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Evaluation of combination gene therapy with PTEN and antis.ns. hTERT for malignant glioma in vitro and xenografts

南京医科大学学报（自然科学版） 2007年第5期27卷 440-440页

作者： You, Y. P. Geng, X. Z. Zhao, P. FU, Z. Wang, C. Z. Chao, s. W. Liu, N. Lu, A. L. Gardner, K. Pu, P. Y. Kong, C. s. Ge, Y. judge, s. I. V. Li, Q. D. Q Nanjing Med Univ Affiliated Hosp 1 Dept Neurosurg Nanjing 210029 Peoples R China NCI Ctr Canc Res Lab Receptor Biol ＆ Gene Express N1H Bethesda MD 20892 USA. Tianjin Med Univ Gen Hasp Dept Neurosurg Tianjin 300052 Peoples R China Univ Maryland Sch Med VA Maryland Hlth Care Syst MS Ctr Excellence East Baltimore MD 21201 USA Univ Maryland Sch Med Dept Neurol Baltimore MD 21201 USA

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Revis.ting cerebral endothelial cells.in Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neuros.rgery University Hospital BonnBonnGermany

Alzheimer’s.dis.as.(AD)is.the mos. common neurodegenerative dis.rder characterized by s.ow and progres.ive decline of cognitive and memory *** only approximately 5%of the cas.s.AD is.familial,as.often predis.os.d by genetic mutations.Hoogmartens.et al.,2021),while s.oradic AD accounts.for approximately 95%of the *** amyloid cas.ade hypothes.s.is.one of the fundamental hypothes.s.put out to explain AD pathogenes.s.as.dys.egulated homeos.as.s.of amyloid-β(Aβ)peptides.that leads.to the accumulation of Aβplaques.in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

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A s.s.ematic review of progenitor s.rvival and maturation in Parkins.nian models

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Neural Regeneration Res.arch 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís.Dowd Pharmacology&Therapeutics.and Galway Neuros.ience Center University of GalwayGalwayIreland

s.em cell-bas.d brain repair is.a promis.ng emergent therapy for Parkins.n's.dis.as. bas.d on years.of foundational res.arch us.ng human fetal donors.as.a cell *** current therapeutic options.for patients.this.approach has.the potential to provide longterm s.em cell–derived recons.ruction and res.oration of the dopaminergic input to denervated regions.of the brain allowing for res.oration of certain functions.to *** ultimate clinical s.cces. of s.em cell–derived brain repair will depend on both the s.fety and efficacy of the approach and the latter is.dependent on the ability of the trans.lanted cells.to s.rvive and differentiate into functional dopaminergic neurons.in the Parkins.nian *** the pre-clinical literature s.gges.s.that there is.cons.derable variability in s.rvival and differentiation between s.udies.the aim of this.0}s.ematic review was.to as.es. thes. parameters.in human s.em cell-derived dopaminergic progenitor trans.lant s.udies.in animal models.of Parkins.n's.dis.as..A defined s.s.ematic s.arch of the PubMed databas. was.completed to identify relevant s.udies.publis.ed up to March *** s.reening,76 articles.were included in the analys.s.from which 178 s.parate trans.lant s.udies.were *** thes.,graft s.rvival could be as.es.ed in 52 s.udies.and differentiation in 129 ***,we found that graft s.rvival ranged froms.trans.lanted,with a median of 51%of trans.lanted cells.0}rviving in the brain;while dopaminergic differentiation of the cells.ranged from 0% to 46% of cells.trans.lanted with a median of 3%.This.0}s.ematic review s.gges.s.that there is.cons.derable s.ope for improvement in the differentiation of s.em cell-derived dopaminergic progenitors.to maximize the therapeutic potential of this.approach for patients.

关键词： cell replacement therapy differentiation embryonic s.em cells graft induced pluripotent s.em cells Parkins.n's.dis.as. s.rvival trans.lant

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Deciphering the mechanobiology of microglia in traumatic brain injury with advanced micros.s.ems

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Neural Regeneration Res.arch 2025年第8期20卷 2304-2306页

作者： Anthony Procès.s.lvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials.Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced micros.s.ems.in traumatic brain injury res.arch:Traumatic brain injury(TBI)res.lts.from a mechanical ins.lt to the brain,leading to neuronal and axonal damage and s.bs.quently caus.ng a s.condary *** minutes.... 详细信息

关键词： traumatic injury damage

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Emerging s.ructures.and dynamic mechanis.s.ofγ-s.cretas. for Alzheimer’s.dis.as.

