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Double-balloon-enteroscopy-based endoscopic retrograde cholangiopancreatography in post-surgical patients

World Journal of Gastroenterology 2011年第18期17卷 2302-2314页

作者： Martin Raithel Harald Dormann Andreas Naegel Frank Boxberger Eckhart G Hahn Markus F Neurath juergen maiss Department of Medicine 1 University of Erlangen-Nürnberg Emergency Unit City Hospital Fürth Dean of the University Witten-Herdecke

AIM: To evaluate double balloon enteroscopy (DBE) in post-surgical patients to perform endoscopic retrograde cholangiopancreatography (ERCP) and interventions. METHODS: In 37 post-surgical patients, a stepwise approach was performed to reach normal papilla or enteral anastomoses of the biliary tract/pancreas. When conventional endoscopy failed, DBE-based ERCP was performed and standard parameters for DBE, ERCP and interventions were recorded. RESULTS: Push-enteroscopy (overall, 16 procedures) reached enteral anastomoses only in six out of 37 post-surgical patients (16.2%). DBE achieved a high rate of luminal access to the biliary tract in 23 of the remaining 31 patients (74.1%) and to the pancreatic duct (three patients). Among all DBE-based ERCPs (86 procedures), 21/23 patients (91.3%) were successfully treated. Interventions included ostium incision or papillotomy in 6/23 (26%) and 7/23 patients (30.4%), respectively. Biliary endoprosthesis insertion and regular exchange was achieved in 17/23 (73.9%) and 7/23 patients (30.4%), respectively. Furthermore, bile duct stone extraction as well as ostium and papillary dilation were performed in 5/23 (21.7%) and 3/23 patients (13.0%), respectively. Complications during DBE-based procedures were bleeding (1.1%), perforation (2.3%) and pancreatitis (2.3%), and minor complications occurred in up to 19.1%. CONCLUSION: The appropriate use of DBE yields a high rate of luminal access to papilla or enteral anastomoses in more than two-thirds of post-surgical patients, allowing important successful endoscopic therapeutic interventions.

关键词：双气囊小肠手术患者胆管造影内镜胃镜检查

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Classical bovine spongiform encephalopathy and chronic wasting disease:two sides of the prion coin

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Animal Diseases 2024年第1期4卷 1-18页

作者： Nicholas J.Haley juergen A.Richt Department of Microbiology and Immunology College of Graduate StudiesMidwestern UniversityGlendaleAZUSA Department of Diagnostic Medicine/Pathobiology College of Veterinary MedicineKansas State UniversityManhattanKSUSA

Transmissible spongiform encephalopathies(TSEs)are a group of progressive and ultimately fatal neurologic diseases of man and animals,all resulting from the propagated misfolding of the host's normal cellular prion *** diseases can be spontaneous,heritable,anthropogenic/iatrogenic,or in some cases horizontally transmissible,and include such notable TSEs as bovine spongiform encephalopathy(BSE)of cattle and chronic wasting disease(CWD)of *** they are both unequivocally protein misfolding disorders,they differ markedly in their pathogenesis,transmissibility,and zoonotic *** the BSE epidemic has largely abated over the past three decades following global feed bans on ruminant meat and bone meal,CWD,which is readily transmitted through various forms of excreta,has rapidly expanded from its original endemic zone to encompass much of North America,along with recently identified foci in *** importantly,although the classical form of BSE has proven transmissible to humans consuming contaminated beef or beef products,so far there have been no conclusive reports on the zoonotic transmission of cWD to *** underlying basis for these differences-whether host or agent directed-are not well understood,though may be due to inherent differences in the three-dimensional structure of the misfolded BSE or CWD prion proteins or the expression levels and tissue distribution of respective cellular prion *** the uncontrolled geographic spread of CWD,it is imperative that we improve our understanding of the factors governing prion disease pathogenesis,transmission,and zoonotic potential.

关键词： Prion Bovine Spongiform Encephalopathy Chronic Wasting Disease Transmission Pathogenesis Zoonosis

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Combining thermal scanning probe lithography and dry etching for grayscale nanopattern amplification

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Microsystems & Nanoengineering 2024年第1期10卷 335-344页

作者： Berke Erbas Ana Conde-Rubio Xia Liu Joffrey Pernollet Zhenyu Wang Arnaud Bertsch Marcos Penedo Georg Fantner Mitali Banerjee Andras Kis Giovanni Boero juergen Brugger Microsystems Laboratory École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Center of MicroNanoTechnology(CMi) EPFLLausanne 1015Switzerland Laboratory of Nanoscale Electronics and Structures École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory for Bio-and Nano-Instrumentation École Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Laboratory of Quantum Physics Topology and CorrelationsÉcole Polytechnique Fédérale de Lausanne(EPFL)Lausanne 1015Switzerland Present address:Institute of Materials Science of Barcelona ICMAB-CSIC Campus UABBellaterra 08193Spain Present address:School of Integrated Circuits and Electronics MIIT Key Laboratory for Low-Dimensional Quantum Structure and DevicesBeijing Institute of TechnologyBeijing 100081China

