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The role of modern i.munotherapy i. metastati. urotheli.l cancer:mi.i.revi.w

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Journal of Cancer Metastasi. and Treatment 2022年第1期8卷 150-159页

作者： Francesca Jackson-Spence Charlotte Toms Yu-Hsuen Yang Leo Jurascheck julia Choy Lucy Flanders Bernadett Szabados Thomas Powles Barts Cancer i.sti.ute Queen Mary University of LondonLondon EC1M 6BQUK Department of Medi.al Oncology St Bartholomew’s HospitalBarts Health NHS TrustLondon EC1A 7BEUK

The approval of i.mune checkpoi.t i.hi.i.ors(i.i.)has changed the treatment landscape i. many aspects of urotheli.l cancer(UC),i. both non-muscle-i.vasi.e bladder cancer and muscle-i.vasi.e bladder cancer and has i.troduced the concept of long-term remi.si.n for some pati.nts i. the metastati. ***-li.e chemotherapy remai.s superi.r at achi.vi.g i.i.i.l control of di.ease compared to front-li.e i.mune ***,long-term durable responses are li.i.ed by chemotherapy *** mai.tenance approach,sequenci.g chemotherapy wi.h i.i.,could be consi.ered a best of both worlds approach,achi.vi.g i.i.i.l control wi.h chemotherapy,whi.h i. mai.tai.ed i. some i.di.i.uals wi.h ***,outcomes for pati.nts wi.h metastati. UC remai. *** are three steps to i.provi.g outcomes for these pati.nts;the fi.st i. to develop better drugs and combi.ati.ns of therapi.s,the second i. the development of novel bi.markers and techni.ues to better select pati.nts for treatment,and the thi.d area of development i. to gi.e the drugs i. the most opti.al setti.g.

关键词： Metastati. urotheli.l cancer bladder cancer i.mune therapy i.mune checkpoi.t i.hi.i.ors bi.markers

Sox9 i. the developi.g central nervous system:a jack of all trades?

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Neural Regenerati.n Research 2021年第4期16卷 676-677页

作者： julia K.Vogel Mi.hael Wegner i.sti.ut für Bi.chemi. Emil-Fischer-ZentrumFriedrich-Alexander-Universität Erlangen-NürnbergErlangenGermany

Sox9–gli.genesi. and beyond:Neurons and gli.l cells are the major neuroectodermal cell types of the vertebrate central nervous system(CNS).Thei. generati.n from common progeni.or cells takes place mostly duri.g embryoni. and early postnatal *** closure of the neural tube,neural epi.heli.l progeni.or cells(NEPs)establi.h the ventri.ular zone(VZ).By asymmetri.al cell di.i.i.n,NEPs fi.st gi.e ri.e to neuronal precursor cells(NPs)that then di.ferenti.te i.to vari.us types of ***,NEPs predomi.antly produce gli.l precursor cells that become ei.her astrogli. or oli.odendrogli..

关键词： development. mostly closure

The Secret Li.e of Chloroplast Precursor Protei.s i. the Cytosol

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Molecular Plant 2020年第8期13卷 1111-1113页

作者： Athi.a Hri.tou julia Gri.mer Sacha Bagi.sky Bi.chemi.try of Plants Faculty of Biochemistry and BiotechnologyRuhr University BochumUniversit(a)tsstrasse 15044801 BochumGermany i.sti.ute of Bi.chemi.try and Bi.technology Martin-Luther-University Halle-WittenbergCharles Tanford ProteinzentrumKurt-Mothes-Str.3a06120 Halle(Saale)Germany

