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Ipsilateral breast tumor recurrence in early stage breast cancer patients treated with breast conserving surgery and adjuvant radiation therapy: Concordance of biomarkers and tumor location from primary tumor to in-breast tumor recurrence

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World Journal of Clinical Oncology 2020年第1期11卷 20-30页

作者： juhi m purswani Fauzia Shaikh S Peter Wu Jennifer Chun Kim Freya Schnabel Nelly Huppert Carmen A Perez Naamit K Gerber Department of Radiation Oncology New York University School of MedicineNew YorkNY 10016United States Department of Surgery New York University School of MedicineNew YorkNY 10016United States

BACKGROUND Patients with an in-breast tumor recurrence(IBTR)after breast-conserving therapy have a high risk of distant metastasis and disease-related *** clinical parameters that increase risk for recurrence after IBTR remains a *** To describe primary and recurrent tumor characteristics in patients who experience an IBTR and understand the relationship between these characteristics and disease *** Patients with stage 0-II breast cancer treated with lumpectomy and adjuvant radiation were identified from institutional databases of patients treated from 2003-2017 at our *** survival(OS),disease-free survival,and local recurrence-free survival(LRFS)were estimated using the Kaplan meier *** identified patients who experienced an isolated *** of hormone receptor status and location of tumor from primary to recurrence was *** effect of clinical and treatment parameters on disease outcomes was also *** We identified 2164 patients who met the eligibility *** median follow-up for all patients was 3.73[interquartile range(IQR)2.27-6.07]***-year OS was 97.7%(95%CI:96.8%-98.6%)with 28 deaths;5-year LRFS was 98.0%(97.2-98.8)with 31 *** identified 37 patients with isolated IBTR,19(51.4%)as ductal carcinoma in situ and 18(48.6%)as invasive disease,of whom 83.3%had an in situ *** time from initial diagnosis to IBTR was 1.97(IQR:1.03-3.5)*** information was available for 30 of 37 *** whole-breast dose was 40.5 Gy and 23 patients received a boost to the tumor ***-five of thirty-two(78.1%)patients had concordant hormone receptor status,HER-2 receptor status,and estrogen receptor(ER)(P=0.006)and progesterone receptor(PR)(P=0.001)status from primary to IBTR were significantly *** were no observed changes in HER-2 status from primary to *** concordance between quadrant of primary to IBTR was 10/19[(62.2%

关键词： Ipsilateral breast tumor recurrence Breast conservation Adjuvant radiation

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Vaccines and Antibodies for Therapeutic Use in Cancers

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Journal of Cancer Therapy 2016年第6期7卷 370-377页

作者： G. P. Talwar Jagdish C. Gupta m. Diwan J. Frick S. K. Sharma S. N. Wadhwa R. m. Gupta S. K. Gupta Shilpi purswani Hemant K. Vyas Talwar Research Foundation New Delhi India Urologische Zentrum Salzburg Salzburg Austria Post Graduate Institute of medical Education and Research (PGImER) Chandigarh India Sir Ganga Ram Hospital New Delhi India National Institute of Immunology New Delhi India

This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. moAb730 and moAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as mOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “magic Bullet”. All mOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved mycobacterium indicus pranii (miP) as adjuvant. miP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, miP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O myelomas in mice.

关键词： Human Chorionic Gonadotropin (hCG) LHRH Prostate Cancer Breast Cancer Antibody-Curcumin magic Bullets

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Knowledge and awareness of infection control practices among nursing professionals:A cross-sectional survey from South Asia and the middle East

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World Journal of Critical Care medicine 2023年第3期12卷 176-187页

作者： Kanwalpreet Sodhi Gunjan Chanchalani muktanjali Arya Gentle S Shrestha juhi N Chandwani manender Kumar monika G Kansal mohammad Ashrafuzzaman Anushka D mudalige Ashraf Al Tayar Bassam mansour Hasan m Saeed madiha Hashmi mitul Das Nehad N Al Shirawi Ranjan mathias Wagih O Ahmed Amandeep Sharma Diptimala Agarwal Prashant Nasa Department of Critical Care Deep HospitalLudhiana 141001PunjabIndia Critical Care medicine Somaiya Hospital and Research CentreMumbai 400001MaharashtraIndia Department of microbiology and Infection Control Deep HospitalLudhiana 141001India Department of Critical Care medicine Tribhuvan University Teaching HospitalKathmandu 44600Nepal Anaesthesia and Intensive Care Unit Royal HospitalMuscat 112Oman Department of Cardiac Anaesthesia Fortis HospitalLudhiana 141002PunjabIndia Intensive Care medicine Ng Teng Fong General HospitalSingapore 609606Singapore Intensive Care Unit Bangabandhu Sheikh Mujib Medical UniversityDhaka 1000Bangladesh Intensive Care Unit Colombo North Teaching HospitalRagama 11010Sri Lanka Intensive Care Unit and Respiratory Therapy Department Security Forces HospitalDamman 34223Saudi Arabia Pulmonary and Critical Care Division Zahraa Hospital-University Medical CenterBeirut 1007Lebanon Pulmonary Division Faculty of Medical SciencesLebanese UniversityBeirut 1007Lebanon Department of Critical Care Salmaniyah Medical ComplexManama 323Bahrain Department of Critical Care medicine Ziauddin UniversityKarachi 75530Pakistan Anaesthesia and Critical Care Swasti HospitalRangia 781354India Department of Critical Care medicine Al Fujairah HospitalFujairah 0000United Arab Emirates Department of Anesthesia and Intensive Care Hamad Medical CorporationDoha 974Qatar Intensive Care Unit Sulaiman Al Habib Medical GroupBuraidah 52211Saudi Arabia Department of Nursing Deep HospitalLudhiana 141001India Anesthesia and Intensive Care Shantived Institute of Medical SciencesAgra 282007India Department of Critical Care medicine NMC Specialty HospitalDubai 7832United Arab Emirates Internal medicine College of Medicine and Health SciencesAl Ain 15551Abu DhabiUnited Arab Emirates

BACKGROUND The proficiency of nursing professionals in the infection prevention and control(IPC)practices is a core component of the strategy to mitigate the challenge of healthcare associated *** To test knowledge of nurses working in intensive care units(ICU)in South Asia and middle East countries on IPC *** An online self-assessment questionnaire based on various aspects of IPC practices was conducted among nurses over three *** A total of 1333 nurses from 13 countries completed the *** average score was 72.8%and 36%of nurses were proficient(mean score>80%).43%and 68.3%of respondents were from government and teaching hospitals,respectively.79.2%of respondents worked inme,type of hospitals,accreditation and teaching status of hospitals and type of *** in high-and upper-middleincome countries(β=4.89,95%CI:3.55 to 6.22)was positively associated,and the teaching status of the hospital(β=-4.58,95%CI:-6.81 to-2.36)was negatively associated with the knowledge score among *** There is considerable variation in knowledge among nurses working in *** like income status of countries,public vs private and teaching status of hospitals and experience are independently associated with nurses’knowledge of IPC practices.

关键词： Knowledge Attitude Policy compliance Infection control Infection control practices Nurses

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