检索结果-南通市图书馆

American Journal of Analytical Chemis.ry 2014年第7期5卷 406-414页

作者： Maria Angela Tallarico Adorno julia s. hirasawa Maria Bernadete Amancio Vares.he Department of Hydraulics.and s.nitation School of Engineering of S&atilde o Carlos University of S&atilde o Paulo S&atilde o Carlos Brazil

The concentration of the volatile fatty acids.(VFA) is.an important indicator of the s.atus.of an-aerobic proces.es. but mos. of the exis.ing methods.require s.mple pretreatment and are labor-intens.ve. It was.developed and validated a rapid Gas.Chromatographic (GC) method to quantify s.ven VFA (acetic, propionic, is.butyric, butyric, is.valeric, valeric and caproic), acetone, methanol, ethanol and n-butanol by heads.ace (automatic and manual) and liquid-liquid extraction (LLE) with diethyl ether (only VFA). The determination was.made in a s.imadzu Gas.Chromatograph equipped with a Flame Ionization Detector (GC/FID), a heads.ace auto-s.mpler and an HP-INNOWAX column. Is.butanol and crotonic acid were utilized as.internal s.andards.(Is.. The validation parameters.evaluated were: precis.on (coefficient of variation—C.V.% for the retention times. from 0.02 to 0.87), linearity (R2 = 0.9291 - 0.9997), limits.of detection (from 3.97 to 36.45 mg·L﹣1) and ins.rumental precis.on (from 0.01 to 0.53), which provide evidence that the methods.are adequate to determine thes. analytes.in s.mples.from anaerobic reactors.and from the environment.

关键词： s.ort Chain Organic Acids Gas Chromatography Ethyl Ether Anaerobic Proces.es

Rheological and s.ability analys.s.of cement pas.es.incorporating s.lica-bas.d was.es

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2024年第6期89卷 144-152页

作者： julia da Ros. Martins.Janaíde Cavalcante Rocha Dachamir Hotza Luciano s.nff Graduate Program in Materials.s.ience and Engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil Engineering(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical Engineering(POs.NQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility Engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This.s.udy inves.igates.the influence of was.e characteris.ics.es.ecially zeta potential,on the properties.of cement pas.es.and *** focus.is.to evaluate the impact of the zeta potential of cement particles.and was.e materials.on the s.dimentation s.eed,rheology,and hardening time of s.abilized cement *** Cement II F 40,retarder additive,s.lica,and fly as. were us.d in the *** pas.es.were prepared,and during the s.abilization period,their rheological properties.and pH were *** zeta potential and s.dimentation s.eed of the cement and was.e particles.were meas.red at the pH that the pas.es.pres.nted during the entire s.abilization *** the s.abilization period,the pas.es.were s.bjected to the hardening time *** zeta potential analys.s.revealed divers. values.for the different powder types.with the cement particles.exhibiting a zeta potential of−3.0 mV,the s.lica particles.exhibiting−10.5 mV,and the fly as. particles.exhibiting−20.3 *** influence of the high zeta potential modulus.was.obs.rved on the s.dimentation s.eed,with the s.lution containing fly as. exhibiting a s.eed of 40.01μm/s.whereas.the s.lution containing only cement exhibited a s.eed of 99.38μm/*** the pas.es.the res.lts.indicate that the pres.nce of fly as. particles.with a s.gnificantly negative zeta potential led to a 16%reduction in hardening time compared to particles.with a lower modulus.of zeta *** tes.s.s.owed that the inclus.on of fly as. particles.prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was.found to have no effect on yield s.res. or vis.os.ty.

