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二氧化硅所致急性肺损伤大鼠肺部菌群的特征及相关性分析

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中国病理生理杂志 2024年第1期40卷 81-88页

作者：刘畅芦俊肖荣李迎秋胡珏田玥张家祥卢芳国湖南中医药大学医学院湖南长沙410208 湖南中医药大学中西医结合学院湖南长沙410208 湖南省中西医结合医院湖南长沙410006

目的:探讨二氧化硅所致急性肺损伤大鼠模型的潜在生物学机制。方法:采用随机数字表法,将SD雄性大鼠划分为正常组和二氧化硅模型组。正常组经气管灌注1 mL生理盐水,模型组经气管灌注等体积50 g/L二氧化硅混悬液。7 d后收集大鼠肺组织和血... 详细信息

目的:探讨二氧化硅所致急性肺损伤大鼠模型的潜在生物学机制。方法:采用随机数字表法,将SD雄性大鼠划分为正常组和二氧化硅模型组。正常组经气管灌注1 mL生理盐水,模型组经气管灌注等体积50 g/L二氧化硅混悬液。7 d后收集大鼠肺组织和血清,HE染色观察肺组织病理学特征,免疫组化检测肺组织核苷酸结合寡聚化结构域样受体蛋白3(NLRP3)和消皮素D(GSDMD)蛋白表达,ELISA法检测血清炎症因子白细胞介素1β(IL-1β)、IL-18和肿瘤坏死因子α(TNF-α)水平;从肺组织中提取细菌DNA,经16S核糖体RNA基因测序描述肺部菌群组成变化,通过生物信息学分析比较正常组与模型组菌群结构差异。结果:与正常组相比,模型组大鼠体重增长率和肺指数有显著差异;模型组大鼠肺组织HE染色可见肺泡结构破坏,炎性细胞增多;模型组大鼠肺组织NLRP3和GSDMD蛋白表达水平均显著升高,血清IL-1β、IL-18和TNF-α水平均显著升高。与正常组相比,模型组丰度增加的肺部菌群为双歧杆菌(Bifidobacterium)、Clostridium sensu stricto 1和副萨特氏菌(Parasutterella)。Spearman相关性分析显示,肺组织NLRP3/GSDMD和血清IL-1β/TNF-α水平与Parasutterella丰度呈正相关。结论:二氧化硅所致急性肺损伤的病理机制可能与肺部菌群结构差异和炎症水平升高有关。因此,调节肺部菌群可能为防治二氧化硅引起的急性肺损伤提供新的思路。

关键词：矽肺二氧化硅急性肺损伤肺部菌群

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高校毕业生“慢就业”倾向影响因素研究——基于浙江省7所省属高校的调查

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浙江工业大学学报（社会科学版） 2024年第2期23卷 235-240页

作者：胡珏李帮彬朱方思宇浙江工业大学浙江省舆情研究中心浙江杭州310023 浙江工业大学公共管理学院浙江杭州310023 浙江工业大学马克思主义学院浙江杭州310023

近年来,高校毕业生就业形势日趋严峻,“慢就业”群体规模不断攀升。为防止“慢就业”倾向蔓延,精准赋能高校毕业生高质量就业,通过问卷调研和访谈调查等实证方法了解浙江省大学生就业倾向的变化,分析“慢就业”群体的特征及影响因素。... 详细信息

近年来,高校毕业生就业形势日趋严峻,“慢就业”群体规模不断攀升。为防止“慢就业”倾向蔓延,精准赋能高校毕业生高质量就业,通过问卷调研和访谈调查等实证方法了解浙江省大学生就业倾向的变化,分析“慢就业”群体的特征及影响因素。结果表明,毕业生的身份特征、就业心理、就业认知等因素对“慢就业”现象的形成有显著影响。据此提出相关建议:政府层面创造就业需求,出台政策保障;高校层面顺应毕业生“慢就业”模式,构建毕业后教育体系;企业改善求职体验与招聘效率,加强校企深度合作等。

关键词：慢就业高校毕业生就业心理就业认知

Ultrastable bimetallic Fe_(2)Mo for efficient oxygen reduction reaction in pH-universal applications

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Nano Research 2022年第6期15卷 4950-4957页

作者： jue hu Chengxu Zhang Mingzi Sun Qianglong Qi Shanxiong Luo Hongchuan Song Jingyi Xiao Bolong huang Michael K.H.Leung Yingjie Zhang The Engineering Laboratory of Advanced Battery and Materials of Yunnan Province Kunming University of Science and TechnologyKunming 650093China Department of Applied Biology and Chemical Technology The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina School of Energy and Environment Science Yunnan Normal UniversityKunming 650500China Ability R&D Energy Research Centre School of Energy and EnvironmentCity University of Hong KongHong KongChina

