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Safety and efficacy of the SeparGateTM balloon-guiding catheter in neurointerventional surgery:A prospective,multicenter,single-arm clinical trial

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Journal of Interventional Medicine 2022年第3期5卷 143-147页

作者： Huan Liu Rufeng Jia Yanyan He Tengfei Zhou Liangfu Zhu Yonghong Ding juha antero hernesniemi Tianxiao Li Yingkun He Department of Cerebrovascular Disease Zhengzhou University People's HospitalHenan University People's HospitalHenan Provincial People's HospitalHenan Provincial Neurointerventional Engineering Research CenterHenan International Joint Laboratory of Cerebrovascular Disease and Henan Engineering Research Center of CerebrovascularInterventionZhengzhou450003China Department of Radiology Mayo CliniRochesterMNUS “juha hernesniemi”International Center for Neurosurgery Henan Provincial People s HospitalZhengzhouChina

Objective:To evaluate the safety and efficacy of the SeparGateballoon-guiding catheter(BGC)for blocking flow and delivering devices in neurointerventional ***:This prospective multicenter single-arm trial enrolled patients who received BGC adjuvant therapy to provide temporary blood flow arrest of the supra-aortic arch arteries and their branch vessels in interventional *** primary endpoint was immediate procedural success rate in flow arrest,device delivery,and *** efficacy endpoints were intraoperative product performance,including rigidity,smoothness,fracture resistance of the catheter wall,catheter push performance,compatibility and radiopaque display,integrity,adhesion thrombus after withdrawal and balloon *** safety endpoints were adverse and serious adverse events associated with the test device and serious adverse events resulting in death or serious health ***:A total of 129 patients were included;of them,128 were analyzed in the full analysis set(FAS)and per protocol set(PPS).Immediate procedural success was achieved in 97.7%of patients with FAS and *** lower bound of the 95%confidence interval was 94.6%,higher than the preset efficacy margin of 94%.Device-related adverse events occurred in 2(1.6%)*** was mild adverse event of vasospasm,which resolved *** other was serious adverse event of dissection aggravation,which was treated with stenting *** device defects were ***:In neurointerventional surgery,the SeparGateBGC can be used to temporarily block the flow of the supra-aortic arch arteries and their branch vessels and guide the interventional device to the target vascular position.

关键词： SeparGateTM balloon guiding catheter Safety and efficacy Neurointerventional surgery

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哺乳动物雷帕霉素靶蛋白在脑动静脉畸形中的表达及其对病灶血管内皮组织增殖与凋亡的影响

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中国脑血管病杂志 2022年第10期19卷 685-690,711页

作者：白卫星郭德华何艳艳康晓雨刘耀许斌 juha antero hernesniemi 贺迎坤李天晓河南省人民医院脑血管病科郑州450003

目的观察哺乳动物雷帕霉素靶蛋白(mTOR)在脑动静脉畸形(bAVM)中的表达情况及其对bAVM病灶血管内皮组织增殖与凋亡的影响,并尝试探索与bAVM中mTOR表达量相关的基线因素。方法收集河南省人民医院神经外科2019年6月至2020年12月行单纯外科... 详细信息

目的观察哺乳动物雷帕霉素靶蛋白(mTOR)在脑动静脉畸形(bAVM)中的表达情况及其对bAVM病灶血管内皮组织增殖与凋亡的影响,并尝试探索与bAVM中mTOR表达量相关的基线因素。方法收集河南省人民医院神经外科2019年6月至2020年12月行单纯外科切除的16例bAVM患者的基线资料[性别、年龄、畸形病灶出血史及Spezler-Martin(S-M)分级等]及bAVM病理标本,同时于病理科获取4例颅外伤患者的正常颞浅动脉标本。应用苏木素-伊红(HE)及Masson染色观察bAVM组织病理特征,免疫组织化学检测mTOR及血管内皮生长因子A(VEGFA)、Ki-67、含半胱氨酸的天冬氨酸蛋白水解酶3(Caspase-3)表达水平并以累积吸光度(IOD)值表示。比较bAVM血管内皮组织与正常颞浅动脉内皮组织mTOR及VEGFA、Ki-67、Caspase-3的表达水平。采用线性相关分析方法分析mTOR与VEGFA、Ki-67、Caspase-3的相关性及年龄对其表达水平的影响。采用单因素分析方法评估不同bAVM病灶出血史、S-M分级及性别间mTOR表达水平。结果所有bAVM标本的HE及Masson染色结果均可见典型的畸形血管组织。免疫组织化学分析结果显示,mTOR主要定位于bAVM内皮组织,bAVM中mTOR、Ki-67、VEGFA、Caspase-3表达量均较正常颞浅动脉显著增加[IOD分别为(157.5±88.2)比(36.5±4.9)、(60.9±29.2)比(20.3±4.5)、(60.4±50.7)比(22.0±6.8)、(28.6±25.2)比(5.3±1.4);P值分别为0.030、0.05)。结论mTOR主要高表达于bAVM血管内皮组织,可能与bAVM病灶内皮组织的增殖与凋亡活动密切相关;mTOR在bAVM血管内皮组织中的表达量与患者年龄有关,而与S-M分级、出血史及性别无关。

