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sexual dimorphism in water and nitrogen use strategies in Honckenya peploides: timing matters

Journal of Plant Ecology 2017年第4期10卷 702-712页

作者： julia sánchez vilas Rubén Retuerto Organisms and Environment Division Sir Martin Evans BuildingCardiff School of BiosciencesMuseum AvenueCardiff UniversityCardiff CF103AXUK Departamento de Biología Celular y Ecología Área de EcologíaFacultad de BiologíaUniversidade Santiago de CompostelaCampus VidaRúa de Lope Gómez de Marzoas/n15782 Santiago de CompostelaA CoruñaSpain

Aims sexes of dimorphic species often differ in ecophysiological traits and display spatial *** differences have been interpreted as an evolved response of the sexes to meet the specific resource demands associated with *** may differ not only in the amount of resources allocated to reproduction but also in the tim-ing of allocation to *** this study,we hypothesize that as a consequence of their specific resource demands for reproduction,the sexes of the dune plant Honckenya peploides differ in terms of tempo-ral patterns of water use efficiency and nitrogen use and *** Water use efficiency,as inferred from leaf carbon isotope discrimi-nation(Δ^(13)C),nitrogen use,estimated by leaf nitrogen isotope com-position(δ^(15)N),and the foliar carbon and nitrogen contents were measured in males and females at three different points in *** Findings Females had greater water use efficiency than males,regardless of *** ratio of N^(15) to N^(14) did not change with time in males,but significantly decreased in August for *** total N content in the leaf tissues of females decreased as the season progressed,while in males a decrease was only found from April to June and then it remained constant from June to August.A similar pattern,but reversed,was followed by the foliar C/N ***,nega-tive relationships between leafΔ^(13)C and N content were found at all times for males and only at the end of the season for ***,our hypothesis that sex-specific patterns of nitrogen and water use efficiency will depend on time was ***,our results highlight the importance of including time in studies of sex-ual dimorphism,and also the role that physiological specialization plays in meeting the specific demands associated with reproduction.

关键词： cost of reproduction Honckenya peploides leaf nitrogen content sexual dimorphism stable isotopes water use efficiency

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Equilibrium Arrivals to Preemptive Queueing system with Fixed and Random Population size

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Journal of the Operations Research society of China 2024年第1期12卷 77-92页

作者： julia Chirkova Vladimir Mazalov Institute of Applied Mathematical Research Karelian Research Centre of RASPetrozavodsk185910Russia school of Mathematics and statistics Qingdao UniversityQingdao266071ShandongChina

A single-server queueing system with preemptive access is *** customer has one attempt to enter the system at its working interval[0,T].As soon as the customer request enters the system,the server immediately starts the *** when the next request arrives in the system,the previous one leaves the system even he has not finished his service *** study a non-cooperative game in which the customers wish to maximize their probability of obtaining service within a certain period of *** characterize the Nash equilibrium and the price of anarchy,which is defined as the ratio between the optimal and equilibrium social *** models are *** the first model the number of players is fixed,while in the second it is random and obeys the Poisson *** demonstrate that there exists a unique symmetric equilibrium for both ***,we calculate the price of anarchy for both models and show that the price of anarchy is not monotone with respect to the number of customers.

关键词： service system Preemptive priorities strategic users Random number of players Optimal arrivals Kolmogorov backward equations Nash equilibrium Price of anarchy

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Rheological and stability analysis of cement pastes incorporating silica-based wastes

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Particuology 2024年第6期89卷 144-152页

作者： julia da Rosa Martins Janaíde Cavalcante Rocha Dachamir Hotza Luciano senff Graduate Program in Materials science and Engineering(PPGMAT) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Civil Engineering(PPGEC) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Graduate Program in Chemical Engineering(POsENQ) Federal University of Santa Catarina(UFSC)Florianópolis88040-900SCBrazil Department of Mobility Engineering Federal University of Santa Catarina(UFSC)Joinville89219-600SCBrazil

This study investigates the influence of waste characteristics,especially zeta potential,on the properties of cement pastes and *** focus is to evaluate the impact of the zeta potential of cement particles and waste materials on the sedimentation speed,rheology,and hardening time of stabilized cement *** Cement II F 40,retarder additive,silica,and fly ash were used in the *** pastes were prepared,and during the stabilization period,their rheological properties and pH were *** zeta potential and sedimentation speed of the cement and waste particles were measured at the pH that the pastes presented during the entire stabilization *** the stabilization period,the pastes were subjected to the hardening time *** zeta potential analyses revealed diverse values for the different powder types,with the cement particles exhibiting a zeta potential of−3.0 mV,the silica particles exhibiting−10.5 mV,and the fly ash particles exhibiting−20.3 *** influence of the high zeta potential modulus was observed on the sedimentation speed,with the solution containing fly ash exhibiting a speed of 40.01μm/s,whereas the solution containing only cement exhibited a speed of 99.38μm/*** the pastes,the results indicate that the presence of fly ash particles with a significantly negative zeta potential led to a 16%reduction in hardening time compared to particles with a lower modulus of zeta *** tests showed that the inclusion of fly ash particles prevented the formation of *** the zeta potential influenced agglomerate formation and hardening time,it was found to have no effect on yield stress or viscosity.