Eukaryoti. cells contai. semi.autonomous organelles that have lost most of thei. codi.g capaci.y for essenti.l protei.s to the ***,thei. functi.ni.g depends on the cytosoli. translati.n products of nuclear-encoded genes that must be i.ported by a speci.li.ed protei. i.port *** i.port between 2500 and 3500 protei.s for thei. functi.ni.g,demonstrati.g that the bulk of the chloroplast proteome i. shutti.d through the cytosol as precursor *** protei.s usually contai. an N-termi.al transi. pepti.e that i. cleaved off by a si.na/processi.g pepti.ase(SPP)and degraded by the chloroplast protease network upon *** the cytosol,precursors can be co-and post-translati.nally modi.i.d,i.teract wi.h a set of chaperones,co-chaperones,14-3-3 protei.s,and/or E3 li.ases before they are ei.her i.ported or degraded by the cytosoli. proteasome *** i. now clear that precursors are not only a transi.nt transport form of functi.nal protei.s but that thei. cytosoli. transi.i.n i. of regulatory i.portance.

关键词： speci.li.ed autonomous i.ported

Bi.si.i.ars:new promi.e for reduci.g healthcare costs

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The Journal of Bi.medi.al Research 2014年第2期28卷 75-77页

作者： julia Munsch Department of Pharmacy UC Davis Medical Center

i.TRODUCTi.N After much anti.i.ati.n, approval of the fi.st U.S. bi.si.i.ar medi.ati.ns may be around the corner. Bi.si.i.ars hold the promi.e of reduci.g healthcare spendi.g by offeri.g lower-cost alternati.es to hi...

关键词： Bi.si.i.ars

The natural thermal sensi.i.i.y of SARS-CoV-2

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i.fecti.us Medi.i.e 2022年第3期1卷 227-228页

作者： Patri.k D Shaw Stewart julia L Bach Newbury BerkshireUK Thousand Oaks CAUSA

We recently publi.hed a revi.w of the factors under-lyi.g the wi.ter seasonali.y and pathogeni.i.y of respi.a-tory vi.uses[1].We showed that many respi.atory vi.uses possess natural thermal sensi.i.i.y,meani.g they repli.cate faster at temperatures below thei. hosts’normal body temperature,confi.i.g them to the upper *** hypothesi. suggests that thi. tropi.m gi.es the vi.us two i.portant advantages:(1)i. i. well-placed to be transmi.-ted;and(2)i. i. less li.ely to i.mobi.i.e i.s host,i.creas-i.g transmi.si.n.

关键词： thermal faster li.ely

Parti.ulate matter characteri.ati.n i. a steelworks usi.g conventi.nal sampli.g and i.novati.e li.ar observati.ns

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Parti.uology 2016年第5期14卷 43-51页

作者： Benjami. Gui.ot Beatri. Gonzalez julia Peri. De Fari. Sumi.a Kecli. Laboratoi.e d'Aerologi. Universite de Toulouse CNRS Universite Paul-Sabatier 14 Avenue Edouard-Belin 31400 Toulouse France

Parti.ulate matter （PM） emi.si.ns from steelworks cause publi. concern. Although end-of-pi.e and pro- cess i.tegrated measures have led to a si.ni.i.ant drop i. emi.si.ns of large parti.les from stacks, fi.e aerosols were not speci.i.ally consi.ered, nor were emi.si.ns from fugi.i.e and open sources. i. thi. study, we deployed aerosol samplers together wi.h a scanni.g ultra-vi.let （UV） li.ar to characteri.e total suspended parti.les （TSP）, PM10, and PM2.5, i. emi.si.ns from a large i.tegrated steelworks i. Spai. over a 16-day peri.d. We determi.ed the content of carbonaceous, soluble i.organi., mi.eral dust, and metal speci.s. A posi.i.e matri. factori.ati.n was carri.d out on our dataset. Despi.e mi.eral dust bei.g predomi.ant i. all si.e fracti.ns, the steelworks was clearly a source of carbonaceous speci.s, resulti.g i. producti.n of secondary i.organi. aerosols. i. parti.ular, stack emi.si.ns were a major contri.utor of fi.e parti.les, whi.e open sources domi.ated the emi.si.ns of TSP, yi.ldi.g up to 80% of parti.les larger than PM10. UV li.ar provi.ed 2D maps of aerosols i. real ti.e, wi.h an abi.i.y to detect PM emi.si.ns and to vi.uali.e complex plumes. We suggest that ai. quali.y management of steelworks needs to focus on controlli.g large and coarse oarti.le emi.si.ns, esoeci.llv those from onen sources.

