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麻醉与镇痛 2011年第4期7卷 46-55页

作者： Matthias Haenggi, MD Heidi Ypparila-Wolters, PhD Sarah Buerki, cand. med Rebekka Schlauri, cand. med Ilkka Korhonen, PhD jukka Takala, MD, PhD Stephan M. Jakob, MD, PhD 马競(译) 王焱林(校) Department of Intensive Care Medicine Bern University Hospital and University of Bern Bern Switzerland VTF Technical Research Centre of Finland Tampere Finland 不详

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始... 详细信息

背景包括镇静评分和常规镇静暂停在内的镇静方案，有助干减少机械通气时间和重症监护病房（ICU）入住时间。因临床上对于镇静深度的评估工作量大、仅能间断进行且干扰镇静和睡眠，所以通过脑电生理信号评估镇静深度的替代方法已经开始倍受青睐：我们想明确听觉诱发相关电位（ERPs）、脑电双频指数（BIS）和墒（Entropy）是否也能够评估临床镇静深度。方法选择10例择期全麻下行胸部或腹部手术的患者。手术后进入ICU，逐渐减少丙泊酚和瑞芬太尼靶控镇静程度[采用Rickmond Agitation镇静评分（RASS），-5分极深镇静，-4分深度镇静，-3～-1分中度镇静，0分清醒]期间，记录脑电图、BIS、状态熵（SE）、反应墒（RE）和ERPs。手术前或手术后数天测量指标的相关基础水平。结果基线、PASS-5分、RASS-4分、RASS-3至-1分和PASS-0分，对应的BIS值分别是94[4]（中位数，四分位数间距）、47[15]、68[9]、75[10]和88[6]；对应的SE值分别是87[3]、46[10]、60[22]、74[21]和87[5]；对应的RE值分别是97[4]、48[9]、71[25]、81[8]和96[3]（P〈0．05，Friedman检验）。BIS和墒都有高变异度。当单独考虑ERP振幅100时，各个镇静水平的ERPs值差异无显著性：但是、复括双参数主要变量分析的ERP辨别分析显示区别深度镇静、中度镇静和清醒状态的推算概率PK大约是0．89。与PK对应的RE，SE和BIS值分别是0．88、0．89和0．85。结论ERPs、BIS和熵均不能替代基于标准评分系统的临床镇静评估。全麻后对于极深镇静、深度到中度镇静和清醒的辨别，ERPs和脑电图仅能提供相似的PK值。BIS和熵存在较高的个体间和个体自身变异度，使其难以确定预测镇静水平的目标值范围，因而在危重患者中的使用受到限制。ERPs的变异度还不清楚。

关键词：脑电双频指数重症监护病房镇静评分危重患者相关电位听觉诱发状态熵 Friedman

DET1-mediated COP1 regulation avoids hy5 activity over second-site gene targets to tune plant photomorphogenesis

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Molecular Plant 2021年第6期14卷 963-982页

作者： Esther Canibano Clara Bourbousse Marta Garcia-Leon Borja Garnelo Gomez Lea Wolff Camila Garcia-Baudino Rosa Lozano-Duran Fredy Barneche Vicente Rubio Sandra Fonseca Centro nacional de Biotecnología CNB-CSICMadrid 28049Spain Institut de biologie de l’École normale supérieure(IBEnS) École normale supérieureCNRSINSERMUniversitéPSLParis 75005France Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Department of Plant Biochemistry Centre for Plant Molecular Biology(ZMBP)Eberhard Karls University72076 TübingenGermany

DE-ETIOLATED 1(DET1)and COnSTITUTIVE PHOTOMORPHOGEnESIS 1(COP1)are two essential repressors of Arabidopsis *** proteins can associate with CULLIn4 to form independent CRL4-based E3 ubiquitin ligases that mediate the degradation of several photomorphogenic transcription factors,including ELOnGATED hyPOCOTYL 5(hy5),thereby controlling multiple gene-regulatory *** extensive biochemical and genetic analyses of their multi-subunit complexes,the functional links between DET1 and COP1 have long remained ***,we report that DET1 associates with COP1 in vivo,enhances COP1-hy5 interaction,and promotes COP1 destabilization in a process that dampens hy5 protein *** regulating its accumulation,DET1 avoids hy5 association with hundreds of second-site genomic loci,which are also frequently targeted by the skotomorphogenic transcription factor PhyTOCHROME-InTERACTInG FACTOR ***,ectopic hy5 chromatin enrichment favors local gene repression and can trigger fusca-like *** study therefore shows that DET1-mediated regulation of COP1 stability tunes down the hy5 cistrome,avoiding hyper-photomorphogenic responses that might compromise plant viability.

