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Feasibility of a finger prick-based self-testing kit in first- and second-degree relatives of children with coeliac disease

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World Journal of Gastroenterology 2011年第14期17卷 1840-1843页

作者： judith pichler Matthias Zilbauer Franco Torrente Robert Heuschkel Alan Phillips Camilla Salvestrini Department of Paediatrics and Adolescent Medicine Medical University of Vienna1090 ViennaAustria Department of Paediatric Gastroenterology Addenbrooke's HospitalCambridge CB2 0QQUnited Kingdom Centre for Paediatric Gastroenterology Royal Free HospitalLondon NW3 2QGUnited Kingdom

AIM:To assess feasibility of a finger prick-based kit as method for self-testing of first and second-degree relatives of coeliac disease (CD) patients. METHODS:A total number of 379 subjects were invited to participate in this study,consisting of 197 first- degree and 182 second-degree relatives of CD patients. The self-testing kit (BiocardTM) was sent out with included instructions for use. Completed tests were sent back to the study coordinator for assessment. RESULTS:One hundred and ninety-six invited relatives carried out the BiocardTM test at home. Amongst these,70% were children. In 97% of the cases the test was performed correctly. Three tests revealed a positive result,all of which were later confirmed by serology and histology as coeliac disease.CONCLUSION:Our study indicates that BiocardTM test is a reliable,easy to use and well-accepted tool for home testing of first- and second-degree relatives of CD patients.

关键词：检测试剂盒第一代腹腔学位疾病儿童手指测试评估

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Growth and bone health in paediatric patients with Crohn's disease receiving subcutaneous tumor necrosis factor antibody

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World Journal of Gastroenterology 2015年第21期21卷 6613-6620页

作者： judith pichler Wolf Dietrich Huber Christoph Aufricht Bettina Bidmon-Fliegenschnee Department of Paediatric and Adolescent Medicine Medical University Vienna

AIM:To study whether adalimumab(ADA) was associated with improvement in growth,bone mineraldensity(BMD) and bone metabolism.METHODS:In children with Crohn's disease(CD) there is a high prevalence of growth failure and reduced BMD.Treatment with infliximab is associated with an improvement in growth.Anthropometry,paediatric CD activity index(PCDAI),bone markers and BMD was measured in 18 patients(72% females) one year before and after start of ADA with a median age of 14.4 years(range:5-19 years) at treatment start.Outcomes were indicators of growth with treatment as well as interval growth.RESULTS:Eleven(61%) children experienced catchup growth after ADA.PCDAI significantly decreased from 52.1 ± 16 to 30.4 ± 23(P ≤ 0.001).Post ADA,body mass index(BMI) standard deviation score(SDS) 0.1[range:2.7-(-0.8)] vs-1 [range:0.1-(-3.6)],P = 0.04 and △BMI SDS in children 0.3 [range:0.7-(-0.2)] vs-1.1 [range:1.2-(-2.3)],P = 0.01 in remission were significantly higher compared to those with moderate to severe inflammation.The main predictors for growth were 25-hydroxycholecalciferol and for bone mineralisation weight and height SDS.ADA had no significant influence on bone markers and BMD.CONCLUSION:Next to improvement of PCDAI,half of the children achieved a positive catch-up growth.A better nutritional status with improvement in BMI and weight is positive predictor for improved growth and bone mineralisation.

关键词： Crohn's disease Adalimumab Growth Bone health Paediatrics

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