关键词：脑动静脉畸形雷帕霉素靶蛋白血管内皮组织

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64例松果体区肿瘤神经内镜治疗效果观察

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中华实用诊断与治疗杂志 2023年第9期37卷 926-929页

作者：李明李召兵张衍 juha antero hernesniemi 陈中灿胡森段林河南省人民医院郑州大学人民医院神经外科河南郑州450003 河南省人民医院郑州大学人民医院病案管理科河南郑州450003 河南省人民医院郑州大学人民医院Juha Hernesniemi国际神经外科中心河南郑州450003

目的观察松果体区肿瘤患者行神经内镜手术治疗的效果,探讨其安全性。方法回顾性分析2009年4月—2020年10月河南省人民医院接受神经内镜手术治疗的64例松果体区肿瘤患者临床资料。结果64例中经幕下小脑上入路(Krause入路)21例,经枕下幕... 详细信息

目的观察松果体区肿瘤患者行神经内镜手术治疗的效果,探讨其安全性。方法回顾性分析2009年4月—2020年10月河南省人民医院接受神经内镜手术治疗的64例松果体区肿瘤患者临床资料。结果64例中经幕下小脑上入路(Krause入路)21例,经枕下幕上入路(Poppen入路)36例,经额皮质入路6例,经三角区侧脑室入路1例,手术均顺利完成,手术时间(6.15±2.26)h,术中出血量(373.44±63.82)mL,住院时间(24.08±11.25)d。术后1~2 d行头颅MRI/CT检查,病灶全部切除55例(86%),次全切除9例(14%)。术后均未发生脑室积血、脑积水、硬脑膜外血肿、视野缺损、颅内感染等并发症,出现视物模糊或同向偏盲7例、耳部麻木2例,给予康复理疗未完全康复;3例出现无感染的脑脊液漏,经保守治疗康复。术后组织病理检查结果证实恶性肿瘤17例,其中生殖细胞瘤11例,松果体母细胞瘤2例,低级别胶质瘤3例,肺癌脑转移1例;良性肿瘤47例,其中脑膜瘤20例,蛛网膜囊肿12例,松果体实质瘤5例,胆脂瘤5例,淋巴瘤3例,血管畸形2例。恶性肿瘤17例中4例术后行伽玛刀治疗,7例行放疗,4例行化疗,2例行放疗+化疗。术后随访至2021年2月,14例失访,37例无症状生存,13例术前症状得到改善。结论松果体区肿瘤组织病理类型复杂,神经内镜手术治疗效果满意、安全性好,恶性松果体区肿瘤患者术后联合放化疗可改善预后。

关键词：松果体区肿瘤神经内镜手术

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Automated registration of wide-baseline point clouds in forests using discrete overlap search

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Forest Ecosystems 2022年第6期9卷 852-877页

作者： Onni Pohjavirta Xinlian Liang Yunsheng Wang antero Kukko Jiri Pyorala Eric Hyyppa Xiaowei Yu Harri Kaartinen juha Hyyppa Department of Remote Sensing and Photogrammetry Finnish Geospatial Research InstituteVuorimiehentie 5Espoo02150Finland The State Key Laboratory of Information Engineering in Surveying Mapping and Remote SensingWuhan UniversityWuhan430070China Department of Forest Sciences University of HelsinkiHelsinkiFI-00014Finland Department of Geography and Geology University of TurkuTurkuFI-20500Finland

Forest is one of the most challenging environments to be recorded in a three-dimensional(3D)digitized geometrical representation,because of the size and the complexity of the environment and the data-acquisition constraints brought by on-site *** studies have indicated that the data-acquisition pattern can have more influence on the registration results than other *** practice,the ideal short-baseline observations,i.e.,the dense collection mode,is rarely feasible,considering the low accessibility in forest environments and the commonly limited labor and time *** wide-baseline observations that cover a forest site using a few folds less observations than short-baseline observations,are therefore more preferable and commonly ***,the wide-baseline approach is more challenging for data registration since it typically lacks the required sufficient overlaps between *** now,a robust automated registration solution that is independent of special hardware requirements has still been *** is,the registration accuracy is still far from the required level,and the information extractable from the merged point cloud using automated registration could not match that from the merged point cloud using manual *** paper proposes a discrete overlap search(DOS)method to find correspondences in the point clouds to solve the low-overlap problem in the wide-baseline point *** proposed automatic method uses potential correspondences from both original data and selected feature points to reconstruct rough observation geometries without external knowledge and to retrieve precise registration parameters at *** extensive experiment was carried out with 24 forest datasets of different conditions categorized in three difficulty *** performance of the proposed method was evaluated using various accuracy criteria,as well as based on data acquired from different hardware,platforms,viewing persp

