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20Mn5锻件密集型缺陷分析及预防措施

大型铸锻件 2024年第3期 42-45页

作者：杨德生张佳丽王炜祁庆花康娟娟兰州兰石集团有限公司铸锻分公司甘肃兰州730314

某钢厂冶炼材质为20Mn5的20 t钢锭,经锻造开坯超声检测后发现密集型缺陷。通过化学成分分析、低倍检测、金相显微分析、能谱分析及THERCAST软件进行数值模拟,对密集型缺陷的产生原因进行了分析研究,并提出了预防措施。结果表明:裂纹附... 详细信息

某钢厂冶炼材质为20Mn5的20 t钢锭,经锻造开坯超声检测后发现密集型缺陷。通过化学成分分析、低倍检测、金相显微分析、能谱分析及THERCAST软件进行数值模拟,对密集型缺陷的产生原因进行了分析研究,并提出了预防措施。结果表明:裂纹附近灰色物质为MnS夹杂物。通过优化冶炼工艺,加强过程控制,得到了合格的钢锭。

关键词： 20Mn5钢密集型缺陷夹杂物

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面向西北地区冬季采暖的交直流双路输入电锅炉可行性研究

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微型电脑应用 2024年第8期40卷 126-129页

作者：杨剑锋徐文涛张志龙康娟娟顾鸿博国网宁夏综合能源服务有限公司宁夏银川750001 国网宁夏电力有限公司宁夏银川750001

我国西北地区因冬季寒冷,对取暖的需求更大,因此电锅炉的使用越加频繁,但是输电走廊用地越来越紧缺。基于这种情况,提出对西北地区交直流线路进行优化,使其可以直接输入电锅炉。为了解决输电线路的混合电场问题,对混合电场的各种参数和... 详细信息

我国西北地区因冬季寒冷,对取暖的需求更大,因此电锅炉的使用越加频繁,但是输电走廊用地越来越紧缺。基于这种情况,提出对西北地区交直流线路进行优化,使其可以直接输入电锅炉。为了解决输电线路的混合电场问题,对混合电场的各种参数和影响条件进行分析,建立模型进行测量电场数据。实验数据选取西北地区近几年冬季的气温,基于气温、离子迁移率、起晕场强等分析各种情况下线路的情况,计算冬季并行线路混合电场的分布情况和冬季并行路线合成电场的数据,证明了研究的可行性,以及交流线路会对直流合成电场产生一定的屏蔽作用。

关键词：混合电场合成电场交直流输电线路冬季用电线路模型

Use of a 6-miRNA panel to distinguish lymphoma from reactive lymphoid hyperplasia

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2478-2480页

作者： juanjuan kang Sisi Yu Song Lu Guohui Xu Jiang Zhu Na Yan Delun Luo Kai Xu Zhihui Zhang Jian Huang Center for Informational Biology University of Electronic Science and Technology of China611731 ChengduChina Sichuan Cancer Hospital&Institute Sichuan Cancer CenterSchool of MedicineUniversity of Electronic Science and Technology of China610041 ChengduChina Innovative Institute of Chinese Medicine and Pharmacy Chengdu University of Traditional Chinese Medicine611137 ChengduChina Research Center Chengdu Nuoen GenomicsLtd.610041 ChengduChina

Dear Editor,Lymphoma is a systemic malignancy originating from the lymphatic system,and it accounts for 3–4%of all *** the United States,lymphoma is ranked 5th among the top causes of cancer deaths,and an estimated 80,500 new cases were diagnosed in 2017.1 Successful treatment relies largely on the correct diagnosis and subclassification of lymphoma in surgically excised biopsies based on cell morphology,immunophenotyping,flow cytometry,in situ fluorescent hybridization,and molecular ***,the ability to distinguish between reactive lymphoid hyperplasia(RLH)and lymphoma is not an easy *** routine pathology practice,lymph nodes in formalin-fixed paraffin-embedded(FFPE)sections show reactive changes more frequently than malignant *** the analysis,many reactive changes display atypical features and often mimic lymphoma,making these benign changes difficult to distinguish from malignant changes.2 New biomarkers that will address this challenge are urgently needed in clinical practice.

关键词： lymphoma lymphoid routine

亚临界水提取固相分散萃取净化测定人参中皂苷含量

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食品工业 2024年第1期45卷 240-245页

作者：李建民莫慧娟沈海波康卷娟刘善鑫张连钢 JIN Wenli ZHANG Jinglei 甘肃省嘉峪关市食品药品和医疗器械检验检测中心嘉峪关735100 不详

为建立一种人参及其制品中人参皂苷的提取方法和检测方法,优化亚临界水提取条件,固相分散萃取填料种类、材料的使用条件。以400 kPa、240℃亚临界水提取,得到提取液后,利用聚乙烯吡咯烷酮(PLS)填料以固相分散萃取的方式富集其中的皂苷... 详细信息

