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某电动汽车减速器微观修形分析

机械工程与自动化 2024年第4期 45-46,49页

作者：曹娟太原城市职业技术学院山西太原030027

新能源电动汽车减速器取代了传统汽车变速器,可以实现汽车的前进、停止、倒退等功能。新能源电动汽车减速器的核心部件是齿轮,齿轮性能的好坏直接影响电动汽车减速器的工作性能。基于Romax软件对新能源电动汽车减速器的齿轮进行了微观分... 详细信息

新能源电动汽车减速器取代了传统汽车变速器,可以实现汽车的前进、停止、倒退等功能。新能源电动汽车减速器的核心部件是齿轮,齿轮性能的好坏直接影响电动汽车减速器的工作性能。基于Romax软件对新能源电动汽车减速器的齿轮进行了微观分析,对一级齿轮副小齿轮进行了齿向修形和齿廓修形,以满足实际工作需要。

关键词：减速器传动误差单位长度载荷齿轮修形

Survival after curative pancreaticoduodenectomy for ampullary adenocarcinoma in a South American population:A retrospective cohort study

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World Journal of Gastrointestinal Surgery 2022年第1期14卷 24-35页

作者： Ramiro Manuel Fernandez-Placencia Paola Montenegro Melvy Guerrero Mariana Serrano Emperatriz Ortega Mercedes Bravo lourdes Huanca Stéphane Bertani juan Manuel Trejo Patricia Webb Jenny Malca-Vasquez luis Taxa Alberto lachos-Davila juan Celis-Zapata carlos luque-Vasquez Eduardo Payet Eloy Ruiz Francisco Berrospi Hepato-Pancreato-Biliary Section Department of Abdominal SurgeryInstituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Medical Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Pathology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru International Joint laboratory of Molecular Anthopological Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Unite Pharmacochim&Pharmacol Dev UMR152F-31062 ToulouseFrance Department of Radiation Oncology Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru Department of Abdominal Surgery Instituto Nacional de Enfermedades NeoplasicasLima 15038Peru

BACKGROUND Ampullary adenocarcinoma(AAC)is a rare neoplasm that accounts for only 0.2%of all gastrointestinal *** incidence rate is lower than 6 cases per million *** prognostic factors have been described for AAC and are associated with a wide range of survival ***,these studies have been exclusively conducted in patients originating from Asian,European,and North American *** To evaluate the histopathologic predictors of overall survival(os)in South American patients with AAC treated with curative pancreaticoduodenectomy(PD).METHODS We analyzed retrospective data from 83 AAC patients who underwent curative(R0)PD at the National Cancer Institute of peru between January 2010 and October 2020 to identify histopathologic predictors of *** Sixty-nine percent of patients had developed intestinal-type AAC(69%),23%had pancreatobiliary-type AAC,and 8%had other ***-one percent of patients were classified as Stage I,according to the AJCC 8 th *** occurred primarily in the liver(n=8),peritoneum(n=4),and lung(n=4).Statistical analyses indicated that T3 tumour stage[hazard ratio(HR)of 6.4,95%confidence interval(CI)of 2.5-16.3,Plymph node metastasis(HR:4.5,95%CI:1.8-11.3,P=0.001),and pancreatobiliary type(HR:2.7,95%CI:1.2-6.2,P=0.025)were independent predictors of *** Extended tumour stage(T3),pancreatobiliary type,and positive lymph node metastasis represent independent predictors of a lower os rate in South American AAC patients who underwent curative PD.

关键词： Gastrointestinal neoplasms Adenocarcinoma Ampulla Pancreaticoduodenectomy Survival South America

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激素和糖分对暗紫贝母生根培养的影响

浙江农业科学 2024年第2期65卷 325-328页

作者：字胡润赵艳娟管世超苏娟文凤张玉蓉王晓李靖瑞岳健云南青谷生物科技有限公司云南昆明650506 云南山里红生物科技有限公司云南昆明650229

本实验以苗龄为90 d的暗紫贝母芽繁苗为实验材料,在组培生根培养过程中添加不同浓度的激素和糖分,研究其对暗紫贝母生根的影响,筛选出暗紫贝母的最适生根培养基。结果表明:在生根培养基为基本培养基(MS)+9.4 g·l^(-1)卡拉胶(car)+0.5 m... 详细信息

