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New advances in visual computing for intelligent processing of visual media and augmented reality

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Science China(Technological Sciences) 2015年第12期58卷 2210-2211页

作者： wang juhong ZHANG SongHai MARTIN Ralph R. Department of Computer Science and Technology Tsinghua University School of Computer Science & Informatics Cardiff University

Visual imagery constitutes the most important sensory information for *** entire field of acquiring,analyzing and synthesizing visual data by means of computers is called visual *** has an extraordinarily wide range of applications,including for example:industrial quality control,street view and driver assistance systems,robot navigation,multimedia systems,and computer games.

关键词： Augmented reality Intelligent computing

Aerobic glycolysis promotes tumor immune evasion and tumor cell stemness through the noncanonical function of hexokinase 2

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Cancer Communications 2023年第3期43卷 387-390页

作者： Haiyan He Liwei Xiao juhong wang Dong Guo Zhimin Lu Department of Pharmacy Sir Run Run Shaw HospitalSchool of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease the First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineZhejiang UniversityHangzhouZhejiangP.R.China Cancer Center Zhejiang UniversityHangzhouZhejiangP.R.China Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China

The Warburg effect is a key metabolic feature of cancer cells and manifests as substantially increased glycolysis regardless of the presence of oxygen[1].The initial step of glycolysis is catalyzed by hexokinase(HK),which converts glucose to the metabolic intermediate glucose-6-phosphate(G-6-P).Four kinds of HK isozymes,HK1,HK2,HK3 and HK4,have been found in ***1 and HK2 bind to the mitochondrial outer membrane through interac-tions with voltage-dependent anion channels(VDACs),and both of thesemolecules have a high affinity for glucose[2].HK2 overexpression is frequently detected in cancer cells,leading to enhanced aerobic glycolysis and tumorigenesis that renders HK2 an attractive target for cancer treatment[3].Important advances in research on cancer metabolism in recent decades have revealed thatmetabolic enzymes have non-metabolic functions,which play pivotal roles in tumor development and progression[4–6].Recent studies uncovered that HK2 directly promoted tumor immune evasion through the activity of a previously unidentified protein kinase and tumor cell stemness via upregulation of CD133 expression.

关键词： glycolysis metabolism attractive

Associations of PGK1 promoter hypomethylation and PGK1-mediated PDHK1 phosphorylation with cancer stage and prognosis:a TCGA pan-cancer analysis

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Cancer Communications 2019年第1期39卷 482-498页

作者： Fei Shao Xueying Yang Wei wang juhong wang Wei Guo Xiaoli Feng Susheng Shi Qi Xue Shugeng Gao Yibo Gao Zhimin Lu Jie He Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeNo.17 PanjiayuannanliChaoyang DistrictBeijing 100021P.R.China Qingdao Cancer Institute Cancer Institute of The Affiliated Hospital of Qingdao UniversityQingdao 266003ShandongP.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospitaland Institute of Translational MedicineZhejiang University School of MedicineHangzhou 310029ZhejiangP.R.China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China

Background:Cancer cells reprogram metabolism for *** kinase 1(PGK1),as a glycolytic enzyme and newly identified protein kinase,coordinates glycolysis and mitochondrial ***,the clini-cal significance of PGK1 expression and function in cancer progression is ***,we investigated the relation-ship between the progression and prognosis of multiple cancer types and PGK1 expression and its function in the mitochondrial metabolism ***:We performed pan-cancer analyses of PGK1 mRNA level and DNA methylation in 11,908 tumor tissues and 1582 paired normal tissues across 34 cancer types in The Cancer Genome Atlas *** specific antibodies against PGK1 S203 and PDHK1 T338 phosphorylation,we performed immunohistochemistry with tissue microarray assay in additional 818 cancer cases with 619 paired normal tissues from five cancer ***:The PGK1 mRNA level was significantly elevated with hypomethylation in promotor regions and associated with advanced TNM stage in 15 and four cancer types,*** breast carcinoma,elevated PGK1 mRNA level and promoter hypomethylation were associated with poor *** correlated PGK1 S203 and PDHK1 T338 phosphorylation levels were significantly associated with short overall survival(OS)in cancers of the breast,liver,lung,stomach,and esophagus and with advanced TNM stage in breast and esophageal ***1 pS203 and PDHK1 pT338 were also independent predictors of short OS in liver,lung,and stomach ***:The elevated expression,promoter hypomethylation,and phosphorylation of PGK1 and PDHK1 were related with disease progression and short OS in diverse types of ***1 and PDHK1 phosphorylation may be potential prognostic biomarkers.