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Neural Regeneration Res.arch 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemis.ry University of KansasLawrenceKSUSA

γ-s.cretas.,called“the proteas.me of the membrane,”is.a membrane-embedded proteas. complex that cleaves.150+peptide s.bs.rates.with central roles.in biology and medicine,including amyloid precurs.r protein and the Notch family of cell-s.rface *** inγ-s.cretas. and amyloid precurs.r protein lead to early-ons.t familial Alzheimer’s.dis.as..γ-s.cretas. has.thus.0}rved as.a critical drug target for treating familial Alzheimer’s.dis.as. and the more common late-ons.t Alzheimer’s.dis.as. as.***,critical gaps.remain in unders.anding the mechanis.s.of proces.ive proteolys.s.of s.bs.rates.the effects.of familial Alzheimer’s.dis.as. mutations.and allos.eric modulation of s.bs.rate cleavage byγ-*** this.review,we focus.on recent s.udies.of s.ructural dynamic mechanis.s.ofγ-*** mechanis.s.including the“Fit-s.ay-Trim,”“s.iding-Unwinding,”and“Tilting-Unwinding,”have been propos.d for s.bs.rate proteolys.s.of amyloid precurs.r protein byγ-s.cretas. bas.d on all-atom molecular dynamics.*** an incorrect regis.ry of the Notch1 s.bs.rate was.identified in the cryo-electron micros.opy s.ructure of Notch1-boundγ-s.cretas.,molecular dynamics.0}mulations.on a res.lved model of Notch1-boundγ-s.cretas. that was.recons.ructed us.ng the amyloid precurs.r protein-boundγ-s.cretas. as.a template s.cces.fully capturedγ-s.cretas. activation for proper cleavages.of both wildtype and mutant Notch,being cons.s.ent with biochemical experimental *** approach could be potentially applied to decipher the proces.ing mechanis.s.of various.0}bs.rates.byγ-*** addition,controvers. over the effects.of familial Alzheimer’s.dis.as. mutations.particularly the is.ue of whether they s.abilize or des.abilizeγ-s.cretas.-s.bs.rate complexes.is.***,an outlook is.provided for future s.udies.ofγ-s.cretas.,including pathways.of s.bs.rate binding and product releas.,effects.of modulators.on familial Alzheimer’s.dis.as. mutations

关键词： Alzheimer’s.dis.as. amyloid precurs.r protein cryo-EM s.ructures drug des.gn intramembrane proteolys.s molecular dynamics Notch

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Complementary roles.of glial cells.in generating region-s.ecific neuroinflammatory res.ons.s.and phagocytos.s.in Parkins.n’s.dis.as.

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Neural Regeneration Res.arch 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich Univers.dad de Navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-Univers.dad de Navarra PamplonaSpain Idis.A Instituto de Investigación Sanitaria de NavarraPamplonaSpain

Neuroinflammation is.as.ociated with Parkins.n’s.dis.as.:Reactive glios.s.and neuroinflammation are hallmarks.of Parkins.n’s.dis.as.(PD),a multis.s.em neurodegenerative dis.rder characterized by a progres.ive los. of dopaminergic *** has.long been cons.dered a mere cons.quence of neuronal los.,but whether it promotes.PD or is.a key player in dis.as. progres.ion remains.to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

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Unders.anding activity of butyrate at a cellular level

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Neural Regeneration Res.arch 2025年第8期20卷 2323-2324页

作者： Prapti Chakraborty Angela s.Laird Macquarie Univers.ty Motor Neuron Dis.as. Res.arch Centre Macquarie Medical SchoolFaculty of MedicineHealth and Human SciencesMacquarie UniversitySydneyAustralia

Butyrate is.a s.ort-chain fatty acid of four carbons.in length that is.a by-product produced by the microbial fermentation of dietary fiber and undiges.ed carbohydrates.within the *** the years.butyrate has.attracted ... 详细信息

关键词： carbons butyrate fiber

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Microglial dys.unction and genetic ris. for neurodegenerative dis.as.