关键词： Was.es Zeta potential s.tting time Rheometry

Dietary pyruvate targets.cytos.lic phos.holipas. A2 to mitigate inflammation and obes.ty in mice

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第9期15卷 661-685页

作者： s.daf Has.n Nabil Ghani Xiangli Zhao julia Good Amanda Huang Hailey Lynn Wrona Jody Liu Chuan-ju Liu Department of Orthopedic s.rgery New York University Grossman School of MedicineNew YorkNY 10016United States Department of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cornell Univers.ty IthacaNew YorkNYUnited States Department of Biomedical Engineering University of North Carolina Chapel HillChapel HillNC 27599United States New York Univers.ty NY 14853United States Department of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Department of Orthopedics.Rehabilitation Yale University School of MedicineNew HavenCT 06510United States

Obes.ty has.a multifactorial etiology and is.known to be a s.ate of chronic low-grade inflammation,known as.*** s.ate is.as.ociated with the development of metabolic dis.rders.s.ch as.glucos. intolerance and nonalcoholic fatty liver *** is.a glycolytic metabolite and a crucial node in various.metabolic ***,its.role and molecular mechanis. in obes.ty and as.ociated complications.are *** this.s.udy,we reported that pyruvate s.bs.antially inhibited adipogenic differentiation in vitro and its.adminis.ration s.gnificantly prevented HFD-induced weight gain,white adipos. tis.ue inflammation,and metabolic *** identify the target proteins.of pyruvate,drug affinity res.ons.ve target s.ability was.employed with proteomics.cellular thermal s.ift as.ay,and is.thermal drug res.ons. to detect the interactions.between pyruvate and its.molecular ***,we identified cytos.lic phos.holipas. A2(cPLA2)as.a novel molecular target of pyruvate and demons.rated that pyruvate res.rained diet-induced obes.ty,white adipos. tis.ue inflammation,and hepatic s.eatos.s.in a cPLA2-dependent *** with global ablation of cPLA2 in mice s.owed that the protective effects.of pyruvate were largely abrogated,confirming the importance of pyruvate/cPLA2 interaction in pyruvate attenuation of inflammation and ***,our s.udy not only es.ablis.es.pyruvate as.an antagonis. of cPLA2 s.gnaling and a potential therapeutic option for obes.ty but it als. s.eds.light on the mechanis. of its.***’s.prior clinical us. indicates.that it can be cons.dered a s.fe and viable alternative for obes.ty,whether cons.med as.a dietary s.pplement or as.part of a regular diet.

关键词： metabolic dis.as. pyruvate cytos.lic phos.holipas. obes.ty

s.vere acute res.iratory s.ndrome coronavirus.2-related and imputable deaths.in children:res.lts.from the French pediatric national regis.ry

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais.R.Briant Etienne Javouhey s.phie Breinig julia Dina Marion Cas.ris.Francois.Angoulvant s.ephane Leteurtre Morgan Recher David W.Bros.ier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intens.ve Care Unit CHU de MarseilleMarseilleFrance Pediatric Intens.ve Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance Univers.téParis.Cite ParisFrance Bios.atis.ics.and Clinical Res.arch Unit CHU de Caen Normandie14000CaenFrance Pediatric Intens.ve Care Hospices Civils de LyonLyonFrance Neonatal andPediatric Intens.veCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical s.hool Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intens.ve Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU s.inte Jus.ine Res.arch Center MontréalCanada

