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Overexpression of the Six1 Homeobox Gene Is Associated with Diffuse Peritoneal Spread and Larger Residual Disease after Maximal Cytoreductive Effort in Advanced Ovarian Cancer

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Journal of Cancer Therapy（癌症治疗） 2015年第14期

作者： julia R. Embry-Schubert Lubna Qamar Monique Spillman Michael G. Kelly Susan A. Davidson Kian Behbakht Department of Obstetrics and Gynecology Kaiser-Permanente Denver CO USA Division of Gynecologic Oncology Department of Obstetrics and Gynecology University of Colorado School of Medicine and Anschutz Medical Campus Aurora CO USA Texas Oncology Sammons Cancer Center Baylor University Medical Center Dallas TX USA Wake Forest University School of Medicine One Medical Center Boulevard Winston-Salem NC USA Denver Health Medical Center Denver CO USA

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国际著名服装商家纷纷而动“虚实互补”

国际商业技术 2010年第6期 55-55页

作者： julia Caesar[英] 单佳灵（编译）

经济危机以来，服饰用品的销售也经受了下挫。或许是受此影响，不少服装零售商都将目光瞄准了网络零售这块大蛋糕。西班牙的国际著名服装品牌ZARA最近就在法国、西班牙、意大利、葡萄牙和英国市场开始其网络零售业务，以挽回销售不振的... 详细信息

经济危机以来，服饰用品的销售也经受了下挫。或许是受此影响，不少服装零售商都将目光瞄准了网络零售这块大蛋糕。西班牙的国际著名服装品牌ZARA最近就在法国、西班牙、意大利、葡萄牙和英国市场开始其网络零售业务，以挽回销售不振的颓势。之前，ZARA的网上商店已经开始试水，现在则与其实体店统一步调，同步销售ZARA的时尚服饰。

关键词：服装零售国际商家 ZARA 服饰用品网络零售经济危机服装品牌

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浮云

疯狂英语（初中天地） 2002年第23期 1-1页

作者： julia B.Straus 曾爱民江西省遂川县堆前中学

起先我看见一个篮子——篮子里面放着一盏灯。接着又看见一个身材魁梧的人, 模样像是山姆大叔。

关键词：浮云

Comparison between neuroimaging classifications and histopathological diagnoses using an international multicenter brain tumor magnetic resonance imaging database

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中国神经肿瘤杂志 2006年第2期4卷 78-78页

作者： julia-Sape M Acosta D Majos C Moreno-Torres A Wesseling P Acebes JJ Griffiths JR Arus C. Department of Biochemistry and Molecular Biology Science Faculty Unit Universitat Autbnoma de Barcelona Cerdanyola del Valles Spain.

OBJECT: The aim of this study was to estimate the accuracy of routine magnetic resonance (MR) imaging studies in the classification of brain tumors in terms of both cell type and grade of malignancy。METHODS: The authors retrospectively assessed the correlation between neuroimaging classifications and histopathological diagnoses by using multicenter database records from 393 patients with brain tumors。An ontology was devised to establish diagnostic agreement。Each tumor category was compared with the corresponding histopathological diagnoses by dichotomization。Sensitivity, specificity, positive and negative predictive values (PPVs and NPVs, respectively), and the Wilson 95% confidence intervals (CI) for each were calculated。

关键词：组织病理学磁共振成像资料库检查方法

Spatial and temporal distributions of mercury species and controlling factors in Hongfeng Reservoir, Guizhou, China

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Acta Geochimica 2006年第S1期 147-148页

作者： Tianrong HE1, Xinbin FENG1, Guangle QIU1, Weiyang BAI1, Zhonggen LI1, julia LU2 1 State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Science, Guiyang 550002, China 2 Department of Chemistry and Biology, Ryerson University, 350 Victoria St., Toronto, ON, Canada

高眼压症治疗研究局部用药可以延缓或预防非洲裔美国人原发性开角型青光眼的发生

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美国医学会眼科杂志（中文版） 2005年第2期17卷 68-75页