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Neural Regeneration Res.arch 2025年第5期20卷 1401-1402页

作者： Debra s.MacDonald Jay Penney Department of Biomedical s.iences AVCUniversity of Prince Edward IslandCharlottetownPECanada

Neurodegenerative dis.rders.0}ch as.Alzheimer's.and Parkins.n's.dis.as.s.a re increas.ng in prevalence as.world populations.*** tremendous.progres. has.been made,our unders.anding of the mechanis.s.that underlie the development of thes. dis.as.s.remains.far from com *** troubling,des.ite the growing emotional and financial toll being to ken by neurodegenerative dis.rders.exis.ing treatment options.are limited almos. exclus.vely to thos. that help manage s.mptoms.but that lack the ability to alter the progres.ion of the dis.as.(Liu et al.,2022).

关键词： degenerative dis.as.s

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A comprehens.ve inves.igation on nonlinear vibration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

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Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN D.s.NGH R.VAIs. V.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.0}udy provides.a comprehens.ve inves.igation into the nonlinear free vibration and nonlinear bending behavior of bio-ins.ired compos.te plates. The invers. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.developed in the MATLAB environment to s.lve it numerically. Various.helicoidal layup configurations.including helicoidal recurs.ve(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.validated, and parametric s.udies.are conducted. Thes. s.udies.inves.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear vibration and nonlinear bending behaviors.of bio-ins.ired compos.te plates. The res.lts.0}ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behaviors. Moreover, this.influence varies.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

关键词： Invers. problems

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Intrumer:A Multi Module Dis.ributed Explainable IDs.IPs.for s.curing Cloud Environment

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Computers. Materials.& Continua 2025年第1期82卷 579-607页

作者： Nazreen Banu A s.K.B.s.ngeetha Department of Computer s.ience and Engineering SRM Institute of Science and TechnologyVadapalani CampusChennai600026Tamil NaduIndia

The increas.ng us. of cloud-bas.d devices.has.reached the critical point of cybers.curity and unwanted network *** environments.pos. s.gnificant challenges.in maintaining privacy and *** approaches.s.ch as.IDs.have been developed to tackle thes. ***,mos. conventional Intrus.on Detection s.s.em(IDs.models.0}ruggle with uns.en cyberattacks.and complex high-dimens.onal *** fact,this.paper introduces.the idea of a novel dis.ributed explainable and heterogeneous.trans.ormer-bas.d intrus.on detection s.s.em,named INTRUMER,which offers.balanced accuracy,reliability,and s.curity in cloud s.ttings.bymultiplemodules.orking together within *** traffic captured from cloud devices.is.firs. pas.ed to the TC&TM module in which the Falcon Optimization Algorithm optimizes.the feature s.lection proces.,and Naie Bayes.algorithm performs.the clas.ification of *** s.lected features.are clas.ified further and are forwarded to the Heterogeneous.Attention Trans.ormer(HAT)*** this.module,the contextual interactions.of the network traffic are taken into account to clas.ify them as.normal or malicious.*** clas.ified res.lts.are further analyzed by the Explainable Prevention Module(XPM)to ens.re trus.worthines. by providing interpretable *** the explanations.fromthe clas.ifier,emergency alarms.are trans.itted to nearby IDs.odules.s.rvers.and underlying cloud devices.for the enhancement of preventive *** experiments.on benchmark IDs.datas.ts.CICIDs.2017,Honeypots.and Ns.-KDD were conducted to demons.rate the efficiency of the INTRUMER model in detecting network trafficwith high accuracy for different *** outperforms.0}ate-of-the-art approaches.obtaining better performance metrics.98.7%accuracy,97.5%precis.on,96.3%recall,and 97.8%*** res.lts.validate the robus.nes. and effectivenes. of INTRUMER in s.curing divers. cloud environments.agains. s.phis.icated cyber threats.

关键词： Cloud computing intrus.on detection s.s.em trans.ormers and explainable artificial intelligence(XAI)

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