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Speak Up! Fostering Oral Communication in the English Classroom Through Dialogic Musical Meetings

Sino-US English Teaching 2019年第4期16卷 143-151页

作者： judit Palencia Gutiérrez University of California Riverside United States

This study, carried out in Spain in 2016, proposes new dialogical pedagogy techniques based on deeply rooted in constructivism to improve the level of English education in Spanish high schools. Spain is the second worst country in the European Union when it comes to English command, especially with regards to oral output, as a consequence of several factors, such as the deficient preparation of teachers, cuts in the education budget or dubbed films. This paper will present the outcomes of a Second Language Acquisition innovation project carried out in the North of Spain. After analyzing data collected to study their low command of the language, the participants, more than 20 students from the Spanish equivalent for US high school 10th grade, performed tasks that prepared them with insight and training to then participate in a musical meeting, where they, without the intervention of the teacher, listened to English music and discussed in the targeted language about some songs and their lyrics. These meetings were recorded to posteriori analysis with the students.

关键词： Second Language Acquisition oral competence English instruction dialogic learning

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匈牙利Nanushka游击店

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现代装饰 2012年第4期 60-63页

作者： Daniel Balo Zsofi Dobos Dora Medveczky judit Emese Konopas Noemi Varga Tamas Bujnovszky 代照

2011年Nanushka秋冬系列新的零售空间位于布迭佩斯形式精心挑选了一堆充满热情的毕业生。最后设计师选定DanielBalo、ZsofiaDobos、DoraMedvecz时、duditEmeseKonopas DNoemiVarga。他们来自于不同的大学．第一次通力合作仅用三周就完... 详细信息

2011年Nanushka秋冬系列新的零售空间位于布迭佩斯形式精心挑选了一堆充满热情的毕业生。最后设计师选定DanielBalo、ZsofiaDobos、DoraMedvecz时、duditEmeseKonopas DNoemiVarga。他们来自于不同的大学．第一次通力合作仅用三周就完成了该项目的设计。

关键词：匈牙利设计师毕业生

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Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic Receptor Tyrosine Kinases

Akt-RSK-S6-kinase Signaling Networks Activated by Oncogenic ...

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“细胞活动生命活力”——中国细胞生物学学会全体会员代表大会暨第十二次学术大会

作者： Albrecht Moritz judit Villen Joan MacNeill Jon Kornhauser Kam Sprott Anthony Possemato Peter Hornbeck Lewis C.Cantley Steven P.Gygi John Rush Michael J.Comb Cell Signaling Technology Inc.Danvers MA 01923 Department of Cell Biology Harvard Medical School BostonMA 02115 Departmcnt of Systems Biology Harvard Medical SchoolBeth Israel Deaconess Medical CenterBostonMA 2115

Receptor tyrosine kinases(RTKs) activate pathways mediated by Ser/Thr kinases such as the PI3K-Akt pathway,the Ras-MAPK-RSK pathway,and the mTOR-p70 s6 pathway that control important aspects of cell growth,proliferation,and *** Akt,RSK,and p70 s6 family of protein kinases transmit signals by phosphorylating substrates on a RxRxxS/T ***,we developed a large-scale proteomic approach to identify over 200 substrates of this kinase family in cancer cell lines driven by the c-Met,

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Human IgG1 antibodies suppress angiogenesis in a target-independent manner

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Signal Transduction and Targeted Therapy 2016年第1期1卷 158-171页

作者： Sasha Bogdanovich Younghee Kim Takeshi Mizutani Reo Yasuma Laura Tudisco Valeria Cicatiello Ana Bastos-Carvalho Nagaraj Kerur Yoshio Hirano judit Z Baffi Valeria Tarallo Shengjian Li Tetsuhiro Yasuma Parthasarathy Arpitha Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Menotti Ruvo Annamaria Sandomenico Miho Nozaki Ryo Ijima Hiroki Kaneko Yuichiro Ogura Hiroko Terasaki Balamurali K Ambati Jeanette HW Leusen Wallace Y Langdon Michael R Clark Kathryn L Armour Pierre Bruhns J Sjef Verbeek Bradley D Gelfand Sandro De Falco Jayakrishna Ambati Department of Ophthalmology and Visual Sciences University of KentuckyLexingtonKYUSA Department of Ophthalmology and Visual Science Nagoya City University Graduate School of Medical SciencesNagoyaJapan Department of Ophthalmology Nagoya University Graduate School of MedicineNagoyaJapan Angiogenesis Lab Institute of Genetics and Biophysics—CNRNaplesItaly Bio-Ker MultiMedica GroupNaplesItaly Department of Advanced Biomedical Sciences University of Naples‘Federico II’NaplesItaly CEINGE—Biotecnologie Avanzate s.c.a.r.l.NaplesItaly Istituto di Biostrutture e Bioimmagini CNRNaplesItaly Department of Ophthalmology and Visual Sciences Moran Eye CenterUniversity of Utah School of MedicineSalt Lake CityUTUSA Department of Ophthalmology Veterans Affairs Salt Lake City Healthcare SystemSalt Lake CityUTUSA Immunotherapy Laboratory Laboratory for Translational ImmunologyUniversity Medical Center UtrechtUtrechtThe Netherlands School of Pathology and Laboratory Medicine University of Western AustraliaCrawleyWAAustralia Division of Immunology Department of PathologyUniversity of CambridgeCambridgeUK Department of Immunology Unit of Antibodies in Therapy and PathologyInstitut PasteurParisFrance Institut National de la Santéet de la Recherche Médicale(INSERM)U1222 ParisFrance Department of Human Genetics Leiden University Medical CenterLeidenThe Netherlands Department of Biomedical Engineering University of KentuckyLexingtonKYUSA Department of Microbiology Immunologyand Molecular GeneticsUniversity of KentuckyLexingtonKYUSA IRCCS MultiMedica MilanoItaly Department of Physiology University of KentuckyLexingtonKYUSA.

Aberrant angiogenesis is implicated in diseases affecting nearly 10%of the world’s *** most widely used antiangiogenic drug is bevacizumab,a humanized IgG1 monoclonal antibody that targets human *** bevacizumab does not recognize mouse Vegfa,it inhibits angiogenesis in *** we show bevacizumab suppressed angiogenesis in three mouse models not via Vegfa blockade but rather Fc-mediated signaling through FcγRI(CD64)and c-Cbl,impairing macrophage *** approved humanized or human IgG1 antibodies without mouse targets(adalimumab,alemtuzumab,ofatumumab,omalizumab,palivizumab and tocilizumab),mouse IgG2a,and overexpression of human IgG1-Fc or mouse IgG2a-Fc,also inhibited angiogenesis in wild-type and FcγR humanized *** anti-angiogenic effect was abolished by Fcgr1 ablation or knockdown,Fc cleavage,IgG-Fc inhibition,disruption of Fc-FcγR interaction,or elimination of FcRγ-initated ***,bevacizumab’s Fc region potentiated its anti-angiogenic activity in humanized VEGFA ***,mice deficient in FcγRI exhibited increased developmental and pathological *** findings reveal an unexpected anti-angiogenic function for FcγRI and a potentially concerning off-target effect of hIgG1 therapies.

关键词： CD64 angiogenesis antibodies

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