检索结果-南通市图书馆

Phylogenomic analyses shed light on the relationships of chiton superfamilies and shell‑eye evolution

Marine Life Science & Technology 2023年第4期5卷 525-537页

作者： Xu Liu julia d.sigwart Jin Sun Key Laboratory of Evolution&Marine Biodiversity(Ministry of Education)and Institute of Evolution&Marine Biodiversity Ocean University of ChinaQingdao 266003China Laoshan Laboratory Qingdao 266237China department of Marine Zoology Senckenberg Research Institute and Natural History Museum Frankfurt60325 Frankfurt Am MainGermany

Mollusca is the second-largest animal phylum with over 100,000 extant species representing eight *** 1000 extant species in the class Polyplacophora,chitons have a relatively constrained morphology but with some notable *** genera possess“shell eyes”,i.e.,true eyes with a lens and retina that are embedded within the dorsal *** phylogeny of the major chiton clades is mostly well established,in a set of superfamily-level and higher level taxa supported by various approaches,including morphological studies,multiple gene markers,mitogenome-phylogeny,and phylotranscriptomic ***,one critical lineage has remained unclear,namely Schizochiton which was controversially suggested as being the potential independent origin of chiton shell ***,with the draft genome sequencing of Schizochiton incisus(superfamily Schizochitonoidea)plus assemblies of transcriptome data from other polyplacophorans,we present phylogenetic reconstructions using both mitochondrial genomes and phylogenomic approaches with multiple *** found that phylogenetic trees from mitogenomic data are inconsistent,reﬂecting larger scale confounding factors in molluscan ***,a consistent and robust topology was generated with protein-coding genes using diﬀerent models and *** results support Schizochitonoidea as the sister group to other Chitonoidea in Chitonina,in agreement with the established classiﬁ*** with evidence from fossils,our phylogenetic results suggest that the earliest origin of shell eyes is in Schizochitonoidea,and that these structures were also gained secondarily in other genera in *** results have generated a holistic review of the internal relationship within Polyplacophora,and a better understanding of the evolution of Polyplacophora.

关键词： Chiton Mollusca Phylogenomics Polyplacophora Shell eyes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acceptability of Kangaroo Mother Care (KMC) by Mothers with Low-Birth-Weight Babies at Arthur davison Children’s Hospital, in Ndola, Zambia

引用

Open Journal of Obstetrics and Gynecology 2024年第5期14卷 790-823页

作者： julia d. Kalito Maureen M. Masumo Chapima Fabian department of Midwifery Women&#8217s and Child Health University of Zambia Lusaka Zambia

Background: Kangaroo Mother Care is a simple safe method used to care for low-birth-weight babies. Low-birth-weight is a global public health issue that pose significant challenge to perinatal care systems. Globally, complications due to low-birth-weight are the leading cause of neonatal mortality, resulting in an estimated 1 million deaths annually. Kangaroo Mother Care (KMC) is a low-cost method of care for low-birth-weight infants in areas with inadequate incubators and power outages with positive outcomes. Objectives: To assess factors influencing acceptability of Kangaroo Mother Care (KMC) in NICU at Arthur davison Children’s Hospital in Ndola, Zambia. Methodology: A cross sectional quantitative analytical study design was used. The study was conducted at Arthur davison Children’s Hospital (AdCH) in Ndola, Zambia. The purposive sampling method was used to select the study participants and a total of 129 mothers with Low Weight Babies A were selected to participate structured closed ended questionnaire was used to collect data from the participants using an interview. data was analyzed using a Statistical Package for Social Scientists (SPSS) software version 26. Cross tabulations were done to determine association of variables using a Chi square (x2) test at 95% confidence interval and were assumptions where not met, fishers exact test was used. Multivariate binary logistic regression analysis was used to quantify the relationship between the dependent and independent variables. Results: Most of the respondents had male babies 77%, 69% of the babies weighed 1000 g - 1400 g, majority 79% had normal delivery, 71% of the respondents were multigravida and most of the respondents 79% were married. The study reviewed that 85% of those who attained secondary education accepted KMC, 74% of the respondents without monthly income accepted KMC, 80% of the respondents had positive attitude and accepted KMC. 82% of the respondents who had positive perception accep

关键词： Acceptability Kangaroo Mother Care Low Birth Weight Babies

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Treatment and prevention of epilepsy in onchocerciasis-endemic areas is urgently needed