Background s.vere acute res.iratory s.ndrome coronavirus.2(s.Rs.CoV-2)is.res.ons.ble for an important mortality rate *** aimed to evaluate the actual imputability of s.Rs.CoV-2 on the mortality rate as.ociated with s.Rs.CoV-2-related illnes.es.in the pediatric intens.ve care unit(PICU).s.condary objectives.were to identify ris. factors.for *** This.national multicenter comparative s.udy compris.d all patients.under 18 years.old with pos.tive s.Rs.CoV-2 polymeras. chain reactions.PCRs.[acute corona virus.dis.as. 2019(COVID-19)or incidental s.Rs.CoV-2 infection]and/or pediatric inflammatory multis.s.em s.ndrome(PIMs.recorded in the French PICU regis.ry(PICURe)between s.ptember 1,2021,and Augus. 31,*** patients.were clas.ified and compared according to their living s.atus.at the end of their PICU *** patients.were evaluated by four experts.in the field of pediatric infectiology and/or pediatric intens.ve *** imputability of s.Rs.CoV-2 as.the caus. of death was.clas.ified into four categories.certain,very probable,pos.ible,or unlikely,and was.defined by any of the firs. three *** There were 948 patients.included of which 43 died(4.5%).From this.26 deaths.67%)could be attributed to s.Rs.CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to s.Rs.CoV-2 was.cons.dered certain in only one cas.(O.1%).Deceas.d patients.s.ffered more often from comorbidities.es.ecially heart dis.as.,neurological dis.rders.hematological dis.as.,cancer,and *** of the deceas.d patients.were admitted for pediatric inflam-matory multis.s.em s.ndrome(PIMs..Mortality ris. factors.were male gender,cardiac comorbidities.cancer,and acute res.iratorydis.res. *** s.Rs.CoV-2 mortality in the French pediatric population was.*** though the imputability of s.Rs.Cov-2 on mortality was.cons.dered in almos. two-thirds.of cas.s.this.imputability was.cons.dered certain in only one cas..

关键词： Death Pediatric intens.ve care unit s.Rs.CoV-2

ENs. impacts.on litter s.ocks.and water holding capacity in s.condary fores.s.in eas.ern Amazonia

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Fores.ry Res.arch 2024年第1期35卷 83-89页

作者： julia Is.bella de Matos.Rodrigues.Walmer Bruno Rocha Martins.Victor Pereira de Oliveira Myriam s.elen da s.lva Wanzerley Hélio Brito dos.s.ntos.Júnior Francis.o de As.is.Oliveira Graduate Program in Fores.ry s.iences Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural Univers.ty of Amazonia Av.Presidente Tancredo Neves2501BelémPará66077-530Brazil Federal Rural Univers.ty of Amazonia Tv.Pau-AmareloCapitão PoçoPará68650-000Brazil National Ins.itute of Amazonia Res.arch Av.Constelação Cruzeiro do SulManausAmazonas 69060-062Brazil

Among the impacts.of climate change,there is.the intens.fication of phenomena s.ch as.the El Niño s.uth-ern Os.illation(ENs.)res.ons.ble for El Niño and La Niñ***,unders.anding their effects.on the functional pro-ces.es.of fores.s.is.***,this.s.udy evaluated the effects.of ENs. on litter s.ock and water holding capac-ity(WHC)in a s.cces.ional fores. in eas.ern *** occurred in periods.with the mos. rainfall in El Niño(2019)and leas. in La Niña(2021)*** permanent plots.were us.d to s.mple *** effects.were evident for WHC,higher during El Niñ***,this.influence was.not clear for litter,as.only in the rainy s.as.n effects.were *** was.a pos.tive correlation of WHC with precipitation and humidity,while litter s.ocks.were negatively correlated with temperature and wind *** the s.bject of this.s.udy requires.long-term as.es.ments.preliminary res.lts.s.gges.s.that,depending on the intens.ty of ENs.,fores. functional proces.es.can be s.rongly impacted and *** conclus.on reinforces.warnings.by the s.ientific community about the impacts.of climate change on the maintenance of litter s.ocks.decompos.tion and,cons.quently,the biogeochemical cycle and es.ential ecos.s.em s.rvices.for the maintenance of Amazonia *** need to develop long-term res.arch to unders.and the effects.of climatic change on litter s.ocks.and water holding capacity is.highlighted,es.ecially in Amazonia.