关键词： Wastes Zeta potential setting time Rheometry

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Parasites of the liver:A global problem?

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World Journal of Gastroenterology 2024年第30期30卷 3554-3559页

作者： Vladislav V Tsukanov Alexander V Vasyutin julia L Tonkikh Clinical Department of the Digestive system Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

Parasitic liver diseases can be caused by trematodes,cestodes,nematodes,and *** pathology is significant because millions of people in different parts of the world have liver parasites,which can manifest themselves in the development of inflammation,liver cysts,cholecystitis,cholelithiasis,pancreatitis and liver cirrhosis that are often threatening their *** International Agency for Research on Cancer considers three species of trematodes,schistosoma haematobium,Opisthorchis viverrini and Clonorchis sinensis,to be *** modern examination methods,in some cases including extensive screening of large populations,are required for diagnosing liver *** of parasitic liver diseases is differentiated and can involve a combination of surgical and therapeutic *** is no doubt that the clinical and epidemiological scale allows one to regard parasitic liver diseases as a global healthcare problem.

关键词： Liver Parasites Epidemiology Diagnosis Clinics Treatment Echinococcosis Opisthorchiasis Fascioliasis schistosomiasis

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Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： julia Castillo-González Elena González-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

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Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

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Protein & Cell 2024年第9期15卷 661-685页

作者： sadaf Hasan Nabil Ghani Xiangli Zhao julia Good Amanda Huang Hailey Lynn Wrona Jody Liu Chuan-ju Liu Department of Orthopedic surgery New York University Grossman School of MedicineNew YorkNY 10016United States Department of Medicine Division of Internal MedicineSaint Peter’s University HospitalRutgers UniversityNew BrunswickNJ 08901United States Cornell University IthacaNew YorkNYUnited States Department of Biomedical Engineering University of North Carolina Chapel HillChapel HillNC 27599United States New York University NY 14853United States Department of Cell Biology New York University Grossman School of MedicineNew YorkNY 10016United States Department of Orthopedics&Rehabilitation Yale University School of MedicineNew HavenCT 06510United States

Obesity has a multifactorial etiology and is known to be a state of chronic low-grade inflammation,known as *** state is associated with the development of metabolic disorders such as glucose intolerance and nonalcoholic fatty liver *** is a glycolytic metabolite and a crucial node in various metabolic ***,its role and molecular mechanism in obesity and associated complications are *** this study,we reported that pyruvate substantially inhibited adipogenic differentiation in vitro and its administration significantly prevented HFD-induced weight gain,white adipose tissue inflammation,and metabolic *** identify the target proteins of pyruvate,drug affinity responsive target stability was employed with proteomics,cellular thermal shift assay,and isothermal drug response to detect the interactions between pyruvate and its molecular ***,we identified cytosolic phospholipase A2(cPLA2)as a novel molecular target of pyruvate and demonstrated that pyruvate restrained diet-induced obesity,white adipose tissue inflammation,and hepatic steatosis in a cPLA2-dependent *** with global ablation of cPLA2 in mice showed that the protective effects of pyruvate were largely abrogated,confirming the importance of pyruvate/cPLA2 interaction in pyruvate attenuation of inflammation and ***,our study not only establishes pyruvate as an antagonist of cPLA2 signaling and a potential therapeutic option for obesity but it also sheds light on the mechanism of its ***’s prior clinical use indicates that it can be considered a safe and viable alternative for obesity,whether consumed as a dietary supplement or as part of a regular diet.

