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Antidiabetic potential of methanol extracts from leaves of Piper umbellatum L. and Persea americana Mill.

Asian Pacific Journal of Tropical Biomedicine 2018年第3期8卷 160-165页

作者： Guy Sedar Singor Njateng Sumera Zaib Larissa Yetenge Chimi Cesaire Feudjio Raymond Simplice Mouokeu Donatien Gatsing jules-roger kuiate Ezekiel Adewole Jamshed Iqbal Laboratory of Microbiology and Antimicrobial Substances Faculty of Science University of Dschang Centre for Advanced Drug Research COMSATS Institute of Information Technology Institute of Fisheries and Aquatic Sciences University of Douala Department of Chemical Sciences Afe Babalola University Ado

Objective: To determine inhibitory activity of methanolic leaf extract of Piper umbellatum and Persea americana(P. americana)(traditionally used in Cameroon against diabetes) on β-glucosidase, β-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities, enzymes involved in starch digestion or diabetic complications. Methods: The methanol extracts from Piper umbellatum and P. americana were prepared by maceration. To assess relative efficacy of these extracts, the determination of concentrations that were needed to inhibit 50% of enzyme activity was done, whereas, gas chromatography-mass spectrum was used to identify components from extracts that may be responsible for the activities. Results:The tested extracts strongly inhibited β-glucosidase, maltase-glucoamylase, aldose reductase and aldehyde reductase activities with IC50 ranging from(1.07 ± 0.03) to(31.77 ± 1.17) μg/*** the tested extracts, P. americana was the most active against sensitive enzymes(IC50 of1.07 ± 0.03 to 15.63 ± 1.23). But, none of the extracts showed interesting inhibitory effect against β-glucosidase as their percentage inhibitions were less than 16%. From gas chromatographymass spectrum analysis, 10 and 8 compounds were identified in Piper umbellatum and *** extracts respectively, using NIST library 2014. Conclusions: Results of this study provide the scientific credential for a prospective usage of these plants to treat diabetes.

关键词： Piper umbellatum Persea americana Glucosidase Maltase-glucoamylase Aldose reductase Aldehyde reductase

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Follow Up of Hypertensive Patients at Regional Hospital of Bafoussam, West Cameroon: Biochemical Profiles in Naive and Hypotensive Drug Treated Patients

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World Journal of Cardiovascular Surgery 2020年第9期10卷 167-185页

作者： Vanessa Linda Nzesseu Charles Kouam Kouam Jean-de-Dieu Tamokou jules-roger kuiate Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Department of Internal Medicine Bafoussam Regional Hospital Bafoussam Cameroon

Objective: The aim of this work was to study the effects of antihypertensive therapies on certain metabolic parameters in hypertensive patients. Methods: A cross-sectional and analytical study conducted within the Bafoussam Re-gional Hospital on 343 patients including 99 normotensives and 244 hyperten-sives distributed in 71 patients naive to treatment and 173 patients under treatment (84 under monotherapy, 67 under bitherapy and 21 under trithera-py). The antihypertensive medications were recorded from the medical records. A questionnaire survey was administered to study participants and potential risk factors for hypertension sought. Blood and urine samples were collected for lipid, renal and hepatic disorder analysis. Two blood pressure measure-ments enabled us to diagnose hypertensive patients. Measurements of bio-chemical parameters such as total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides, creatinine, glucose, aspartate aminotransferase (ASAT), alanine aminotransferase (ALT), potassium, chloride and calcium were done in serum by methods resulting from commercial kits. Results: Cal-cium Channel Blockers were significantly associated with increases in blood potassium (odd-ratios (OR) = 8.63, p = 0.036) and sodium (OR = 0.20, p = 0.037). Angiotensin-converting enzyme/Angiotensin II receptor blockers were significantly associated with an increase in plasma activity of ASAT (OR = 0.12, p = 0.03) whereas Diuretics were significantly associated with an increase in ALAT plasma activity (OR = 0.003, p = 0.012). Dual therapies were associ-ated with highest frequencies of hypercreatininemia (41.8%) and hyperglyce-mia (44.8%) whereas hypocholesterolemia HDL (38.1%) was most observed in hypertensive patients on triple therapy. The different therapies resulted in very low frequencies of abnormal liver profiles (in general almost all below 10%). Tritherapy h

