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selexipag as Add-on Therapy for Patients with Pulmonary Arterial Hypertension Associated with Congenital Heart Disease:A Single-Center Retrospective Study

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Congenital Heart Disease 2021年第3期16卷 233-244页

作者： se Yong Jung Doyoung Jung Ah Young kim Jae Hee seol Jung Min Park Jo won Jung Jae Young Choi Division of Pediatric Cardiology Congenital Heart Disease CenterSeverance Cardiovascular HospitalDepartment of PediatricsYonsei University College of MedicineSeoulKorea

Purpose:This study examined the efficacy and safety of selexipag in treating pulmonary arterial hypertension(PAH)associated with congenital heart disease(CHD).Materials and Methods:We conducted a retrospective study of patients with CHD-associated PAH,treated with selexipag since December *** adult patients(mean age,45.4 years;women,77%)were treated with selexipag as add-on *** characteristics,World Health Organization functional class,6-minute walking distance(6MWD)test results,N-terminal pro-B-type natriuretic peptide levels,echocardiographic data,and incidence of side effects were ***:The majority of patients(12/13,92.3%)experienced more than one treatment-associated complication;one patient dropped out of the study due to intolerable *** results of 6MWD test(from 299.2±56.2 m to 363.8±86.5 m,p=0.039)and tricuspid regurgitation(TR)pressure gradient(from 84.7±20.5 mmHg to 61.6±24.0 mmHg,p=0.018)improved and remained improved after selexipag treatment in 12 *** on the results of a non-invasive risk assessment,8(66.7%)patients showed improvement,3(25.0%)showed no interval change,and the status of one patient(8.3%)***,compared to patients treated with a low dosage,patients treated with a medium-to-high dosage showed a greater increase in 6MWD results(88.3±26.4 m vs.55.3±27.6 m,p=0.043)and a greater reduction in the TR pressure gradient(-33.7±10.9 mmHg vs.-12.5±12.0 mmHg,p=0.015).Conclusion:selexipag is an efficient pulmonary vasodilator as add-on therapy in treating CHD-associated PAH.

关键词： selexipag congenital heart disease pulmonary arterial hypertension

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Effects of chitosan inhibitor on the electrochemical corrosion behavior of 2205 duplex stainless steel

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International Journal of Minerals,Metallurgy and Materials 2017年第11期24卷 1260-1266页

作者： se-fei Yang ying Wen Pan yi Kui Xiao Chao-fang Dong Department of Stomatology General Hospital of the People’s Liberation Army Beijing 100853 China Institute for Advanced Materials and Technology University of Science and Technology Beijing Beijing 100083 China Journals Publishing Center University of Science and Technology Beijing Beijing 100083 China

The effects of chitosan inhibitor on the corrosion behavior of 2205 duplex stainless steel were studied by electrochemical measurements, immersion tests, and stereology microscopy. The influences of immersion time, temperature, and chitosan concentration on the corrosion inhibition performance of chitosan were investigated. The optimum parameters of water-soluble chitosan on the corrosion inhibition performance of 2205 duplex stainless steel were also determined. The water-soluble chitosan showed excellent corrosion inhibition performance on the 2205 duplex stainless steel. Polarization curves demonstrated that chitosan acted as a mixed-type inhibitor. When the stainless steel specimen was immersed in the 0.2 g/L chitosan solution for 4 h, a dense and uniform adsorption film covered the sample surface and the inhibition efficiency(IE) reached its maximum value. Moreover, temperature was found to strongly influence the corrosion inhibition of chitosan; the inhibition efficiency gradually decreased with increasing temperature. The 2205 duplex stainless steel specimen immersed in 0.4 g/L water-soluble chitosan at 30°C displayed the best corrosion inhibition among the investigated specimens. Moreover, chitosan decreased the corrosion rate of the 2205 duplex stainless steel in an FeCl_3 solution.

