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Containment of high-speed rotating disk fragments

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第9期13卷 665-673页

作者： Hai-jun XUAN Lu-lu liU Yi-ming FENG Qing HE juan-juan li High-Speed Rotating Machinery Laboratory Institllte of Chemical MachineryFacldly of EngineeringZhejiang UniversityHangzhou 310027China

Disk burst accidents sometimes happen in *** avoid tragic consequences,aeroengine casings must have sufficient containment *** and simulations need to be conducted to study the impact,distortion,and perforation caused by disk burst and which may give important clues to potential failure *** paper presents some containment tests of high-speed rotating disk fragments,in which the original disks were burst into three equal fragments within a predetermined rotating speed *** failure modes of the containment casing varied significantly with the thickness of the containment ***,tearing,tensile fracture,and large plastic stretching deformation occurred in a thin-walled containment casing,while a thick-walled casing could contain disk fragments and withstand large plastic *** simulations were carried out to study the impact process and failure modes *** agreement was found between the results of the simulations and the tests.

关键词： Aeroengine Disk fragments Engine casing Containment capability Numerical simulation

Adipose tissue macrophages:implications for obesity-associated cancer

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Military Medical Research 2023年第5期10卷 636-651页

作者： Bei li Si Sun juan-juan li Jing-Ping Yuan Sheng-Rong Sun Qi Wu Department of Pathology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Clinical Laboratory Renmin Hospitalof Wuhan UniversityWuhan 430060China Department of Breast and Thyroid Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Tongji University Cancer Center Shanghai Tenth People’s Hospital of Tongji UniversitySchool of MedicineTongji UniversityShanghai 200092China

Obesity is one of the most serious global health problems,with an incidence that increases yearly and coincides with the development of *** tissue macrophages(ATMs)are particularly important in this context and contribute to linking obesity-related inflammation and tumor ***,the functions of ATMs on the progression of obesity-associated cancer remain *** this review,we describe the origins,phenotypes,and functions of ***,we summarize the potential mechanisms on the reprogramming of ATMs in the obesity-associated microenvironment,including the direct exchange of dysfunctional metabolites,inordinate cytokines and other signaling mediators,transfer of extracellular vesicle cargo,and variations in the gut microbiota and its metabolites.A better understanding of the properties and functions of ATMs under conditions of obesity will lead to the development of new therapeutic interventions for obesity-related cancer.

关键词： Adipose tissue macrophages Macrophage Adipose Obesity Cancer Therapy

Penetration of disk fragments following impact on thin plate

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第5期10卷 677-684页

作者： juan-juan li Hai-jun XUAN lian-fang liAO Wei-rong HONG Rong-ren WU Insititute of Chemical Machinery Zhejiang University Hangzhou 310027 China Shenyang Aeroengine Research Institute Shenyang 110015 China

To investigate the ballistic resistance and failure pattern of aeroengine casing following the impact of disk fragments, and to determine the optimum case structure, the phenomena of a 1/3rd disk fragment impact on single and double-layered thin plate targets were simulated using nonlinear dynamical analysis software ***. Strain rate effect was introduced in a Johnson-Cook (JC) material model for the disk fragment and the plate. Impact modeling was based on the Arbitrary Lagrange-Eulerian method, and simulated using explicit finite element method (FEM). Simulation results showed that the major failure pattern of the plate is shearing and tensile fracture with large plastic deformation. It was also concluded that the ballistic limit velocity increases with the standoff distance when it is beyond a certain value, and that greater resistance is obtained when the front plate has either a proportionately low or high thickness. The impact resistance of a double-layered plate may exceed that of a single plate if the thicknesses and standoff distance of the two plates are set appropriately.

关键词： Aeroengine Disk burst failure Case containment capability Ballistic limit velocity

Clinical significance of platelet mononuclear cell aggregates in patients with sepsis and acute respiratory distress syndrome

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World Journal of Clinical Cases 2024年第5期12卷 966-972页

作者： Chong-Min Huang juan-juan li Wei-Ke Wei Department of Intensive Medicine The Second People's Hospital of Haining CityHaining 314419Zhejiang ProvinceChina Department of Integrated Traditional Chinese and Western Medicine Qingyang HospitalHangzhou 310023Zhejiang ProvinceChina