本实验以苗龄为90 d的暗紫贝母芽繁苗为实验材料,在组培生根培养过程中添加不同浓度的激素和糖分,研究其对暗紫贝母生根的影响,筛选出暗紫贝母的最适生根培养基。结果表明:在生根培养基为基本培养基(MS)+9.4 g·l^(-1)卡拉胶(car)+0.5 ml·l^(-1)萘乙酸(NAA)+0.5 ml·l^(-1)吲哚丁酸(IBA)+30 g·l^(-1)蔗糖时暗紫贝母生根情况最好,生根率高达81.3%,根系粗壮,且有效根数最多,平均每株有3.4条根系,且没有被污染。本研究为以后建立暗紫贝母组培快繁体系、大规模标准化生产优良暗紫贝母种苗提供参考。

关键词：暗紫贝母组织培养激素糖分生根

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Safety of digoxin in nonagenarian patients with atrial fibrillation:lessons from the Spanish Multicenter Registry

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Journal of Geriatric cardiology 2021年第10期18卷 809-815页

作者： Pablo Domínguez-Erquicia Sergio Raposeiras-Roubín Emad Abu-Assi María Cespón-Fernández David Alonso-Rodríguez Santiago Jesús Camacho-Freire Naiara Cubelos-Fernández Álvaro lópez-Masjuán Ríos María Melendo-Viu AndrésÍñiguez-Romo Department of cardiology University HospitalÁlvaro CunqueiroVigoSpain Health Research Institute Galicia Sur VigoSpain Department of cardiology University Hospital of LeónLeónSpain Department of cardiology University Hospital Juan Ramón JiménezHuelvaSpain

BACKGROUND The association between digoxin and mortality is an unclear *** older patients with atrial fibrillation(AF),where use of digoxin is frequent,the evidence of its safety is *** aim is to assess the safety of digoxin in nonagenarian patients with *** We evaluated data from 795 nonagenarian patients with non-valvular AF from the Spanish Multicenter *** analyzed the relationship between digoxin and all-cause mortality with the Cox proportional-hazards *** Follow-up was 27.7±18.3 *** age was 92.5±3.8 years,and 71%of nonagenarian patients were *** was not associated with increased risk of mortality[adjusted hazard ratio(aHR)=1.16,95%CI:0.96−1.41,P=0.130].However,we found a significant increase in mortality in the subgroup with estimated glomerular filtration rate(eGFR)l/min per 1.73 m^(2)(aHR=2.01,95%CI:1.13−3.57,P=0.018),but not in the other subgroups of eGFR(30−59 ml/min per 1.73 m^(2) and≥60 ml/min per 1.73 m^(2)).When exploring the risk of mortality according to sex,male subgroup was associated with an in-crease in mortality(aHR=1.48,95%CI:1.02−2.14,P=0.041).This was not observed in females subgroup(aHR=1.03,95%CI:0.81−1.29,P=0.829).Based on the presence or absence of heart failure,we did not find significant differences(aHR=1.20,95%CI:0.87−1.65,P=0.268 ***=1.15,95%CI:0.90−1.47,P=0.273,respectively).CONClUSIONS In our large registry of nonagenarian patients with AF,we did not find an association between digoxin and mortality in the total ***,in the subgroup analyses,we found an increase in mortality with the use of digoxin in men and in patients with an eGFRl/min per 1.73 m^(2).

关键词： patients digoxin fibrillation

Evaluation of Early Action Mechanisms in peru Regarding Preparedness for El Nino

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International Journal of Disaster Risk Science 2019年第4期10卷 493-510页

作者： Julio Aguirre Daniel De la Torre Ugarte juan Bazo Paulo Quequezana Mauricio Collado Department of Economics Universidad del Pacifico15072 LimaPeru Red Cross Red Crescent Climate Centre 2502 KC The HagueThe Netherlands Centro de Investigacion de Riesgo Resiliencia y Cambio Climatico(CIRCA)Universidad Tecnologica del Peru(UTP)15046 LimaPeru

