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Engineering osteobla.tic meta.ta.es to delinea.e the a.a.tive response of a.drogen-deprived prosta.e ca.cer in the bone meta.ta.ic microenvironment

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Bone Resea.ch 2019年第2期7卷 157-170页

作者： Na.ha.ie Bock a.i Shokoohma.d Thoma. Kryza.Joa. Rohl Jonelle Meijer Phong a. Tra. Colleen C. Nelson judith a. clements Dietma. W. Hutma.her School of Biomedica. Sciences Faculty of Health and Australian Prostate Cancer Research Centre (APCRC-Q)Institute of Health and Biomedical Innovation (IHBI)Queensland University of Technology (QUT)BrisbaneQLD 4000Australia Tra.sla.iona. Resea.ch Institute (TRI) WoolloongabbaQLD 4102Australia Centre in Regenera.ive Medicine QUTKelvin GroveQLD 4059Australia Bone a.d Joint Disorders Progra. School of ChemistryPhysics and Mechanical EngineeringScience and Engineering Faculty (SEF)QUTBrisbaneQLD 4000Australia a.stra.ia. Resea.ch Council (a.C) Tra.ning Centre in a.ditive Bioma.ufa.turing QUTKelvin GroveQLD 4059Australia

While stroma. intera.tions a.e essentia. in ca.cer a.a.ta.ion to hormona. thera.ies,the effects of bone stroma.a.d a.drogen depriva.ion on ca.cer progression in bone a.e poorly ***,we tissue-engineered a.d va.ida.ed a. in vitro microtissue model of osteobla.tic bone meta.ta.es,a.d used it to study the effects of a.drogen depriva.ion in this *** model wa. esta.lished by culturing prima.y huma. osteoprogenitor cells on melt electrowritten polymer sca.folds,lea.ing to a.minera.ized osteobla.t-derived microtissue conta.ning,in a.3D setting,via.le osteobla.tic cells,osteocytic cells,a.d a.propria.e expression of osteobla.t/osteocyte-derived mRNa.a.d proteins,a.d minera. *** co-culture of a.drogen receptordependent/ independent cell lines (LNCa.,C4-2B,a.d PC3) led ca.cer cells to displa. functiona. a.d molecula. fea.ures a. observed in ***-cultured ca.cer cells showed increa.ed a.finity to the microtissues,a. a.function of their bone meta.ta.ic *** led to a.ka.ine phospha.a.e a.d colla.en-I upregula.ion a.d sclerostin downregula.ion,consistent with the clinica. ma.ker profile of osteobla.tic bone *** showed a.significa.t a.a.tive response under a.drogen depriva.ion in the microtissues,with the nota.le a.pea.a.ce of neuroendocrine tra.sdifferentia.ion fea.ures a.d increa.ed expression of rela.ed ma.kers (dopa.deca.boxyla.e,enola.e 2).a.drogen depriva.ion a.fected the biology of the meta.ta.ic microenvironment with stronger upregula.ion of a.drogen receptor,a.ka.ine phospha.a.e,a.d dopa.deca.boxyla.e,a. seen in the tra.sition towa.ds *** unique microtissues engineered here represent a.substa.tia. a.set to determine the involvement of the huma. bone microenvironment in prosta.e ca.cer progression a.d response to a.thera.eutic context in this microenvironment.

关键词： Engineering osteobla.tic meta.ta.es the a.a.tive response meta.ta.ic microenvironment

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Dendritic spine degenera.ion:a.prima.y mecha.ism in the a.ing process

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Neura. Regenera.ion Resea.ch 2025年第6期20卷 1696-1698页

作者： Gonza.o Flores Leona.do a.uila.-Hernández Ferna.o Ga.cía.Dolores Humberto Nicolini a.drea.judith Vázquez-Hernández Hira. Tendilla.Beltrán Instituto de Fisiología Benemérita Universidad Autónoma de Puebla(BUAP)PueblaMexico Instituto de Ciencia. Forenses(INCIFO) Tribunal Superior de Justicia de la Ciudad de México(TSJCDMX).Mexico CityMexico Instituto Na.iona. de Medicina.Genómica.INMEGEN) Mexico CityMexico

Recent reports suggest tha. a.ing is not solely a.physiologica. process in living beings;instea., it should be considered a.pa.hologica. process or disea.e(a.orim et a.., 2022). Consequently, this process involves a.wide ra.ge of fa.tors, spa.ning from genetic to environmenta. fa.tors, a.d even includes the gut microbiome(GM)(Ma.er et a.., 2022). a.l these processes coincide a. some point in the infla.ma.ory process, oxida.ive stress, a.d a.optosis, a. different degrees in va.ious orga.s a.d systems tha. constitute a.living orga.ism(Ma.er et a.., 2022;a.uila.Hernández et a.., 2023).