关键词： Close-range sensing Forest Registration Point cloud Wide-baseline Terrestrial laser scanning Unmanned aerial vehicle Drone In situ Discrete overlap search

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Seamless integration of above-and undercanopy unmanned aerial vehicle laser scanning for forest investigation

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Forest Ecosystems 2021年第1期8卷 124-138页

作者： Yunsheng Wang antero Kukko Eric Hyyppä Teemu Hakala Jiri Pyörälä Matti Lehtomäki Aimad El Issaoui Xiaowei Yu Harri Kaartinen Xinlian Liang juha Hyyppä Department of Remote Sensing and Photogrammetry Finnish Geospatial Research Institute FGIThe National Land Survey of Finland02431 MasalaFinland Department of Forest Sciences University of HelsinkiFI-00014 HelsinkiFinland Department of Geography and Geology University of TurkuFI-20500 TurkuFinland

Background:Current automated forest investigation is facing a dilemma over how to achieve high tree-and plotlevel completeness while maintaining a high cost and labor *** study tackles the challenge by exploring a new concept that enables an efficient fusion of aerial and terrestrial perspectives for digitizing and characterizing individual trees in forests through an Unmanned Aerial Vehicle(UAV)that flies above and under canopies in a single *** advantage of such concept is that the aerial perspective from the above-canopy UAV and the terrestrial perspective from the under-canopy UAV can be seamlessly integrated in one flight,thus grants the access to simultaneous high completeness,high efficiency,and low ***:In the experiment,an approximately 0.5 ha forest was covered in ca.10 min from takeoff to *** GNSS-IMU based positioning supports a geometric accuracy of the produced point cloud that is equivalent to that of the mobile mapping systems,which leads to a 2–4 cm RMSE of the diameter at the breast height estimates,and a 4–7 cm RMSE of the stem curve ***:Results of the experiment suggested that the integrated flight is capable of combining the high completeness of upper canopies from the above-canopy perspective and the high completeness of stems from the terrestrial ***,it is a solution to combine the advantages of the terrestrial static,the mobile,and the above-canopy UAV observations,which is a promising step forward to achieve a fully autonomous in situ forest *** studies should be aimed to further improve the platform positioning,and to automatize the UAV operation.

关键词： Forest In situ Inventory Above canopy Under canopy Unmanned aerial vehicle Laser scanning Point cloud Close range remote sensing

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Estimation of drag forces caused by natural woody vegetation of different scales

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Journal of Hydrodynamics 2014年第4期26卷 608-623页

作者： JALONEN Johanna JRVEL juha Department of Civil and Environmental Engineering Aalto University

To reliably estimate water levels and velocities in vegetated rivers and floodplains, flow resistance models based on physical plant properties are advantageous. The purpose of this study is （1） to assess the suitable parameterization of woody riparian vegetation in estimating the drag forces, （2） to address the effect of plant scale on the drag estimates and reconfiguration, and （3） to evaluate the applicability of three recently developed flow resistance models. Experiments on four tree species in a towing tank together with detailed characterization of tree properties were carried out to establish a novel dataset. Despite the variability in the tree height （0.9 m-3.4 m）, the stem, leaf and total areas proved to be suitable characteristic dimensions for estimating the flow resistance at different scales. Evaluations with independent data revealed that the tested models produced reasonable results. The performance of the models was controlled by the parameter values used rather than the model structure or the plant scale.

关键词： drag force flow resistance woody vegetation modelling

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The comparison of design airflow rates with dynamic and steady-state displacement models in varied dynamic conditions

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Building Simulation 2021年第4期14卷 1201-1219页

作者： Natalia Lastovets Risto Kosonen juha Jokisalo Department of Mechanical Engineering Aalto UniversityEspooFinland College of Urban Construction Nanjing Tech UniversityNanjingChina