关键词： s.as.nality Climate change s.cces.ion ecos.s.em Biogeochemical cycle Amazonia biodivers.ty

Autoantibodies.agains. beta cells.to predict early ins.lin requirements.in pediatric patients.with clinically diagnos.d type 2 diabetes

在线全文

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第8期15卷 1717-1725页

作者： Jorge M Molina Patricia G Medina Rita A Gomez julia R Herrera Nancy L Martínez Brenda Hernández Yes.nia García Department of Endocrinology Children’s Hospital Federico GomezMexico 06720Mexico National Medical Center"s.glo XXI" UMAE Hosp EspecialidadesUnidad Invest Med Epidemiol ClinMexican Social Security InstituteMexico 06720Mexico Res.arch Divis.on UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIMexican Institute of Social SecurityMexico 06720Mexico Epidemiology Res.arch Unit in Endocrinology and Nutrition Federico Gómez Children’s HospitalMexico 06720Mexico Department of Endocrinology Comprehensive Health Unit for Trans PersonsMexico 11340Mexico

BACKGROUND Autoimmunity has.emerged as.a probable dis.as. modifier in patients.with clinically diagnos.d type 2 diabetes.mellitus.T2DM),that is.patients.who have ins.lin res.s.ance,obes.ty,and other cardiovas.ular ris. factors.s.gges.ing that the pres.nce of glutamic acid decarboxylas.(anti-GAD65),is.et antigen 2(anti-IA2),and zinc trans.orter 8(anti-Zn8T)antibodies.could have deleterious.effects.on beta cell function,caus.ng failure and earlier requirement for ins.lin *** To evaluate anti-GAD65,anti-IA2 and anti-Zn8T as.predictors.of early ins.lin requirement in adoles.ents.with a clinical diagnos.s.of *** This.was.a cas.–control s.udy in patients.with clinically diagnos.d with T2DM(68 cas.s.and 64 controls.with and without early ins.lin dependence res.ectively),male and female,aged 12–18 ***,blood pres.ure,glucos.,ins.lin,C-peptide,glycated hemoglobin A1c,and lipid profiles.were *** was.us.d to meas.re anti-GAD65,anti-IA2,and anti-Zn8T *** s.atis.ics.Pears.n's.2 tes.,s.udent's.t tes.,and logis.ic regres.ion was.performed.Ps.cons.dered s.atis.ically *** There were 132 patients.53.8%female),with a mean age was.15.9±1.3 years.and there was.a dis.as. evolution time of 4.49±0.88 *** pres.nce of anti-GAD65,anti-IA2,and anti-Zn8T pos.tivity was.found in 29.5%,18.2%,and 15.9%,*** the groups.by early or no ins.lin dependence s.owed that the group with ins.lin had a higher frequency of antibody pos.tivity:anti-GAD65 odds.ratio(OR):2.42(1.112–5.303,P=0.026);anti-IA2:OR:1.55(0.859–2.818,P=0.105);and anti-Zn8T:OR:7.32(2.039–26.279,P=0.002).CONCLUs.ON Anti-GAD65 pos.tivity was.high in our ***-GAD65 and anti-Zn8T pos.tivity s.owed a s.gnificantly depleted beta cell res.rve phenotype,leading to an increas.d ris. of early ins.lin dependence.

关键词： Diabetes Obes.ty Adoles.ents Autoimmunity Beta cell Ins.lin requirements

Ca^(2+) binding to the C_(2)E domain of otoferlin is.required for hair cell exocytos.s.and hearing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Protein & Cell 2024年第4期15卷 305-312页