关键词： hy5 DET1 COP1 photomorphogenesis light signaling fusca

Stability-indicating assay method for determination of actarit,its process related impurities and degradation products:Insight into stability profile and degradation pathways

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Journal of Pharmaceutical Analysis 2014年第6期4卷 374-383页

作者： A.Abiramasundari Rahul P.Joshi Hitesh B.Jalani Jayesh A.Sharma Dhaivat H.Pandya Amit n.Pandya Vasudevan Sudarsanam Kamala K.Vasu Department of Medicinal Chemistry B.V. Pat el PERD Centre Ahmedcibad Gujarat 380054 India

The stability of the drug actarit was studied under different stress conditions like hydrolysis（acid,alkaline and neutral）,oxidation,photolysis and thermal degradation as recommended hy International Conference on Harmonization（ICH） *** was found to be unstable in acidic,basic and photolytic conditions and produced a common degradation product while oxidative stress condition produced three additional degradation *** was impassive to neutral hydrolysis,dry thermal and accelerated stability *** products were identified,isolated and characterized by different spectroscopic *** and the degradation products were synthesized by a new route using green *** chromatographic separation of the drug and its impurities was achieved in a phenomenex luna C18 column employing a step gradient elution by high performance liquid chromatography coupled to photodiode array and mass spectrometry detectors（HPLC-PDAMS）.A specilic and sensitive stability-indicating assay method for the simultaneous determination of the drug *** process related impurities and degradation products was developed and validated.

关键词： Actarit Forced degradation Stability-indicating assay method

Preserving cognitive function in patients with Alzheimer's disease:The Alzheimer's disease neuroprotection research initiative(ADnRI)

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neuroprotection 2023年第2期1卷 84-98页

作者： Jie Liu Heleen van Beusekom Xian-Le Bu Gong Chen Paulo Henrique Rosado de Castro Xiaochun Chen Xiaowei Chen Andrew n.Clarkson Tracy D.Farr Yuhong Fu Jianping Jia jukka Jolkkonen Woojin Scott Kim Paula Korhonen Shen Li Yajie Liang Guang-Hui Liu Guiyou Liu Yu-Hui Liu Tarja Malm Xiaobo Mao Joaquim Miguel Oliveira Mike M.Modo Pedro Ramos-Cabrer Karsten Ruscher Weihong Song Jun Wang Xuanyue Wang Yun Wang Haitao Wu Lize Xiong Yi Yang Keqiang Ye Jin-Tai Yu Xin-Fu Zhou Marietta Zille Colin L.Masters Piotr Walczak Boltze Johannes Xunming Ji Yan-Jiang Wang Department of neurology Daping HospitalThird Military Medical UniversityChongqingChina Chongqing Key Laboratory of Ageing and Brain Diseases ChongqingChina Division of Experimental Cardiology Department of CardiologyErasmus MCUniversity Medical CenterRotterdamThe Netherlands Institute of Brain and Intelligence Third Military Medical UniversityChongqingChina Guangdong-HongKong-Macao Institute of CnS Regeneration(GHMICR) Jinan UniversityGuangzhouGuangdongChina Institute of Biomedical Sciences Federal University of Rio de JaneiroRio de JaneiroRio de JaneiroBrazil Fujian Key Laboratory of Molecular neurology Department of Neurology and GeriatricsFujian Institute of GeriatricsFujian Medical University Union HospitalInstitute of NeuroscienceFujian Medical UniversityFuzhouFujianChina Guangyang Bay Laboratory Chongqing Institute for Brain and IntelligenceChongqingChina Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghaiChina Department of Anatomy Brain Health Research Centre and Brain Research New ZealandUniversity of OtagoDunedinNew Zealand School of Life Sciences University of NottinghamNottinghamUK Brain and Mind Centre&School of Medical Sciences The University of SydneySydneyNew South WalesAustralia Innovation Center for neurological Disorders and Department of neurology Xuanwu HospitalNational Clinical Research Center for Geriatric DiseasesCapital Medical UniversityBeijingChina A.I.Virtanen Institute for Molecular Sciences University of Eastern FinlandKuopioFinland Department of neurology and Psychiatry Beijing Shijitan HospitalCapital Medical UniversityBeijingChina Department of Diagnostic Radiology and nuclear Medicine University of Maryland School of MedicineBaltimoreMarylandUSA University of Chinese Academy of Sciences BeijingChina State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute of Brain Disorders Laboratory of Brain DisordersMinistry of Sci

