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Combined treatment of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer

World Journal of Gastroenterology 2009年第7期15卷 871-876页

作者： Tian-Jie Qin Gai-Li An Xin-Han Zhao Fang Tian Xiao-Hua Li juan-wen lian Bo-Rong Pan Shan-Zhi Gu Department of Medical Oncology First Affiliated Hospital of Medical School of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China Department of Oncology Cancer Institute Fourth Military Medical University Xi'an 710032 Shaanxi Province China Key Laboratory of Environment and Genes Related to Diseases Ministry of Education School of Medicine of Xi'an Jiaotong University Xi'an 710061 Shaanxi Province China

AIM:To investigate the efficacy and side effects of the combined therapy of oxaliplatin and capecitabine in patients with metastatic esophageal squamous cell cancer(ESCC) and the survival of the ***:Sixty-four patients(median age of 63 years) with histological or cytological confirmation of ESCC received oxaliplatin 120 mg/m2 intravenously on day 1 and capecitabine 1000 mg/m2 orally twice daily on days 1 to 14 in a 21-d treatment cycle as palliative *** patient received at least two cycles of *** efficacy,side effects and patient survival were ***:The partial response(PR) rate was 43.8%(28/64).Stable disease(SD) rate was 47.9%(26/64),and disease progression rate was 15.6%(10/64).The clinical benefit rate(PR + SD) was 84.4%.The main toxicities were leukopenia(50.0%),nausea and vomiting(51.6%),diarrhea(50.0%),stomatitis(39.1%),polyneuropathy(37.5%) and hand-foot syndrome(37.5%).No grade 4 event in the entire cohort was *** median progression-free survival was 4 mo,median overall survival was 10 mo(95% CI:8.3-11.7 mo),and the 1-and 2-year survival rates were 38.1% and 8.2%,*** Karnofsky index,single metastatic lesion and response to the regimen indicated respectively good ***:Oxaliplatin plus capecitabine regimen is effective and tolerable in metastatic ESCC *** regimen has improved the survival moderately and merits further studies.

关键词： Oxaliplatin Capecitabine Metastaticesophageal squamous cell cancer Survival analysis

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Phenylalanine Hydroxylase Deficiency and Citrin Deficiency in a Chinese Infant

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Chinese Medical Journal 2015年第21期128卷 2979-2980页

作者： Jun Ye wen-juan Qiu lian-Shu Han Hui-wen Zhang Xue-Fan Gu Department of Pediatric Endocrinology/Genetics Shanghai Institute for Pediatric Research Xin Hua Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200092 China

To the Editor： Tandem mass spectrometry （MS/MS）-based expanded newborn screening was first introduced in Pediatric Endocrinology/ Genetics of Xin Hua Hospital in 2003. The screening is expected to detect genetic disorders leading to a secondary increase in blood phenylalanine （Phe） in newborns. We reported a rare case in a Chinese infant with hyperphenylalaninemia （HPA） caused by phenylalanine hydroxylase （PAH） deficiency and neonatal intrahepatic cholestasis caused by citrin deficiency （NICCD）. This constellation of two different metabolic pathway defects in one patient has not been reported previously.

关键词： Phenylalanine Hydroxylase Deficiency Citrin Deficiency Chinese Infant

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Return to work in young and middle-aged colorectal cancer survivors:Factors influencing self-efficacy,fear,resilience,and financial toxicity

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World Journal of Gastroenterology 2025年第1期31卷 79-92页

作者： Dan Hu Yue Li Hua Zhang lian-lian Wang wen-wen Liu Xin Yang Ming-Zhao Xiao Hao-Ling Zhang juan Li Department of Nursing The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Nursing National Clinical Research Center for Child Health and DisordersMinistry of Education Key Laboratory of Child Development and DisordersChildren’s Hospital of Chongqing Medical UniversityChongqing 400014China Department of Gastrointestinal Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China Department of Biomedical Science Advanced Medical and Dental InstituteUniversity Sains MalaysiaPenang 13200Malaysia Academic Affairs Office The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400016China

