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Journal of Materials Science & Technology 2018年第1期34卷 92-101页

作者： judy schneider Josef Cobb John S.Carpenter Nathan A.Mara Department of Mechanical & Aerospace Engineering University of Alabama in Huntsville Department of Mechanical Engineering Mississippi State University Materials Science and Technologies Division Los Alamos National Laboratory Center for Integrated Nanotechnologies and the Institute for Materials ScienceLos Alamos National Laboratory

Accumulative roll bonded （ARB） Copper Niobium （Cu-Nb） nano-lamellar composite （NLC） panels were friction stir welded （FSWed） to evaluate the ability to join panels while retaining the nano-lamellar structure. During a single pass of the friction stir welding （FSW） process, the nano-lamellar structure of the parent material （PM） was retained but was observed to fragment into equiaxed grains during the second pass. FSW has been modeled as a severe deformation process in which the material is subjected to an instantaneous high shear strain rate followed by extreme shear strains. The loss of the nano-lamellar layers was attributed to the increased strain and longer time at temperature resulting from the second pass of the FSW process. Kinematic modeling was used to predict the global average shear strain and shear strain rates experienced by the ARB material during the FSW process. The results of this study indicate that through careful selection of FSW parameters, the nano-lamellar structure and its associated higher strength can be maintained using FSW to join ARB NLC panels.

关键词： Nano-lamellar materials Accumulative roll bonded Cu-Nb FSW Solid state joining

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Histological healing favors lower risk of colon carcinoma in extensive ulcerative colitis

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World Journal of Gastroenterology 2014年第17期20卷 4980-4986页

作者： Burton I Korelitz Keith Sultan Megha Kothari Leo Arapos judy schneider Georgia Panagopoulos Department of Gastroenterology Lenox Hill HospitalNew YorkNY 10075United States Department of Gastroenterology and Hepatology and Nutrition North Shore HospitalManhassetNY 11030United States North Oaks Medical Center HammondLA 70403United States Department of Research Lenox Hill HospitalNew YorkNY 10075United States

AIM: To search for the answer in extensive ulcerative colitis as to whether histological inflammation persisting despite endoscopic mucosal healing serves to increase the risk of colon cancer (CC) or high grade dyspla... 详细信息

关键词： Histological inflammation Risk Colon cancer Ulcerative colitis High grade dysplasia

Solute flow and particle transport in aquatic ecosystems: A review on the effect of emergent and rigid vegetation

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Environmental Science and Ecotechnology 2024年第5期21卷 77-91页

作者： judy Q.Yang St.Anthony Falls Laboratory Department of CivilEnvironmentaland Geo-EngineeringUniversity of Minnesota Twin CitiesMNUSA

In-channel vegetation is ubiquitous in aquatic environments and plays a critical role in the fate and transport of solutes and particles in aquatic *** studies have advanced our understanding of the role of vegetation in solute flow and particle transport in aquatic *** review summarizes these papers and discusses the impacts of emergent and rigid vegetation on the surface flow,the advection and dispersion of solutes,suspended load transport,bedload transport,and hyporheic *** two competing effects of emergent vegetation on the above transport processes are *** the one hand,emergent vegetation reduces mean flow velocity at the same surface slope,which reduces mass *** the other hand,at the same mean flow velocity,vegetation generates turbulence,which enhances mass *** understanding of these two competing effects and predictive equations derived from laboratory experiments are *** equations for the mean flow velocity and turbulent kinetic energy inside an emergent vegetation canopy are derived based on force and energy *** impacts of emergent vegetation on the advection-dispersion process,the suspended load and bedload transport,and the hyporheic exchange are *** impacts of other vegetation-related factors,such as vegetation morphology,submergence,and flexibility,are briefly *** role of vegetation in transporting other particles,such as micro-and macro-plastics,is also briefly ***,suggestions for future research directions are proposed to advance the understanding of the dynamic interplays among natural vegetation,flow dynamics,and sedimentary processes.

