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Laparoscopic liver resection: Current role and limitations

World Journal of Gastrointestinal Oncology 2012年第8期4卷 187-192页

作者： Rouzbeh Mostaedi Zoran Milosevic ho-Seong Han Vijay P Khatri Department of Surgery University of California Davis Cancer Center University of CaliforniaDavis Medical Center Sacramento CA 95817 United States Clinic for Abdominal Endocrine and Transplantation Surgery Clinical Center Vojvodina21000 Novi Sad Serbia Department of Surgery Seoul National University Bundang Hospital Seoul National University College of Medicine300 Gumi-dong Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

Laparoscopic liver resection (LLR) for the treatment of benign and malignant liver lesions is often performed at specialized centers. technological advances, such as laparoscopic ultrasonography and electrosurgical tools, have afforded surgeons simultaneous improvements in surgical technique. the utilization of minimally invasive techniques for liver resection has been reported to reduce operative time, decrease blood loss, and shorten length of hospital stay with equivalent postoperative mortality and morbidity rates compared to open liver resection (OLR). Non-anatomic liver resection and left lateral sectionectomy are now routinely performed laparoscopically at many institutions. Furthermore, major hepatic resections are performed by pure laparoscopy, hand-assisted technique, and the hybrid method. In addition, robotic surgery and single port surgery are revealing early promising results. the consensus recommendation for the treatment of benign liver disease and malignant lesions remains unchanged when considering a laparoscopic approach, except when comorbidities and anatomic limitations of the liver lesion preclude this technique. Disease free and survival rates after LLR for hepatocellular carcinoma and metastatic colon cancer correspond to OLR. Patient selection is a significant factor for these favorable outcomes. the limitations include LLR of superior and posterior liver lesions; however, adjustments in technique may now consider a laparoscopic approach as a viable option. As growing data continue to reveal the feasibility and efficacy of laparoscopic liver surgery, this skill is increasingly being adopted by hepatobiliary surgeons. Although the full scope of laparoscopic liver surgery remains infrequently used by many general surgeons, this technique will become a standard in the treatment of liver diseases as studies continue to show favorable outcomes.

关键词： Laparoscopic liver resection Laparoscopic hepatectomy Minimally invasive liver surgery Handassisted technique Hybrid technique

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Gastric mucin expression in Helicobacter pylori-related, nonsteroidal anti-inflammatory drug-related and idiopathic ulcers

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World Journal of Gastroenterology 2012年第33期18卷 4597-4603页

作者： Doron Boltin marisa Halpern Zohar Levi Alex Vilkin Sara Morgenstern Samuel B ho Yaron Niv Department of Gastroenterology Rabin Medical Center Tel Aviv University Petah Tikva 49100 Israel Department of Pathology Rabin Medical Center Hasharon Hospital Petah Tikva 49100 Israel Department of Pathology Rabin Medical Center Beilinson Hospital Petah Tikva 49100 Israel Department of Medicine University of California and VA San Diego Healthcare System San Diego CA 92161 United States

AIM: to determine the pattern of secreted mucin expression in Helicobacter pylori (H. pylori)-related, nonsteroidal anti-inflammatory drug (NSAID)-related and idiopathic gastric ulcers. MEthoDS: We randomly selected 92 patients with H. pylori-associated (n = 30), NSAID-associated (n = 18), combined H. pylori and NSAID-associated gastric ulcers (n = 24), and patients with idiopathic gastric ulcers (n = 20). Immunohistochemistry for t-cell CD4/CD8, andfor mucin 5AC (MUC5AC) and mucin 6 (MUC6), was performed on sections of the mucosa from the ulcer margin. Inflammation score was assessed according to the Sydney system. RESULtS: MUC5AC was expressed on the surface epithelium (98.9%) and neck glands (98.9%) with minimal expression in the deep glands (6.5%). MUC6 was strongly expressed in the deep glands (97.8%), variable in the neck glands (19.6%) and absent in the surface epithelium (0%). the pattern of mucin expression in idiopathic ulcer margins was not different from the expression in ulcers associated with H. pylori, NSAIDs, or combined H. pylori and NSAIDs. CD4/CD8 ratio was higher in H. pylori-positive patients (P = 0.009). Idiopathic ulcers are associated with hospitalized patients and have higher bleeding and mortality rates. CONCLUSION: Idiopathic ulcers have a unique clinical profile. Gastric mucin expression in idiopathic gastric ulcers is unchanged compared with H. pylori and/or NSAID-associated ulcers.