In this article,we provide an impact evaluation of an intervention in peru regarding preparedness for El Nino impacts in Picsi District of Chiclayo Province in peru’s northwestern coastal lambayeque *** effort involved the provision of special kits that reduce the potential damage to homes as a consequence of rainfall and floods associated with an El Nino-Southern oscillation *** was collected in 2016 when this Forecast-based Financing early action was activated by an El Nino forecast,and after a coastal El Nino actually struck in *** dual database permits us to estimate the impact of the intervention on the damage level of homes by comparing those homes supported by the program with those homes not receiving pilot-program *** comparison is achieved by using propensity score matching techniques,which identify the most comparable homes to the ones that were supported by the *** main findings of the study suggest a positive impact of the program in terms of its effectiveness in mitigating the damage caused by the 2017 El Ni?*** results suggest a drop in the scale of house damage(less damage)by around 63%for a home that received the modular kit *** considering other specifications of the model,the decrease in the scale of house damage improves up to approximately 66%.

关键词： Early warning Early action El Ninosouthern oscillation Forecast-based Financing Matching propensity score perú Red Cross

人参花蕾黄芪合剂对D-半乳糖模型雄性大鼠骨质疏松骨量的影响

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中国中西医结合杂志 2023年第12期43卷 1454-1460页

作者：叶冠希肖茜吴铁戴娟秀广东医科大学公共卫生学院广东523808 广东医科大学药学院广东523808 广东医科大学公共卫生学院卫生检验与检疫系广东523808 东莞市生物医药产业实验动物资源开发与应用研究重点实验室广东523808

目的观察人参花蕾黄芪合剂对雄性大鼠衰老时出现的原发性骨质疏松的预防作用。方法将3月龄60只雄性SD大鼠随机分为6组,对照组(NC组)、D-半乳糖模型组(DG组)、复方司坦唑醇(司坦唑醇+吡拉西坦)阳性对照组(SP组)、仙灵骨葆中药对照组(GB组... 详细信息

目的观察人参花蕾黄芪合剂对雄性大鼠衰老时出现的原发性骨质疏松的预防作用。方法将3月龄60只雄性SD大鼠随机分为6组,对照组(NC组)、D-半乳糖模型组(DG组)、复方司坦唑醇(司坦唑醇+吡拉西坦)阳性对照组(SP组)、仙灵骨葆中药对照组(GB组)、人参花蕾黄芪合剂低剂量组(GFRAl组)及人参花蕾黄芪合剂高剂量组(GFRAH组),每组10只;连续给药3个月后,处死老鼠后取左胫骨进行骨形态计量学检测,取右股骨进行生物力学性能测定,取左股骨进行骨钙、磷酸、羟脯氨酸(Hyp)浓度测定。结果与NC组比较,DG组胫骨上段静态参数中骨小梁百分率(%***)、骨小梁数目(Tb.N)降低,骨小梁分离度(***)增加(Pl组胫骨上段静态参数中的%***、***、Tb.N增加(Pl组的股骨Hyp降低(P<0.05)。结论人参花蕾黄芪合剂与复方司坦唑醇和仙灵骨葆胶囊的预防效果相似,可有效预防D-半乳糖导致雄性大鼠的骨质疏松改变。

关键词：人参花蕾黄芪合剂 D-半乳糖雄性大鼠骨质疏松中成药

Clinical outcomes of newly diagnosed primary central nervous system lymphoma treated with zanubrutinib-based combination therapy

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World Journal of Clinical Oncology 2023年第12期14卷 606-619页

作者： Ning Wang Fei-li Chen lu Pan Yan Teng Xiao-juan Wei Han-Guo Guo Xin-Miao Jiang ling Huang Si-Chu liu Zhan-li liang Wen-Yu li School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Guangdong Provincial People’s Hospital Guangdong Academy of Medical SciencesGuangzhou 510080Guangdong ProvinceChina