关键词： transport load flow

The Making of a Health Profession:How Chinese Medicine Became a Nationally Registered Allied Health Profession in Australia

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Chinese Medicine and Culture 2024年第1期7卷 51-62页

作者： John L McDonald judy B James School of Chinese Medicine Endeavour College of Natural HealthSouthport 4215Australia Acupuncture Now Australia Brisbane 4120Australia

In 2012, traditional Chinese medicine(TCM) practitioners in Australia became nationally-registered allied health professionals in three categories: acupuncturist, Chinese herbal medicine practitioner, and Chinese herbal medicine dispenser. Australia was the first Western country to introduce national registration for Chinese medicine, followed by Portugal and, recently, New Zealand. The practice of TCM in Australia can be traced back to the beginning of Chinese immigration to Australia during the Victorian Gold Rush which began in the 1850s. The process which led to national registration commenced in the early 1970s with the establishment of the first acupuncture courses. Decades of gradual development of courses from unaccredited part-time diplomas to accredited bachelor degrees, and the development, by the profession, of national consensus on educational standards were essential elements in the process which led to registration. Professional associations, such as the Australian Acupuncture and Chinese Medicine Association Ltd.(AACMA), also developed a framework of professional selfregulation, including Codes of Ethics, Codes of Conduct, ongoing professional development requirements and Infection Control Guidelines, and provided leadership in the development of the profession. After decades of tribalism and division within the TCM profession, the National Academic Standards Committee brought almost all stakeholders together to reach a consensus on the Australian Guidelines for Traditional Chinese Medicine Education which were published by AACMA in 2001. Professional associations also collaborated on joint submissions to the government in support of registration, which was introduced first in the state of Victoria in 2000, and subsequently became national in 2012. Despite national registration, some barriers still remain, and professional associations continue to lobby the federal government for inclusion in Medicare, chronic disease management scheme, and Veterans

关键词： Acupuncture Chinese medicine Registration Regulation Education Standards Australia TCM

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Assembling the RNA therapeutics toolbox

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Medical Review 2024年第2期4卷 110-128页

作者： Mona Teng Ziting judy Xia Nicholas Lo Kashif Daud Housheng Hansen He Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoTorontoONCanada Princess Margaret Cancer Centre University Health NetworkTorontoONCanada Department of Medical Biophysics Temerty Faculty of MedicineUniversity of TorontoToronto M2J 4A6ONCanada Princess Margaret Cancer Centre University Health NetworkToronto M2J 4A6ONCanada

From the approval of COVID-19 mRNA vaccines to the 2023 Nobel Prize awarded for nucleoside base modifications,RNA therapeutics have entered the spotlight and are transforming drug *** the term“RNA therapeutics”has been used in various contexts,this review focuses on treatments that utilize RNA as a component or target RNA for therapeutic *** summarize the latest advances in RNA-targeting tools and RNA-based technologies,including but not limited to mRNA,antisense oligos,siRNAs,small molecules and RNA *** focus on the mechanisms of current FDA-approved therapeutics but also provide a discussion on the upcoming *** clinical utility of RNA-based therapeutics is enabled not only by the advances in RNA technologies but in conjunction with the significant improvements in chemical modifications and delivery platforms,which are also briefly discussed in the *** summarize the latest RNA therapeutics based on their mechanisms and therapeutic effects,which include expressing proteins for vaccination and protein replacement therapies,degrading deleterious RNA,modulating transcription and translation efficiency,targeting noncoding RNAs,binding and modulating protein activity and editing RNA sequences and *** review emphasizes the concept of an RNA therapeutic toolbox,pinpointing the readers to all the tools available for their desired research and clinical *** the field advances,the catalog of RNA therapeutic tools continues to grow,further allowing researchers to combine appropriate RNA technologies with suitable chemical modifications and delivery platforms to develop therapeutics tailored to their specific clinical challenges.

关键词： RNA therapeutics delivery of nucleic acids chemical modifications

Combining video and GPS-tracking to study the spatial foraging distribution of a single-prey loading seabird

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Avian Research 2024年第3期15卷 316-325页

作者： Ruben C.Fijn Wouter Courtens Bas W.R.Engels Emiel E.van Loon judy Shamoun-Baranes Waardenburg Ecology Deparonent of Bird EcologyCulemborgthe Netherlands University of Amsterdam Insnitute for Biodiversity and Ecoasystem DymaomicsAmsterdamthe Netherlands Research Insitute for Nature and Forest(INBO) BrusselsBcgium