作者： Eve J. Higginbotham Mae O. Gordon julia A. Beiser Michael V. Drake G. Richard Bennett M. Roy Wilson Michael A. Kass 张世杰（译）任泽钦（校） From the Department of Ophthalmology Maryland Center for Eye Care Associates Baltimore the Department of Ophthalmology and Visual Sciences Washington University School of Medicine St Louis Mo the University of California San Francisco Oakland Pennsylvania CoLlege of Optometry Philadelphia and Texas Tech University Health Sciences Center Lubbock 不详

背景：非洲裔美国人青光眼的患病率高于白种人。目的：报道高眼压症治疗研究中局部降眼压药延缓或预防非洲裔美国人原发性开角型青光眼（PO-AG）发生的安全性和有效性。方法：入选标准包括年龄在40-80；1只眼眼压在24—32mmHg（1kP=7．5... 详细信息

背景：非洲裔美国人青光眼的患病率高于白种人。目的：报道高眼压症治疗研究中局部降眼压药延缓或预防非洲裔美国人原发性开角型青光眼（PO-AG）发生的安全性和有效性。方法：入选标准包括年龄在40-80；1只眼眼压在24—32mmHg（1kP=7．5mm Hg），另一只眼在21-32mm Hg之间：经过标准的临床检查排除明显的青光眼性结构和功能损害。参加者随机分为观察组和用药组。1636例随机化参加者中，408例自称是非洲裔美国人。主要测量指标：主要指标是发生由POAG引起的可重复性视野异常和（或）可重复性视盘恶化。结果：在非洲裔美国人参加者中。用药组203例中17例（8．4％）在研究期间（平均随访时间78个月）发生了POAG。而观察组205例中33例（16．1％）发生POAG（危险比0．50。95％可信区间0．28—0．90；P=0．02）。结论：局部降眼压的治疗对于延缓或预防非洲裔美国人高眼压症患者POAG的发生是有效的。

关键词：原发性开角型青光眼非洲裔美国人高眼压症局部用药治疗预防延缓局部降眼压药 POAG 可重复性

Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation

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Bone Research 2018年第1期6卷 83-94页

作者： Heather A.Carey Blake E.Hildreth III Jennifer A.Geisler Mara C.Nickel Jennifer Cabrera Sankha Ghosh Yue Jiang Jing Yan James Lee Sandeep Makam Nicholas A.Young Giancarlo R.Valiente Wael N.Jarjour Kun Huang Thomas J.Rosol Ramiro E.Toribio julia F.Charles Michael C.Ostrowski Sudarshana M.Sharma Department of Cancer Biology and Genetics and Comprehensive Cancer Center The Ohio State University Wexner Medical Center College of Veterinary Medicine The Ohio State University Department of Biochemistry and Molecular Biology and Hollings Cancer Center Medical University of South Carolina Division of Rheumatology Immunology and Allergy Department of Medicine Brigham and Women’s Hospital and Harvard Medical School Division of Rheumatology and Immunology Department of Internal Medicine The Ohio State University Wexner Medical Center Department of Biomedical Informatics The Ohio State University Wexner Medical Center

Genome-wide association studies(GWASs) have been instrumental in understanding complex phenotypic traits. However, they have rarely been used to understand lineage-specific pathways and functions that contribute to the trait. In this study, by integrating lineage-specific enhancers from mesenchymal and myeloid compartments with bone mineral density loci, we were able to segregate osteoblast-and osteoclast(OC)-specific functions. Specifically, in OCs, a PU.1-dependent transcription factor(TF)network was revealed. Deletion of PU.1 in OCs in mice resulted in severe osteopetrosis. Functional genomic analysis indicated PU.1 and MITF orchestrated a TF network essential for OC differentiation. Several of these TFs were regulated by cooperative binding of PU.1 with BRD4 to form superenhancers. Further, PU.1 is essential for conformational changes in the superenhancer region of Nfatc1. In summary, our study demonstrates that combining GWASs with genome-wide binding studies and model organisms could decipher lineage-specific pathways contributing to complex disease states.

关键词： Genome-wide GWASs MITF

Kohler’s Disease Secondary to Tarsal Pyogenic Arthritis

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International Journal of Clinical Medicine（临床医学国际期刊） 2011年第5期

作者： Alfredo Tagarro julia Yebra Martina Steiner Nuria Bonsfills José Carmelo Albillos Aida Sánchez Lorena Cid Alfonso Ca？ete

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父母离婚后孩子走过的内心路

父母离婚后孩子走过的内心路