关键词： Idiopathic ulcer Mucin Mucin 5AC Mucin 6 Helicobacter pylori

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Bioengineered miR-27b-3p and miR-328-3p modulate drug metabolism and disposition via the regulation of target ADME gene expression

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Acta Pharmaceutica Sinica B 2019年第3期9卷 639-647页

作者： Xin Li Ye tian Mei-Juan tu Pui Yan ho Neelu Batra Ai-Ming Yu Key Laboratory of Molecular target&Clinical Pharmacology School of Pharmaceutical Sciences&the Fifth Affiliated HospitalGuangzhou Medical UniversityGuangzhou511436China Lab for Bone Metabolism Key Lab for Space Biosciences and BiotechnologySchool of Life SciencesNorthwestern PolytechnicalUniversityXi'an710072China Department of Biochemistry&Molecular Medicine UC Davis School of MedicineSacramentoCA95817USA

Drug-metabolizing enzymes, transporters, and nuclear receptors are essential for the absorption, distribution, metabolism, and excretion(ADME) of drugs and xenobiotics. MicroRNAs participate in the regulation of ADME gene expression via imperfect complementary Watson–Crick base pairings with target transcripts. We have previously reported that Cytochrome P450 3A4(CYP3A4) and AtP-binding cassette sub-family G member 2(ABCG2) are regulated by miR-27b-3p and miR-328-3p,respectively. Here we employed our newly established RNA bioengineering technology to produce bioengineered RNA agents(bera), namely bera/miR-27b-3p and bera/miR-328-3p, via fermentation. When introduced into human cells, bera/miR-27b-3p and bera/miR-328-3p were selectively processed to target miRNAs and thus knock down CYP3A4 and ABCG2 mRNA and their protein levels,respectively, as compared to cells treated with vehicle or control RNA. Consequently, bera/miR-27b-3p led to a lower midazolam 10-hydroxylase activity, indicating the reduction of CYP3A4 activity. Likewise,bera/miR-328-3p treatment elevated the intracellular accumulation of anticancer drug mitoxantrone, a classic substrate of ABCG2, hence sensitized the cells to chemotherapy. the results indicate that biologic miRNA agents made by RNA biotechnology may be applied to research on miRNA functions in the regulation of drug metabolism and disposition that could provide insights into the development of more effective therapies.

关键词： Bioengineered RNA miR-27b miR-328 CYP3A4 ABCG2 Drug disposition

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Large ferro-pyro-phototronic effect in 0.5Ba(Zr_(0.2)ti_(0.8))O_(3)-0.5(Ba_(0.7)ca_(0.3))tiO_(3)thin films integrated on silicon for photodetection

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carbon Energy 2023年第6期5卷 1-10页

作者： JoséP.B.Silva Katarzyna Gwozdz Luís S.marques mario Pereira maria J.M.Gomes judith L.macmanus‐Driscoll Robert L.Z.hoye Centre of Physics of Universities of Minho and Porto(CF‐UM‐UP) University of MinhoBragaPortugal Laboratory of Physics for materials and Emergent technologies LapMETUniversity of MinhoBragaPortugal Department of Quantum technologies Faculty of Fundamental Problems of TechnologyWroclaw University of Science and TechnologyWroclawPoland Department of materials Science and Metallurgy CambridgeUK Inorganic Chemistry Laboratory Department of ChemistryUniversity of OxfordOxfordUK Department of materials Imperial College LondonLondonUK