为建立一种人参及其制品中人参皂苷的提取方法和检测方法,优化亚临界水提取条件,固相分散萃取填料种类、材料的使用条件。以400 kPa、240℃亚临界水提取,得到提取液后,利用聚乙烯吡咯烷酮(PLS)填料以固相分散萃取的方式富集其中的皂苷类化合物,以5 mL甲醇洗脱目标物,进入液相色谱检测。结果显示,在添加质量分数分别为0.2,0.5和1.0 g/kg时,亚临界水提取,仅耗时5 min,能将样品中人参皂苷完全提取。加标回收率为90.59%~99.06%,精密度(SRSD)为0.92%~2.53%,小于3%。待测液质量浓度在5~500μg/mL,即人参皂苷含量0.02~4.0 g/kg范围内,线性关系良好,R^(2)大于0.9990。方法检出限在5.68~8.08μg/g,满足微量检测和常量检测的要求。利用亚临界水提取人参样品中的人参皂苷,并结合PLS填料固相分散萃取净化富集样品,液相色谱检测,是一种快捷、高效、准确、稳定、绿色环保的检测方法。

关键词：亚临界水人参皂苷聚乙烯吡咯烷酮固相分散萃取液相色谱

Nanoparticles targeting at methylases with high correlation to N^(6)-methyladenosine-related lncRNA signatures as potential therapy of kidney clear cell carcinoma

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Chinese Chemical Letters 2022年第10期33卷 4610-4616页

作者： Ruixuan Chen Ping Ouyang Licong Su Xi Xu Penghu Lian Yanqin Li Qi Gao Yifan Zhang Sheng Nie Fan Luo Ruqi Xu Xiaodong Zhang Xiaoxi Li Yue Cao Peiyan Gao juanjuan kang Jun Wu Lu Li National Clinical Research Center for Kidney Disease State Key Laboratory of Organ Failure ResearchGuangdong Provincial Clinical Research Center for Kidney DiseaseNanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Health Management Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Department of Urology Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical College(CAMS&PUMC)Beijing 100730China Department of Urology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China Affiliated Foshan Maternity&Child Healthcare Hospital Southern Medical UniversityFoshan 528000China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Department of Radiation Oncology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000China

Clear cell renal cell carcinoma(ccRCC)is a heterogeneous malignancy with poor *** of the N^(6) position of adenosine(m^(6)A),the most common epigenetic modification in both messenger RNAs and noncoding RNAs,has been reported to regulate the initiation and progression of ***,whether and how m^(6)A-related long noncoding RNAs(m^(6)ArlncRNAs)signify the progression of ccRCC remain *** found m^(6)ArlncRNAs are effective signatures illustrating immune landscape and risk stratification in *** identified two differently expressed m^(6)ArlncRNAs(DEm^(6)ArlncRNAs),AC008870.2 and EMX2OS,as independent risk factors for overall survival of ccRCC patients,by applying stringent variable selection procedure to data from the Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma *** risk score generated from the DEm^(6)ArlncRNA expression categorizes patients into either high or low-risk groups,between which,enrichment analysis indicated an enrichment in immune-related *** different DEm^(6)ArlncRNA transcription pattern,the two risk groups differ in immune cell population composition and expression levels of therapy targeting *** is satisfactory strategy to delivering therapeutic *** further clinical translation,we designed a novel nanoparticle delivery system packaged STM2457(STM@8P4 NPs),which selectively inhibits AC008870.2-correlated m^(6)A ***@8P4 NPs loaded drug successfully with uniform particle size,long-term stability and high release ***@8P4 NPs can easily enter ccRCC cells and showed a highly efficient ccRCC killing activity in *** results therefore indicate that m^(6)ArlncRNAs expression can depict tumor microenvironment,predict prognosis for ccRCC patient and give hint to therapeutic strategies in ccRCC.

关键词： Nanoparticle Methylation Long noncoding RNA Clear cell renal carcinoma Immunotherapy

Artificial intelligence and its applications in digital hematopathology

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Blood Science 2022年第3期4卷 136-142页

作者： Yongfei Hu Yinglun Luo Guangjue Tang Yan Huang juanjuan kang Dong Wang Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Dermatology Hospital Southern Medical UniversityGuangzhouChina Cancer Research Institute School of Basic Medical SciencesSouthern Medical UniversityGuangzhouChina Affiliated Foshan Maternity&Child Healthcare Hospital Southern Medical University(Foshan Maternity&Child Healthcare Hospital)FoshanChina

The advent of whole-slide imaging,faster image data generation,and cheaper forms of data storage have made it easier for pathologists to manipulate digital slide images and interpret more detailed biological processes in conjunction with clinical *** parallel,with continuous breakthroughs in object detection,image feature extraction,image classification and image segmentation,artificial intelligence(AI)is becoming the most beneficial technology for high-throughput analysis of image data in various biomedical imaging *** digital images into biological workflows,advanced algorithms,and computer vision techniques expands the biologist’s horizons beyond the microscope ***,we introduce recent developments in AI applied to microscopy in *** give an overview of its concepts and present its applications in normal or abnormal hematopoietic cells *** discuss how AI shows great potential to push the limits of microscopy and enhance the resolution,signal and information content of acquired *** shortcomings are discussed,as well as future directions for the field.