引用

Infectious diseases of Poverty 2024年第1期13卷 85-89页

作者： Robert Colebunders Joseph Nelson Siewe Fodjo Olivia Kamoen Luis-Jorge Amaral Amber Hadermann Chiara Trevisan Mark J.Taylor julia Gauglitz Achim Hoerauf Yasuaki Sato Katja Polman Maria-Gloria Basanez dan Bhwana Thomson Lakwo Gasim Abd-Elfarag Sebastien d.Pion Global Health Institute University of AntwerpAntwerpBelgium department of Neurology Heilig Hart ZiekenhuisLierBelgium department of Public Health Institute of Tropical MedicineAntwerpBelgium Liverpool School of Tropical Medicine LiverpoolUK department of Computer Science University of AntwerpAntwerpBelgium Institute of Medical Microbiology Immunology and ParasitologyUniversity Hospital BonnBonnGermany German Center for Infection Research(dZIF) Partner Site Bonn-CologneBonnGermany School of Global Humanities and Social Sciences Nagasaki UniversityNagasakiJapan MRC Centre for Global Infectious disease Analysis and London Centre for Neglected Tropicaldisease Research Department of Infectious Disease EpidemiologySchool of Public HealthImperial College LondonLondonUK National Institute for Medical Research TangaTanzania Vector Control division Ministry of HealthKampalaUganda School of Public Health University of JubaJubaSouth Sudan Access for Humanity JubaSouth Sudan French National Research Institute for Sustainable development MontpellierFrance

Background There is increasing epidemiological evidence supporting the association between onchocerciasis and seizures, reinforcing the concept of onchocerciasis-associated epilepsy (OAE). The aim of this paper is to provide an update on the new knowledge about OAE and to propose recommendations to the World Health Organization how to address this public health *** text during the 2nd International Workshop on OAE held on 19-21 September, 2023, in Antwerp, Belgium, participants recognised OAE as a substantial yet neglected public health problem, particularly in areas of sub-Saharan Africa where onchocerciasis remains hyperendemic. Evidence from prospective population-based studies suggest that strengthening onchocerciasis elimination efforts leads to a significant reduction of OAE incidence. There is a need to validate an OAE case definition to estimate the burden of disease and identify onchocerciasis-endemic areas requiring intensification of onchocerciasis elimination programmes and integration of epilepsy care. It is expected that raising awareness about OAE will boost the population uptake of ivermectin. The implementation of a community-based epilepsy treatment programme offering free anti-seizure medications (ASMs) has shown high effectiveness in reducing the frequency of seizures and improving the overall quality of life of people with *** To reduce OAE burden, enhanced collaboration between onchocerciasis and mental health programmes at community, national, and international levels is required. Urgent efforts are needed to ensure the uninterrupted provision of free ASMs in onchocerciasis-endemic areas. Furthermore, OAE should be included in the quantification of the onchocerciasis disease burden.

关键词： Onchocerciasis Morbidity Burden of disease Prevention Ivermectin Epilepsy Nodding syndrome Treatment Children Policy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

EZH2 inhibitors promote β-like cell regeneration in young and adult type 1 diabetes donors

引用

Signal Transduction and Targeted Therapy 2024年第2期9卷 679-692页

作者： Keith Al-Hasani Safiya Naina Marikar Harikrishnan Kaipananickal Scott Maxwell Jun Okabe Ishant Khurana Thomas Karagiannis julia J.Liang Lina Mariana Thomas Loudovaris Thomas Kay Assam El-Osta Epigenetics in Human Health and disease Program Baker Heart and Diabetes Institute75 Commercial RoadMelbourne 3004 VICAustralia department of diabetes Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia Epigenetics in Human Health and disease Laboratory Central Clinical SchoolMonash UniversityMelbourne 3004 VICAustralia School of Science STEM CollegeRMIT UniversityMelbourne 3001 VICAustralia Immunology and diabetes Unit St Vincent’s Institute of Medical ResearchFitzroy 3065 VICAustralia department of Medicine and Therapeutics The Chinese University of Hong KongSha TinHong Kong SAR Hong Kong Institute of diabetes and Obesity Prince of Wales HospitalThe Chinese University of Hong Kong3/F Lui Che Woo Clinical Sciences Building30-32-Ngan Shing StreetSha TinHong Kong SAR Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongSha TinHong Kong SAR Biomedical Laboratory Science Department of TechnologyFaculty of HealthUniversity College CopenhagenCopenhagenDenmark