关键词： inhibitor chitosan stainless steel corrosion behavior electrochemistry

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Conditional survival in patients with gallbladder cancer

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Chinese Journal of Cancer 2017年第12期36卷 744-756页

作者： yi-Jun kim Kyubo kim Department of Radiation Oncology Ewha Womans University College of Medicine1071 Anyangcheon.roYangcheon.guSeoul 07985Republic of Korea

Background: Conditional survival(CS) has been established as a clinically relevant prognostic factor for cancer survivors, and the CS in gallbladder(GB) cancer has not yet been fully evaluated. In this study, we evaluated the cancerspecific CS rate and cancer-specific survival(CSS) rate in patients with GB cancer at multiple time points and investigated prognostic factors which affect cancer-specific CS rate to provide more accurate survival ***: Between 2004 and 2013, a total of 9760 patients with GB cancer were identified from the Surveillance,Epidemiology, and End Results(seER) data. The 3-year cancer-specific CS rate was calculated using the covariateadjusted survival function in the Cox model for each year since diagnosis, and the results were analyzed together with the adjusted CSS rates at the same time points. Cox proportional hazards regression was performed to ascertain the individual contribution of factors associated with CSS rate at diagnosis and cancer-specific CS rates at 1,3, and 5 years after ***: The adjusted 5-year CSS rate was 26.1 %. The adjusted 3-year cancer-specific CS rates at 1,2,3,4, and 5 years after diagnosis were 55.5,72.2,81.5,86.8, and 90.5%, respectively. At the time of diagnosis, age, race, histology, grade,T, N, and M categories, surgery, radiotherapy, insurance status, and marriage status were significant prognostic factors of CSS. Five years after diagnosis, however,T and M categories were significant prognostic factors for survivors(P = 0.007 and P = 0.009, respectively), whereas surgery and radiotherapy were ***: T and M categories were significant prognostic factors even 5 years after the initial diagnosis, whereas local treatments at the time of diagnosis were not, suggesting that patients with GB cancer at high risks might need further adjuvant therapy after primary treatments. The combined analysis of CSS and cancer-specific CS rates offered more accurate survival information for pa

关键词： Gallbladder cancer Conditional survival seER

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Effect of methanol extract of Schisandrae Fructus on high fat diet induced hyperlipidemic mice

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Journal of Traditional Chinese Medicine 2019年第6期39卷 818-825页

作者： se-Eun Lee Hyungwoo kim Chang-Hyun kim Chiyeon Lim Suin Cho Department of Korean Medicine School of Korean MedicineYangsan Campus of Pusan National UniversityYangsan 50612Republic of Korea Department of Medicine College of MedicineDongguk UniversityGoyang 10326Republic of Korea

OBJECTIVE:To investigate the effects and molecular targets of Schisandrae Fructus(SF)methanol extract(SFme)in mice with hyperlipidemia induced by high fat ***:We observed changes in body weight,blood serum content of total cholesterol,high-density lipoprotein(HDL)-cholesterol,and *** extent of accumulation of lipid peroxide due to lipid metabolism disorder also evaluated by measuring malondialdehyde(MDA)*** addition,after getting gene expression in hepatic tissues,target protein of SFme was identified using a protein interaction ***:SFme significantly decreased total cholesterol and triglyceride levels without alteration of body weight in mice,and the livercontent of MDA was statistically decreased by *** expression changes of cyclindependent kinase 1(Cdk1)and leucine-rich repeat kinase 2(Lrrk2)were restored by ***:The effect of SFme on the highfat-diet induced hyperlipidemia via decreasing total cholesterol and triglyceride levels may involve the expression of Cdk1 and Lrrk2 proteins.