关键词： PGK1 Cancer metabolism Epigenetics Phosphorylation Methylation The Cancer Genome Atlas Pan-cancer analysis Prognosis Overall survival

A non-metabolic function of hexokinase 2 in small cell lung cancer:promotes cancer cell stemness by increasing USP11-mediated CD133 stability

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Cancer Communications 2022年第10期42卷 1008-1027页

作者： juhong wang Fei Shao Yannan Yang Wei wang Xueying Yang Renda Li Hong Cheng Sijin Sun Xiaoli Feng Yibo Gao Jie He Zhimin Lu Department of Thoracic Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Laboratory of Translational Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Department of Pathology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021P.R.China Central Laboratory National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital&Shenzhen HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeShenzhenGuangdong 518116P.R.China Zhejiang Provincial Key Laboratory of Pancreatic Disease The First Affiliated Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310029P.R.China Cancer Center Zhejiang UniversityHangzhouZhejiang 310029P.R.China

Background:Maintenance of cancer stem-like cell(CSC)stemness supported by aberrantly regulated cancer cell metabolism is critical for CSC self-renewal and tumor *** a key glycolytic enzyme,hexokinase 2(HK2)plays an instrumental role in aerobic glycolysis and tumor ***,whether HK2 directly contribute to CSC stemness maintenance in small cell lung cancer(SCLC)is largely *** this study,we aimed to investgate whether HK2 independent of its glycolytic activity is directly involved in stemness maintenance of CSC in ***:Immunoblotting analyses were conducted to determine the expression of HK2 in SCLC CSCs and their differentiated ***-like properties and tumorigenesis of SCLC cells with or without HK2 depletion or overexpression were examined by sphere formation assay and xenograft mouse *** and mass spectrometry analyses were performed to identify the binding proteins of *** expression levels of CD133-associated and CSC-relevant proteins were evaluated by immunoblotting,immunoprecipitation,immunofluorescence,and immunohistochemistry *** expression levels of Nanog,POU5F1,Lin28,HK2,Prominin-1 were analyzed through quantitative reverse transcription *** of CD133 was examined by in vitro or in vivo ubiquitination ***133+cells were sorted by flow cytometry using an anti-CD133 ***:We demonstrated that HK2 expression was much higher in CSCs of SCLC than in their differentiated ***2 depletion inhibited CSC stemness and promoted CSC ***,nonmitochondrial HK2 directly interacted with CD133 and enhanced CD133 expression without affecting CD133 mRNA *** interaction of HK2 and CD133 promoted the binding of the deubiquitinase ubiquitin-specific protease 11(USP11)to CD133,thereby inhibiting CD133 polyubiquitylation and ***2-mediated upregulation of CD133 expression enhanced the expression of cell rene

关键词： HK2 metabolic enzyme non-metabolic function cancer stem-like cell CD133 USP11 ubiquitylation SCLC

中俄东线天然气管道智能化关键技术创新与思考

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油气储运 2020年第7期39卷 730-739页

作者：王振声陈朋超王巨洪中国石油管道公司河北省廊坊市065000

中俄东线天然气管道是中国第三代长距离、大输量天然气管道标志性工程,是全球单体规模最大的输气管道,在中国乃至世界管道建设史上创下了多项新纪录。以该管道为试点,打造了中国首个智能管道样板工程。系统阐释了智能管道与智慧管网的... 详细信息

中俄东线天然气管道是中国第三代长距离、大输量天然气管道标志性工程,是全球单体规模最大的输气管道,在中国乃至世界管道建设史上创下了多项新纪录。以该管道为试点,打造了中国首个智能管道样板工程。系统阐释了智能管道与智慧管网的基本内涵与关键技术,梳理了支撑管道"全数字化移交、全智能化运营、全生命周期管理"的关键技术及阶段性成果,为持续推进中国管道智能化建设、助力打造智慧互联大管网提供了重要指引。同时,从认识与技术等层面,就管道智能化的技术本质、管道数字基建、管道瓶颈技术攻关、管网智慧大脑等问题,给出了进一步思考与建议。(图1,参23)

关键词：中俄东线天然气管道智能管道智慧管网

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绿色建筑智能化系统在节能减排中的应用研究

陶瓷 2024年第4期 213-215页

作者：王聚鸿山东峄州生态建设有限公司山东枣庄277300

本研究聚焦于分析绿色建筑智能化系统在降低能源消耗与减少排放方面的实际效能,对建筑内外环境实时高频监控与深度解析,利用先进的传感器技术,精准调控建筑系统的功能运作。在系统设计中,我们采用了基于大数据分析的智能决策模型,历史... 详细信息