BACKGROUND Return to work(RTW)serves as an indication for young and middle-aged colorectal cancer(CRC)survivors to resume their normal social ***,these survivors encounter significant challenges during their RTW ***,scientific research is necessary to explore the barriers and facilitating factors of returning to work for young and middle-aged CRC *** To examine the current RTW status among young and middle-aged CRC survivors and to analyze the impact of RTW self-efficacy(RTW-SE),fear of progression(FoP),eHealth literacy(eHL),family resilience(FR),and financial toxicity(FT)on their RTW *** A cross-sectional investigation was adopted in this *** September 2022 to February 2023,a total of 209 participants were recruited through a convenience sampling method from the gastrointestinal surgery department of a class A tertiary hospital in *** investigation utilized a general information questionnaire alongside scales assessing RTW-SE,FoP,eHL,FR,and *** analyze the factors that influence RTW outcomes among young and middle-aged CRC survivors,Cox regression modeling and Kaplan-Meier survival analysis were *** A total of 43.54%of the participants successfully returned to work,with an average RTW time of 100 *** regression univariate analysis revealed that RTW-SE,FoP,eHL,FR,and FT were significantly different between the non-RTW and RTW groups(P<0.05).Furthermore,Cox regression multivariate analysis identified per capita family monthly income,job type,RTW-SE,and FR as independent influencing factors for RTW(P<0.05).CONCLUSION The RTW rate requires further *** levels of RTW-SE and FR were found to significantly increase RTW among young and middle-aged CRC *** professionals should focus on modifiable factors,such as RTW-SE and FR,to design targeted RTW support programs,thereby facilitating their timely reintegration into mainstream society.

关键词： Return to work Colorectal neoplasms Return-to-work self-efficacy Fear of progression Family resilience Financial toxicity

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Dynamical complexity of Anosov systems driven by a quasi-periodic force

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Science China Mathematics 2025年第1期 89-136页

作者： wen Huang Zeng lian Kening Lu Department of Mathematics University of Science and Technology of China School of Mathematics Sichuan University

Consider C2Anosov systems on a compact manifold driven by a quasi-periodic *** study their dynamical complexity on various levels from the perspectives of both path-wise dynamics and stochastic *** that these systems are non-wandering（i.e.,every point in the phase space is nonwandering）,we prove a set of results:（1） the existence of abundance of random periodic points;（2） a random Liv?ic theorem;（3） a random Ma?é-Bousch-Conze-Guivarc'h lemma;（4） the existence of strong random ***,a concrete example constructed on a 2-dimensional torus is also given to uncover some interesting phenomena of the systems.

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配电变压器的高原环境适应性验证方法分析

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环境技术 2017年第3期35卷 31-33页

作者：吴炳卫刘文娟贾连华张林昆明高海拔电器检测有限公司昆明650221

叙述了配电变压器进行高原环境条件下适应性验证的试验方法,说明了配电变压器的高原环境适应性验证在变压器性能优化和提升过程中的重要意义。

关键词：高原环境条件配电变压器适应性验证

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World Journal of Clinical Cases 2025年第6期13卷 24-29页

作者： wen-Jin Yuan Yi-juan Zheng Bing-Rong Zhang Yi-Jie Lin You Li Yan-Yan Qiu Xue-Ping Yu Department of Infection Disease Clinical Medical Research Center for Bacterial and Fungal Infectious Diseases of Fujian provinceFujian Medical University Affiliated First Quanzhou HospitalQuanzhou 362000Fujian ProvinceChina

BACKGROUND Hydroxyurea,an antimetabolite,is frequently prescribed for various hemato-logical disorders,and its common side effects include gastrointestinal problems,cutaneous or mucosal lesions and pyrexia/*** SUMMARY This study reports the case of a 67-year-old woman who developed recurrent abdominal pain after 10 years of continuous hydroxyurea therapy for primary *** revealed an ileocecal *** discontinuing hydroxyurea therapy for 6 months,follow-up colonoscopy showed a significant reduction in the *** We consider cecal ulcers as a rare complication of hydroxyurea therapy which typically resolves upon stopping the drug.

关键词： Hydroxyurea Ulcer Abdominal pain Thrombocythemia Colonoscopy Case report

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Acyclic Edge Coloring of IC-planar Graphs

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Acta Mathematicae Applicatae Sinica 2020年第3期36卷 581-589页

作者： wen-yao SONG Yuan-yuan DUAN juan WANG lian-ying MIAO School of Mathematics and Statistics Zaozhuang UniversityZaozhuang 277160China School of Mathematics China University of Mining and TechnologyXuzhou 221116China

A proper edge coloring of a graph G is acyclic if there is no 2-colored cycle in *** acyclic chromatic index of G is the least number of colors such that G has an acyclic edge coloring and denoted byχ′a(G).An IC-plane graph is a topological graph where every edge is crossed at most once and no two crossed edges share a *** this paper,it is proved thatχ′a(G)≤Δ(G)+10,if G is an IC-planar graph without adjacent triangles andχ′a(G)≤Δ(G)+8,if G is a triangle-free IC-planar graph.