Seabirds are valuable indicators of marine ecosystem processes and studying seabird diets can shed light on natural or human-induced variability in food-web *** single-prey loading seabird species such as terns have the potential to act as visual sentinels of prey availability ***,obtaining diet information from remote bird colonies is often challenging and time *** this pilot study we present a novel approach to combine two established methods to study seabird foraging ecology,providing a powerful and cost-effective tool to study the distribution of prey items available to *** combined GPS tracking data of Sandwich Terns(Thalasseus sandvicensis)with prey-observations from a hide in 2012 and 2013,and from semicontinuously recorded camera footage in *** doing so,we identified 115 approximate catch locations of prey(86 herring/sprat Clupeidae,29 sandeel Ammodytidae).Combining GPS-data and prey observations yielded detailed knowledge on the movements and chick diets of tracked birds as well as the spatial origin and lengths of captured prey *** catch distances of both Clupeidae and Ammodytidae resulted in deliveries of larger prey items and thus higher energy yield per trip,but also a higher energy expenditure per *** discuss the limitations and potential of our methodological approach to study foraging energetics during chick-provisioning of seabirds that carry prey items visible in their beaks.

关键词： Diet Digitalfilm Geo-referencing Non-invasive monitoring Provisioning Sandwich Tern Thalasseus sandvicensis

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A Literature Review: Potential Effects That Health Apps on Mobile Devices May Have on Patient Privacy and Confidentiality

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E-Health Telecommunication Systems and Networks 2024年第3期13卷 23-44页

作者： Anna Sheri George Jomin George judy Jenkins Faculty of Medicine and Health Life Sciences Swansea University Swansea UK

Purpose: This research aims to evaluate the potential threats to patient privacy and confidentiality posed by mHealth applications on mobile devices. Methodology: A comprehensive literature review was conducted, selecting eighty-eight articles published over the past fifteen years. The study assessed data gathering and storage practices, regulatory adherence, legal structures, consent procedures, user education, and strategies to mitigate risks. Results: The findings reveal significant advancements in technologies designed to safeguard privacy and facilitate the widespread use of mHealth apps. However, persistent ethical issues related to privacy remain largely unchanged despite these technological strides.

关键词： Mobile Devices Patient Privacy Confidentiality Breaches Data Security Data Protection Regulatory Compliance User Consent Data Encryption Third-Party Integration User Awareness

NHE7 upregulation potentiates the uptake of small extracellular vesicles by enhancing maturation of macropinosomes in hepatocellular carcinoma

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Cancer Communications 2024年第2期44卷 251-272页

作者： Yue Yao Yi Xu Liang Yu Ting-Mao Xue Zhi-Jie Xiao Pui-Chi Tin Hiu-Ling Fung Hoi-Tang Ma Jing-Ping Yun judy Wai Ping Yam Department of Pathology School of Clinical MedicineLi Ka Shing Faculty of MedicineThe University of Hong KongHong KongP.R.China Department of Endocrinology and Metabolism Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China Department of Hepatopancreatobiliary Surgery Second Affiliated Hospital of Harbin Medical UniversityHarbinHeilongjingP.R.China State Key Laboratory of Oncology in South China Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China Department of Hepatobiliary Surgery II Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdongP.R.China Scientific Research Center The Seventh Affiliated HospitalSun Yat-sen UniversityShenzhenGuangdongP.R.China State Key Laboratory of Liver Research The University of Hong KongHong KongP.R.China Department of Pathology Cancer Center of Sun Yat-sen UniversityGuangzhouGuangdongP.R.China