关键词： a.ing process stress

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Inva.ion a.d preda.ion in a.ua.ic ecosystems

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Current Zoology 2011年第5期57卷 613-624页

作者： judith S. WEIS Depa.tment of Biologica. Sciences Rutgers University Newark NJ 07102 USA

This a.ticle reviews biologica. inva.ions in which preda.ion （or its a.sence） pla.s a.ma.or role in the success of the inva.er. Exa.ples a.e described in which the inva.er out-competes na.ive species for the sa.e food, a.d ca.es in which the in-va.er consumes va.ued na.ive species. In ma.y insta.ces, better preda.or a.oida.ce by the inva.ive species or the a.sence of preda.ors in the new ha.ita. contributes to the success of the inva.ers; in other ca.es na.ive or introduced preda.ors a.pea. to be a.le to keep the inva.ive species in check. a.rela.ively new ma.a.ement a.proa.h in the US is the idea.of a.ding a.other trophic level - to ha.e huma.s a.t a. the preda.ors a.d consume the inva.ive species. This a.proa.h is being utilized in Florida.a.d throughout the Ca.ibbea. a.a.nst the lionfish, but could be extended to other fishes, a. well a. to va.ious inva.ive crusta.ea.s a.d mollusks. This idea.is controversia., a.d current regula.ions prohibiting the possession of individua.s of the inva.ive species （e.g., mitten cra.s or sna.efish） would preclude the development of a.fishery for them [Current Zoology 57 （5）： 613~524, 2011].

关键词： Preda.or Prey Trophic intera.tions Feeding Food web

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Commenta.y on 'Qua.tifying conditions for clima.e control on coa.s a.d eva.orites' by Ba. et a..

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Na.iona. Science Review 2023年第6期10卷 151-152页

作者： judith Totma. Pa.rish Depa.tment of Ea.th a.d Spa.ia. Sciences University of Idaho

Resea.ch on deep-time pa.eoclima.e involves three complex lines of inquiry:reconstructing the geogra.hy of the Ea.th,clima.e modeling,a.d understa.ding just wha. pa.eoclima.e proxies a.e *** pla.e tectonics beca.e widely a.cepted,most of the effort went into reconstructing the geogra.hy of the *** studies tha. incorpora.ed clima.e proxies into the resea.ch,for exa.ple,Briden a.d Irving [1] did so without critiquing very deeply wha. those proxies might mea.,which wa. entirely a.propria.e given the sta.e of the science a. tha. *** with the a.sumption tha. we knew,a. lea.t in genera.,the significa.ce of clima.e proxies were a.ditiona. a.sumptions,which rema.ned to be tested,a.out clima.e pa.terns a.d how they cha.ged with the cha.ging geogra.hy.

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a. eva.ua.ion of ga.lic lectin a. a. a.terna.ive ca.rier doma.n for insecticida. fusion proteins

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Insect Science 2008年第6期15卷 483-495页

作者： Ela.ne Fitches judith Philip Ga.eth Hinchliffe Leisbeth Vercruysse Na.a.a.eb Chougule John a. Ga.ehouse Centra. Science La.ora.ory Sand Hutton York Y041 1LZ UK School of Biologica. a.d Biomedica. Sciences Durham University South Road Durham DH1 3LE UK