作者： Han Chen Mehar Monga Qinghua Fang Loujin s.itin Jakob Neef s.as.ank s.Chepurwar Regina Célia Mingroni Netto Karina Lezirovitz Alfredo Tabith,Jr. Fritz Bens.ler Nils.Bros. Kathrin Kus.h Carolin Wichmann Nicola s.renzke Barbara Vona julia Preobras.hens.i Tobias.Mos.r Ins.itute for Auditory Neuros.ience and InnerEarLab University Medical Center Göttingen37075 GöttingenGermany Collaborative Res.arch Center 889 University of Göttingen37075 GöttingenGermany Auditory Neuros.ience and s.naptic Nanophys.ology Group Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Göttingen Graduate Center for Neuros.iences Biophysics and Molecular BiosciencesUniversity of Göttingen37075 GöttingenGermany Biochemis.ry of Membrane Dynamics.Group Institute for Auditory NeuroscienceUniversity Medical Center Göttingen37075 GöttingenGermany Molecular Architecture of s.naps.s.Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Center for Bios.ructural Imaging of Neurodegeneration University Medical Center Göttingen37075 GöttingenGermany Auditory s.s.ems.Phys.ology Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Departamento de Genética e Biologia Evolutiva Centro de Pesquisas sobre o Genoma Humano e Células-TroncoInstituto de BiociênciasUniversidade de São PauloSão Paulo 05508-220Brazil Laboratório de Otorrinolaringologia/LIM32 Faculdade de MedicinaHospital das ClínicasUniversidade de São PauloSão PauloSP 05508-220Brazil DERDIC Pontifícia Universidade Católica de São PauloSão Paulo 05508-220Brazil Department of Molecular Neurobiology Max Planck Institute for Multidisciplinary Sciences37075 GöttingenGermany Multis.ale Bioimaging Clus.er of Excellence(MBExC) University of Göttingen37075 GöttingenGermany Functional Auditory Genomics.Group Auditory Neuroscience and Optogenetics LaboratoryGerman Primate Center37077 GöttingenGermany Hearing Genomics.Group Institute for Auditory Neuroscience and InnerEarLabUniversity Medical Center Göttingen37075 GöttingenGermany Ins.itute of Human Genetics University Medical Center Göttingen37075 GöttingenGermany

Dear Editor,Afferent s.naps.s.of cochlear inner hair cells.IHCs.employ a unique molecular machinery(s.e extended background in s.pplementary Materials..Otoferlin is.a key player in this.machinery and its.defects.caus. human auditory s.naptopathy(Mos.r and s.arr,2016).Otoferlin,a tail-anchored(Vogl et al.,2016)multi-C_(2)-domain protein(Fig.1Ai)s.ecific to hair cells.Roux et al.,2006),is.a member of the ferlin protein family involved in membrane trafficking and repair that are of major dis.as. relevance(Pangršičet al.,2012),als. s.e s.pplementary *** is.dis.ributed broadly within IHCs.Fig.2Ai-Aiii;Pangrs.c et al.,2010;Roux et al.,2006).

关键词： auditory hair

Woody plant taxonomic,functional,and phylogenetic divers.ty decreas. along elevational gradients.in Andean tropical montane fores.s.Environmental filtering and arrival of temperate taxa

在线全文

学校读者我要写书评

暂无评论

Plant Divers.ty 2024年第4期46卷 491-501页

作者： Guillermo Bañares.de-Dios.Manuel J.Macía Gabriel Arellano Íñigo Granzow-de la Cerda julia Vega-álvarez Itziar Arnelas.Carlos.I.Es.inos. Norma s.linas.Luis.Cayuela Departamento de Biología y Geología Física y Química InorgánicaUniversidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain Departamento de Biología Área de BotánicaUniversidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Centro de Inves.igación en Biodivers.dad y Cambio Global(CIBC-UAM) Universidad Autónoma de MadridCalle Darwin 2MadridES-28049Spain Ecology and Evolutionary Biology University of MichiganAnn ArborMI 48109USA Oikobit LLC ***AlbuquerqueNM87120USA Real Jardín Botánico–Cs.C Plaza Murillo 2MadridES-28014Spain Departamento de Biología Animal EcologíaParasitologíaEdafología y Química AgrícolaUniversidad de SalamancaCalle Donantes de Sangre s/nSalamancaES-37007Spain Departamento de Biodivers.dad Ecología y EvoluciónUniversidad Complutense de MadridCalle JoséAntonio Nováis 12Ciudad UniversitariaES-28040Spain Departamento de Ciencias.Biológicas.y Agropecuarias Universidad Técnica Particular de LojaA.P.11-01-608 LojaEcuador s.cción Química Pontificia Universidad Católica del PerúA.P.Lima 32LimaPeru ECI School of Geography and EnvironmentUniversity of OxfordOX13QYOxfordshireUnited Kingdom Ins.ituto de Inves.igación en Cambio Global(IICG-URJC) Universidad Rey Juan CarlosCalle Tulipán s/nMóstolesMadridES-28933Spain

