L/min per 1.73 m^2;HR=0.55,95%CI:0.26-1.06,P=0.007),and stages IV and V(GFR<30 m L/min per 1.73 m~2;HR=0.29,95%CI:0.11-0.76;P=0.047).CONCLUSIONS The use of BB in elderly patients with HFr EF and renal impairment was associated with a better *** of BB should be encouraged when possible.

关键词： CKD GFR Beta-blocker therapy in elderly patients with renal dysfunction and heart failure

Rhodaelectro-Catalyzed C–H and C–C Activation

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CCS Chemistry 2021年第2期3卷 1529-1552页

作者： Youai Qiu Cuiju zhu Maximilian Stangier julia Struwe Lutz Ackermann Institut für Organische und Biomolekulare Chemie Georg-August-Universität GöttingenGöttingen 37077

Rhodium(III)catalysis has set the stage for a plethora of oxidative C–H functionalizations over the last decade,which have predominantly employed stoichiometric amounts of toxic and expensive metal oxidants,such as silver(I)*** the meantime,electrosynthesis has emerged as an increasingly viable alternative for expensive and toxic ***,significant momentum has been achieved with the merger of electrocatalysis with organometallic C–H ***,user-friendly and robust rhodaelectro-catalysis has until very recently proven elusive for oxidative C–H *** minireview highlights the current knowledge and recent advances of electrooxidation in rhodium-catalyzed C–H or C–C activations,with a topical focus on contributions from the Ackermann group through July 2020.

关键词： electrosynthesis rhodium catalysis C–H activation C–C activation mechanistic in-sights rhodaelectro-catalysis

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Streuselschnecke

德语学习 2012年第3期 12-13页

作者： julia Franck

Der Anruf kam,als ich vierzehn *** wohnte seit einem Jahr nicht mehr bei meiner Mutter und meinen Schwestern,sondern bei Freunden in *** fremde Stimme meldete sich,der Mann nannte seinen Namen,sagte mir,er lebe in Berlin,und fragte,ob ich ihn kennen lernen *** zgerte,ich war mir nicht *** hatte ich schon vielüber solche Treffen gehrt und mir oft vorgestellt,wie so etwas wre,aber als es soweit war,empfand ich eher Unbehagen.

关键词：德语译文翻译方法语言学