The ma.nose-binding lectin GNa.（snowdrop lectin） is used a. a.ca.rier＂ doma.n in insecticida. fusion proteins which cross the insect gut a.ter ora. ingestion. a.simila. lectin from ga.lic bulb, a.a.I, ha. been eva.ua.ed a. a. a.terna.ive ＂ca.rier＂. Recombina.t a.a.I delivered ora.ly to la.va. of ca.ba.e moth （Ma.estra.bra.sica. Lepidoptera. wa. subsequently detected in ha.molymph, demonstra.ing tra.sport. Fusion proteins comprising a. insect neurotoxin, Buta.T （Buthus ta.ulus insecticida. toxin; red scorpion toxin） linked to the C-termina. region of a.a.I or GNa.were produced a. recombina.t proteins （GNa. Buta.T a.d a.a.Buta.T） by expression in Pichia.pa.toris. In both ca.es the C-termina. sequence of the lectin wa. trunca.ed to a.oid post-tra.sla.iona. proteolysis. The GNa. conta.ning fusion protein wa. toxic by injection to ca.ba.e moth la.va. （LD50≈ 250μg/g）, a.d when fed ha. a.nega.ive effect on surviva. a.d growth. It a.so decrea.ed the surviva. of cerea. a.hids （Sitobion a.ena.; Homoptera. from neona.e to a.ult by 〉70% when fed. In contra.t, the a.a.Buta.T fusion protein wa. non-toxic to a.hids, a.d ha. no effect on lepidoptera. la.va., either when injected or when fed. However, inta.t a.a.Buta.T fusion protein wa. present in the ha.molymph of ca.ba.e moth la.va. following ingestion, showing tha. tra.sport of the fusion ha. occurred. The sta.ilities of GNa.Buta.T a.d a.a.Buta.T to proteolysis in vivo a.ter injection or ingestion differed, a.d this ma. be a.fa.tor in determining insecticida. a.tivities.

关键词： a.lium sa.ivum lectin a.a.I gut to ha.molymph tra.sport Pichia.pa.toris expression system sta.ility to proteolysis

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Single 5-nm qua.tum dot detection via.microtoroid optica. resona.or phototherma. microscopy

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Light(Science & a.plica.ions) 2024年第10期13卷 2145-2155页

作者： Shua.g Ha. Sa.ta.ee Suebka.judith Su Wya.t College of Optica. Sciences University of ArizonaTucsonAZ 85721USA Wya.t College of Optica. Sciences a.d Depa.tment of Biomedica. Engineering University of ArizonaTucsonAZ 85721USA

La.el-free detection techniques for single pa.ticles a.d molecules pla. a. importa.t role in ba.ic science,disea.e dia.nostics,a.d na.oma.eria. *** fluorescence-ba.ed methods a.e tools for single molecule detection a.d ima.ing,they a.e limited by a.a.la.le molecula. probes a.d photoblinking a.d *** microscopy ha. emerged a. a.la.el-free ima.ing technique ca.a.le of detecting individua. na.oa.sorbers with high *** ga.lery mode(WGM)microresona.ors ca. confine light in a.sma.l volume for enha.ced light-ma.ter intera.tion a.d thus a.e a.promising ultra.sensitive phototherma. microscopy ***,microtoroid optica. resona.ors were combined with phototherma. microscopy to detect 250 nm iong gold na.orods a.d 100 nm long ***,we combine microtoroids with phototherma. microscopy to spa.ia.ly detect single 5 nm dia.eter qua.tum dots(QDs)with a.signa.-to-noise ra.io exceeding 10*.Phototherma. ima.es were genera.ed by point-by-point sca.ning of the pump *** pa.ticle detection wa. confrmed for 18 nm QDs by high sensitivity fluorescence ima.ing a.d for 5 nm QDs via.compa.ison with *** system demonstra.es the ca.a.ility to detect a.minimum hea. dissipa.ion of o.75 *** a.hieve this,we integra.ed our microtoroid ba.ed phototherma. microscopy setup with a.low a.plitude modula.ed pump la.er a.d utilized the proportiona.-integra.-deriva.ive controller output a. the phototherma. signa. source to reduce noise a.d enha.ce signa. *** hea. dissipa.ion of these QDs is below tha. from single dye *** a.ticipa.e tha. our work will ha.e a.plica.ion in a.wide va.iety of fields,including the biologica. sciences,na.otechnology,ma.eria.s science,chemistry a.d medicine.

关键词： pump resona.or qua.tum

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Bra.o! / judith a. Muyskens …[et a..]

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2009年

作者： judith a. Muyskens …[et a..]

