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Comparison of hyperthermic intraperitoneal chemotherapy regimens for treatment of peritoneal-metastasized colorectal cancer

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World Journal of Gastrointestinal Oncology 2020年第8期12卷 903-917页

作者： julia spiegelberg Hannes Neeff Philipp Holzner Mira Runkel Stefan Fichtner-Feigl Torben Glatz Department of General and Visceral Surgery Medical Center–University of FreiburgFreiburg 79106Germany Department of Surgery Marien Hospital HerneRuhr-University BochumHerne 44625Germany

BACKGROUND Cytoreductive surgery(CRS)in combination with hyperthermic intraperitoneal chemotherapy(HIPEC)improves patient survival in colorectal cancer(CRC)with peritoneal carcinomatosis(PC).Commonly used cytotoxic agents include mitomycin C(MMC)and *** have reported varying results,and the evidence for the choice of the HIPEC agent and uniform procedure protocols is *** To evaluate therapeutic benefits and complications of CRS+MMC vs oxaliplatin HIPEC in patients with peritoneal metastasized CRC as well as prognostic *** One hundred and two consecutive patients who had undergone CRS and HIPEC for CRC PC between 2007 and 2019 at the Medical Center of the University Freiburg regarding interdisciplinary cancer conference decision were retrospectively *** and MMC were used in 68 and 34 patients,*** patient’s demographics and tumour characteristics,operative details,postoperative complications and survival were *** were stratified and graded using Clavien/Dindo *** outcome factors were identified using univariate and multivariate analysis of *** The two groups did not differ significantly regarding baseline *** found no difference in median overall survival between MMC and oxaliplatin *** postoperative complications,patients treated with oxaliplatin HIPEC suffered increased complications(66.2%vs 35.3%;P=0.003),particularly intestinal atony,intraabdominal infections and urinary tract infection,and had a prolonged intensive care unit stay compared to the MMC group(7.2 d vs 4.4 d;P=0.035).Regarding univariate analysis of survival,we found primary tumour factors,nodal positivity and resection margins to be of prognostic value as well as peritoneal cancer index(PCI)-score and the completeness of cytoreduction regarding peritoneal *** analysis of survival confirmed primary distant metastasis and primary tumour resec

关键词： Colorectal cancer Peritoneal carcinomatosis Cytoreductive surgery Hyperthermic intraperitoneal chemotherapy Chemotherapy Mitomycin

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