The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease(AD)and associated socioeconomic *** metabolism of amyloid-β(Aβ)has been proposed as a significant pathomechanism in AD,supported by results of recent clinical trials using anti-Aβ***,the cognitive benefits of the current treatments are *** etiology of AD is multifactorial,encompassing Aβand tau accumulation,neuroinflammation,demyelination,vascular dysfunction,and comorbidities,which collectively lead to widespread neurodegeneration in the brain and cognitive ***,solely removing Aβfrom the brain may be insufficient to combat neurodegeneration and preserve *** attain effective treatment for AD,it is necessary to(1)conduct extensive research on various mechanisms that cause neurodegeneration,including advances in neuroimaging techniques for earlier detection and a more precise characterization of molecular events at scales ranging from cellular to the full system level;(2)identify neuroprotective intervention targets against different neurodegeneration mechanisms;and(3)discover novel and optimal combinations of neuroprotective intervention strategies to maintain cognitive function in AD *** Alzheimer's Disease neuroprotection Research Initiative's objective is to facilitate coordinated,multidisciplinary efforts to develop systemic neuroprotective strategies to combat *** aim is to achieve mitigation of the full spectrum of pathological processes underlying AD,with the goal of halting or even reversing cognitive decline.

关键词： Alzheimer's disease early intervention neural regeneration neuroprotection systematic perspective

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腰椎外科学第3版第3版

Interplay between HEAT SHOCK PROTEIn 90 and hy5 Controls PhAnG Expression in Response to the GUn5 Plastid Signal

丛书名：世界权威医学著作译丛

2006年

作者：（美）Harry n. Herkowitz等海涌郑召民陈仲强主译

本书详细介绍了世界范围内腰椎外科基础研究与临床实践的最新进展。

ISBN: (纸本)7533143345

本书详细介绍了世界范围内腰椎外科基础研究与临床实践的最新进展。

关键词：医药、卫生外科学骨科学(运动系疾病、矫形外科学)

来源：汇雅图书（南通市图书馆... 评论

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Molecular Plant 2012年第4期5卷 901-913页

作者： Peter Kindgren Louise noren Juan de Dios Barajas Lopez Jehad Shaikhali Asa Strand Umea Plant Science Centre Department of Plant Physiology Umea University S-901 87 Umea Sweden

The presence of genes encoding organellar proteins in different cellular compartments necessitates a tight coordination of expression by the different genomes of the eukaryotic cell. This coordination of gene expression is achieved by organelle-to-nucleus or retrograde communication. Stress-induced perturbations of the tetrapyrrole pathway trigger large changes in nuclear gene expression in plants. Recently, we identified HSP90 proteins as ligands of the pu- tative plastid signal Mg-ProtolX. In order to investigate whether the interaction between HSP90 and Mg-ProtolX is bio- logically relevant, we produced transgenic lines with reduced levels of cytosolic HSP90 in wild-type and gun5 backgrounds. Our work reveals that HSP90 proteins respond to the tetrapyrrole-mediated plastid signal to control expres- sion of photosynthesis-associated nuclear genes （PhAnG） during the response to oxidative stress. We also show that the hy5 mutant is insensitive to tetrapyrrole accumulation and that Mg-ProtolX, cytosolic HSP90, and hy5 are all part of the same signaling pathway. These findings suggest that a regulatory complex controlling gene expression that includes HSP90 proteins and a transcription factor that is modified by tetrapyrroles in response to changes in the environment is evolutionarily conserved between yeast and plants.

关键词： abiotic/environmental stress cell signaling organelle biogenesis/function.

