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Journal of Geriatric Cardiology 2020年第9期17卷 574-579页

作者： Fritz Kather Miralem Hadzic Teresa Hehle Sarah Eichler julia klein Heinz Völler Annett Salzwedel Department of Rehabilitation Medicine University of PotsdamFaculty of Health Sciences BrandenburgGermany Klinik am See Rehabilitation Center for Internal MedicineRüdersdorfGermany

Malnutrition is described as a state of insufficient intake of energy,protein and other nutrients leading to changes in body composition(weight loss,reduced fat-free mass)as well as adverse functional and clinical outcomes.[1]Depending on the assessments and definition used,the prevalence in older patients ranges between 12%in communitydwelling adults to 60%of patients in geriatric care facilities.[2–5]Older populations are at high risk of nutritional deficiencies because of risk factors such as multimorbidity,polypharmacy,cognitive and physical decline,poor appetite,depressive syndromes and socioeconomic changes.[4,6].

关键词： Cardiac rehabilitation Malnutrition Octogenarians Test-retest reliability

Estimation of aboveground biomass using in situ hyperspectral measurements in five major grassland ecosystems on the Tibetan Plateau

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Journal of Plant Ecology 2008年第4期1卷 247-257页

作者： Miaogen Shen Yanhong Tang julia klein Pengcheng Zhang Song Gu Ayako Shimono Jin Chen State Key Laboratory of Earth Surface Processes and Resource Ecology Academy of Disaster Reduction and Emergency ManagementBeijing Normal UniversityBeijing 100875China National Institute for Environmental Studies TsukubaIbaraki 305-8569Japan Colorado State University Fort CollinsCO 80523USA Terrestrial Ecology Lab Graduate School of Life and Environment ScienceUniversity of TsukubaTennodai 1-1-1TsukubaIbaraki 305-8577Japan Northwest Plateau Institute of Biology Chinese Academy of ScienceXining 810001China

Aims There are numerous grassland ecosystem types on the Tibetan *** include the alpine meadow and steppe and degraded alpine meadow and *** study aimed at developing a method to estimate aboveground biomass(AGB)for these grasslands from hyperspectral data and to explore the feasibility of applying air/satellite-borne remote sensing techniques to AGB estimation at larger *** We carried out a field survey to collect hyperspectral reflectance and AGB for five major grassland ecosystems on the Tibetan Plateau and calculated seven narrow-band vegetation indices and the vegetation index based on universal pattern decomposition(VIUPD)from the spectra to estimate ***,we investigated correlations between AGB and each of these vegetation indices to identify the best estimator of AGB for each ecosystem ***,we estimated AGB for the five pooled ecosystem types by developing models containing dummy *** last,we compared the predictions of simple regression models and the models containing dummy variables to seek an ecosystem type-independent model to improve prediction of AGB for these various grassland ecosystems from hyperspectral *** findings When we considered each ecosystem type separately,all eight vegetation indices provided good estimates of AGB,with the best predictor of AGB varying among different *** AGB of all the five ecosystems was estimated together using a simple linear model,VIUPD showed the lowest prediction error among the eight vegetation *** regression models containing dummy variables predicted AGB with higher accuracy than the simple models,which could be attributed to the dummy variables accounting for the effects of ecosystem type on the relationship between AGB and vegetation index(VI).These results suggest that VIUPD is the best predictor of AGB among simple regression ***,both VIUPD and the soil-adjusted VI could provide accurate estimates of AGB with d

关键词： biomass estimation dummy variable hyperspectral remote sensing Tibetan Plateau regression analysis vegetation index VIUPD

Estimation of aboveground biomass using in situ hyperspectral measurements in five major grassland ecosystems on the Tibetan Plateau

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Journal of Plant Ecology 2009年第1期2卷 42-42页

作者： Miaogen Shen Yanhong Tang julia klein Pengcheng Zhang Song Gu Ayako Shimono Jin Chen 不详

In the the original published figure,the‘Achnatherum grassland’chart showed six lines when there should have been *** see below the corrected figure.

