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Management of Testicular Cancers in Brazzaville

Open Journal of Urology 2024年第5期14卷 324-332页

作者： Roland Bertile Banga-Mouss Yanick Dimi Nyanga Brice Nkoua Epala Armel Melvin Atipo Ondongo Steve Aristid Ondziel-Opara Eliane Ndounga Alexis Bolenga Louis Constant Mbele Mantsouaka judith nsonde malanda Aanani Séverin Wencesl Odzébé Prosper Alain Bouya Departement of Urology and Andrology University Hospital of Brazzaville Brazzaville Republic of the Congo Departement of Medicale Oncology and Radiotherapy University Hospital of Brazzaville Brazzaville Republic of the Congo

Introduction: Testicular cancer accounts for 5% of urological tumors, predominantly affecting young men. The aim of our study was to report the diagnostic and evolutionary aspects of testicular cancer cases treated in our center. Patients and Methods: A retrospective study conducted over a 15-year period involving 12 patients treated for testicular cancer at the University Hospital of Brazzaville. Results: The median age was 31 years (range 11 to 49 years), with a median consultation delay of 10.6 months (range 3 to 27 months). Scrotal mass was the most common reason for consultation. Cancer was bilateral in two patients. Two patients were admitted with metastatic disease. Histopathological examination favored germ cell tumors in 7 cases, two cases of non-Hodgkin’s malignant lymphoma, and one case of epididymo-testicular adenocarcinoma. Adjuvant chemotherapy resulted in complete remission in patients with germ cell tumors. However, neoadjuvant chemotherapy was not effective in patients admitted with advanced-stage disease. Conclusion: Testicular cancer is a rare condition that is curable in the majority of cases, but its management is often complicated in our setting due to delayed diagnosis caused by taboos surrounding genital organ pathologies.

关键词： Testicular Cancer Germ Cell Tumor Cisplatin Testicular Lymphoma Testicular Adenocarcinoma

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Management of Testicular Cancers in Brazzaville

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Open Journal of Urology（泌尿学期刊） 2024年第5期 324页

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Immunoscreening of Alpha-Tocopherol in Breast, Prostate Cancers and in Gestational Choriocarcinoma Tissues

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CellBio 2021年第2期10卷 11-21页

作者： Henriette Poaty Franck Arnaud Moukobolo Kinsangou Alexis F. Bolenga Liboko judith nsonde malanda Michel Geffard Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo National Research Institute on Health Sciences (IRSSA) Brazzaville Congo Oncology Service Teaching hospital Brazzaville Congo Institut pour le Développement de la Recherche en Pathologie Humaine et Thérapeutique Talence France

Background: Many literature reviews report vitamin E supplementation as a benefit chemopreventive and adjuvant therapy in breast and prostate cancers. We investigated in the present work, alpha-tocopherol (α-T) expression (the current active form of vitamin E) from tissues of Congolese patients neither smokers nor alcohol drinkers and without intake antioxidant vitamins supplement. Methods: α-T was analysed in one normal placenta of nine weeks of gestation and in nineteen cancerous tissues, including seven breast cancers, six prostate cancers, and six gestational choriocarcinomas. The study was performed by immunohistochemistry method after diagnosis confirmation by histological analysis. Results: α-T staining in membrane cells and collagen fibers presented a moderate expression in healthy sections of tissues (positive control), but the labelling was strong in breast, prostate adenocarcinomas, and in choriocarcinomas. Conclusion: Tumors immunohistochemistry of α-tocopherol in breast, prostate cancers and in choriocarcinoma show elevated immunostaining suggesting a probable oncogenic effect of the micronutrient.

关键词： Vitamin E Alpha-Tocopherol Immunohistochemistry Breast Cancer Prostate Cancer Choriocarcinoma

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