关键词： Antihypertensives Therapy Metabolic Abnormalities

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Seroprevalence of <i>Brucella</i>Antibodies and Risk Factors Associated with Human Brucellosis in High-Risk Occupational Groups of the Noun Division in the West Region of Cameroon

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Journal of Biosciences and Medicines 2021年第3期9卷 105-123页

作者： Rolin Mitterran Ndefo Kamga Barberine Silatsa Assongo Eugenie Melaine Kemta Magang Amadou Fouapon Moussa Salihou jules-roger kuiate Gustave Simo Molecular Parasitology & Entomology Unit Department of Biochemistry Faculty of Science University of Dschang Dschang Cameroon Divisional Delegation of Livestock Fisheries and Animal Industries Noun Cameroon Laboratory of Microbiology and Antimicrobial Substances Department of Biochemistry Faculty of Sciences University of Dschang Dschang Cameroon

Brucellosis is an anthropozoonotic disease with an important public health impact. Although the transmission of Brucella from animals to humans can occur in different epidemiological settings of sub-Saharan African countries, little data has been published on human brucellosis. This study aimed to detect Brucella antibodies and the risk factors associated to brucellosis among high-risk occupational groups of people in the Noun Division of Cameroon. For this study, a structured questionnaire was used to assess risk factors associated with human brucellosis. Thereafter, blood samples were collected from high-risk occupational groups of people in four villages. Plasma was extracted from each sample and Brucella antibodies were detected using Rose Bengal Plate Test (RBPT) and indirect Enzyme-Linked Immunosorbent Assay (i-ELISA). Of the 273 participants enrolled, the overall seroprevalence of Brucella antibodies was 12.45% with RBPT and 10.26% with i-ELISA test. This seroprevalence was significantly (P = 0.04;X2 = 9.73) higher among livestock herdsmen (15.8%), slaughterhouse workers (9.8%), butchers (4.8%), participants having no educational level (14.3%) and those experiencing above 5 years of risky activity (15%). Raw milk consumption (OR: 4.8;P = 0.001), no formal education (OR: 6.4;P = 0.03) and assistance of animal during parturition (OR: 7.2;P Brucella infections. The detection of Brucella antibodies indicates the risk of human brucellosis in some groups of people of the Noun division. Consuming unpasteurized milk, participating in parturition and lacking knowledge on brucellosis appeared as risk factors associated with human brucellosis in western Cameroon. It raises the need of developing and implementing control measures for human and animal brucellosis.

关键词： Brucellosis Risk Factors High-Risk Occupational Groups Cameroon

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A sphingolipid message promotes neuronal health across generations

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Neural Regeneration Research 2024年第11期19卷 2325-2326页

作者： Wenyue Wang roger Pocock Development and Stem Cells Program Monash Biomedicine Discovery Institute and Department of Anatomy and Developmental BiologyMonash UniversityMelbourneVICAustralia

Maternal nutrition can affect brain function of offspring in later life(Fitzgerald et al.,2020).Emerging studies have also shown that the maternal environment can modify susceptibility to neurodegenerative disease(Boots et al.,2023).Transmission of environmental information from mother to offspring depends on maternal nutrient *** the nematode Caenorhabditis elegans,maternal yolk,which is synthesized in the intestine and transferred to nourish oocytes and early embryos,can provide extranuclear inheritance factors to mediate phenotypic plasticity across ***,the molecular mechanisms of regulating such intergenerational effects remain largely unknown.