关键词： grassland Plateau aboveground

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模拟增温效应对矮嵩草草甸影响的初步研究

模拟增温效应对矮嵩草草甸影响的初步研究

放牧与气候变化的生态效应及其青藏高原高寒地区集约化生态畜牧业模式探讨

草业与西部大开发学术研讨会暨中国草原学会2000年学术年会

作者：周华坤周兴民赵新全 julia klein 中国科学院西北高原生物研究所加利福尼亚大学伯克利分校

本项研究采用国际冻原计划(ITEX)模拟增温效应对植被影响的方法,于1997年8月至9月设置矮嵩草草甸样地,1998年植物生长季(4～10月)进行野外观察和参数测定,结果证明:(1)温室内气温、地表温度、土壤表层温度可分别提高1.47℃、1.54℃、1.0... 详细信息

本项研究采用国际冻原计划(ITEX)模拟增温效应对植被影响的方法,于1997年8月至9月设置矮嵩草草甸样地,1998年植物生长季(4～10月)进行野外观察和参数测定,结果证明:(1)温室内气温、地表温度、土壤表层温度可分别提高1.47℃、1.54℃、1.00℃;(2)组成植物群落的种群物候期可以提前和延迟,植物生长期延长;(3)组成植物群落的主要种群在高度、盖度、重要值等方面均有提高,种群结构发生一定变化;(4)地上生物量发生变化,其中禾草增加12.3%,莎草增加1.18%,杂草减少21.13%,总量增加3.53%.

关键词：矮嵩草草甸增温效应物候群落结构地上生物量

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放牧与气候变化的生态效应及其青藏高原高寒地区集约化生态畜牧业...

Rare co-occurrence of osteogenesis imperfecta type Ⅰ and autosomal dominant polycystic kidney disease

三江源区生态保护与可持续发展高级学术研讨会

作者：赵新全 julia A.klein 徐世晓周华坤董全民中国科学院西北高原生物研究所 Department of Environmental Science Policy and Management Division of Ecosystem ScienceUniversity of California151 Hilgard Hall 中国科学院西北高原生物研究所中国科学院西北高原生物研究所中国科学院西北高原生物研究所

＜正＞放牧与气候变暖被认为是青藏高原高寒草地最主要的人为和气候扰动因素。本文通过上开口式增温小室（OTC）和不同海拔梯度间的温度差异进行的模拟增温实验以及不同放牧强度下的牦牛和藏系绵羊放牧试验,系统研究了放牧和气候变暖对...

＜正＞放牧与气候变暖被认为是青藏高原高寒草地最主要的人为和气候扰动因素。本文通过上开口式增温小室（OTC）和不同海拔梯度间的温度差异进行的模拟增温实验以及不同放牧强度下的牦牛和藏系绵羊放牧试验,系统研究了放牧和气候变暖对高寒草甸影响。研究结果表明:

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World Journal of Pediatrics 2016年第4期12卷 501-503页

作者： julia Hoefele Karin Mayer Christoph Marschall Martin Alberer Hanns-Georg klein Martin Kirschstein Center for Human Genetics and Laboratory Diagnostics Dr.klein Dr.Rost and ColleaguesMartinsriedGermany Institute of Human Genetics Technische Universitat MünchenMunichGermany Department of Infectious Diseases and Tropical Medicine Ludwig-Maximilians UniversityMunichGermany Department of Pediatrics General HospitalCelleGermany

Background:There are several clinical reports about the co-occurrence of autosomal dominant polycystic kidney disease(ADPKD)and connective tissue disorders.A simultaneous occurrence of osteogenesis imperfecta(OI)type I and ADPKD has not been observed so ***:This report presents the first patient with OI type I and ***:Mutational analysis of PKD1 and COL1A1 in the index patient revealed a heterozygous mutation in each of the two *** analysis of the parents indicated the mother as a carrier of the PKD1 mutation and the father as a carrier of the COL1A1 *** simultaneous occurrence of both disorders has an estimated frequency of 3.5:***:In singular cases,ADPKD can occur in combination with other rare disorders,*** tissue disorders.

关键词： kidney disease osteogenesis imperfecta polycystic kidney

Prevalence and Incidence of HIV and Sexual Risk Behaviors in Crack Users in the San Salvador Metropolitan Area, El Salvador

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World Journal of AIDS 2013年第4期3卷 357-363页

作者： julia Dickson-Gomez julia Lechuga Laura Glasman Steven Pinkerton Gloria Bodnar Pamela klein Center for AIDS Intervention Research Department of Psychiatry and Behavioral Medicine The Medical College of Wisconsin Milwaukee USA Departamento de Investigación Fundación Antidrogas de El Salvador (FUNDASALVA) San Salvador El Salvador University of Texas El Paso USA

Objective: It is in order to estimate the prevalence and incidence of HIV, the frequency of sexual risk behaviors, and perceptions of available resources to prevent and treat HIV among crack users in the San Salvador Metropolitan Area. Methods: We conducted a survey of 420 crack users by using respondent-driven sampling to measure demographic characteristics, the quantity and frequency of drug use, history of STIs, including HIV, and experiences with organizations which provide prevention and treatment of HIV. Each participant offered a free and voluntary HIV test and was asked permission to share the results of the test with the study. Bernoullian modeling was used to estimate the prevalence and incidence of HIV among heterosexual males in this population. Results: The estimated prevalence was 7% (95% CI: 2.3% -9.8%) among participants who agreed to take the test and share the results, and 4.9% (95% CI: 2.8% -7.8%) assuming that those who did not take the test or share results were seronegative. Participants reported a high frequency of sexual risk behaviors. In addition, participants were reported to have little knowledge of organizations to prevent or treat HIV/AIDS;58% had never taken an HIV test prior to survey administration. Conclusions: Crack users in San Salvador are at high risk for HIV acquisition. HIV prevention interventions are urgently needed, especially interventions increasing access to HIV testing and prevention.

