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Plasma carnitine ester profile in adult celiac disease patients maintained on long-term gluten free diet

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World Journal of Gastroenterology 2005年第42期11卷 6671-6675页

作者： judit Bene Katalin Komlósi Beáta Gasztonyi Márk Juhász Zsolt Tulassay Béla Melegh Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary MTA PTE Clinical Genetics Research Group of Hungarian Academy of Sciences at the University of Pécs Hungary Department of Medical Genetics and Child Development School of Medicine University of Pécs Hungary 1st Department of Medicine School of Medicine University of Pécs Hungary 2nd Department of Medicine Semmelweis University Budapest Hungary

AIM： To determine the fasting plasma carnitine ester in patients with celiac disease. METHODS： We determined the fasting plasma carnitine ester profile using ESI triple quadrupol mass spectrometry in 33 adult patients with biopsy-confirmed maturity onset celiac disease maintained on long term gluten free diet. RESULTS： The level of free camibine did not differ as the celiac disease patients were compared with the healthy controls, whereas the acetylcarnitine level was markedly reduced （4.703± 0.205 vs 10.227 ± 0.368 nmol/mL, P〈0.01）. The level of propionylcarnitine was 61.5%, butyrylcarnitine 56.9%, hexanoylcarnitine 75%, octanoylcarnitine 71.1%, octenoylcarnitine 52.1%, decanoylcarnitine 73.1%, cecenoylcarnitine 58.3%, lauroylcarnitine 61.5%, miristoylcarnitine 66.7%, miristoleylcarnitine 62.5% and oleylcarnitine 81.1% in the celiac disease patients compared to the control values, respectively （P〈0.01）. CONCLUSION： The marked decrease of circulating acetylcarnitine with 50-80 % decrease of 11 other carnitine esters shows that the carnitine ester metabolism can be influenced even in clinically asymptomatic and well being adult celiac disease patients, and gluten withdrawal alone does not necessarily normalize all elements of the disturbed carnitine homeostasis.

关键词： Plasma carnitine ester profile Celiac disease

Regulation of neuronal survival by DNA methyltransferases

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Neural Regeneration Research 2017年第11期12卷 1768-1775页

作者： judit Symmank Geraldine Zimmer Institute of Human Genetics University Hospital JenaJenaGermany

The limited regenerative capacity of neuronal cells requires tight orchestration of cell death and survival regulation in the context of longevity, age-associated diseases as well as during the development of the nervous system. Subordinate to genetic networks epigenetic mechanisms like DNA methylation and histone modifications are involved in the regulation of neuronal development, function and aging. DNA methylation by DNA methyltransferases （DNMTs）, mostly correlated with gene silencing, is a dynamic and reversible process. In addition to their canonical actions performing cytosine methylation, DNMTs influence gene expression by interactions with histone modifying enzymes or complexes increasing the complexity of epigenetic transcriptional networks. DNMTs are expressed in neuronal progenitors, post-mi- totic as well as adult neurons. In this review, we discuss the role and mode of actions of DNMTs including downstream networks in the regulation of neuronal survival in the developing and aging nervous system and its relevance for associated disorders.

关键词： DNA methyltransferase I cortical interneurons PAK6 neuronal aging neuropsychiatric diseases neurodevelopment neuronal death

Proteomics and the genetics of sperm chromatin condensation

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Asian Journal of Andrology 2011年第1期13卷 24-30页

作者： Rafael Oliva judit Castillo Human Genetics Research Group IDI BAPS Department of Ciencias Fisiologicas I Faculty of Medicine University of Barcelona Barcelona 08036 Spain Biochemistry and Molecular Genetics Service Hospital Clinic i Provincial Barcelona 08036 Spain

Spermatogenesis involves extremely marked cellular, genetic and chromatin changes resulting in the generation of the highly specialized sperm cell. Proteomics allows the identification of the proteins that compose the spermatogenic cells and the study of their function. The recent developments in mass spectrometry （MS） have markedly increased the throughput to identify and to study the sperm proteins. Catalogs of thousands of testis and spermatozoan proteins in human and different model species are becoming available, setting up the basis for subsequent research, diagnostic applications and possibly the future development of specific treatments. The present review intends to summarize the key genetic and chromatin changes at the different stages of spermatogenesis and in the mature sperm cell and to comment on the presently available proteomic studies.

