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Evaluation of preoperative blood markers for predicting intraabdominal infection during colorectal cancer resection:A commentary on recent findings

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World journal of Gastrointestinal Surgery 2024年第10期16卷 3371-3373页

作者： Shi-Yan Zhang juan Chen Na Cai Department of Clinical Laboratory Fuding HospitalFujian University of Traditional Chinese MedicineFuding 355200Fujian ProvinceChina

This commentary evaluates the study by Liu et *** study investigates the predictive utility of the neutrophil-lymphocyte ratio,platelet-lymphocyte ratio,systemic immune-inflammation index,and carcinoembryonic antigen levels for post-operative intra-abdominal infection following colorectal cancer(CRC)*** study highlights the critical need for analyzing diverse patient demogra-phics and delves into the potential impact of various confounding factors on the predictive accuracy of these ***,the commentary advocates for the initiation of prospective studies aimed at validating and enhancing the clinical utility of these biomarkers in the context of CRC *** commentary aims to underscore the importance of broadening the research framework to include a wider patient demographic and more comprehensive factor analyses,thereby enriching the predictive model's applicability and relevance in clinical settings.

关键词： Neutrophil-lymphocyte ratio Platelet-lymphocyte ratio Systemic immune-inflammation index Carcinoembryonic antigen Intra-abdominal infection Colorectal cancer Predictive model Nomogram

The HIF-1α/PLoD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo Conan juan Alec C.Bancroft ji Hae Choi Chase A.Pagani Aysel A.Fernandes Michael Woodard juhoon Lee Sowmya Ramesh Aaron W.james David Hudson Kevin N.Dalby Lin Xu Robert j.Tower Benjamin Levi Center for organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research Center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of Chemical Biology and Medicinal Chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

While hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(ECM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(Ho)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPCs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced Ho model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the Ho site,we found that collagen ECM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-CreER^(T2);Hif1a^(fl/fl))significantly mitigated Ho in ***-seq analysis of these Hoxa11-CreER^(T2);Hif1a^(fl/fl)mice identified the PLoD2/LoXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPCs is most highly impacted by HIF-1α*** a translational aspect,a pan-LoX inhibitor significantly decreased Ho.A newly screened compound revealed that the inhibition of PLoD2 activity in MPCssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLoD2/LoX axis linked tometabolism regulates Ho-forming MPC *** results suggest that the HIF-1α/PLoD2/LoX pathway represents a promisingstrategy to mitigate Ho formation.

关键词： metabolism skeletal aberrant

Deficiency of circadian gene Per2 blocks luteolin-induced adipocyte browning in mice through weakening liver PPARα/RXRα/FGF21 pathway

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Food Science and Human Wellness 2024年

作者： Shanshan Shui juan Chen Yan Lin jingjing Yuan Xin Wang Xian Zhang jian Liu Lei Zheng Engineering Research Center of Bio-process， Ministry of Education， Hefei University of Technology Key Laboratory of Health Risk Factors for Seafood of Zhejiang Province， College of Food Science and Pharmacy， Zhejiang ocean University School of Food and Biological Engineering， Hefei University of Technology

During the development of diet-induced obesity， the change of energy matebolism is closely related to the function of the circadian clock in mammals. Luteolin (LU)， one of the most common natural flavonoids riched in many edible plants， can ameliorate obesity by activating adipose tissue browning， but its effect on circadian clock in this process remains poorly understood. Here we found that dietary LU improved circadian misalignment of energy expenditure in high-fat diet (HFD)-fed wild-type (WT) mice. Moreover， dietary LU efficiently elevated UCP1 levels in adipose tissue during the dark period， which was similar to the LU-increased hepatic PER2 expressions. Hepatic PPARα/RXRα/FGF21 pathway was rhythmically elevated by dietary LU in HFD-fed WT mice， whereas the promotion was inhibited in Per2-/-mice. Meanwhile， Per2 deletion abolished the effects of dietary LU on adipose tissue browning in HFD-fed mice. Further， LU treatment directly activated PPARα/RXRα/FGF21 signaling in primary cultured hepatocytes from WT mice rather than Per2-/-mice. Taken together， the deletion of the core clock component Per2 impedes LU-induced adipose tissue browning through weakening PPARα/RXRα/FGF21 pathway in mice， providing a new insight into the interplay of energy metabolism and circadian clock for the anti-obesity activity of LU.