关键词： Artificial intelligence Hematopathology Whole-slide imaging

The metabolic profiling of Chinese yam fermented by Saccharomyces boulardii and the biological activities of its ethanol extract in vitro

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Food Science and Human Wellness 2024年第5期13卷 2718-2726页

作者： Xue Li Yiwen Shao Limin Hao Qiaozhen kang Xiaolong Wang Jiaqing Zhu Changcheng Zhao Yanling Shi Jike Lu juanjuan Yi School of Life Sciences Zhengzhou UniversityZhengzhou 450001China Food Laboratory of Zhongyuan Zhengzhou UniversityLuohe 462300China Systems Engineering Institute Academy of Military Sciences(AMS)Beijing 100010China Henan Yinfeng Biological Engineering Technology Co. Ltd.Zhengzhou 450000China

Chinese yam(Dioscorea opposita Thunb.),as one of the medicinal and edible homologous plants,is rich in various nutrients and functional *** this study,Chinese yam fermented by Saccharomyces boulardii was performed to investigate its bioactive components and metabolic *** then,the main bioactive components and biological activities of fermented Chinese yam ethanol extract(FCYE)were *** showed that there were 49 up-regulated metabolites and 52 down-regulated metabolites in fermented Chinese yam compared to unfermented Chinese ***,corresponding metabolic pathways analysis initially revealed that the distribution of bioactive substances was concentrated on alcoholsoluble small molecular ***,the total polyphenol content and the total flavonoid content in FCYE were significantly increased,and the corresponding antioxidant and immunomodulatory activities in vitro were also significantly *** study provided a new reference for the comprehensive utilization of Chinese yam and laid a theoretical foundation for the development and application of natural probiotic-fermented products.

关键词： Chinese yam Saccharomyces boulardii Metabolites Antioxidant Immunomodulation

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沙参对正常小鼠免疫功能影响的实验研究

北京中医药大学学报 1999年第6期22卷 39-41页

作者：谭允育康娟娟王娟娟北京中医药大学微生物学与免疫学教研室北京100029

观察中药沙参的水煎剂、醇沉液、多糖对正常小鼠免疫功能的影响。结果表明 :10 0 %水煎剂对巨噬细胞 (MΦ)吞噬功能、血清溶菌酶水平、迟发超敏反应 (DTH)有非常显著的促进作用 ;对B细胞增殖也有显著促进作用 ,但对T细胞增殖有非常显著... 详细信息

观察中药沙参的水煎剂、醇沉液、多糖对正常小鼠免疫功能的影响。结果表明 :10 0 %水煎剂对巨噬细胞 (MΦ)吞噬功能、血清溶菌酶水平、迟发超敏反应 (DTH)有非常显著的促进作用 ;对B细胞增殖也有显著促进作用 ,但对T细胞增殖有非常显著抑制作用。 10 %水煎剂对MΦ吞噬功能、DTH有非常显著促进作用。 2 0 %醇沉液对B细胞增殖有非常显著抑制作用。 5 %醇沉液对MΦ吞噬功能、血清溶菌酶水平、DTH有非常显著的促进作用 ,对血清抗体水平有显著的促进作用 ;对B细胞增殖有非常显著的抑制作用。 2 0 %多糖对MΦ吞噬功能有非常显著促进作用 ;对血清抗体水平有显著促进作用 ;对T、B细胞增殖能力均有非常显著抑制作用。 5 %多糖对MΦ吞噬功能有显著促进作用 ,对B细胞增殖有非常显著抑制作用。提示沙参的水煎剂、醇沉液。

关键词：沙参沙参水煎剂沙参醇沉液免疫功能实验研究

Trace Lasso Regularization for Adaptive Sparse Canonical Correlation Analysis via Manifold Optimization Approach

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Journal of the Operations Research Society of China 2024年第3期12卷 573-599页

作者： kang-kang Deng Zheng Peng Beijing International Center for Mathematical Research Peking UniversityBeijing100871China School of Mathematics and Computational Science Xiangtan UniversityXiangtan411105China

Canonical correlation analysis(CCA)describes the relationship between two sets of variables by finding a linear combination that maximizes the correlation ***,in high-dimensional settings where the number of variables exceeds sample size,or in the case that the variables are highly correlated,the traditional CCA is no longer *** this paper,a new matrix regularization is introduced,which is an extension of the trace Lasso in the vector *** we propose an adaptive sparse version of CCA(ASCCA)to overcome these disadvantages by utilizing the trace Lasso *** adaptability of ASCCA is that the sparsity regularization of canonical vectors depends on the sample data,which is more realistic in practical *** ASCCA model is further reformulated to an optimization problem on the Riemannian *** we adopt a manifold inexact augmented Lagrangian method to solve the resulting optimization *** performance of the ASCCA model is compared with some existing sparse CCA techniques in different simulation settings and real datasets.

关键词： Canonical correlation analysis Sparsity of canonical vectors Trace Lasso regularization Manifold optimization