关键词： epigenetic imprinting protamine proteome spermatozoa

LHX1–a multifunctional regulator in preoptic area-derived interneuron development

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Neural Regeneration Research 2019年第7期14卷 1213-1214页

作者： judit Symmank Geraldine Zimmer-Bensch Polyclinic for Orthodontics University Hospital Jena Department of Functional Epigenetics in the Animal Model Institute for Biology ⅡRWTH Aachen University

In the cerebral cortex,local inhibition is achieved by different types of gamma-aminobutyric(GABA)-expressing interneurons,representing essential key players of cortical information processing(Marin,2012).Their development has to be highly orchestrated to ensure proper numbers and subtype composition in the adult cortex and defects in interneuron development contribute to the pathophysiology of psychiatric diseases(Marin,2012).

关键词： cerebral cortex different types gamma-aminobutyric

The Effect of Reaction Conditions on the Synthesis of Thermoplastic Elastomers Containing Polyalloocimene, Polyisobutylene and Tapered Blocks

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Chinese Journal of Polymer Science 2019年第9期37卷 884-890页

作者： Jozsef Kantor judit E. Puskas Gabor Kaszas Department of Chemical and Biomolecular Engineering The University of Akron Akron OH 44325 USA Department of Food Agricultural and Biological Engineering (1/1/2019) The Ohio State University Wooster OH 44691 USA PolyFiberMatrix LLC 2295 W. Market St. Suite D. Akron OH 44313 USA

This work investigates the effect of reaction conditions on the copolymerization of isobutylene (IB) with alloocimene (Allo) in methyl chloride (MeCl) using AlCh and ethylaluminum dichloride (EtAlCh) as coinitiators and adventitious moisture as the initiator. Both AlCh and EtAlCb produced high molecular weight (Mn > 1.0 x 10^5 g/mol) thermoplastic elastomers (TPEs) with good mechanical properties in short reaction time (< 10 min). These unique TPEs have unsaturations in the end blocks, leading to easy functionalization and/or crosslinking.

关键词： Polyisobutylene Alloocimene Triblock copolymer Carbocationic polymerization

Deactivation of Streptococcus mutans Biofilms on a Tooth Surface Using He Dielectric Barrier Discharge at Atmospheric Pressure

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Plasma Science and Technology 2013年第6期15卷 535-541页

作者： Imola MOLNAR judit PAPP Alpar SIMON Sorin Dan ANGHEL Babes-Bolyai University Faculty of Biology and GeologyCluj-Napoca 400015Romania Babes-Bolyai University Faculty of PhysicsCluj-Napoca 400084Romania

This paper presents a study of the effect of the low temperature atmospheric helium dielectric barrier discharge（DBD） on the Streptococcus mutans biofilms formed on tooth surface. Pig jaws were also treated by plasma to detect if there is any harmful effect on the *** plasma was characterized by using optical emission *** data indicated that the discharge is very effective in deactivating Streptococcus mutans *** can destroy them with an average decimal reduction time（D-time） of 19 s and about 98%of thein were killed after a treatment time of 30 *** to the survival curve kinetic an overall 32 s treatment time would be necessary to perform a complete *** experimental results presented in this study indicated that the helium dielectric barrier discharge,in plan-parallel electrode configuration,could be a very effective tool for deactivation of oral bacteria and might be a promising technique in various dental clinical applications.