关键词： Fi.e aerosols Fugi.i.e emi.si.ns Open sources Chemi.al composi.i.n Trace metals UV li.ar

Thermodynami.s of Hurri.anes Revi.i.ed

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Journal of Appli.d Mathemati.s and Physi.s 2022年第8期10卷 2508-2515页

作者： Pi.ooz Mohazzabi.julia Ann Smi.h Jones Andrea Ci.ati Department of Mathemati.s and Physi.s University of Wisconsin-Parkside Kenosha WI

Hurri.anes and tropi.al storms are heat engi.es operati.g between warm tropi.al oceans and the cold upper troposphere. The purpose of thi. arti.le i. to exami.e the exi.ti.g theori.s for hurri.anes and tropi.al storms, and to di.cuss thei. vali.i.y. i. i. argued that contrary to previ.us clai.s that hurri.anes are Carnot engi.es, these systems operate at effi.i.nci.s consi.erably below thei. maxi.um thermodynami. effi.i.ncy. As such, the vali.i.y of the current theori.s of thermodynami.s of hurri.anes remai.s questi.nable, and the phenomenon conti.ues to be a geophysi.al eni.ma.

关键词： Hurri.ane Tropi.al Cyclone Thermodynami.s Heat Engi.e

Towards Soci.ti.s Li.i.g wi.h COVi.-19

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Chi.a CDC weekly 2021年第7期3卷 144-145页

作者： Peter Pi.t julia Spencer London School of Hygi.ne&Tropi.al Medi.i.e LondonUK

The coronavi.us di.ease 2019(COVi.-19)pandemi. i. undoubtedly the greatest challenge i. peaceti.e faci.g the world for more than 100 *** country i. untouched wi.h more than 100 mi.li.n confi.med cases and over 2 mi.li.n deaths as of January 28,2021(1),and the actual number of i.fecti.ns i. probably closer to one bi.li.n as few countri.s had suffi.i.nt testi.g capaci.y to i.enti.y all cases,parti.ularly throughout early 2020.

关键词： doubt closer peace

UV-B Radi.ti.n i.duces Mu Element Somati. Transposi.i.n i. Mai.e

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Molecular Plant 2013年第6期6卷 2004-2007页

作者： julia Questa Vi.gi.i. Walbot Paula Casati Centro de Estudi.s Fotosi.téti.os y Bi.quími.os (CEFOBi. Universidad Nacional de Rosario Rosario Argentina Cell and Developmental Bi.logy John Innes Centre Norwich Research Park UK Department of Bi.logy Stanford University Stanford CA 94305-5020 USA

Dear Edi.or, The mai.e Mutator （MuDRi.u） transposon fami.y i. the most acti.e DNA transposon i. plants （Li.ch, 2002）. The Mu fami.y contai.s di.erse elements, all shari.g si.i.ar -215-bp termi.al i.verted repeats （Ti.s）. MuDR i. the autonomous element, and a transcri.ti.nally acti.e MuDR i. requi.ed for transposi.i.n of the non-autonomous Mu elements （Chomet et al., 1991）. MuDR contai.s two genes, mudrA and mudrB （Fi.ure 1A）; mudrA encodes the MURA transposase, and mudrB encodes a protei. wi.h unknown functi.n. To avoi. the deleteri.us effects of transposons, plants have acqui.ed mechani.ms to epi.eneti.ally si.ence them. Si.enced Mu ele- ments become heavi.y methylated, and thei. reacti.ati.n i. very rare. To date, only UV-B radi.ti.n treatments have reac- ti.ated si.enced Mu （Walbot, 1999）.

关键词： UV-B 元素辐射诱导玉米换位表观遗传学转座子赋值函数