Iron-based nanostructures represent an emerging class of catalysts with high electroactivity for oxygen reduction reaction(ORR)in energy storage and conversion ***,current practical applications have been limited by insufficient durability in both alkaline and acidic *** particular,limited attention has been paid to stabilizing iron-based catalysts by introducing additional metal by the alloying ***,we report bimetallic Fe_(2)Mo nanoparticles on N-doped carbon(Fe_(2)Mo/NC)as an efficient and ultra-stable ORR electrocatalyst for the first *** Fe_(2)Mo/NC catalyst shows high selectivity for a four-electron pathway of ORR and remarkable electrocatalytic activity with high kinetics current density and half-wave potential as well as low Tafel slope in both acidic and alkaline *** demonstrates excellent long-term durability with no activity loss even after 10,000 potential *** functional theory(DFT)calculations have confirmed the modulated electronic structure of formed Fe_(2)Mo,which supports the electron-rich structure for the ORR ***,the mutual protection between Fe and Mo sites guarantees efficient electron transfer and long-term stability,especially under the alkaline *** work has supplied an effective strategy to solve the dilemma between high electroactivity and long-term durability for the Fe-based electrocatalysts,which opens a new direction of developing novel electrocatalyst systems for future research.

关键词： oxygen reduction reaction Fe2Mo bimetallic nanoparticles zeolitic imidazolate frameworks(ZIFs) ultralong stability superior oxygen reduction reaction(ORR)performance

Ultra reliability and massive connectivity provision in integrated internet of military things(IoMT)based on tactical datalink

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Defence Technology（防务技术） 2024年第3期33卷 386-398页

作者： Li Bing Yating Gu Lanke hu Li Bowen Yang Lihua jue Wang Yue Yin Northwestern Polytechnical University Xi'an 710072China China Academy of Information and Communications Technology Beijing 100191China China Intelligent and Connected Vehicles(Beijing)Research Institute Co. LtdBeijing 100176China The 20th Research Institute of China Electronic Technology Group Corporation Xi’an 710068China Xidian University Xi'an 710071China

One of the major challenges arising in internet of military things(IoMT)is accommodating massive connectivity while providing guaranteed quality of service(QoS)in terms of ultra-high *** this regard,this paper presents a class of code-domain nonorthogonal multiple accesses(NOMAs)for uplink ultra reliable networking of massive IoMT based on tactical datalink such as Link-16 and joint tactical information distribution system(JTIDS).In the considered scenario,a satellite equipped with Nr antennas servers K devices including vehicles,drones,ships,sensors,handset radios,*** coded modulation,a special form of multiple input multiple output(MIMO)-NOMA is *** discussion starts with evaluating the output signal to interference-plus-noise(SINR)of receiver filter,leading to the unveiling of a closed-form expression for overloading systems as the number of users is significantly larger than the number of devices admitted such that massive connectivity is *** expression allows for the development of simple yet successful interference suppression based on power allocation and phase shaping techniques that maximizes the sum rate since it is equivalent to fixed-point programming as can be *** proposed design is exemplified by nonlinear modulation schemes such as minimum shift keying(MSK)and Gaussian MSK(GMSK),two pivotal modulation formats in IoMT standards such as Link-16 and *** results show that near capacity performance is ***,the performance is obtained using simple forward error corrections(FECs)of higher coding rate than existing schemes do,while the transmit power is reduced by 6 *** proposed design finds wide applications not only in IoMT but also in deep space communications,where ultra reliability and massive connectivity is a keen concern.

关键词： Satellite network Deep space communications Internet of military things Non-orthogonal multiple access MIMO Link-16 JITDS

Online algorithms for scheduling with machine activation cost on two uniform machines

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第1期8卷 127-133页

作者： HAN Shu-guang JIANG Yi-wei hu jue-liang Department of Mathematics Zhejiang University Hangzhou 310027 China Faculty of Science Zhej iang Sci- Tech University Hangzhou 310018 China

In this paper we investigate a variant of the scheduling problem on two uniform machines with speeds 1 and s. For this problem, we are given two potential uniform machines to process a sequence of independent jobs. Machines need to be activated before starting to process, and each machine activated incurs a fixed machine activation cost. No machines are initially activated, and when a job is revealed, the algorithm has the option to activate new machines. The objective is to minimize the sum of the makespan and the machine activation cost. We design optimal online algorithms with competitive ratio of (2s+1)/(s+1) for every s≥1.

关键词：同类机在线算法在线排序机器激活成本竞争分析

Minimizing makespan in a two-stage hybrid flow shop scheduling problem with open shop in one stage

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Applied Mathematics(A Journal of Chinese Universities) 2013年第3期28卷 358-368页

作者： DONG Jian-ming hu jue-liang CHEN Yong Department of Mathematics Zhejiang Sci-Tech University Institute of Operational Research and Cybernetics Hangzhou Dianzi University

This paper considers a scheduling problem in two-stage hybrid flow shop, where the first stage consists of two machines formed an open shop and the other stage has only one machine. The objective is to minimize the makespan, i.e., the maximum completion time of all jobs. We first show the problem is NP-hard in the strong sense, then we present two heuristics to solve the problem. Computational experiments show that the combined algorithm of the two heuristics performs well on randomly generated problem instances.