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Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. one sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. one specific inflammasome, the NoD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NoD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NoD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

LonP1 Links Mitochondria–ER Interaction to Regulate Heart Function

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Research 2024年第1期2023卷 595-609页

作者： Yujie Li Dawei Huang Lianqun jia Fugen Shangguan Shiwei Gong Linhua Lan Zhiyin Song juan Xu Chaojun Yan Tongke Chen Yin Tan Yongzhang Liu Xingxu Huang Carolyn K.Suzuki Zhongzhou Yang Guanlin Yang Bin Lu The Affiliated Nanhua Hospital and School of Basic Medical Sciences Hengyang Medical SchoolUniversity of South ChinaHengyangHunan 421001China School of Laboratory Medicine and Life Sciences Wenzhou Medical UniversityWenzhouZhejiang 325035China National Health Commission Key Laboratory of Birth Defect Research and Prevention Hunan Provincial Maternal and Child Health Care HospitalChangshaHunan 410008China Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications Ministry of Education of ChinaLiaoning University of Traditional Chinese MedicineShenyangLiaoning 110847China Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Hubei Key Laboratory of Cell Homeostasis College of Life SciencesWuhan UniversityWuhanHubei 430072China Nanjing Maternity and Child Health Care Hospital Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical UniversityNanjing 210004China Animal Center Wenzhou Medical UniversityWenzhouZhejiang 325035China Department of Cardiology The First Affiliated Hospital of University of South ChinaHengyangHunanChina School of Life Science and Technology Shanghai Tech UniversityShanghai 201210China Department of Microbiology Biochemistry and Molecular GeneticsNew Jersey Medical School-RutgersThe State University of New JerseyNewarkNJUSA State Key Laboratory of Pharmaceutical Biotechnology Department of CardiologyNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical School and MOE Key Laboratory of Model Animal for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China

Interorganelle contacts and communications are increasingly recognized to play a vital role in cellular function and *** particular,the mitochondria–endoplasmic reticulum(ER)membrane contact site(MAM)is known to regulate ion and lipid transfer,as well as signaling and organelle ***,the regulatory mechanisms of MAM formation and their function are still ***,we identify mitochondrial Lon protease(LonP1),a highly conserved mitochondrial matrix protease,as a new MAM tethering *** removal of LonP1 substantially reduces MAM formation and causes mitochondrial ***,deletion of LonP1 in the cardiomyocytes of mouse heart impairs MAM integrity and mitochondrial fusion and activates the unfolded protein response within the ER(UPR^(ER)).Consequently,cardiac-specific LonP1 deficiency causes aberrant metabolic reprogramming and pathological heart *** findings demonstrate that LonP1 is a novel MAM-localized protein orchestrating MAM integrity,mitochondrial dynamics,and UPR^(ER),offering exciting new insights into the potential therapeutic strategy for heart failure.

关键词： offering programming insight

亚太地区社区学习中心建设的成效、挑战与应对

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成人教育 2024年第9期44卷 86-93页

作者：李娟沈岚霞余小娟上海开放大学发展研究部上海200433

挖掘社区潜力、促进终身学习是建设学习型社会的重要举措。亚太地区社区学习中心经过15年的探索实践,实现了从增加社会边缘群体的受教育机会,到促进个体的终身学习及其与社区的联结,再到培养积极的公民意识和促进社会可持续发展的功能拓... 详细信息

挖掘社区潜力、促进终身学习是建设学习型社会的重要举措。亚太地区社区学习中心经过15年的探索实践,实现了从增加社会边缘群体的受教育机会,到促进个体的终身学习及其与社区的联结,再到培养积极的公民意识和促进社会可持续发展的功能拓展,并在建设理念、内容供给、包容参与、加强合作和发展保障等方面形成了共识性实践。同时,为应对生存保障不足、长效机制不足、参与活力不够、认可度不高等挑战,各国正在联合国教科文组织的六项行动原则指导下探索可持续发展策略,包括增强对本土需求的响应、提升从业队伍专业能力、争取社会多方支持、提高社区学习吸引力、探索数字化变革等,为我国进一步完善和推广社区学习中心建设、加快推进实施学习型大国战略提供了可行的方向和策略。

关键词：社区学习中心功能路径挑战可持续发展

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球腔内低雷诺数流体中颗粒输运研究进展

力学学报 2024年第5期56卷 1284-1296页

作者：孙壮陈高峰胡安˙德˙巴勃罗蒋玺恺中国科学院力学研究所非线性力学国家重点实验室北京100190 中国科学院大学工程科学学院北京100049 芝加哥大学普利兹克分子工程学院美国芝加哥60637 阿贡国家实验室材料科学部美国莱蒙特60439

受限环境下低雷诺数流体中的颗粒输运与生物、医药、化工和能源等应用密切相关.近年来,球腔内低雷诺数流体中的颗粒输运引起了广泛关注,它在细胞内生命活动和微流控封装技术中发挥着关键作用.为了掌握颗粒输运规律、揭示微观力学机理,... 详细信息