关键词： mother intestine transferred

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Understanding antimicrobial pharmacokinetics in critically ill patients to optimize antimicrobial therapy:A narrative review

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Journal of Intensive Medicine 2024年第3期4卷 287-298页

作者： Claire roger Department of Anesthesiology and Intensive Care Pain and Emergency MedicineNîmes-Caremeau University HospitalNîmesFrance UR UM 103 IMAGINE(Initial Management and prévention of orGan failures IN critically ill patiEnts) Faculty of MedicineMontpellier UniversityMontpellierFrance

Effective treatment of sepsis not only demands prompt administration of appropriate antimicrobials but also requires precise dosing to enhance the likelihood of patient survival. Adequate dosing refers to the administration of doses that yield therapeutic drug concentrations at the infection site. This ensures a favorable clinical and microbiological response while avoiding antibiotic-related toxicity. Therapeutic drug monitoring (TDM) is the recommended approach for attaining these goals. However, TDM is not universally available in all intensive care units (ICUs) and for all antimicrobial agents. In the absence of TDM, healthcare practitioners need to rely on several factors to make informed dosing decisions. These include the patient's clinical condition, causative pathogen, impact of organ dysfunction (requiring extracorporeal therapies), and physicochemical properties of the antimicrobials. In this context, the pharmacokinetics of antimicrobials vary considerably between different critically ill patients and within the same patient over the course of ICU stay. This variability underscores the need for individualized dosing. This review aimed to describe the main pathophysiological changes observed in critically ill patients and their impact on antimicrobial drug dosing decisions. It also aimed to provide essential practical recommendations that may aid clinicians in optimizing antimicrobial therapy among critically ill patients.

关键词： Pharmacokinetics/pharmacodynamics ICU Antibiotics Dose optimization TDM

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Eco-friendly polysaccharide coatings for antifouling and dragreduction and potential application for marine devices

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Friction 2024年第4期12卷 726-744页

作者： Hao YANG Liguo QIN Wenhui ZHAO Fagla jules MAWIGNON Hui GUO Yongkang WU Yali ZHANG Guangneng DONG Key Laboratory of Education Ministry for Modern Design and Rotor-Bearing System Institute of Design Science and Basic ComponentsSchool of Mechanical EngineeringXi’an Jiaotong UniversityXi’an 710049China Key Laboratory of Biomedical Information of Ministry of Education School of Life Science and TechnologyXi’an Jiaotong UniversityXi’an 710049China Department of Endocrinology First Affiliated Hospital of Medical CollegeXi'an Jiaotong UniversityXi’an 710061China

Traditional antifouling agents usually have a certain toxic effect on marine environments and non-target *** this study,Dictyophora indusiata polysaccharide(DIP)was applied as a natural antifouling surface modifier to prepare the surface coating for marine *** DIP coatings were prepared:*** spore polysaccharide(DISP),*** volva polysaccharide(DIVP),and *** embryonic body polysaccharide(DIEP).The antifouling,tribological,and anticorrosion behavior of the coatings were *** revealed that the three kinds of DIP coatings had excellent antifouling properties,which could effectively prevent the adhesion of Chlorella and the attachment of water-based and oily stains on the ***,the coatings showed great mechanical stability and could maintain an extremely low coefficient of friction(COF<0.05)after continuous *** drag reduction rate of the coated surfaces reached 5%,showing a powerful lubrication ***,the DIP coatings presented an outstanding corrosion resistance,where the equivalent circuit impedances were 4-9 orders of magnitude higher than the control *** research showed a promising prospect of surface coating fabrication with DIP for marine devices to achieve the purpose of antifouling and drag reduction.

关键词： Dictyophora indusiata polysaccharide(DIP)coating antifouling anticorrosion lubrication and drag reduction

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Making topological protein links using enzymatic reactions

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National Science Review 2024年第3期11卷 50-51页

作者： roger Castells-Graells Todd O.Yeates Department of Chemistry and Biochemistry University of California UCLA-DOE Institute for Genomics and Proteomics

Proteins are exceedingly complex molecules though, at their heart, they are essentially linear polymers. Pull at their ends and one obtains an extended backbone. While that is true in most cases, some natural proteins... 详细信息

关键词： DESIGN

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Dynamics analysis and cryptographic implementation of a fractional-order memristive cellular neural network model

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Chinese Physics B 2024年第4期33卷 418-433页