BACKGROUND High-dose methotrexate(HD-MTX)combined with other chemotherapeutic agents is an effective treatment for patients with newly diagnosed primary central nervous system lymphoma(PCNSl);however,some patients have adverse *** To retrospectively evaluate disease outcomes and mutational profiles in newly diagnosed PCNSl patients treated with a zanubrutinib/HD-MTX combination *** Nineteen newly diagnosed PCNSl patients were treated with zanubrutinib/HDMTX until disease progression,intolerable toxicities,or physician/patientdirected *** and efficacy were assessed per the CTCAE v5.0 and RECIST v1.1 criteria,*** primary endpoint was the objective response rate(ORR),and the secondary endpoints were progression-free survival,overall survival(os),and *** The median follow-up duration was 14.7 mo(range,3.9–30 mo).The ORR for all patients was 84.2%,and 2-year progression-free-and os rates were 75.6%and 94.1%,*** patients completed the induction phase,and nine patients underwent autologous stem cell transplantation as consolidation therapy,resulting in an ORR of 88.9%.Ten patients received zanubrutinib as maintenance therapy and achieved an ORR of 80%.All patients showed an acceptable safety *** sequencing results for cerebrospinal fluid(CSF)and tumor tissue showed that PIM1 mutations were the most frequent genetic *** tumor DNA was correlated with disease relapse and *** Our empirical observations demonstrated that the combination of zanubrutinib with HD-MTX yielded a marked clinical response and tolerability among newly diagnosed PCNSl ***-invasive CSF liquid biopsy profiling may be feasible for evaluating treatment response and tumor burden.

关键词： Zanubrutinib High-dose methotrexate Primary central nervous system lymphoma liquid biopsy Circulating tumor DNA

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城市客运交通规划的碳排放估算方法

交通运输研究 2022年第3期8卷 42-48页

作者：金昱苏红娟上海市城市规划设计研究院上海200040

为了在城市客运交通规划阶段科学开展交通碳排放定量计算,研究提出按照现状参数标定、规划参数推算、规划排放预测三个步骤估算未来交通碳排放的总体思路。以上海城市客运交通为例,计算现状小客车、公交车、轨道交通等各类交通工具运营... 详细信息

为了在城市客运交通规划阶段科学开展交通碳排放定量计算,研究提出按照现状参数标定、规划参数推算、规划排放预测三个步骤估算未来交通碳排放的总体思路。以上海城市客运交通为例,计算现状小客车、公交车、轨道交通等各类交通工具运营能耗和碳排放。然后,结合汽车、轨道交通以及能源等相关行业研究成果,研判未来各类客运交通工具运营能耗强度因子和碳排放强度因子。最后,结合城市客运交通规划方案,提出对私人和公共交通工具交通活动量差别化估算方法,并采用多情景分析方法估算未来城市客运交通活动量以及对应的交通能耗、碳排放情况。研究表明,通过优化职住空间结构、改善交通方式结构、推广清洁能源应用,均可降低交通碳排放;从具体减碳效果来看,提高私人小客车电动化比例和降低当地电网排放因子共同作用可取得最好的减碳效果,碳排放对其的弹性为0.91;其次是居民出行距离,碳排放对其的弹性达0.85。

关键词：碳排放城市客运交通估算方法排放因子多情景分析

AcMNPV p95基因一段339 bp序列在病毒复制中的作用

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复旦学报（自然科学版） 2017年第2期56卷 222-227页

作者：朱明骏尹隽钟江复旦大学生命科学学院微生物学与微生物工程系上海200438

杆状病毒苜蓿银纹夜蛾核型多角体病毒(AcMNPV)的p95基因编码的P95蛋白是病毒核衣壳的组成部分,也是虫体经口感染相关因子PIF(per os Infectivity Factor)复合体的组成部分.前期研究表明,完整的P95蛋白对病毒的复制是非必需的,其中一段45... 详细信息

杆状病毒苜蓿银纹夜蛾核型多角体病毒(AcMNPV)的p95基因编码的P95蛋白是病毒核衣壳的组成部分,也是虫体经口感染相关因子PIF(per os Infectivity Factor)复合体的组成部分.前期研究表明,完整的P95蛋白对病毒的复制是非必需的,其中一段450bp的序列可以部分弥补p95基因的作用.本研究将p95基因一段339bp的片段(Core339,AcMNPV基因组位置:69 576~69 914bp)以正反两个方向分别插入到p95基因敲除的AcMNPV基因组中多角体位点的polyA之后,构建了两株重组病毒vP95K/EGFP/339+和vP95K/EGFP/339-.该两株病毒能在Sf9细胞中正常复制,复制水平与p95基因正常的AcEGFP相当,但复制速度较慢.重组病毒感染细胞的Western blot分析未检测到P95蛋白的表达.这一结果表明P95蛋白的缺失对病毒在细胞中的复制没有显著影响,但核心片段Core339对于病毒复制具有关键作用.

关键词：杆状病毒 p95 复制基因表达