Coupling together the ferroelectric,pyroelectric,and photovoltaic characteristics within a single material is a novel way to improve the performance of *** this work,we take advantage of the triple multifunctionality shown by 0.5Ba(Zr_(0.2)ti_(0.8))O_(3)-0.5(Ba_(0.7)ca_(0.3))tiO_(3)(BCZt),as demonstrated in an Al/Si/SiOx/BCZt/ItO thin-film *** Si/SiOx acts as an n-type layer to form a metal-ferroelectric-insulator-semiconductor heterostructure with the BCZt,and with Al and ItO as *** photo-response of the device,with excitation from a violet laser(405 nm wavelength),is carefully investigated,and it is shown that the photodetector performance is invariant with the chopper frequency owing to the pyro-phototronic effect,which corresponds to the coupling together of the pyroelectric and photovoltaic ***,the photodetector performance was significantly better than that of the devices operating based only on the pyro-phototronic effect by a factor of 4,due to the presence of ferroelectricity in the ***,after a poling voltage of−15 V,for a laser power density of 230mW/cm^(2)and at a chopper frequency of 400Hz,optimized responsivity,detectivity,and sensitivity values of 13.1ma/W,1.7×10^(10)Jones,and 26.9,respectively,are ***,ultrafast rise and fall times of 2.4 and 1.5μs,respectively,are obtained,which are 35,000 and 36,000 times faster rise and fall responses,respectively,than previous reports of devices with the ferro-pyro-phototronic *** is understood based on the much faster ferroelectric switching in ferroelectric thin films owing to the predominant 180°domains in a single direction out of plane.

关键词： ferroelectric ferro-pyro-phototronic effect photodetector polarization-controlled response

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Protein misfolding in neurodegenerative diseases:implications and strategies

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translational Neurodegeneration 2017年第1期6卷 37-49页

作者： Patrick Sweeney Hyunsun Park marc Baumann John Dunlop judith Frydman Ron Kopito Alexander Mccampbell Gabrielle Leblanc Anjli Venkateswaran Antti Nurmi Robert hodgson Discovery Services Charles Rivers LaboratoriesWilmingtonMAUSA Royal Veterinary College University of LondonLondonUK Health&Life Science Consulting Los AngelesCAUSA Biochemistry and Developmental Biology University of HelsinkiHelsinkiFinland Neuroscience Innovation Medicines Astra ZenecaCambridgeMAUSA Stanford University StanfordCAUSA Neurology Biogen IdecCambridgeMAUSA Leblanc Bioscience Consulting BerkeleyCAUSA

A hallmark of neurodegenerative proteinopathies is the formation of misfolded protein aggregates that cause cellular toxicity and contribute to cellular proteostatic *** options are currently being explored that target different steps in the production and processing of proteins implicated in neurodegenerative disease,including synthesis,chaperone-assisted folding and trafficking,and degradation via the proteasome and autophagy *** therapies,like mtOR inhibitors and activators of the heat shock response,can rebalance the entire proteostatic ***,there are major challenges that impact the development of novel therapies,including incomplete knowledge of druggable disease targets and their mechanism of action as well as a lack of biomarkers to monitor disease progression and therapeutic response.A notable development is the creation of collaborative ecosystems that include patients,clinicians,basic and translational researchers,foundations and regulatory agencies to promote scientific rigor and clinical data to accelerate the development of therapies that prevent,reverse or delay the progression of neurodegenerative proteinopathies.