作者：周新卫蒋东华 Jean De Dieu Nkapkop Musheer Ahmad jules Tagne Fossi Nestor Tsafack 吴建华 Department of Information Engineering Gongqing CollegeNanchang UniversityJiujiang 332020China School of Computer Science and Engineering Sun Yat-Sen UniversityGuangzhou 511400China Department of Electrical Engineering and Industrial Computing University Institute of TechnologyDoualaCameroon Department of Computer Engineering Jamia Millia IslamiaNew Delhi 110025India Department of Physics Faculty of ScienceUniversity of YaoundeCameroon Electrical Engineering Department and Industrial Computing of ISTAMA University of DoualaDoualaCameroon

Due to the fact that a memristor with memory properties is an ideal electronic component for implementation of the artificial neural synaptic function,a brand-new tristable locally active memristor model is first proposed in this ***,a novel four-dimensional fractional-order memristive cellular neural network(FO-MCNN)model with hidden attractors is constructed to enhance the engineering feasibility of the original CNN model and its ***,its hardware circuit implementation and complicated dynamic properties are investigated on multi-simulation ***,it is used toward secure communication application *** it as the pseudo-random number generator(PRNG),a new privacy image security scheme is designed based on the adaptive sampling rate compressive sensing(ASR-CS)***,the simulation analysis and comparative experiments manifest that the proposed data encryption scheme possesses strong immunity against various security attack models and satisfactory compression performance.

关键词： cellular neural network memristor hardware circuit compressive sensing privacy data protection

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Mechanistic modeling of copper corrosions in data center environments

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Building Simulation 2024年第3期17卷 483-492页

作者： Rui Zhang Jianshun Zhang roger Schmidt Jeremy L.Gilbert Department of Mechanical and Aerospace Engineering College of Engineering and Computer ScienceSyracuse UniversitySyracuseNY13244USA Buildings and Transportation Science Division Oak Ridge National LaboratoryOak RidgeTN37830USA SyracuseCoE-New York Center of Excellence in Environmental and Energy Systems Syracuse University727 E.Washington StreetSyracuseNY13244USA Department of Bioengineering Clemson UniversityClemson-Medical University of South Carolina Bioengineering ProgramCharlestonSC29425USA

Air-side economizers are increasingly used to take advantage of“free-cooling”in data centers with the intent of reducing the carbon footprint of ***,they can introduce outdoor pollutants to indoor environment of data centers and cause corrosion damage to the information technology *** evaluate the reliability of information technology equipment under various thermal and air-pollution conditions,a mechanistic model based on multi-ion transport and chemical reactions was *** model was used to predict Cu corrosion caused by Cl_(2)-containing pollutant *** also accounted for the effects of temperature(25℃and 28℃),relative humidity(50%,75%,and 95%),and *** also identified higher air temperature as a corrosion barrier and higher relative humidity as a corrosion accelerator,which agreed well with the experimental *** average root mean square error of the prediction was 13.7Å.The model can be used to evaluate the thermal guideline for data centers design and operation when Cl_(2)is present based on pre-established acceptable risk of corrosion in data centers’environment.

关键词： chloride pollutant mixture copper corrosion model data center temperature relative humidity synergistic effect

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Exactly Solvable Two-Parameter Models of Relativistic δ′s -Sphere Interactions in Quantum Mechanics

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1263-1285页

作者： jules Manirambona Juma Shabani Alfred Vyabandi Doctoral School University of Burundi Bujumbura Burundi Faculty of Sciences Doctoral School University of Burundi Bujumbura Burundi Institute of Applied Pedagogy University of Burundi Bujumbura Burundi

We make a systematic study of two-parameter models of δ ′ s -sphere interaction and δ ′ s -sphere plus a Coulomb interaction. Where δ ′ s interaction denotes the δ ′ -sphere interaction of the second kind. We provide the mathematical definitions of Hamiltonians and obtain new results for both models, in particular the resolvents equations, spectral properties and some scattering quantities.

关键词： Boundary Conditions Problem -Sphere Interactions Self-Adjoint Operator Resolvent Equation Spectral Properties Scattering Theory

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