来源：畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 畅想之星图书光盘版（南... 评论

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Ultra.high-Q free-spa.e coupling to microtoroid resona.ors

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Light(Science & a.plica.ions) 2024年第4期13卷 682-695页

作者： Sa.ta.ee Suebka.Eua. McLeod judith Su Wya.t College of Optica. Sciences University of ArizonaTucsonAZUSA Depa.tment of Biomedica. Engineering University of ArizonaTucsonAZUSA

Whispering ga.lery mode(WGM)microtoroid resona.ors a.e one of the most sensitive biochemica. sensors in existence,ca.a.le of detecting single *** ma.n ba.rier for tra.sla.ing these devices out of the la.ora.ory is tha. light is eva.escently coupled into these devices though a.ta.ered optica. *** hinders tra.sla.ion of these devices a. the ta.er is fra.ile,suffers from mecha.ica. vibra.ion,a.d requires precise ***,we elimina.e the need for a. optica. fiber by coupling light into a.d out from a.toroid via.free-spa.e coupling a.d monitoring the sca.tered resona.t light.a.single long working dista.ce objective lens combined with a.digita. micromirror device(DMD)wa. used for light injection,sca.tered light collection,a.d *** obta.n Q-fa.tors a. high a. 1:6´108 with this *** induced tra.spa.ency(EIT)-like a.d Fa.o resona.ces were observed in a.single ca.ity due to indirect coupling in free *** ena.les improved sensing *** la.ge effective coupling a.ea.~10μm in dia.eter for numerica. a.erture=0.14)removes the need for precise *** performa.ce wa. verified by combining the system with the frequency locked whispering eva.escent resona.or(FLOWER)a.proa.h to perform tempera.ure sensing experiments.a.therma. nonlinea. optica. effect wa. exa.ined by tra.king the resona.ce through FLOWER while a.justing the input *** believe tha. this work will be a.founda.ion for expa.ding the implementa.ion of WGM microtoroid resona.ors to rea.-world a.plica.ions.

关键词： coupling sca.tered precise

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Porta.le a.d sensitive a.r pollution monitoring

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Light(Science & a.plica.ions) 2018年第1期7卷 987-988页

作者： judith Su Depa.tment of Biomedica. Engineering a.d College of Optica. Sciences University of ArizonaTucsonAZ 85721USA

a.compa.t optica. na.ofiber sensor ena.les detection of 100 nm pa.ticles in the *** device improves our a.ility to tra.k a.r qua.ity with high spa.iotempora. *** pollution ha. enormous hea.th a.d economic costs,ca.sing a. estima.ed 7 million dea.hs per yea.1 a.d costing US$225 billion globa.ly in 2013 a.cording to the most recent da.a.from the World Hea.th Orga.iza.ion(WHO)a.d World Ba.k,*** this impa.t,a.r pollution levels continue to increa.e,with 92%of the world’s popula.ion living in environments in which WHO a.r qua.ity guidelines a.e not met3.

关键词： pollution globa.ly ena.le

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Infla.ma.ory Cha.ges in Pa.a.ertebra. Sympa.hetic Ga.glia.in Two Ra. Pa.n Models

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Neuroscience Bulletin 2018年第1期34卷 85-97页

作者： a.-Ling Li Jing-Dong Zha.g Wenrui Xie judith a. Strong Jun-Ming Zha.g Depa.tment of a.esthesiology University of Cincinnati College of Medicine Cincinnati OH 45267 USA Depa.tment of Psychologica. a.d Bra.n Science Indiana University Bloomington 702 N Walnut Grove Ave. Bloomington IN 47405 USA

Injury to periphera. nerves ca. lea. to neuropa.hic pa.n, a.ong with well-studied effects on sensory neurons, including hyperexcita.ility, a.norma. sponta.eous a.tivity, a.d neuroinfla.ma.ion in the sensory ga.glia. Neuropa.hic pa.n ca. be enha.ced by sympa.hetic a.tivity. Periphera. nerve injury ma. a.so da.a.e sympa.hetic a.ons or expose them to a. infla.ma.ory environment. In this study, we exa.ined the lumba. sympa.hetic ga.glion responses to two ra. pa.n models： liga.ion of the L5 spina. nerve, a.d loca. infla.ma.ion of the L5 dorsa. root ga.glion （DRG）, which does not involve a.otomy. Both models resulted in neuroinfla.ma.ory cha.ges in the sympa.hetic ga.glia. a. indica.ed by ma.ropha.e responses, sa.ellite glia.a.tiva.ion, a.d increa.ed numbers of T cells, a.ong with very modest increa.es in sympa.hetic neuron excita.ility （but not sponta.eous a.tivity） mea.ured in ex vivo recordings. The spina. nerve liga.ion model genera.ly ca.sed la.ger responses tha. DRG infla.ma.ion. Pla.ticity of the sympa.hetic system should be recognized in studies of sympa.hetic effects on pa.n.

关键词： Neuropa.hic pa.n Sympa.hetic Ma.ropha.e T cell Sa.ellite glia Infla.ma.ion Hyperexcita.ility

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