关键词： Neurodegeneration Proteostasis Mouse models Biomarkers Chaperones Drug discovery

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Label-free detection of single nanoparticles and biological molecules using microtoroid optical resonators

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Light(Science & Applications) 2016年第1期5卷 863-868页

作者： judith Su Alexander FG Goldberg Brian M Stoltz Division of Biology and Biological Engineering California Institute of TechnologyPasadenaCAUSA Divison of Chemistry and Chemical Engineering California Institute of TechnologyPasadenaCAUSA

Single-molecule detection is one of the fundamental challenges of modern *** experiments often use labels that can be expensive,difficult to produce,and for small analytes,might perturb the molecular events being *** size plays an important role in determining *** we use laser-frequency locking in the context of sensing to improve the signal-to-noise ratio of microtoroid optical resonators to the extent that single nanoparticles 2.5 nm in radius,and 15.5 kDa molecules are detected in aqueous solution,thereby bringing these detectors to the size limits needed for detecting the key macromolecules of the *** results,covering several orders of magnitude of particle radius(100 nm to 2 nm),agree with the‘reactive’model prediction for the frequency shift of the resonator upon particle *** confirms that the main contribution of the frequency shift for the resonator upon particle binding is an increase in the effective path length due to part of the evanescent field coupling into the adsorbed *** anticipate that our results will enable many applications,including more sensitive medical diagnostics and fundamental studies of single receptor–ligand and protein–protein interactions in real time.

关键词： biosensing frequency locking label-free microtoroid single molecule

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Status of the chiral magnetic effect and collisions of isobars

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Chinese Physics C 2017年第7期41卷 1-13页

作者： Volker Koch Soeren Schlichting Vladimir Skokov Paul Sorensen Jim thomas Sergei Voloshin Gang Wang ho-Ung Yee Nuclear Science Division Lawrence Berkeley National Laboratory Berkeley CA 94720 USA Department of Physics University of Washington Seattle WA 98195-1560 USA RIKEN/BNL Brookhaven National Laboratory Upton NY 11973 USA Wayne State University 666 W. Hancock Detroit MI 48201 USA Department of Physics and Astronomy University of California Los Angeles California 90095 USA Department of Physics University of Illinois Chicago Illinois 60607 USA

In this review, we examine the current theoretical and experimental status of the chiral magnetic *** discuss possible future strategies for resolving uncertainties in interpretation including recommendations for theoretical work, recommendations for measurements based on data collected in the past five years, and recommendations for beam use in the coming years of RHIC. We specifically investigate the case for colliding nuclear isobars（nuclei with the same mass but different charge） and find the case compelling. We recommend that a program of nuclear isobar collisions to isolate the chiral magnetic effect from background sources be placed as a high priority item in the strategy for completing the RHIC mission.

关键词： chiral magnetic effect heavy ion collisions QCD

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machine learning guided discovery of ternary compounds involving La and immiscible Co and Pb elements

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npj Computational materials 2022年第1期8卷 2462-2470页

作者： Renhai Wang Weiyi Xia tyler JSlade Xinyu Fan Huafeng Dong Kai-Ming ho Paul C.canfield cai-Zhuang Wang School of Physics and Optoelectronic Engineering Guangdong University of Technology510006GuangzhouChina Department of Physics and Astronomy Iowa State UniversityAmesIA50011USA Ames Laboratory-USDOE Iowa State UniversityAmesIA50011USA Department of Physics University of Science and Technology of China230026HefeiChina

ternary compounds with an immiscible pair of elements are relatively unexplored but promising for novel quantum materials *** what third element and its ratio that can be added to make stable ternary compounds out of an immiscible pair of elements remains a great *** this work,we combine a machine learning(ML)method with ab initio calculations to efficiently search for the energetically favorable ternary La-Co-Pb compounds containing immiscible elements Co and *** previously reported structures are correctly captured by our ***,we predict a ground state La_(3)CoPb compound and 57 low-energy La-Co-Pb ternary *** to synthesize La_(3)CoPb via multiple techniques produce mixed or multi-phases samples with,at best,ambiguous signals of the predicted lowest-energy La_(3)CoPb and the second lowest-energy La_(18)Co_(28)Pb_(3)*** calculated results of Gibbs free energy are consistent with experiments,and will provide very useful guidance for further experimental synthesis.