受限环境下低雷诺数流体中的颗粒输运与生物、医药、化工和能源等应用密切相关.近年来,球腔内低雷诺数流体中的颗粒输运引起了广泛关注,它在细胞内生命活动和微流控封装技术中发挥着关键作用.为了掌握颗粒输运规律、揭示微观力学机理,各国学者进行了广泛的理论、数值和实验研究,取得了一系列成果.本文将梳理当前的研究进展,分别从理论模型、数值模拟和实验研究三方面,介绍关于球腔内低雷诺数流体中颗粒输运的重要工作.理论模型方面,主要工作包括刚性无滑移壁面、边界滑移和可变形壁面等情况下单个及多个颗粒输运的研究;数值模拟方面,重要工作包括模拟不同形状颗粒在静止与旋转球腔内的输运,研究颗粒的水动力迁移率与运动轨迹;实验研究方面,相关工作包含水液滴内颗粒三维轨迹、扩散系数的观测,以及利用球腔内颗粒布朗运动来计算受限环境性质的相关研究.通过总结相关成果,旨在为微纳尺度流动与颗粒输运领域的专家学者提供参考.

关键词：低雷诺数流体颗粒输运限域效应

Comparison of the pathological characteristics of uninjured skin tissues of diabetic rodents and diabetic patients

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中华内分泌外科杂志（中英文） 2024年第3期18卷 339-345页

作者： Du juan Liu Ying Zhu Anfeng Song Dongming Qu Shiguang Yuan Zhixin Emergency Critical and Translational Medicine LaboratoryJilin Province People’s HospitalChangchun 130021China Emergency Medicine Department of General Hospital of Northern Theater Command Laboratory of Rescue Center of Severe Wound and Trauma PLAShenyang 110016China Department of Pathology the Centre Hospital of ChangchunChangchun 130021China Department of Emergency Surgery Jilin Province People’s HospitalChangchun 130021China

objective To study uninjured diabetic skin structure and compare the pathological characteristics of skin tissue from mouse and rat models of diabetes mellitus(DM)and humans with *** Establishing the DM C57BL/6j mice skin tissue models and db/db mice skin tissue models,as well as DM rat skin tissue *** tissues were collected from the animal models and DM *** biopsy specimens were stained with hematoxylin and eosin(HE)staining,Masson trichrome staining and periodic acid-Schiff(PAS)***(1)Skin from mice with streptozotocin(STZ)-induced DM was thinner and had less hair than skin from control *** epidermis had abnormal keratinization and dermal collagen and elastin fibers were dense and significantly atrophied.(2)Compared with the control group,skin tissue from db/db mice was thinner and had less *** was no aberrant keratinization in the epidermis,and dermal collagen and elastin fibres were loose.(3)Skin tissue from rats with STZ-induced DM was significantly thinner than control *** epidermis had mildly abnormal keratinization,and the dermis layer was atrophied and partly *** focal lipofuscin was deposited.(4)Whole skin tissue from patients with diabetes was significantly thinner than skin from subjects without *** epidermis had mild hyper keratinization,and the dermal elastin fibers were atrophied,loose,irregular,and showed focal mucoid *** Uninjured DM skin tissues were thinner and more irregular than normal *** changes in rat DM skin were most like those seen in the skin of patients with DM.

关键词： Diabetes mellitus Skin Human Mouse Rat

社区何以促进终身学习?——基于联合国教科文组织社区学习中心项目运行实践的分析

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职业技术教育 2024年第5期45卷 58-63页

作者：李娟顾凤佳上海开放大学发展研究部上海200433

如何挖掘社区潜能、促进全民终身学习是我国加快建设学习型大国和学习型社会面临的研究课题。联合国教科文组织的社区学习中心项目作为支持各国实施终身学习战略而推出的重要举措,不仅实现了从扩大教育机会为主到促进社会治理、再到促... 详细信息

如何挖掘社区潜能、促进全民终身学习是我国加快建设学习型大国和学习型社会面临的研究课题。联合国教科文组织的社区学习中心项目作为支持各国实施终身学习战略而推出的重要举措,不仅实现了从扩大教育机会为主到促进社会治理、再到促进可持续发展社会的功能拓展,而且形成了系统的运行指导方案,促进各国在运行主体、服务对象、供给内容、合作伙伴、支持保障等方面积累了成功经验,还提出了社区学习中心可持续运行的行动原则。我国需要进一步引导社区学习中心逐步实现功能拓展,优化政府主导、社区主体、多元参与的运行机制,以现代信息技术为支撑赋能社区学习服务创新,加强社区学习中心的特色发展和持续保障。

关键词：社区学习中心终身学习功能路径启示