关键词： metabolic disease pyruvate cytosolic phospholipase obesity

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Exploring research on ecotechnology through artificial intelligence and bibliometric maps

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Environmental science and Ecotechnology 2024年第5期21卷 405-412页

作者： Ricardo Ruiz-sanchez Ricardo Arencibia-Jorge julia Tagüena Jose Luis Jimenez-Andrade Humberto Carrillo-Calvet Unidad Profesional Interdisciplinaria de Ingeniería Palenque(UPIIP) Instituto Politecnico NacionalPalenqueChiapasCP 29960Mexico Complexity sciences Center National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico Institute of Renewable Energies(IER) National Autonomous University of MexicoPriv.Xochicalco s/nCol.CentroTemixcoMorelosCP 62580Mexico Faculty of sciences National Autonomous University of MexicoCircuito Centro Cultural s/nCoyoacan04510Mexico CityMexico

Ecotechnology,quintessential for crafting sustainable socio-environmental strategies,remains tantalizingly *** analysis,steered by the nuances of machine learning and augmented by bibliometric insights,delineates the expansive terrain of this domain,elucidates pivotal research themes and conundrums,and discerns the vanguard nations in this ***,we deftly connect our discoveries to the United Nations'2030 sustainable Development Goals,thereby accentuating the profound societal ramifications of ecotechnology.

关键词： Ecotechnologies Bibliometrics sustainable development goals Network analysis sOM neural networks

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Molecular insights into clinical trials for immune checkpoint inhibitors in colorectal cancer:Unravelling challenges and future directions

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World Journal of Gastroenterology 2024年第13期30卷 1815-1835页

作者： samantha sharma Naresh singh Anita Ahmed Turk Isabella Wan Akshay Guttikonda julia Lily Dong Xinna Zhang Mateusz Opyrchal Department of Medical and Molecular Genetics Indiana University School of MedicineIndianapolisIN 46202United States Division of Hematology/Oncology Department of MedicineIndiana University School of MedicineIndianapolisIN 46202United States Melvin and Bren simon Comprehensive Cancer Center Indiana University School of MedicineIndianapolisIN 46202United States

Colorectal cancer(CRC)is a complex disease with diverse etiologies and clinical *** considerable progress in development of CRC therapeutics,challenges remain regarding the diagnosis and management of advanced stage metastatic CRC(mCRC).In particular,the five-year survival rate is very low since mCRC is currently rarely *** the past decade,cancer treatment has significantly improved with the introduction of cancer immunotherapies,specifically immune checkpoint *** aimed at blocking immune checkpoints such as PD-1,PD-L1,and CTLA-4 target inhibitory pathways of the immune system,and thereby enhance anti-tumor *** therapies thus have shown promising results in many clinical trials alone or in *** efficacy and safety of immunotherapy,either alone or in combination with CRC,have been investigated in several clinical *** trials,including KEYNOTE-164 and CheckMate 142,have led to Food and Drug Administration approval of the PD-1 inhibitors pembrolizumab and nivolumab,respectively,for the treatment of patients with unresectable or metastatic microsatellite instability-high or deficient mismatch repair ***,these drugs benefit only a small percentage of patients,with the benefits of immunotherapy remaining elusive for the vast majority of CRC *** this end,primary and secondary resistance to immunotherapy remains a significant issue,and further research is necessary to optimize the use of immunotherapy in CRC and identify biomarkers to predict the *** review provides a comprehensive overview of the clinical trials involving immune checkpoint inhibitors in *** underlying rationale,challenges faced,and potential future steps to improve the prognosis and enhance the likelihood of successful trials in this field are discussed.

关键词： Colorectal cancer Immune checkpoint inhibitors Clinical trials Immunotherapy Microsatellite instability Microsatellite stability DNA mismatch repair

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Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： Vladislav V Tsukanov julia L Tonkikh Edward V Kasparov Alexander V Vasyutin Clinical Department of the Digestive system Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages(TAM)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,M2 TAM polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAM and the differentiation of the functions of M1 and M2 phagocytes are of great importance for the progression of *** is assumed that M2 TAM promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： Liver cancer Treatment Calculus bovis Tumor-associated macrophages M2 tumor Macrophage polarization Wnt/β-catenin pathway

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severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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World Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey sophie Breinig julia Dina Marion Caseris Francois Angoulvant stephane Leteurtre Morgan Recher David W.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive Care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive Care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-Cite ParisFrance Biostatistics and Clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive Care Hospices Civils de LyonLyonFrance Neonatal andPediatric IntensiveCare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical school Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department Women-Mother-Child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive Care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance CHU sainte Justine Research Center MontréalCanada

Background severe acute respiratory syndrome coronavirus-2(sARs-CoV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of sARs-CoV-2 on the mortality rate associated with sARs-CoV-2-related illnesses in the pediatric intensive care unit(PICU).secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive sARs-CoV-2 polymerase chain reactions(PCRs)[acute corona virus disease 2019(COVID-19)or incidental sARs-CoV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMs)recorded in the French PICU registry(PICURe)between september 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PICU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of sARs-CoV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to sARs-CoV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to sARs-CoV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMs).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** sARs-CoV-2 mortality in the French pediatric population was *** though the imputability of sARs-Cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit sARs-CoV-2

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