关键词： Acyclic chromatic index acyclic edge coloring IC-planar graph

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A Heuristic Sampling Method for Maintaining the Probability Distribution

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Journal of Computer Science & Technology 2021年第4期36卷 896-909页

作者： Jiao-Yun Yang Jun-Da Wang Yi-Fang Zhang wen-juan Cheng lian Li Key Laboratory of Knowledge Engineering with Big Data of Ministry of Education Hefei University of Technology Hefei 230601China National Smart EldeTca/re International Science and Technology Coopemtion Base Hefei University of Technology Hefei 230601China School of Computer Science and Information Engirwering Hefei University of TechnologyHefei 230601China School of Mathematics Hefei University of TechnologyHefei 230601China

Sampling is a fundamental method for generating data *** many data analysis methods are developed based on probability distributions,maintaining distributions when sampling can help to ensure good data analysis ***,sampling a minimum subset while maintaining probability distributions is still a *** this paper,we decompose a joint probability distribution into a product of conditional probabilities based on Bayesian networks and use the chi-square test to formulate a sampling problem that requires that the sampled subset pass the distribution test to ensure the ***,a heuristic sampling algorithm is proposed to generate the required subset by designing two scoring functions:one based on the chi-square test and the other based on likelihood *** on four types of datasets with a size of 60000 show that when the significant difference level,a,is set to 0.05,the algorithm can exclude 99.9%,99.0%,93.1%and 96.7%of the samples based on their Bayesian networks-ASIA,ALARM,HEPAR2,and ANDES,*** subsets of the same size are sampled,the subset generated by our algorithm passes all the distribution tests and the average distribution difference is approximately 0.03;by contrast,the subsets generated by random sampling pass only 83.8%of the tests,and the average distribution difference is approximately 0.24.

关键词： Bayesian network chi-square test sampling probability distribution

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Automatic ^(40)Ar/^(39)Ar Dating Techniques Using Multicollector ARGUS VI Noble Gas Mass Spectrometer with Self-Made Peripheral Apparatus

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Journal of Earth Science 2018年第2期29卷 408-415页

作者： Xiu-juan Bai Hua-Ning Qiu wen-Gui Liu lian-Fu Mei Key Laboratory of Tectonics and Petroleum Resources Ministry of Education China University of Geosciences State Key Laboratory of Isotope Geochemistry Guangzhou Institute of Geochemistry Chinese Academy of Sciences State Key Laboratory of Geological Processes and Mineral Resources China University of Geosciences

A new fully automatic ^40Ar/^39Ar laboratory with a Thermo Scientific ARGUS VI mass spectrometer has been established in China University of Geosciences （Wuhan）. We designed and developed a mini efficient preparation system （80 mL）, a CO2 laser for heating samples, a crusher for extracting fluid inclusions within K-poor minerals and an air reservoir （31 L） and pipette （0.1 mL） system. The ARGUS VI mass spectrometer is operated by the Qtegra Noble Gas software, which can control the peripheral accessories, such as pneumatic valves, CO2 laser and crusher through a PeriCon （peripheral controller）. The experimental procedures of atmospheric argon ana- lyses, ^40Ar/^39Ar dating by laser stepwise heating and by progressive crushing in vacuo, can be fully automatically performed. The weighted mean of atmospheric ^40Ar/^36Ar ratios is 302.22＋0.03 （1σ, MSWD=0.74, n=200）, indicating that air reservoir and pipette system and the whole instrument sys- tem are very stable. This laboratory is a successful pioneer example in China to establish a new no- ble gas laboratory with self-made peripheral accessories expect for the mass spectrometer.

关键词： ^40Ar/^39Ar dating fully automatic CO2 laser ARGUS VI mass spectrometer Qtegra noble gas software.

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Horseshoes for Anosov Systems on Fibers Driven by an Equicontinuous System

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Acta Mathematica Sinica,English Series 2022年第1期38卷 281-290页

作者： wen HUANG Zeng lian School of Mathematical Sciences University of Science and Technology of ChinaHefei 230026P.R.China College of Mathematical Sciences Sichuan UniversityChengdu 610016P.R.China

In this paper,we construct random horseshoes of Anosov systems driven by an equicontinuous system based on an ergodic measure with positive entropy.

关键词： Random horseshoe Anosov diffeomorphism entropy

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