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建筑实践 2015年第1期 12-19页

作者：李莹 Pawel Paniczko Photoroom juha salminen Wojciech Krynskii

1970年12月7日.华沙一个很寻常的冬日,阴湿寒冷.万木萧疏.德国前总理勃兰特在华沙犹太隔离区起义纪念碑(The Memorial to the Warsaw Ghetto Uprising)前献花后.突然下跪为在纳粹德国侵略期间被杀害的死难者默哀.“华沙之跪“的瞬间被... 详细信息

1970年12月7日.华沙一个很寻常的冬日,阴湿寒冷.万木萧疏.德国前总理勃兰特在华沙犹太隔离区起义纪念碑(The Memorial to the Warsaw Ghetto Uprising)前献花后.突然下跪为在纳粹德国侵略期间被杀害的死难者默哀.“华沙之跪“的瞬间被永远定格于历史的影像中。44年后.就在起义纪念碑后方.崭新的波兰犹太人历史博物馆揭下神秘的面纱.向世人缓缓讲述漫漫历史长河中犹太人的前世今生。其实.波兰犹太人历史博物馆项目早在上个世纪90年代中期便开始筹备.经过多年的论证与商

关键词：建筑师纪念碑主入口博物馆建筑体量犹太人玻璃幕墙勃兰特希伯来文立面设计拉丁文玻璃相

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A GIS-Based Methodology to Estimate the Regional Balance of Potential and Demand of Forest Chips

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Journal of Geographic Information System 2016年第5期8卷 633-662页

作者： Mikko Nivala Perttu Anttila juha Laitila Olli salminen Martti Flyktman University of Eastern Finland Joensuu Finland Natural Resources Institute of Finland Joensuu Finland VTT Technical Research Centre of Finland Ltd Jyv?skyl? Finland

Finland’s national aim for annual consumption of forest chips is 25 terawatt hours (TWh) (equivalent to 13.5 million solid cubic metres) in combined heat and power (CHP) production and heat production in 2020. On average, the techno-economic potential of forest chips enables reaching the target at the national level. However, there is a geographical mismatch between the supply and demand regions. In this study, the regional balance of potential and demand from 2012 until 2020 was assessed using GIS-based methods. Economical, technical and ecological constraints were taken into account when different scenarios for municipality-level potentials were calculated. The forest chips’ consumption scenarios for plant-level were determined statistically (2012) or predicted (2020) by assuming that the total consumption of forest chips will reach the 13.5 Mm3. With help of procurement model, the use of different forest energy fuel types (stumps, logging residues and small-sized thinning wood) was spread to the procurement ring with the help of GIS coding. The forest chips’ regional balance map was made by subtracting the use of heat and combined heat and power plants’ (CHP) forest chips’ consumption from the municipality level potential data. The GIS-based method for balance calculation requires a significant amount of computer power but works well for local, municipality, regional and national-level balance calculations. The study showed that there are enough forest chips to supply the current and future demand when all forest energy assortments are used efficiently and in a sustainable manner. However, the results indicate that already at the present rate of forest chip consumption, in some areas there will not be any extra potential left. When consumption increases, the zero-potential area, in particular on the coast, expands. The highest free potential can be found in eastern and northern areas of Finland while the western and southern areas lack free potential.

关键词： GIS-Based Methodology Forest Chips Potential Balance Bioenergy

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AMP-activated protein kinase inhibits NF-κB signalingand inflammation:impact on healthspan and lifespan

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世界最新医学信息文摘 2015年第5期 6-6页

作者： Antero salminen juha M.T.Hyttinen Kai Kaarniranta

Adenosinemonophosphate-activated protein kinase( AMPK) is a crucial regulator of energymetabolic homeostasis and thus a major survival factor in a variety of metabolic stresses and also in the aging process. Metabolic syndrome is associated with a low-grade, chronic inflammation, primarily in adipose tissue. A low-level of inflammation is also present in the aging process. There are emerging results indicating that AMPK signaling can inhibit the inflammatory responses induced by the nuclear factor-κB(NF-κB) system. The NF-κB subunits are not direct phosphorylation targets of AMPK, but the inhibition of NF-κB signaling is mediated by several downstream targets of AMPK, e.g., SIRT1, PGC-1α, p53, and Forkhead box O(Fox O)factors. AMPK signaling seems to enhance energy metabolism while it can repress inflammatory responses linked to chronic stress, e.g., in nutritional overload and during the aging process. AMPK can inhibit endoplasmic reticulum and oxidative stresses which are involved in metabolic disorders and the aging process. Interestingly, many target proteins of AMPK are so-called longevity factors, e.g., SIRT1, p53, and Fox Os, which not only can increase the stress resistance and extend the lifespan of many organisms but also inhibit the inflammatory responses. The activation capacity of AMPK declines in metabolic stress and with aging which could augment the metabolic diseases and accelerate the aging process. We will review the AMPK pathways involved in the inhibition of NF-κB signaling and suppression of inflammation. We also emphasize that the capacity of AMPK to repress inflammatory responses can have a significant impact on both healthspan and lifespan.

关键词： Diabetes Inflammation Metabolic syndrome NF-κB SIRT1

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