A temperature-based method is usually applied in displacement ventilation (DV) design when overheating is the primary indoor climate concern. Different steady-state models have been developed and implemented to calculate airflow rate in rooms with DV. However, in practical applications, the performance of DV depends on potentially dynamic parameters, such as strength, type and location of heat gains and changing heat gain schedule. In addition, thermal mass affects dynamically changing room air temperature. The selected steady-state and dynamic models were validated with the experimental results of a lecture room and an orchestra rehearsal room. Among the presented models, dynamic DV model demonstrated a capability to take into account the combination of dynamic parameters in typical applications of DV. The design airflow rate is calculated for the case studies of dynamic DV design in the modelled lecture room in both dynamic and steady-state conditions. In dynamic conditions of heavy construction in 2–4 hours occupancy periods, the actual airflow rate required could be 50% lower than the airflow rate calculated with the steady-state models. The difference between steady-state and dynamic multi-nodal model is most significant with heavyweight construction and short occupancy period (17%–28%). In cases with light construction, the dynamic DV model provides roughly the same airflow rates for four-hour occupancy period than the Mund’s model calculates. The dynamic model can significantly decrease the design airflow rate of DV, which can result in a reduction of investment costs and electrical consumption of fans.

关键词： displacement ventilation design airflow rate temperature gradient dynamic model simplified building energy models

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Geometrically modeling 2D scattered points: a review of the potential for methodologically improving mobile laser scanning in data processing

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International Journal of Digital Earth 2014年第6期7卷 432-449页

作者： Yi Lin juha Hyyppa Department of Remote Sensing and Photogrammetry Finnish Geodetic Institute MasalaFinland

As a state-of-the-art mapping technology,mobile laser scanning(MLS)is increasingly applied to fields such as digital presentations of city ***,its application has recently met a bottleneck in data *** has been found that conventional methods for geometrically modeling 3D scattered points are inadequate when dealing with large volumes of MLS *** fact,this is a challenge that has already been noted in the MLS-relevant fields,*** sensing,robot perception,and pattern recognition.A variety of algorithms under the schematic frame of analysis,modeling and synthesis(AMS)have been developed in these *** AMS paradigm is to first extract the implicit geometric primitives within each scan profile by geometrically modeling its 2D scattered points(GM2P).The resultant 2D geometric primitives are then integrated to restore the real 3D geometrical *** this process,GM2P is a kernel procedure whereby a review of the GM2P algorithms is assumed to be of significance for developing new efficient algorithms for geometrically modeling 3D scattered *** idea is supported by MLS sampling often being executed via parallel scan ***,the results of the literature review indicate an avenue for methodologically improving MLS in data processing.

关键词： MLS geometrically modeling scattered points GM2P AMS scan profile

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Variation in the timing of river entry of Atlantic salmon (Salmo salar L.) in the Baltic

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Current Zoology 2009年第5期55卷 342-349页

作者： Anna KUPARINEN juha MERIL Department of Biological and Environmental Sciences

The timing of river entry in the Atlantic salmon is known to depend on genetic, demographic and environmental factors, but little is known about the relative magnitude of among population and among year variation and covariation in this respect in natural state Atlantic salmon rives. To investigate this, variability in the timing of river entry in three historical Finnish Atlantic salmon populations were analyzed using salmon trap data collected during 1870- 1902. The analyses reveled that 1 ） the timing of river entry differed substantially and consistently among the rivers, and that 2） variation among the rivers was much larger than variation among years. Annual variations were not explained by regional environmental conditions, whereas in one river the timing of the local flood peak was a significant predictor of the timing of river entry. Differences in the timing of salmon entry to geographically closely situated rivers suggests that a regionally fixed opening date for coastal fisheries might not be the best management strategy as it may lead to uneven exploitation of salmon populations from different rivers [ Current Zoology 55 （5）： 342 - 349, 2009] .

关键词： Atlantic salmon Coastal fisheries Fisheries management Freshwater entry Migration River entry

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Fluid dynamic modeling of a free piston engine with labyrinth seals

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Journal of Thermal Science 2010年第2期19卷 141-147页

作者： Jaakko Larjola juha Honkatukia Petri Sallinen Jari Backman Lappeenranta University of Technology P.O.Box 2053851 Lappeenranta

Preliminary design and simulation of a free piston engine suitable for small-scale energy production in distributed energy systems is presented in this *** properties,particularly the properties of gas seals of the engine are simulated using a simulation program developed for this case,and the results are utilized in preliminary main design parameter *** engine simulation program was developed by combining and modifying the source codes of the simulation and calculation programs obtained from Helsinki University of Technology,Tampere University of Technology,and Lappeenranta University of *** of the contact-free labyrinth seal used in the piston,the efficiency of the motor is lower than the efficiency of a conventional motor with oil lubricated piston *** the other hand,the lack of bearing losses,and the lack of losses associated with a crankshaft system and a gearbox,as well as the lack of lubrication oil expenses,compensates this *** a net result,this new motor would perform slightly better than the conventional *** completely oil-free,it is very environmentally friendly,and its exhaust gases are completely free of oil residuals which are causing problems in normal gas motors.

关键词： free piston engine distributed energy systems simulation labyrinth seal

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