Grayscale structured surfaces with nanometer-scale features are used in a growing number of applications in optics and *** scanning probe lithography achieves a lateral resolution below 10 nm and a vertical resolution below 1 nm,but its maximum depth in polymers is ***,we present an innovative combination of nanowriting in thermal resist and plasma dry etching with substrate cooling,which achieves up to 10-fold amplification of polymer nanopatterns into SiO_(2) without proportionally increasing surface *** nanopatterns in SiO_(2) with 400 nm pitch and 150 nm depth are fabricated free of shape distortion after dry *** exemplify the possible applications of the proposed method,grayscale dielectric nanostructures are used for scalable manufacturing through nanoimprint lithography and for strain nanoengineering of 2D *** a method for aspect ratio amplification and smooth grayscale nanopatterning has the potential to find application in the fabrication of photonic and nanoelectronic devices.

关键词： lithography thermal pattern

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Large anomalous Hall, Nernst effect and topological phases in the 3d-4d/5d-based oxide double perovskites

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npj Computational Materials 2023年第1期9卷 613-622页

作者： Kartik Samanta Jonathan Noky Iñigo Robredo juergen Kuebler Maia G.Vergniory Claudia Felser Max Planck Institute for Chemical Physics of Solids 01187 DresdenGermany Donostia International Physics Center 20018 Donostia-San SebastiánSpain Technische Universitaet Darmstadt 64289 DarmstadtGermany Department of Physics and Astronomy University of Nebraska-LincolnLincolnNE 68588USA

Magnetism and spin-orbit coupling are two fundamental and interconnected properties of oxide materials,that can give rise to various topological transport phenomena,including anomalous Hall and anomalous Nernst *** transport responses can be significantly enhanced by designing an electronic structure with a large Berry *** this context,rocksalt-ordered double perovskites(DP),denoted as A2BB’O6,with two distinct transition metal sites are very powerful platforms for exploration and *** this work,we present a comprehensive study based on the intrinsic anomalous transport in cubic and tetragonal stable DP compounds with 3d-4d/5d *** findings reveal that certain DP compounds show a large anomalous Hall effect,displaying topological band crossings in the proximity of the Fermi energy.

关键词： topological perovskite Nernst

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Improvement on straightness of metal bar based on straightening stroke-deflection model

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Science China(Technological Sciences) 2009年第7期52卷 1866-1873页

作者： LEOPOLD juergen Fraunhofer Institute for Machine Tools and Forming Technology Chemnitz Germany

The straightening technics is one of important means to improve the straightness of metal bar. A nove way of predicting the straightening stroke is proposed based on mathematical methods and bending experimental and numerical simulation. The experimental and numerical simulation is conducted by following the mathematical load-stroke model of press straightening process under the elastic-plastic theory. For the linear guide rails, as an example, the stroke-deflection model focusing on the straight-ening stroke prediction can be achieved by contrasting and integrating the bending experimental results and finite element methods (FEM) simulation data. And then the formula for predicting the straightening stroke is presented based on the precise straightening stroke-deflection model. The stroke prediction formula with high precision can be applied to the straightening stroke prediction in the high straightness metal bar manufacturing process and automatic straightening machine conveniently.

关键词： straightness straightening stroke deflection stroke prediction metal bar

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Mapping of liver-enriched transcription factors in the human intestine

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World Journal of Gastroenterology 2010年第31期16卷 3919-3927页

作者： Frank Lehner Ulf Kulik juergen Klempnauer juergen Borlak Department of General Visceral and Transplantation SurgeryHanover Medical School Molecular Medicine and Medical Biotechnol-ogy Fraunhofer Institute of Toxicology and Experimental Medi-cine Center of Pharmacology and Toxicology Hanover Medical School

AIM: To investigate the gene expression pattern of hepatocyte nuclear factor 6 (HNF6) and other liverenriched transcription factors in various segments of the human intestine to better understand the differentiation of the gut epithelium. METHODS: Samples of healthy duodenum and jejunum were obtained from patients with pancreatic cancer whereas ileum and colon was obtained from patients undergoing right or left hemicolectomy or (recto)sigmoid or rectal resection. All surgical specimens were subjected to histopathology. Excised tissue was shock-frozen and analyzed for gene expression of liver-enriched transcription factors by semiquantitative reverse transcription polymerase chain and compared to the human colon carcinoma cell line Caco-2. Protein expression of major liver-enriched transcription factors was determined by Western blotting while the DNA binding of HNF6 was investigated by electromobility shift assays. RESULTS: The gene expression patterning of liverenriched transcription factors differed in the various segments of the human intestine with HNF6 gene expression being most abundant in the duodenum (P < 0.05) whereas expression of the zinc finger protein GATA4 and of the HNF6 target gene ALDH3A1 was most abundant in the jejunum (P < 0.05). Likewise, expression of FOXA2 and the splice variants 2 and 4 of HNF4α were most abundantly expressed in the jejunum (P < 0.05). Essentially, expression of transcription factors declined from the duodenum towards the colon with the most abundant expression in the jejunum and less in the ileum. The expression of HNF6 and of genes targeted by this factor, i.e. neurogenin 3 (NGN3) was most abundant in the jejunum followed by the ileum and the colon while DNA binding activity of HNF4α and of NGN3 was conf irmed by electromobility shift assays to an optimized probe. Furthermore, Western blotting provided evidence of the expression of several liver-enriched transcription factors in cultures of colon epithelial cells, albeit at