BACKGROUND The diagnosis of sepsis combined with acute respiratory distress syndrome(ARDS)has increased owing to the enhanced awareness among medical profes-sionals and the continuous development of modern medical technologies,while early diagnosis of ARDS still lacks specific *** of the main patho-genic mechanisms of sepsis-associated ARDS involves the actions of various pathological injuries and inflammatory factors,such as platelet and white blood cells activation,leading to an increase of surface adhesion *** adhesion molecules further form platelet-white blood cell aggregates,including platelet-mononuclear cell aggregates(PMAs).PMAs has been identified as one of the markers of platelet activation,here we hypothesize that PMAs might play a potential biomarker for the early diagnosis of this *** We selected 72 hospitalized patients diagnosed with sepsis as the study population between March 2019 and March *** them,30 patients with sepsis and ARDS formed the study group,while 42 sepsis patients without ARDS comprised the control *** diagnosis,venous blood samples were imme-diately collected from all *** cytometry was employed to analyze the expression of PMAs,platelet neutrophil aggregates(PNAs),and platelet aggregates(PLyAs)in the ***,the Acute Physiology and Chronic Health Evaluation(APACHE)II score was calculated for each patient,and receiver operating characteristic curves were generated to assess diagnostic *** The study found that the levels of PNAs and PLyAs in the serum of the study group were higher than those in the control group,but the difference was not statistically significant(P>0.05).However,the expression of PMAs in the serum of the study group was significantly upregulated(P<0.05)and positively correlated with the APACHE II score(r=0.671,P<0.05).When using PMAs as a diagnostic indicator,the area under the curve value was 0.957,indicating a high diagnostic va

关键词： Sepsis Acute respiratory distress syndrome Platelet leukocyte aggregates Platelet mononuclear cell aggregates,Biomarker

Calixarenes enabling well-adjusted organic-inorganic interface for inverted organic solar cells with 18.25%efficiency and multifold improved photostability under max power point tracking

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Science China Chemistry 2023年第1期66卷 195-201页

作者： Shitong li Zheng Xiao juan-juan li Zong-Ying Hu Yang Yang Bin Kan Dong-Sheng Guo Xiangjian Wan Zhaoyang Yao Chenxi li Yongsheng Chen State Key Laboratory of Elemento-Organic Chemistry The Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer MaterialsRenewable Energy Conversion and Storage Center(RECAST)College of ChemistryNankai University Tianjin300071China College of Materials Science and Engineering Nankai UniversityTianjin 300350China The Institute of Seawater Desalination and Multipurpose Utilization Ministry of Natural Resources(Tianjin)Tianjin 300192China

Compared with organic solar cells(OSCs) adopting conventional architecture,inverted OSCs have offered generally better stability,where Zn O is the most widely used electron transporting layer(ETL) *** ZnO-based inverted OSCs,a welltuned interface of organic(active layer)-inorganic(Zn O film) with matched surface energy(γS) is critical for both high performance and high *** this work,two typical calixarenes,C4A and Bu C4A,were employed as the tuning agents to adjust this organic-inorganic interface for ZnO-based inverted *** a result,with PM6:L8-BO as the active layer,significantly promoted power conversion efficiencies(PCEs) from 17.14%(for ZnO) to 18.25%(for ZnO/C4A) and 17.80%(for ZnO/Bu C4A) were *** studies indicate that the enhanced performance is due to the faster charge extraction process,the suppressed recombination and more ideal internal electric field in ZnO/calixarene-based *** addition,wellmatched interface energy and more ordered molecular aggregation in active layer effectively improved photostability and thermal stability for ZnO/calixarene-based *** results indicate that calixarenes could act as effective modifying agents of ZnO to improve inverted OSCs’ performance and stability simultaneously,and likely also stimulate calixarenes’ and other macromolecules’ broader studies in other organic electronic devices.

关键词： organic solar cell calixarenes interface adjustment ZnO modification high performance high stability

Conjugation of Chitooligosaccharide-5-fluorouracil with Bovine Serum Albumin

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Chinese Chemical Letters 2006年第11期17卷 1495-1498页

作者： Rong Min WANG Jing Feng SONG Yu Feng HE juan juan MAO Yan li Key Laboratory of Polymer Materials of Gansu Province Institute of Polymer Northwest Normal University Lanzhou 730070

The interaction between chitooligosaccharide-5-fluorouracil （COS-5FU） and bovine serum albumin （BSA） was studied by fluorescence spectroscopy. It was found that an energy transfer between COS-5FU and BSA had been occurred. The binding constants were calculated, k298K=1.175×10^4 L·mol^-1. Based on the mechanism of energy transfer of dipole-dipole interaction between the donor and acceptor, the distance between BSA and COS-SFU was determined.

关键词： Chitooligosaccharide-5-fluorouracil BSA fluorescence spectroscopy.