本研究聚焦于分析绿色建筑智能化系统在降低能源消耗与减少排放方面的实际效能,对建筑内外环境实时高频监控与深度解析,利用先进的传感器技术,精准调控建筑系统的功能运作。在系统设计中,我们采用了基于大数据分析的智能决策模型,历史能耗数据的研究与学习,系统根据实需,能瞬时对各场景实施智能化适应。实际建筑项目中的应用验证显示,该方法成效显著,该系统在日常能耗管理方面表现卓越,在极端气候条件下,其卓越适应性得以显现,建筑行业提升层次迈向可持续发展的目标,先进技术赋予深远且实质的保障。

关键词：绿色建筑智能化系统节能减排大数据分析传感器技术

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沙埋对河西走廊4种旱生植物种子萌发和幼苗生长的影响

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中国沙漠 2015年第6期35卷 1532-1537页

作者：陈文王桔红朱慧齐威韩山师范学院地理与旅游管理学院广东潮州521041 韩山师范学院生命科学与食品科技学院广东潮州521041 兰州大学生命科学学院甘肃兰州730000

测定了驼蹄瓣(Zygophyllum fabago)、骆驼蒿(Peganum nigellastrum)、唐古特白刺(Nitraria tangutorum)和黒果枸杞(Lycium ruthenicum)等4种旱生植物种子重量、形状、萌发及活性,试验了沙埋深度(0、1、2、3、4、5cm)对种子萌发、幼苗出土和生长的影响。结果表明:4种植物的种子扩散时为中度休眠;种子活性与重量、形状之间为显著负相关关系(p<0.05);种子初次萌发率与重量之间为不显著负相关关系;大而不规则种子有较低的活性,小种子扩散时有较高萌发率。随沙埋深度的增加,4种植物种子出苗率下降,首次出苗时间推迟,茎高、绝对株高和根长呈现先上升后下降的趋势,地下和地上生物量比值呈先上升后下降或随埋深增加而下降。幼苗出土和生长的最佳沙埋深度是:驼蹄瓣1~3cm,骆驼蒿0~1cm,唐古特白刺0~2cm,黑果枸杞1~2cm。在植被恢复过程中应考虑破除种子休眠的方法以及浅层沙埋等条件,以提高出苗率、增大幼苗定植率。

关键词：旱生植物种子萌发幼苗生长沙埋

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图像辨识性特征的自动学习方法

中国科技论文 2014年第7期9卷 803-807,811页

作者：王梓桐王巨宏张松海清华大学可视媒体智能处理与内容安全工程研究中心北京100084 清华-腾讯互联网创新技术联合实验室北京100084

针对以关键字进行检索分类的图像,首先利用经验设置规则提取初始图像块;对于类中每个备选图像块,寻找所有备选图像块中与其最相似的图像块,并根据梯度方向直方图特征进行聚类,形成特征组;最后,利用图像注册的方式将特征组进行合并,形成... 详细信息

针对以关键字进行检索分类的图像,首先利用经验设置规则提取初始图像块;对于类中每个备选图像块,寻找所有备选图像块中与其最相似的图像块,并根据梯度方向直方图特征进行聚类,形成特征组;最后,利用图像注册的方式将特征组进行合并,形成商品图像完整的特征。本文以电商图像为例对算法进行了测试,实验结果表明,辨识性特征区域提取的准确率可达70%以上,且与已有方法相比提取特征区域更加完整。

关键词：图像分类图像块特征

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数字孪生体及其在智慧管网应用的可行性

油气储运 2018年第10期37卷 1081-1087页

作者：李柏松王学力王巨洪中国石油管道公司智慧管道建设项目中心

伴随着工业4.0时代的来临,数字孪生体(Digital Twin)概念蓬勃发展,在航空航天、汽车制造、军事、能源等行业中逐步得到应用,为其在管道行业的应用发展起到良好示范。介绍了数字孪生体的内涵和发展演化过程,分析了数字孪生体在产品设计... 详细信息

伴随着工业4.0时代的来临,数字孪生体(Digital Twin)概念蓬勃发展,在航空航天、汽车制造、军事、能源等行业中逐步得到应用,为其在管道行业的应用发展起到良好示范。介绍了数字孪生体的内涵和发展演化过程,分析了数字孪生体在产品设计、飞机故障预测、汽车制造、电厂发电机组智能健康管理、复杂产品装配等行业的应用案例,并从管道设计、调度优化、管道设备运行维护、管道全生命周期管理4个方面分析数字孪生体在油气管道中的应用前景。数字孪生体为真实管道系统与虚拟管道系统的信息交互及融合提供了新的技术手段,可以实现虚拟管道的仿真优化,有利于促进智慧管网建设。

关键词：油气管道数字孪生体智能化数据融合