关键词： Schisandra hyperlipidemias Obesity Cardiovascular diseases CDC2 protein kinase

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Update of sentinel lymph node mapping assessment in endometrial cancer

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Gynecology and Obstetrics Clinical Medicine 2023年第1期3卷 1-6页

作者： se Ik kim Jae-Weon kim Department of Obstetrics and Gynecology Seoul National University College of MedicineSeoul03080Republic of Korea

Endometrial cancer is the most common gynecologic malignancy in developed *** confirmation of lymph node metastasis is important for risk stratification and the administration of adjuvant ***,comprehensive,systematic lymphadenectomy has been routinely performed but has been associated with various ***,the concept of sentinel lymph node(SLN)mapping and biopsy has emerged and is now accepted as an alternative to conventional systematic lymphadenectomy in early-stage endometrial *** better management of endometrial cancer,we conducted a literature review to summarize the role and diagnostic accuracy of the SLN mapping strategy in endometrial *** from the monumental and recent literature and ongoing clinical trials will be introduced.

关键词： Endometrial cancer sentinel lymph node Lymph node metastasis Accuracy Prognosis Survival

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Hepatothorax due to a right diaphragmatic rupture related to duodenal ulcer perforation

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World Journal of Gastroenterology 2012年第39期18卷 5649-5652页

作者： se-Jin Baek Jin kim Sung-Ho Lee Department of Surgery Korea University Anam HospitalSeoul 136-705South Korea Department of Thoracic Surgery Korea University Anam HospitalSeoul 136-705South Korea

Here, we present the case of a 53-year-old man with a hepatothorax due to a right diaphragmatic rupture related to duodenal ulcer perforation. On admission, the patient complained of severe acute abdominal pain, with physical examination findings suspicious for a perforated peptic ulcer. Of note, the patient had no history of other medical conditions or recent trauma, and the initial chest radiography and laboratory findings were not specific. A subsequent abdominal computed tomography revealed intrathoracic displacement of the liver, gallbladder, transverse colon and omentum through a right diaphragmatic defect. The patient then underwent an explorative laparotomy that confirmed duodenal ulcer perforation. A primary repair of the duodenal perforation was performed, and the diaphrag-matic defect was repaired using a polytetrafluoroeth-ylene patch after the organs were reduced and the cavity irrigated. This particular case proves interesting as right-sided spontaneous diaphragmatic ruptures are very rare and difficult to diagnose. Additionally, the best treatment for such large diaphragmatic defects is still controversial, especially in cases of intrathoracic or intra-abdominal contamination.

关键词： Diaphragmatic rupture Hepatothorax Du-odenal ulcer perforation Polytetrafluoroethylene mesh

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Effects of Cr interlayer on mechanical and tribological properties of Cr-Al-Si-N nanocomposite coating

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 62-67页

作者： Young Su HONG se Hun Kwon Tiegang WANG Doo-In kim Jihwan CHOI Kwang Ho kim School of Materials Science and Engineering Pusan National University National Core Research Center for Hybrid Materials Solution Pusan National University

Cr-A1-Si-N coatings were deposited on SUS 304 substrate by a hybrid coating system. A Cr interlayer was introduced between Cr-A1-Si-N coating and SUS 304 substrate to improve the coating adherence. The effects of Cr interlayer on the microhardness, adhesion, and tribological behavior of Cr-A1-Si-N coatings were systematically investigated. The results indicate that the microhardness of the Cr-A1-Si-N coatings gradually deceases with increasing thickness of Cr interlayers. The adhesion between Cr-A1-Si-N and SUS 304 substrate is improved by addition of the Cr interlayers. A peak critical load of-50 N is observed for the coating containing Cr interlayer of 60 nm as compared - 20 N for the coating without Cr interlayer. The thicker Cr interlayers result in reduced critical load values. Moreover, the wear resistance of the Cr-AI-Si-N coatings is greatly enhanced by introducing the Cr interlayer with thickness of 60 nm in spite of the decreased microhardness. The friction coefficient of the coating system is also moderately reduced.