Background:Small extracellular vesicles(sEVs)mediate intercellular commu-nication that contributes to hepatocellular carcinoma(HCC)progression via multifaceted *** success of cell entry determines the effect of sEV on recipient ***,we aimed to delineate the mechanisms underlying the uptake of sEV in ***:AF,Alexa Fluor;ANOVA,analysis of variance;ATP9A,ATPase Phospholipid Transporting 9A;BCECF-AM,2’,7’-bis-(2-barboxyethyl)-5-(and-6)-carboxyfluorescein,acetoxymethyl ester;BSA,bovine serum albumin;CCMR,Centre for Comparative Medicine Research;CRISPR,clustered regularly interspaced short palindromic repeats;CTL,ctrl;CXCR4,C-X-C Chemokine Receptor Type 4;DAPI,4′,6-diamidino-2-phenylindole;DFS,disease-free survival;DMEM,Dulbecco’s Modified Eagle Medium;DMSO,dimethyl sulfoxide;Dox,doxycycline;EEA1,early endosome antigen 1;EIPA,5-(N-ethyl-N-isopropyl)-amiloride;FBS,fetal bovine serum;FITC,fluorescein isothiocyanate;GAPDH,glyceraldehyde-3-phosphate dehydrogenase;GM130,Golgi matrix protein 130;HCC,hepatocellular carcinoma;HEPES,4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid;HPRT1,hypoxanthine phosphoribosyltransferase 1;H-score,histoscore;IAA,indole-3-acetic acid;KD,knockdown;KO,knockout;mAID,mini-auxin-inducible degron;MTT,3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide;NHE7,Na(+)/H(+)exchanger 7;ns,non-significant;OD,optical density;OS,overall survival;PBS,phosphate-buffered saline;PCR,polymerase chain reaction;pHe,endosomal pH;pHi,intracellular pH;PKH67,Paul Karl Horan 67;Rab21,Ras-associated binding protein 21;RIPA,radioimmunoprecipitation assay;SAM,synergistic activation mediator;SEMs,standard error of the means;sEVs,small extracellular vesicles;sgRNA,single-guide RNA;shRNA,short-hairpin RNA;SLC9,solute carrier gene 9;SLiCE,Seamless Ligation Cloning Extract;TCGA,The Cancer Genome Atlas;TCL,total cell lysates;TGN,trans-Golgi network;TMA,tissue microarray;TMR,tetramethyl rhodamine;TSG101,tumor susceptibility gene *** Yao an

关键词： hepatocellular carcinoma small extracellular vesicles macropinocytosis pH regulation sodium-hydrogen exchanger

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转基因番木瓜生物育种现状与展望

中国科学:生命科学 2024年第10期54卷 1863-1873页

作者：贾瑞宗 ZHU Yun judy 刘标郭安平中国热带农业科学院热带生物技术研究所中国热带农业科学院三亚研究院/海南省南繁生物安全与分子育种重点实验室生态环境部南京环境科学研究所

转基因番木瓜于1998年被允许商业化生产,是世界上第一例被允许商业化生产的热带水果,目前已在多个国家广泛种植.当前所有的转基因番木瓜主要是基于致病菌衍生抗性原理,通过RNA沉默途径,使入侵的病毒不能够复制从而导致病毒的群体下降.... 详细信息

转基因番木瓜于1998年被允许商业化生产,是世界上第一例被允许商业化生产的热带水果,目前已在多个国家广泛种植.当前所有的转基因番木瓜主要是基于致病菌衍生抗性原理,通过RNA沉默途径,使入侵的病毒不能够复制从而导致病毒的群体下降.本文回顾了转基因番木瓜的研究进展,并对转基因番木瓜抗病毒策略、遗传转化体系、功能基因挖掘、生物育种技术研发和转基因番木瓜生物安全评价进行了讨论.本篇综述还重点分析了番木瓜生物安全的其他相关问题,如异壳体化病毒、重组、合成、基因飘逸、对非靶标生物的影响、食品安全以及各种可能的致敏性等.通过对这些问题的综述与探讨,为开展我国具有自主知识产权的热带水果的生物技术育种提供理论支持

关键词：转基因番木瓜生物育种抗病毒

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未来使者

上海服饰 2024年第6期 4-5页

作者： judy

在科技的浪潮中，鎏金短裙如同未来世界的使者，其以独特的光泽和设计展现出现代与时尚的完美融合。它不仅是一件服饰，还是科技与艺术的结晶，每一寸布料都透露着创新与前卫。鎏金如同流淌在短裙上的液态阳光，它们在光线的折射下闪烁...

在科技的浪潮中，鎏金短裙如同未来世界的使者，其以独特的光泽和设计展现出现代与时尚的完美融合。它不仅是一件服饰，还是科技与艺术的结晶，每一寸布料都透露着创新与前卫。鎏金如同流淌在短裙上的液态阳光，它们在光线的折射下闪烁着金属的光泽，仿佛将整个时代的辉煌都凝聚在裙摆之上。短裙的剪裁简洁而有力，它紧贴着身体的曲线，展现出穿着者的活力与自信。裙摆随着步伐轻轻摆动，如同电流在导线中穿梭，每一次摇曳都是一场动感的展示。

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