关键词： elements immiscible ternary

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Neutrophil-to-lymphocyte ratio and carbohydrate antigen 19-9 as prognostic markers for advanced pancreatic cancer patients receiving first-line chemotherapy

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World Journal of Gastrointestinal Oncology 2021年第8期13卷 915-928页

作者： Kabsoo Shin Eun-Kyo Jung Se Jun Park Sangwoon Jeong In-ho Kim Myung-ah Lee Division of Medical Oncology Department of Internal MedicineSeoul St.Mary's HospitalCollege of MedicineThe Catholic University of KoreaSeoul 06591South Korea catholic cancer Research Institute College of MedicineThe Catholic University of KoreaSeoul 06591South Korea

BACKGROUND A decline in serum carbohydrate antigen 19-9(ca19-9)levels during systemic chemotherapy is considered as a prognostic marker for patients with advanced pancreatic ***-to-lymphocyte ratio(NLR)has been extensively studied as a simple and useful indicator of prognosis in various cancers including pancreatic *** to assess the prognostic significance of NLR and ca19-9 in patients with advanced pancreatic adenocarcinoma received first-line chemotherapy according to ca19-9 *** We retrospectively analyzed patients diagnosed with advanced pancreatic cancer who received first-line chemotherapy between January 2010 and July 2017 at the catholic University of Seoul ***’s *** were divided according to ca19-9 positivity(ca19-9-positive vs-negative groups)and pre-and posttreatment NLR *** determine cut-off value of NLR and ca19-9 reduction,time-dependent receiver operating characteristic curve was *** evaluated overall survival(OS)and progression-free survival(PFS)for each group using Kaplan-Meier method,and we performed multivariate analyses on the entire *** We included 271 patients in this ***-off value of NLR and ca19-9 reduction was determined as 2.62 and 18%.Multivariate analysis showed that post-treatment NLRtion of≥18%of baseline ca19-9 were significantly associated with OS and ***-treatment NLR≥2.62 showed hazard ratio(HR)of 2.47[95%confidence interval(CI):1.84-3.32,Pca19-9 decline(≥18%)showed HR of 0.51(95%CI:0.39-0.67,Pca19-9-positive patients were divided into groups according to ca19-9 response(responder vs non-responder)and post-treatment NLR(ca19-9 responder and post-treatment NLRhowed better survival than ca19-9 non-responder and post-treatment NLR≥2.62 group(OS 11.0 mo vs 3.9 mo,Pthe combination of ca19-9 decline and post-treatment NLR showed a significant c

关键词： Pancreatic adenocarcinoma Serum carbohydrate antigen 19-9 Neutrophil-tolymphocyte ratio Multivariate analysis Prognosis Chemotherapy

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Metal intercalation-induced selective adatom mass transport on graphene

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Nano Research 2016年第5期9卷 1434-1441页

作者： Xiaojie Liu cai-Zhuang Wang Myron Hupalo Hai-Qing Lin Kai-Ming ho Patricia A. thiel Michael C. tringides Center for Quantum Science and School of Physics Northeast Normal University Changchun 730777 China Ames Laboratory-U.S. Department of Energy and Department of Physics and Astronomy Iowa State University Ames IA 50011 USA Beijing Computational Science Research Center Beijing 100084 China Ames Laboratory-U.S. Department of Energy Department of Chemistry and Department of Materials Science and Engineering Iowa State University Ames IA 50011 USA

Recent experiments indicate that metal intercalation is a very effective method to manipulate the graphene-adatom interaction and control metal nanostructure formation on graphene. A key question is mass transport, i.e., how atoms deposited uniformly on graphene populate different areas depending on the local intercalation. Using first-principles calculations, we show that partially intercalated graphene, with a mixture of intercalated and pristine areas, can induce an alternating electric field because of the spatial variations in electron doping, and thus, an oscillatory electrostatic potential. this alternating field can change normal stochastic adatom diffusion to biased diffusion, leading to selective mass transport and consequent nucleation, on either the intercalated or pristine areas, depending on the charge state of the adatoms.

关键词： graphene intercalation electrostatic potential selective adsorption first-principle calculation

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