Mountains.are paramount for exploring biodivers.ty patterns.due to the mos.ic of topographies.and climates.encompas.ed over s.ort *** res.arch has.traditionally focus.d on taxonomic divers.ty when inves.igating changes.along elevational gradients.but other facets.s.ould be *** firs. time,we s.multaneous.y as.es.ed elevational trends.in taxonomic,functional,and phylogenetic divers.ty of woody plants.in Andean tropical montane fores.s.and explored their underlying ecological and evolutionary *** inves.igation covered four trans.cts.travers.ng ca.2200 m a.s.l.) encompas.ing 114 plots.of 0.1 ha acros. a broad latitudinal range(ca.10°).Us.ng Hill numbers.to quantify abundance-bas.d divers.ty among 37,869 individuals.we obs.rved a cons.s.ent decreas. in taxonomic,functional,and phylogenetic divers.ty as.elevation increas.d,although the decreas. was.les. pronounced for higher Hill *** exception was.a s.ight increas. in phylogenetic divers.ty when dominant s.ecies.were *** decreas. in taxonomic and functional divers.ty might be attributed to an environmental filtering proces. towards.highlands.where the increas.ngly hars.er conditions.exclude s.ecies.and functional ***,the differences.in s.eepnes. decreas. between Hill orders.s.gges. that rare s.ecies.dis.roportionately contribute to functional *** phylogenetic divers.ty the s.ifting elevational trend between Hill orders.indicates.a greater than previous.y cons.dered influence in central Andean highlands.of tropical lowlands.originated s.ecies.with s.rong niche cons.rvatis. relative to dis.antly related temperate *** could be explained by a decreas.ng pres.nce and abundance of temperate,extratropical taxa towards.the central Andes.relative to northern or s.uthern Andes.where they are more prevalent.

关键词： Altitudinal gradients Andes Environmentalﬁltering Out of the Tropical Lowlands Functional rarity Tropical Niche Cons.rvatis.

EZH2 inhibitors.promote β-like cell regeneration in young and adult type 1 diabetes.donors

在线全文

学校读者我要写书评

暂无评论

s.gnal Trans.uction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Has.ni s.fiya Naina Marikar Harikris.nan Kaipananickal s.ott Maxwell Jun Okabe Is.ant Khurana Thomas.Karagiannis.julia J.Liang Lina Mariana Thomas.Loudovaris.Thomas.Kay As.am El-Os.a Epigenetics.in Human Health and Dis.as. Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia Department of Diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics.in Human Health and Dis.as. Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia s.hool of s.ience STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and Diabetes.Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia Department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Ins.itute of Diabetes.and Obes.ty Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka s.ing Ins.itute of Health s.iences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory s.ience Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells.are a type of endocrine cell found in pancreatic is.ets.that s.nthes.ze,s.ore and releas. *** type 1 diabetes.T1D),T-cells.of the immune s.s.em s.lectively des.roy the ins.lin-producingβ-*** of thes. cells.leads.to a lifelong dependence on exogenous.ins.lin adminis.ration for ***,there is.an urgent need to identify novel therapies.that s.imulateβ-cell growth and induceβ-cell *** and others.have s.own that pancreatic ductal progenitor cells.are a promis.ng s.urce for regeneratingβ-cells.for T1D owing to their inherent differentiation *** trans.riptional s.ppres.ion is.refractory to exocrine reaction and tightly controls.the regenerative potential by the EZH2 *** the pres.nt s.udy,we s.ow that trans.ent s.imulation of exocrine cells.derived from juvenile and adult T1D donors.to the FDAapproved EZH2 inhibitors.Gs.126 and Tazemetos.at(Taz)influence a phenotypic s.ift towards.aβ-like cell *** trans.tion from repres.ed to permis.ive chromatin s.ates.are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is.fundamental toβ-cell regenerative *** pancreatic ductal cells.exhibit ins.lin production and s.cretion in res.ons. to a phys.ological glucos. challenge ex *** pre-clinical s.udies.unders.ore the potential of s.all molecule inhibitors.as.novel modulators.of ductal progenitor differentiation and a promis.ng new approach for the res.oration ofβ-like cell function.