关键词： Liver-enriched transcription factors Human intestine Caco-2 Gene expression

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Compressive holographic sensing simplifies quantitative phase imaging

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Light(Science & Applications) 2023年第6期12卷 946-948页

作者： Jiawei Sun juergen W.Czarske Competence Center for Biomedical Computational Laser Systems(BIOLAS) TU DresdenDresdenGermany Laboratory of Measurement and Sensor System Technique(MST) TU DresdenHelmholtzstrasse 1801069 DresdenGermany Cluster of Excellence Physics of Life TU DresdenDresdenGermany Institute of Applied Physics TU DresdenDresdenGermany

Quantitative phase imaging (QPI) has emerged as method for investigating biological specimen and technical objects. However, conventional methods often suffer from shortcomings in image quality, such as the twin image artifact. A novel computational framework for QPI is presented with high quality inline holographic imaging from a single intensity image. This paradigm shift is promising for advanced QPI of cells and tissues.

关键词： holographic phase shortcomings

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The future of geospatial intelligence

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Geo-Spatial Information Science 2017年第2期20卷 151-162页

作者： juergen Dold Jessica Groopman Hexagon Geosystems HeerbruggSwitzerland Independent Industry Analyst and IoT Advisor BerkeleyCAUSA

For centuries,humans’capacity to capture and depict physical space has played a central role in industrial and societal ***,the digital revolution and the emergence of networked devices and services accelerate geospatial capture,coordination,and intelligence in unprecedented *** the digital transformation of industry and society is the fusion of the physical and digital worlds-‘perceptality’-where geospatial perception and reality *** paper analyzes the myriad forces that are driving perceptality and the future of geospatial intelligence and presents real-world implications and examples of its industrial *** of sensors,robotics,cameras,machine learning,encryption,cloud computing and other software,and hardware intelligence are converging,enabling new ways for organizations and their equipment to perceive and capture ***,demands for performance,reliability,and security are pushing compute‘to the edge’where real-time processing and coordination are *** data place new restraints on economics,as pressures abound to actually use these data,both in real-time and for longer term strategic analysis and *** challenges require orchestration between information technology(IT)and operational technology(OT)and synchronization of diverse systems,data-sets,devices,environments,workflows,and people.

关键词： Big data virtual reality digital reality cloud computing edge computing geospatial data

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Hepatitis B virus replication

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World Journal of Gastroenterology 2007年第1期13卷 48-64页

作者： juergen Beck Michael Nassal Department of Internal Medicine II/Molecular Biology University Hospital FreiburgGermany

Hepadnaviruses,including human hepatitis B virus(HBV),replicate through reverse transcription of an RNAintermediate,the pregenomic RNA(pgRNA).Despite thiskinship to retroviruses,there are fundamental differencesbeyond the fact that hepadnavirions contain DNAinstead of *** peculiar is the initiation of reversetranscription:it occurs by protein-priming,is strictlycommitted to using an RNA hairpin on the pgRNA,ε,as template,and depends on cellular chaperones;moreover,proper replication can apparently occur onlyin the specialized environment of intact *** complexity has hampered an in-depth *** recent successful reconstitution inthe test tube of active replication initiation complexesfrom purified components,for duck HBV(DHBV),now allows for the analysis of the biochemistry ofhepadnaviral replication at the molecular *** wereview the current state of knowledge at all steps of thehepadnaviral genome replication cycle,with emphasison new insights that turned up by the use of such cell-free *** this time,they can,unfortunately,not be complemented by three-dimensional structurainformation on the involved ***,atleast for the ε RNA element such information is emerging,raising expectations that combining biophysics withbiochemistry and genetics will soon provide a powerfuintegrated approach for solving the many *** ultimate,though most challenging goal,will be to visualize the hepadnaviral reverse transcriptasein the act of synthesizing DNA,which will also havestrong implications for drug development.

关键词：乙型病毒肝炎治疗临床病毒复制

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Fast Modification of Microdischarge Emission Bands by Fracture of Sugar

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Chinese Physics Letters 2011年第8期28卷 304-306页

作者： Sergej Aman juergen Tomas AStreletskii Otto-von-Guericke University MagdeburgP.O.Box 412039106 MagdeburgGermany Institute of Chemical Physics RASKosygina 4Moscow 119991Russia

Intensive light pulses with widths of about 10 ns were observed during the crack propagation by cleavage of crystalline sugar at atmospheric *** observed light pulses were caused by a sequence of gas microdischarges(MDs).The pulses were detected in the UV/VIS and NIR wavelength *** the light pulses appear in the UV/VIS wavelength range,and then after a delay of about 0.4–1.2 ns in the NIR wavelength *** characteristic feature of MDs can be used for the characterization of crack propagation.

关键词： delay sugar Fast

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