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Sox9 in the developing central nervous system:a jack of all trades?

Neural Regeneration Research 2021年第4期16卷 676-677页

作者： julia k.vogel Michael Wegner Institut für Biochemie Emil-Fischer-ZentrumFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Sox9–gliogenesis and beyond:Neurons and glial cells are the major neuroectodermal cell types of the vertebrate central nervous system(CNS).Their generation from common progenitor cells takes place mostly during embryonic and early postnatal *** closure of the neural tube,neural epithelial progenitor cells(NEPs)establish the ventricular zone(VZ).By asymmetrical cell division,NEPs first give rise to neuronal precursor cells(NPs)that then differentiate into various types of ***,NEPs predominantly produce glial precursor cells that become either astroglia or oligodendroglia.

关键词： development. mostly closure

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Multidimensional assessment of neuro-psychiatric symptoms in patients with low-grade hepatic encephalopathy: A clinical rating scale

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World Journal of Gastroenterology 2005年第37期11卷 5893-5898页

作者： Sergei Mechtcheriakov Ivo W Graziadei André kugener julia Wiedemann Chantal Galbavy Hartmann Hinterhuber Josef Marksteiner Wolfgang vogel Department of General Psychiatry Medical University Innsbruck Austria Department of Gastroenterology and Hepatology Medical University Innsbruck Anichstrasse 35 AT-6020 Innsbruck Austria

AIM： To evaluate the feasibility of a new clinical rating scale for a standardized assessment of cirrhosis-associated neuro-psychiatric symptoms. METHODS： Forty patients with liver cirrhosis （LC, with or without low-grade hepatic encephalopathy） were investigated using a clinical neuro-psychiatric rating scale based on a comprehensive list of neurological, psychomotor, cognitive, affective, behavioral symptoms, and symptoms of disturbed bioregulation. RESULTS： The analysis revealed that the majodty of cirrhotic patients showed, besides characteristic neurological symptoms of hepatic encephalopathy, various psychomotor, affective and bioregulatory symptoms （disturbed sleep and sexual dysfunction）. Patients were impaired in the following subscales： sleep and biorhythm disorder （75.0% of patients）, Parkinsonoid symptoms （25.0%）, affective symptoms （17.5%）, and psychomotor retardation （12.5%）. The increase of total neuro-psychiatric clinical score was significantly associated with the degree of hepatic encephalopathy. CONCLUSION： This study suggests that a substantial number of patients with LC and low-grade hepatic encephalopathy manifest various clinical neuro-psychiatric symptoms. The use of a rating scale, which explores clinical dimensions of hepatic encephalopathy, would improve the management of patients with LC.

关键词： Liver cirrhosis Hepatic encephalopathy Neuropsychiatric symptoms Clinical neuro-psychiatric rating Bradykinesia

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Interventional treatment of the left subclavian in 2 patients with coronary steal syndrome

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World Journal of Cardiology 2017年第1期9卷 65-70页

作者： julia Heid Britta vogel Arnt kristen Wanda kloos Benedikt kohler Hugo A katus Grigorios korosoglou Department of Internal MedicineⅢ University Hospital Heidelberg69120 HeidelbergGermany

In patients with history of coronary artery disease angina pectoris is usually attributed to the progression of atherosclerotic lesions. However,in patients with previous coronary artery bypass graft operation(CABG) using internal mammary artery grafts,great vessel disease should also be considered. Herein we present two patients with history of CABG whose symptoms were suspicious for coronary ischemia. During cardiac catheterization reverse blood flow was observed from the left artery disease to the left internal mammary artery(LIMA) graft in both cases. After angioplasty and stent implantation of the left subclavian artery antegrade flow was restored in the LIMA grafts and both patients had complete resolution of symptoms.

关键词： Coronary steal syndrome Coronary artery bypass graft Left subclavian artery Reverse blood flow Cardiac catheterization

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