关键词： EZH2 s.ruction inhibitors

Treatment and prevention of epileps. in onchocercias.s.endemic areas.is.urgently needed

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infectious.Dis.as.s.of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders.Jos.ph Nels.n s.ewe Fodjo Olivia Kamoen Luis.Jorge Amaral Amber Hadermann Chiara Trevis.n Mark J.Taylor julia Gauglitz Achim Hoerauf Yas.aki s.to Katja Polman Maria-Gloria Bas.nez Dan Bhwana Thoms.n Lakwo Gas.m Abd-Elfarag s.bas.ien D.Pion Global Health Ins.itute University of AntwerpAntwerpBelgium Department of Neurology Heilig Hart ZiekenhuisLierBelgium Department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool s.hool of Tropical Medicine LiverpoolUK Department of Computer s.ience University of AntwerpAntwerpBelgium Ins.itute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Res.arch(DZIF) Partner Site Bonn-CologneBonnGermany s.hool of Global Humanities.and s.cial s.iences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious.Dis.as. Analys.s.and London Centre for Neglected TropicalDis.as. Res.arch Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Ins.itute for Medical Res.arch TangaTanzania Vector Control Divis.on Ministry of HealthKampalaUganda s.hool of Public Health University of JubaJubaSouth Sudan Acces. for Humanity JubaSouth Sudan French National Res.arch Ins.itute for s.s.ainable Development MontpellierFrance

Background There is.increas.ng epidemiological evidence s.pporting the as.ociation between onchocercias.s.and s.izures. reinforcing the concept of onchocercias.s.as.ociated epileps. (OAE). The aim of this.paper is.to provide an update on the new knowledge about OAE and to propos. recommendations.to the World Health Organization how to addres. this.public health *** text During the 2nd International Works.op on OAE held on 19-21 s.ptember, 2023, in Antwerp, Belgium, participants.recognis.d OAE as.a s.bs.antial yet neglected public health problem, particularly in areas.of s.b-s.haran Africa where onchocercias.s.remains.hyperendemic. Evidence from pros.ective population-bas.d s.udies.s.gges. that s.rengthening onchocercias.s.elimination efforts.leads.to a s.gnificant reduction of OAE incidence. There is.a need to validate an OAE cas. definition to es.imate the burden of dis.as. and identify onchocercias.s.endemic areas.requiring intens.fication of onchocercias.s.elimination programmes.and integration of epileps. care. It is.expected that rais.ng awarenes. about OAE will boos. the population uptake of ivermectin. The implementation of a community-bas.d epileps. treatment programme offering free anti-s.izure medications.(As.s. has.s.own high effectivenes. in reducing the frequency of s.izures.and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocercias.s.and mental health programmes.at community, national, and international levels.is.required. Urgent efforts.are needed to ens.re the uninterrupted provis.on of free As.s.in onchocercias.s.endemic areas. Furthermore, OAE s.ould be included in the quantification of the onchocercias.s.dis.as. burden.

关键词： Onchocercias.s Morbidity Burden of dis.as. Prevention Ivermectin Epileps. Nodding s.ndrome Treatment Children Policy