The families Distoseptisporaceae ***.,Kirschsteiniotheliaceae,Sporormiaceae and Torulaceae,with new species from freshwater in Yunnan Province,China

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Fungal Diversity 2016年第5期80卷 375-409页

作者： HongYan Su Kevin D.hyde Sajeewa S.n.Maharachchikumbura Hiran A.Ariyawansa ZongLong Luo Itthayakorn Promputtha Qing Tian ChuanGen Lin QiuJu Shang YongChang Zhao HongMei Chai XiaoYing Liu Ali H.Bahkali Jayarama D.Bhat Eric H.C.McKenzie DeQun Zhou Faculty of Environmental Sciences&Engineering Kunming University of Science&TechnologyKunming 650500YunnanChina College of Agriculture and Biology Dali UniversityDaliYunnan 671003China Center of Excellence in Fungal Research Mae Fah LuangUniversityChiang Rai 57100Thailand Guizhou Key Laboratory of Agricultural Biotechnology Guizhou Academy of Agricultural SciencesGuiyangGuizhou 550006People’s Republic of China Department of Botany and Microbiology King Saudi UniversityRiyadhSaudi Arabia School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Departent of Biology Chiang Mai UniversityChiang MaiThailand Institute of Biotechnology and Germplasmic Resources Yunnan Academy of Agricultural SciencesKunming 650223People’s Republic of China College of Basic Medicine Dali UniversityDaliYunnan 671000China no.128/1-J Azad Housing SocietyCurcaP.OGoa Velha 403108India Department of Botany Goa UniversityGoa 403206India Manaaki Whenua Landcare Research Private Bag 92170AucklandNew Zealand

During a north–south latitudinal survey of aquatic fungi on submerged wood and herbaceous material in streams in the Asian region,we collected several hyphomycetous *** paper is part of a series where we provide illustrated accounts of these taxa and place them in a natural classification in the *** sequence based phylogenies in recent literature have shown that Dendryphion,Sporidesmium and Torula-like species are polyphyletic in the phylum Ascomycota and their taxonomyhas been problematic due to a lack of understanding of the importance of morphological characters used to delimit taxa,as well as the lack of ex-type or reference *** on multi-locus phylogenies together with morphology,we propose the novel family Distoseptisporaceae(Sordariomycetes)and three novel genera neotorula(Pleosporales,Dothideomycetes),Distoseptispora(Sordariomycetes)and Pseudosporidesmium(Sordariomycetes).In addition,Dendryphion aquaticum,***,Distoseptispora fluminicola,***,Kirschsteiniothelia submersa,neotorula aquatica,Sporidesmium aquaticum,*** and *** are introduced as new *** knawiae *** proposed to accommodate Sporidesmium knawiae in *** polyphyletic nature of Dendryphion,Sporidesmium and Torula-like species are partially resolved,but further sampling with fresh collections and molecular data of species are needed to obtain a natural classification.

关键词： Asexual fungi Dothideomycetes Freshwater fungi hyphomycetes new species Phylogeny Sordariomycetes

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宜宾大塔轻烃回收项目工艺设计及参数优化

石油与天然气化工 2014年第3期43卷 271-274页

作者：朱琳天津市振津工程设计咨询有限公司

宜宾大塔轻烃回收项目是对宜宾大塔浅层油气田气进行处理以回收天然气中的轻烃并联产液化天然气(LnG)的项目。根据油气田天然气组分和项目的特点,轻烃回收工艺采用DHX工艺,天然气液化采用单循环双节流混合冷剂制冷工艺。由于宜宾地区的... 详细信息

宜宾大塔轻烃回收项目是对宜宾大塔浅层油气田气进行处理以回收天然气中的轻烃并联产液化天然气(LnG)的项目。根据油气田天然气组分和项目的特点,轻烃回收工艺采用DHX工艺,天然气液化采用单循环双节流混合冷剂制冷工艺。由于宜宾地区的外输气管网压力已定,需要对典型的DHX工艺进行调整优化。采用hySYS模拟软件对轻烃回收及天然气液化过程进行模拟、计算和优化,对比不同操作温度下工艺装置运行结果,并从能耗、回收率、经济效益等方面进行比较以确定最优的工艺操作参数。

关键词：轻烃回收 DHX 回收率能耗宜宾大塔

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OER固液界面中阳离子的调控

OER固液界面中阳离子的调控