Synchronous colonic mucosa-associated lymphoid tissue lymphoma found after surgery for adenocarcinoma:A case report and review of literature

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World Journal of Clinical Cases 2020年第24期8卷 6456-6464页

作者： juan-juan li Bing-Chen Chen Jie Dong You-Wei Chen Yuan Chen Department of Intensive Care Unit and Comprehensive Support Wang-Jiang-Shan Branch of Zhejiang Provincial People's HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Colorectal Surgery Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Gastroenterology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina Department of Pathology Zhejiang Provincial People’s HospitalPeople’s Hospital of Hangzhou Medical CollegeHangzhou 310014Zhejiang ProvinceChina

BACKGROUND Mucosa-associated lymphoid tissue (MALT) lymphoma is a subtype of non-Hodgkin lymphoma that is mainly involved in the gastrointestinal tract. Thesynchronous occurrence of colonic MALT lymphoma and adenocarcinoma in thesame patient is extremely rare. We here report a case of synchronous colonicMALT lymphoma found on surveillance colonoscopy five months after surgeryand chemotherapy for sigmoid *** SUMMARY A 67-year-old man was admitted because of hematochezia for two *** suggested a colonic tumor before hospitalization. Abdominalcomputed tomography (CT) revealed local thickening of the sigmoid colon. Thepatient underwent a left hemicolectomy with local lymph node dissection. Thehistopathology revealed moderately differentiated adenocarcinoma and partiallymucinous adenocarcinoma. The pTNM stage was T3N1Mx. The patient receivedchemotherapy with six cycles of mFOLFOX6 after surgery. Colonoscopy wasperformed five months later and revealed single, flat, polypoid lesions of thecolon 33 cm away from the anus. Subsequently, the patient underwent endoscopic mucosal resection for further diagnosis. The pathological diagnosis was MALTlymphoma. Positron emission tomography /CT suggested metastasis. The patientrefused further treatment and died ten months *** Colonic MALT lymphoma may occur after surgery and chemotherapy foradenocarcinoma as a synchronous malignancy. Regular surveillance colonoscopyand careful monitoring after surgery are critical.

关键词： Mucosa-associated lymphoid tissue lymphoma Adenocarcinoma Colon Synchronous malignancy Surgery Case report

Clinical and Sonographic Assessment of Cervical Lymph Node Metastasis in Papillary Thyroid Carcinoma

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 823-827页

作者： Qi WU Yi-min ZHANG Si SUN juan-juan li juan WU Xiang li Shan ZHU Wen WEI Sheng-rong SUN Department of Breast and Thyroid Surgery Department of Clinical Laboratory Department of Pathology Renmin Hospital of Wuhan University Wuhan 430060 China Department of Breast Surgery Hubei Cancer Hospital Wuhan 430079 China

The purpose of this study was to assess the differences in clinical and sonographic features of papillary thyroid carcinoma（PTC） between cervical lymph node metastatic（CLNM） and nonmetastatic *** data of PTC patients（414 patients with 624 malignant nodules） who underwent a preoperative ultrasonography and surgery between June 2010 and March 2015 at Renmin Hospital of Wuhan University were retrospectively *** factors,preoperative ultrasound features and the final pathological findings were *** differences in the sonographic features of PTC between the CLNM group and the non-CLNM group were *** were 187 CLNM and 227 non-CLNM *** median age at the diagnosis of this cohort was 45.4 years old（ranging from 18 to 77 years）.Ultrasonographic parameters that were significantly associated with CLNM [OR=2.569（1.502,4.393）,P〈0.001）] were as follows：the mulifocality of the nodules,size over 2 cm,the presence of microcalcifications,the distance ratio（DR） pattern showing the contact of the nodules with the thyroid capsule,and the extracapsular spread of the *** significant differences in age,gender,thyroid stimulating hormone（TSH） levels and other ultrasonography parameters were found between the CLNM and the non-CLNM ***,our results suggest that a larger size,microcalcifications,mulifocality,and the DR pattern showing the contact of the nodules with the thyroid capsule and extracapsular spread are significantly more indicative of CLNM in PTC.

关键词： clinical and sonographic assessment papillary thyroid carcinoma cervical lymph node metastasis

Synthesis and biological evaluation of novel 1,2,4-triazole containing 1,2,3-thiadiazole derivatives

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Chinese Chemical Letters 2013年第12期24卷 1134-1136页

作者： Yue-Dong li Wu-Tao Mao Zhi-Jin Fan juan-juan li Zhen Fang Xiao-Tian Ji Xue-Wen Hua Guang-Ning Zong Feng-Yun li Chao-Lun liu Jian-Hua Yu State Key Laboratory of Elemento-Organic Chemistry Nankai University Division of Hematology College of Medicine and School of Public HealthThe Ohio State University

A series of novel 1,2,4-triazoles containing 1,2,3-thiadiazole derivatives were designed and synthesized. Their structures were confirmed by melting points, IR, 1H NMR, and elemental analysis and ESI-MS or HRMS. Preliminary bioassays indicated that these compounds exhibited very good insecticidal activity against Aphis laburni at 100 μg/mL, with mortality no less than 95%. Compounds 6a, 6c, 6f, 61 showed higher curative activity against TMV and compound 6h showed a higher induction effects against TMV in vivo at 100 μg/mL. Collectively, our data demonstrate a new strategy for control of insects and viruses.

关键词： 1 2 3-Thiadiazole 1 2 4-Triazole Insecticidal activity Anti-TMV activity