关键词： Incidence and Prevalence of HIV Sexual Risk Behavior Crack El Salvador

Characterization of the Stem Cell Fraction in Pancreatobiliary Carcinomas: The Notch Signaling Pathway as a Potential Therapeutic Target

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Journal of Cancer Therapy 2018年第6期9卷 480-502页

作者： Elisabeth Seidel Cynthia de Carvalho Fischer Christopher Neumann Anja Reutzel-Selke Andreas Andreou Joseph Gassner julia Gogolok Peter Tang Anja Schirmeier Fritz klein Igor M. Sauer Johann Pratschke Marcus Bahra Rosa B. Schmuck Charité—Universitatsmedizin Berlin Corporate Member of Freie Universitat Berlin Humboldt-Universitatzu Berlin and Berlin Institute of Health Institute of Surgery Augustenburger Platz 1 Berlin Germany

Pancreatic adenocarcinoma (PDAC) and extrahepatic cholangiocarcinoma (ECC) are highly lethal malignancies with limited treatment options. Both a small subpopulation of cancer stem cells (CSC) and the deregulation of the notch pathway have been considered potential sources of tumor formation. In this study, flow cytometry (FCM) was conducted to identify the CSC population and Notch-associated proteins in ECC and PDAC cell lines. Additionally, the treatment effect of Gemcitabine and the specific notch-inhibitor DAPT on ECC and PDAC cell lines was evaluated. Our results show that the amount of SP cells in ECC cell lines is significantly higher than in PDAC cell lines, and that SP-ECC cells show a higher sensitivity to therapy. In conclusion, inhibition of Notch signaling with DAPT may be of therapeutic value in ECC, but seems to show no effect on more aggressive PDAC. As it could be essential for the improvement in outcomes of the ECC patients, other trials are needed to determine the role of further Notch components.

关键词： Notch Pathway Cancer Stem Cells Pancreatic Adenocarcinoma Extrahepatic Cholangiocarcinoma Targeted Therapy

Approach to Paroxysmal Atrial Fibrillation Type Arrhythmia in a Cardiology Service:A Case Report

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Modern Research in Inflammation 2020年第2期9卷 9-17页

作者： Miriam Viviane Baron Luis Manuel Ley Dominguez Carolina Paz Mohamad Isa Gabriela Di Lorenzo Garcia Scherer Michele Paula dos Santos Vitoria Pereira Itaquy Talia Guimaraes dos Santos julia Braga da Silveira Paulo Ricardo Martins Amanda Correa dos Santos Marcus Vinicius de Mello Pinto Janine Koepp Daiana klein Weber Carissimi Joice Nedel Ott Carolina Goncalves Pinheiro Nathalia Ken Pereira Iketani Gabriela Feltez Bartira Ercília Pinheiro da Costa Postgraduate Program in Medicine and Health Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Improvement of Higher Education Personnel Brazil(CAPES)Distrito FederalBrazil School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil School of Health and Life Sciences of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS) Porto AlegreBrazil Celulare Institute PetrópolisBrazil Undergraduate Nursing Course of the University of Santa Cruz do Sul(UNISC) Santa Cruz do SulBrazil Postgraduate Program in Health Sciences of the Faculty of Medicine of ABC(FMABC) Sao PauloBrazil Undergraduate Physiotherapy Course of the Vale do Salgado Faculty(FVS) CearáBrazil Physiotherapy of the Hospital Beneficiente Portuguesa of Belém ParáBrazil Rehabilitation Sciences of the Federal University of Health Sciences of Porto Alegre Porto AlegreBrazil Postgraduate Program in Medicine and Health Sciences School of Medicine of the Pontifical Catholic University of Rio Grande do Sul(PUC/RS)Porto AlegreBrazil