关键词： Cr-A1-Si-N coating Cr interlayer hardness adhesion wear

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Early bile duct cancer

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World Journal of Gastroenterology 2007年第25期13卷 3409-3416页

作者： Jae Myung Cha Myung-Hwan kim.se Jin Jang Department of Internal Medicine University of Kyunghee College of Medicine East-West Neo Medical Center Seoul Korea Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center Seoul Korea Department of Pathology University of Ulsan College of Medicine Asan Medical Center Seoul Korea

Bile duct cancers are frequently diagnosed as advanced diseases. Over half of patients with advanced bile duct cancer present with unresectable malignancies and their prognosis has been very poor even after curative resections. Although there has been a need to diagnose bile duct cancer at its eady stage, it has been a difficult goal to achieve due to our lack of knowledge regarding this disease entity. Early bile duct cancer may be defined as a carcinoma whose invasion is confined within the fibromuscular layer of the extrahepatic bile duct or intrahepatic large bile duct without distant metastasis irrespective of lymph node involvement. Approximately 3%-10% of resected bile duct cancers have been reported to be early cancers in the literature. The clinicopathological features of patients with early bile duct cancer differ from those of patients with advanced bile duct cancer, with more frequent asymptomatic presentation, characteristic histopathological findings, and excellent prognosis. This manuscript is organized to emphasize the need for convening an international consensus to develop the concept of early bile duct cancer.

关键词： Early bile duct cancer Prognosis Histopathology

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Production of germline chimeric quails following spermatogonial cell transplantation in busulfan-treated testis

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Asian Journal of Andrology 2018年第4期20卷 414-416页

作者： Young Min kim Jin se Park Jong won Yoon Hee Jung Choi Kyung Je Park Tamao Ono Jae Yong Han Department of Agricultural Biotechnology Research Institute of Agriculture and Life Sciences College of Agriculture and Life Sciences Seoul National University Seou108826 Korea Division of Animal Science Faculty of Agriculture Shinshu University Minamiminowa Nagano 399-4598 Japan Institute for Biomedical Sciences Shinshu University Minamiminowa Nagano 399-4598 Japan

Dear Editor, The merits of using quaff as an avian experimental model include high egg production, low maintenance cost, small body size, and short generation period （approximately 6-8 weeks）. Indeed, these characteristics make quail an ideal species for many biological areas including transgenic research. Methods of primordial germ cell （PGC）-mediated germline chimera production are considered very reliable and have been used in avian transgenesis.

关键词： COTURNIX-JAPONICA TRANSGENIC QUAIL TESTICULAR CELLS JAPANEse-QUAIL STEM-CELLS SPERMATOGENESIS TRANSMISSION CHICKEN

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Electrophoretic deposition of a supercapacitor electrode of activated carbon onto an indium-tin-oxide substrate using ethyl cellulose as a binder

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Journal of Materials Science & Technology 2020年第23期58卷 188-196页

作者： Taeuk kim.seong-Hoon yi Sang-Eun Chun School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

A transparent energy storage device is an essential component for transparent *** increasing demand for high-power devices stimulates the development of transparent supercapacitors with high power density.A transparent electrode for such supercapacitors can be assembled via the electrophoretic deposition of an active material powder with a binder onto a transparent *** properties of the binder critically influence the electrochemical behavior and performance of the resulting *** cellulose(EC)is known as an eco-friendly,transparent,flexible,and inexpensive ***,we fabricated an electrode film with EC binder via electrophoretic deposition on an indium tin oxide(ITO)substrate instead of using the conventional polytetrafluoroethylene(PTFE)*** assembled electrodes with EC and PTFE were compared to investigate the feasibility of EC as a binder from different perspectives,including homogeneity,wettability,electrochemical behavior,and mechanical *** EC enabled the formation of a homogeneous film composed of smaller particles and with a higher specific capacitance compared with films prepared with *** annealing improved the adhesion strength of the EC because of its glass transition;however,its hydrophobic nature limited utilization of the active material for charge *** electrochemical activation improved the wettability of the electrode,resulting in an increased capacitance of 60 F g^(-1).Furthermore,even with the lower wettability of EC compared with that of PTFE,better rate performance was possible with the EC *** increased mechanical stability after the annealing process ensured an excellent cycle life of 95%capacitance retention for 15,000 cycles.

关键词： Electrophoretic deposition Transparent electrode Activated carbon Ethyl cellulose Indium tin oxide

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