关键词： hybrid flow shop open shop Heuristic algorithm.

龙眼叶黄酮类有效组分配伍体外降糖作用的研究

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广西科学院学报 2024年第2期40卷 135-144页

作者：梁晶春胡珏安施佳郑飘雪陆春莲梁炎丽陈明伟梁洁广西中医药大学药学院广西南宁530200 广西高校中药提取纯化与质量分析重点实验室广西南宁530200 广西壮瑶药重点实验室广西南宁530200

基于体外降糖活性优选龙眼(Dimocarpus longan Lour.)叶黄酮有效成分山柰酚、槲皮素、槲皮苷的配伍比例。建立HepG2细胞胰岛素抵抗模型,分别考察不同浓度的胰岛素及不同诱导时间对胰岛素抵抗模型的诱导情况,并以山柰酚、槲皮素、槲皮苷... 详细信息

基于体外降糖活性优选龙眼(Dimocarpus longan Lour.)叶黄酮有效成分山柰酚、槲皮素、槲皮苷的配伍比例。建立HepG2细胞胰岛素抵抗模型,分别考察不同浓度的胰岛素及不同诱导时间对胰岛素抵抗模型的诱导情况,并以山柰酚、槲皮素、槲皮苷三者用量为考察因素,以对胰岛素抵抗的HepG2细胞葡萄糖消耗率为指标,运用星点设计-效应面法(CCD-RSM)优化三者配伍比例。结果表明,建立HepG2细胞胰岛素抵抗模型的最佳条件为1×10^(-7)mol/L胰岛素诱导24 h;山柰酚、槲皮素、槲皮苷体外降糖最佳配伍比例为山柰酚105.0μmol/L、槲皮素78.9μmol/L、槲皮苷194.0μmol/L,配伍比例优化试验拟合方程为Y=20.94+1.55×A-0.44×B-2.05×C-0.66×AB+1.68×AC-1.53×A^(2)-3.2×B^(2)-2.68×C^(2)。山柰酚、槲皮素、槲皮苷3种单体的联合使用对HepG2细胞的葡萄糖消耗率预测值是21.52%,实验值是(21.05±0.52)%。优选出的最佳配伍比例的龙眼叶黄酮类有效组分,对HepG2细胞的葡萄糖消耗率最高,降糖活性较好,可为龙眼叶治疗糖尿病的有效性提供科学方法与实验依据。

关键词：龙眼叶组分配伍山柰酚槲皮素槲皮苷

Three rare anti-inflammatory sesquiterpene lactones from Magnolia grandiflora

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Chinese Journal of Natural Medicines 2024年第3期22卷 265-272页

作者： XU Shuangyu ZHANG Feng TAO Linlan JIANG Yangming huANG Tao LI Yanan hu Zhanxing YANG jue HAO Xiaojiang YUAN Chunmao State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical UniversityGuiyang 550014China School of Pharmaceutical Sciences Guizhou Medical UniversityGuiyang 550025China Natural Products Research Center of Guizhou Province Guiyang 550014China State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China

Four new sesquiterpene lactones(SLs)(1–4),along with a biosynthetically related SL(5),have been isolated from the leaves of Magnolia *** A(1)is notable as the first C18 homogemarane type SL,featuring a unique 1,7-dioxaspiro[4.4]nonan-6-one *** 2 and 3,representing the first instances of chlorine-substituted gemarane-type SL analogs in natural products,were also *** structures of these isolates were elucidated through a combination of spectroscopic data analysis,electronic circular dichroism calculations,and X-ray single-crystal diffraction *** isolates demonstrated anti-inflammatory activity in lipopolysaccharide-stimulated RAW264.7 ***,3–5 showed a significant inhibitory effect on nitric oxide production,with IC50 values ranging from 0.79 to 4.73μmol·L^(−1).Additionally,4 and 5 exhibited moderate cytotoxic activities against three cancer cell lines,with IC50 values between 3.09 and 11.23μmol·L^(−1).

关键词： Magnolia grandiflora Sesquiterpene lactones Isolation and identification Anti-inflammatory activity

Competitive analysis of price online inventory problem with cost function

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Applied Mathematics(A Journal of Chinese Universities) 2017年第4期32卷 493-502页

作者： HAN Shu-guang GUO Jiu-ling ZHANG Lu-ping hu jue-liang Department of Mathematics Zhejiang Sci-Tech University Hangzhou 310018 China

In this paper,a new price is given to the online decision maker at the beginning of each *** trader must decide how many items to purchase according to the current *** present three variants and an online algorithm based on cost *** competitive ratio of the online algorithm is given for each variant,which is a performance measure of an online *** importantly,we show that the online algorithm is optimal.

关键词： inventory problem price online cost function competitive analysis