β-cells are a type of endocrine cell found in pancreatic islets that synthesize,store and release *** type 1 diabetes(T1d),T-cells of the immune system selectively destroy the insulin-producingβ-*** of these cells leads to a lifelong dependence on exogenous insulin administration for ***,there is an urgent need to identify novel therapies that stimulateβ-cell growth and induceβ-cell *** and others have shown that pancreatic ductal progenitor cells are a promising source for regeneratingβ-cells for T1d owing to their inherent differentiation *** transcriptional suppression is refractory to exocrine reaction and tightly controls the regenerative potential by the EZH2 *** the present study,we show that transient stimulation of exocrine cells,derived from juvenile and adult T1d donors to the FdAapproved EZH2 inhibitors GSK126 and Tazemetostat(Taz)influence a phenotypic shift towards aβ-like cell *** transition from repressed to permissive chromatin states are dependent on bivalent H3K27me3 and H3K4me3 chromatin *** EZH2 is fundamental toβ-cell regenerative *** pancreatic ductal cells exhibit insulin production and secretion in response to a physiological glucose challenge ex *** pre-clinical studies underscore the potential of small molecule inhibitors as novel modulators of ductal progenitor differentiation and a promising new approach for the restoration ofβ-like cell function.

关键词： EZH2 struction inhibitors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Tumor microenvironment involvement in colorectal cancer progression via Wnt/β-catenin pathway:Providing understanding of the complex mechanisms of chemoresistance

引用

World Journal of Gastroenterology 2022年第26期28卷 3027-3046页

作者： María Belén Novoa díaz María julia Martín Claudia Gentili departamento de Biología Bioquímica y FarmaciaUniversidad Nacional del Sur(UNS)-INBIOSUR(CONICET-UNS)Bahía Blanca 8000Argentina departamento de Química Universidad Nacional del Sur(UNS)-INQUISUR(CONICET-UNS)Bahía Blanca 8000Argentina

Colorectal cancer(CRC)continues to be one of the main causes of death from cancer because patients progress unfavorably due to resistance to current *** of the Wnt/β-catenin pathway plays a fundamental role in the genesis and progression of several types of cancer,including *** many subtypes of CRC,hyperactivation of theβ-catenin pathway is associated with mutations of the adenomatous polyposis coli ***,it can also be associated with other *** recent years,studies of the tumor microenvironment(TME)have demonstrated its importance in the development and progression of *** this tumor nest,several cell types,structures,and biomolecules interact with neoplastic cells to pave the way for the spread of the ***-communications between tumor cells and the TME are then established primarily through paracrine factors,which trigger the activation of numerous signaling *** advances in the field of oncology have been made in the last *** Minireview aims to actualize what is known about the central role of the Wnt/β-catenin pathway in CRC chemoresistance and aggressiveness,focusing on crosscommunication between CRC cells and the *** this analysis,our main objective was to increase the understanding of this complex disease considering a more global *** many treatments for advanced CRC fail due to mechanisms involving chemoresistance,the data here exposed and analyzed are of great interest for the development of novel and effective therapies.

关键词： Colorectal cancer β-catenin pathway Tumor stroma Tumor microenvironment factors Cancer progression drug resistance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Enabling Virtual Met Masts for wind energy applications through machinelearning-methods

引用

能源与人工智能(英文) 2023年第1期11卷 26-42页

作者： Sandra Schwegmann Janosch Faulhaber Sebastian Pfaffel Zhongjie Yu Martin dörenkämper Kristian Kersting julia Gottschall Fraunhofer IWES Küpkersweg 7026129 OldenburgGermany Fraunhofer IEE Königstor 5934119 KasselGermany Technical University of darmstadt Karolinenplatz 564289 DarmstadtGermany Hessian Center for AI(hessian.AI) Mornewegstraße 3064293 DarmstadtGermany

As wind is the basis of all wind energy projects, a precise knowledge about its availability is needed. For ananalysis of the site-specific wind conditions, Virtual Meteorological Masts (VMMs) are frequently used. VMMsmake use of site calibrated numerical data to provide precise wind estimates during all phases of a wind energyproject. Typically, numerical data are used for the long-term correlation that is required for estimating theyield of new wind farm projects. However, VMMs can also be used to fill data gaps or during the operationalphase as an additional reference data set to detect degrading sensors. The value of a VMM directly dependson its ability and precision to reproduce site-specific environmental conditions. Commonly, linear regressionis used as state of the art to correct reference data to the site-specific conditions. In this study, a frameworkof 10 different machine-learning methods is tested to investigated the benefit of more advanced methods ontwo offshore and one onshore site. We find significantly improving correlations between the VMMs and the reference data when using more advanced methods and present the most promising ones. The K-NearestNeighbors and AdaBoost regressors show the best results in our study, but Multi-Output Mixture of GaussianProcesses is also very promising. The use of more advanced regression models lead to decreased uncertainties;hence those methods should find its way into industrial applications. The recommended regression models canserve as a starting point for the development of end-user applications and services.