Atrial fibrillation is a cardiac arrhythmia of high prevalence in the population, especially in the elderly. Its main electrical characteristics are the interval between two successive irregular R waves, absence of P waves and presence of f waves between QRS complexes. The most common symptoms of atrial fibrillation are irregular palpitations associated with dyspnea, dizziness, feeling tired, fatigue and general malaise, but not all patients have any symptoms. The present report presents the history of an elderly patient who arrived at the hospital’s emergency department with irregular heart rhythm and palpitations. The patient’s symptoms, associated with the electrocardiogram results, indicated paroxysmal atrial fibrillation. Electrical cardioversion was performed, and after, cardiac ablation via the femoral vein at the hospital’s cardiology service. There were no complications during the procedure. As a routine imaging exam after ablation, control esophagogastroduodenoscopy was requested to verify that there was no formation of atrio-esophageal fistula developed by the invasive ablation procedure and electrocardiogram, which showed normal sinus rhythm. The patient remained in the cardiac intensive care unit for observation for 24 hours. After the electrical cardioversion and catheter ablation procedures, the patient improved his clinical picture of atrial fibrillation and was discharged after 24 hours of hospitalization. He received treatment to perform at home, to reduce acid reflux into the esophagus and to prevent thrombosis. He did not present pulmonary thromboembolism after hospital discharge. It is believed, therefore, that this form of treatment and management of paroxysmal atrial fibrillation is effective for the solution of the proposed problem and can also serve as a reference for other professionals within the cardiology service.

关键词： Atrial Fibrillation Electrical Cardioversion Catheter Ablation Hypertension Obstructive Sleep Apnea Syndrome

Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease(GCKD)cohort

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Bone Research 2023年第4期11卷 764-771页

作者： Katharina Charlotte Reimer Jennifer Nadal Heike Meiselbach Matthias Schmid Ulla T.Schultheiss Fruzsina Kotsis Helena Stockmann Nele Friedrich Matthias Nauck Vera Krane Kai-Uwe Eckardt Markus P.Schneider Rafael Kramann Jürgen Floege Turgay Saritas Department of Nephrology Rheumatologyand Clinical ImmunologyUniversity Hospital RWTH AachenAachenGermany Institute of Experimental Medicine and Systems Biology RWTH Aachen UniversityAachenGermany Institute for Cell and Tumor Biology RWTH Aachen UniversityAachenGermany Institute of Medical Biometry Informatics and EpidemiologyUniversity Hospital of BonnBonnGermany Department of Nephrology and Hypertension University of Erlangen-NürnbergErlangenGermany Institute of Genetic Epidemiology Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Medicine IV-Nephrology and Primary Care Faculty of Medicine and Medical Center-University of FreiburgFreiburgGermany Department of Nephrology and Medical Intensive Care Charité-Universitätsmedizin BerlinBerlinGermany Department of Nephrology University Medical Center RegensburgRegensburgGermany Institute of Clinical Chemistry and Laboratory Medicine University Medicine GreifswaldGreifswaldGermany DZHK(German Centre for Cardiovascular Research) Partner Site GreifswaldUniversity MedicineGreifswaldGermany Department of Medicine I Division of NephrologyUniversity Hospital WürzburgWürzburgGermany

Mineral and bone disorder(MBD)in chronic kidney disease(CKD)is tightly linked to cardiovascular disease(CVD).In this study,we aimed to compare the prognostic value of nine MBD biomarkers to determine those associated best with adverse cardiovascular(CV)outcomes and *** 5217 participants of the German CKD(GCKD)study enrolled with an estimated glomerular filtration rate(eG FR)between 30–60 mL·min-1 per 1.73 m2 or overt proteinuria,serum osteoprotegerin(OPG),C-terminal fibroblast growth factor-23(FGF23),intact parathyroid hormone(iP TH),bone alkaline phosphatase(BAP),cross-linked C-telopeptide of type 1 collagen(CTX1),procollagen 1intact N-terminal propeptide(P1NP),phosphate,calcium,and 25-OH vitamin D were measured at *** with missing values among these parameters(n=971)were excluded,leaving a total of 4246 participants for *** a median follow-up of6.5 years,387 non-CV deaths,173 CV deaths,645 nonfatal major adverse CV events(MACEs)and 368 hospitalizations for congestive heart failure(CHF)were *** and FGF23 were associated with all outcomes,with the highest hazard ratios(HRs)for *** the final Cox regression model,adjusted for CV risk factors,including kidney function and all other investigated biomarkers,each standard deviation increase in OPG was associated with non-CV death(HR 1.76,95%CI:1.35–2.30),CV death(HR 2.18,95%CI:1.50–3.16),MACE(HR 1.38,95%CI:1.12–1.71)and hospitalization for CHF(HR 2.05,95%CI:1.56–2.69).Out of the nine biomarkers examined,stratification based on serum OPG best identified the CKD patients who were at the highest risk for any adverse CV outcome and mortality.

关键词： Kidney cardiovascular vitamin