关键词： Streptococcus mutans dielectric barrier discharge plasma treatment biofilm deactivation sterilization

Attention-deficit/hyperactivity disorder and suicide:A systematic review

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World Journal of Psychiatry 2017年第1期7卷 44-59页

作者： judit Balazs Agnes Kereszteny Vadaskert Child and Adolescent Psychiatry Hospital Institute of Psychology Eotvos Loránd University School of Ph.D. Studies Semmelweis University

AIM To investigate suicidality and attention-deficit/hyperactivity disorder(ADHD), this paper aims to systematically review the literature as an extension of previous *** We searched five databases(Ovid MEDLINE, Psychinfo, PubM ed, Scopus, Web of Science) with two categories of search terms:(1) suicide; suicidal; suicide behavior; suicide attempt; suicidal thought; and(2) ADHD. RESULTS The search resulted 26 articles. There is a positive association between ADHD and suicidality in both sexes and in all age groups. Comorbid disorders mediate between suicidality and ADHD. CONCLUSION Recognizing ADHD, comorbid conditions and suicidality is important in prevention.

关键词： Attention-deficit/hyperactivity disorder Suicide Systematic review

Drying of suspensions and solutions on inert particle surface in mechanically spouted bed dryer

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China Particuology 2007年第5期5卷 337-344页

作者： Elisabeth Pallai-Varsányi judit Tóth János Gyenis University of Pannonia Faculty of Information TechnologyResearch Institute of Chemical and Process Engineering Egyetem u. 2H-8200 VeszprémHungary Hungarian Academy of Sciences Chemical Research CentreInstitute of Materials and Environmental ChemistryPusztaszeri u. 59-67H-1025 BudapestHungary

To eliminate some disadvantages of the conventional spouted bed dryers the mechanically spouted bed （MSB） system was developed. This dryer type is convenient to use inert particles providing an increased surface area for drying of materials of high-moisture content and heat sensitive materials. On three different drying tasks are demonstrated the experimental optimization of process parameters to obtain products of demanded quality. The main object was at drying of AIO（OH） suspension to preserve the particle size under 2.5μm and to obtain product with a moisture content of about 0.05 kg/kg （d.b.）. For this reason a very thin particle coating and intensive abrasion had to be assured. At drying of tomato concentrates the thermoplasticity makes the process very difficult. To jump over the deliquescent and sticky state developed at the critical temperature-moisture content values a very short drying time （8-10 s） must be provided. The third task was to form powder-like product from bovine serum albumin （BSA） solution having very low solid content （2-4%）. The selected process parameters given in this paper resulted in a mean particle size of less than 20 μm while the soluble oreserved orotein content was higher than 90%.

关键词： Mechanically spouted bed Film-like drying Inert particles Heat sensitive material

Measurement of serum paraoxonase-1 activity in the evaluation of liver function

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World Journal of Gastroenterology 2009年第16期15卷 1929-1933页

作者： Jordi Camps judit Marsillach Jorge Joven Centre of Biomedical Research University Hospital Sant JoanInstitute of Health Research Pere VirgiliUniversity Rovira i Virgili

Paraoxonase-1 (PON1) is an esterase and lactonase synthesized by the liver and found in the circulation associated with high-density lipoproteins. The physiological function of PON1 seems to be to degrade specific oxidized cholesteryl esters and oxidized phospholipids in lipoproteins and cell membranes. PON1 is, therefore, an antioxidant enzyme. Alterations in circulating PON1 levels have been reported in a variety of diseases involving oxidative stress including chronic liver diseases. Measurement of serum PON1 activity has been proposed as a potential test for the evaluation of liver function. However, this measurement is still restricted to research and has not been extensively applied in routine clinical chemistry laboratories. The reason for this restriction is due to the problem that the substrate commonly used for PON1 measurement, paraoxon, is toxic and unstable. The recent development of new assays with non-toxic substrates makes this proposal closer to a practical development. The present editorial summarizes PON1 biochemistry and function, its involvement with chronic liver impairment, and some aspects related to the measurement of PON1 activity in circulation.

关键词： Lipoproteins Liver cirrhosis Liver function tests Oxidative stress Paraoxonase-1