关键词： Virtual Met Mast(VMM) Wind power Machine learning Reanalysis data Site assessment Weather Research and Forecasting Model(WRF) Measure-Correlate-Predict(MCP)

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

dietary branched-chain amino acids modulate the dynamics of calcium absorption and reabsorption in proteinrestricted pigs

引用

Journal of Animal Science and Biotechnology 2022年第4期13卷 1083-1098页

作者： Mohammad Habibi Cedrick NShili julia Sutton Parniyan Goodarzi Adel Pezeshki department of Animal and Food Sciences Oklahoma State University206C Animal Science BuildingStillwaterOK 74078USA

Background:Very low-protein(VLP)diets negatively impact calcium(Ca)metabolism and *** objective of this study was to investigate the effect of supplemental branched-chain amino acids(BCAA)and limiting amino acids(LAA)on Ca digestibility,absorption and reabsorption in pigs fed with VLP ***-eight piglets were assigned to six treatments:positive control(PC),negative control(NC),and NC containing LAA 25%,LAA 50%,LAA+BCAA 25%(LB25)and LAA+BCAA 50%(LB50)more than ***:Relative to PC or NC,LB25 and LB50 had higher digestibility of Ca and plasma Ca and phosphorus(P),but lower plasma vitamin ***50 tended to increase vitamin d receptor transcript and protein in the gut,but decreased mRNA or protein abundance of parathyroid hormone 1 receptor(PTH1R),calbindin 1(CALB1),cytochrome P450 family 27 subfamily B member 1 and occludin in small ***50 increased the transcript of cytochrome P450 family 24 subfamily A member 1 and PTH1R but decreased the transcript of transient receptor potential cation channel subfamily V member 5,CALB1 and solute carrier family 17 member 4 in ***:Overall,BCAA increased Ca digestibility through regulating the transcellular and paracellular Ca absorption in the gut and reabsorption in kidney during protein restriction.

关键词： Branched-chain amino acids Calcium absorption and reabsorption Calcium digestibility Pig Very low protein diets

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Ultra-transparent nanostructured coatings via flow-induced one-step coassembly

引用

Nano Materials Science 2022年第2期4卷 97-103页

作者： Jingjing Liu Sonia E.Chavez Hao ding Maria M.Farooqui Zaili Hou Sharon Lin Thomas d.d'Auria julia M.Kennedy Anna Marie LaChance Luyi Sun Polymer Program Institute of Materials ScienceUniversity of ConnecticutStorrsConnecticut06269United States department of Chemical&Biomolecular Engineering University of ConnecticutStorrsConnecticut06269United States department of Biomedical Engineering University of ConnecticutStorrsConnecticut06269United States

Polyvinyl alcohol(PVA)/laponite(LP)nanocomposite coatings were fabricated via a facile one-step coassembly *** formed nanocoatings contain a high concentration of LP nanosheets,which can be well aligned along the substrate surface during the coassembly *** to the highly orientated structure,the flexible nanocoatings exhibit ultra-high transparency and superior mechanical properties,and can also act as excellent gas *** nanocoatings can be exceptional candidates for a variety of applications,such as food packaging.

关键词： Nanocoating Coassembly Polyvinyl alcohol Laponite

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Axon guidance in regeneration of the mature central nervous system:step by step

引用

Neural Regeneration Research 2023年第12期18卷 2665-2666页

作者： julia Schaeffer Noemie Vilallongue Stephane Belin Homaira Nawabi Univ.Grenoble Alpes InsermU1216Grenoble Institut NeurosciencesGrenobleFrance

Unlocking axon regeneration in the injured central nervous system:In adult mammals,central nervous system(CNS)neurons fail to regenerate a?ter a lesion,whether it is traumatic–after spinal cord injury for example–or... 详细信息

关键词： traumatic system regeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IL-33: a jack of all trades in the orchestration of respiratory antibacterial immunity

引用

Cellular & Molecular Immunology 2017年第11期14卷 875-877页

作者： julia d Boehme dunja Bruder Infection Immunology Group Institute of Medical Microbiology and Hospital HygieneOtto-von-Guericke UniversityMagdeburgGermany Immune Regulation Group Department of Immune ControlHelmholtz Centre for Infection ResearchBraunschweigGermany

Influenza A virus(IAV)is the causative agent of mostly mild to moderate seasonal respiratory infections and several pandemic outbreaks,the most recent of which was reported in *** IAV pandemics were associated with an enormous death toll;for example,the 1918 H1N1 pandemic affected hundreds of millions of people globally and resulted in~50 million deaths.1 Microbiologic analyses of patient samples revealed a strong incidence of bacterial pathogens in fatal complications of viral infection.2 To date,many pieces of epidemiologic and experimental evidence reveal pronounced susceptibility to detrimental bacterial superinfection in IAVinfected individuals.

关键词： immunity respiratory hundreds

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：