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Overview of the anterolateral complex of the knee

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World Journal of Clinical Cases 2022年第24期10卷 8474-8481页

作者： Ignacio Garcia-Mansilla juan pablo zicaro Ezequiel Fernando Martinez juan Astoul Carlos Yacuzzi MatiasCosta-Paz Knee Surgery Hospital Italiano de Buenos AiresBuenos Aires 1199Argentina

In the last few years,much more information on the anterolateral complex of the knee has become *** has now been demonstrated how it works in conjunction with the anterior cruciate ligament(ACL)controlling anterolateral rotatory *** studies have shown that the anterolateral complex(ALC)has a role as a secondary stabilizer to the ACL in opposing anterior tibial translation and internal tibial *** is of utmost importance that surgeons comprehend the intricate anatomy of the entire anterolateral aspect of the *** most studies have only focused on the anterolateral ligament(ALL),the ALC of the knee consists of a functional unit formed by the layers of the iliotibial band combined with the anterolateral joint *** interest has also been given to imaging evaluation using magnetic resonance and several studies have targeted the evaluation of the ALC in the setting of ACL *** are inconsistent with a lack of association between magnetic resonance imaging evidence of injury and clinical *** ACL reconstruction may not always reestablish knee rotatory stability in patients with associated ALC *** such cases,additional procedures,such as anterolateral reconstruction or lateral tenodesis,may be *** are several techniques available for ALL *** options include the iliotibial band,gracilis or semitendinosus tendon autograft,or allograft.

关键词： Anterolateral complex Knee instability Anterolateral ligament Anterior cruciate ligament reconstruction

Failure rate,return-to-sports and magnetic resonance imaging after meniscal repair:119 patients with 7 years mean follow up

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World Journal of Orthopedics 2023年第8期14卷 612-620页

作者： juan pablo zicaro Nicolas Garrido Ignacio Garcia-Mansilla Carlos Yacuzzi Matias Costa-Paz Department of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

BACKGROUND One of the most important factors to consider in relation to meniscal repair is the high failure rate reported in the existing *** To evaluate failure rates,return to sports(RTS)rate,clinical outcomes and magnetic resonance image(MRI)evaluation after meniscus suture repair for longitudinal tears at a minimum *** We conducted a retrospective review of meniscal repairs between January 2004 and December *** patients treated for longitudinal tears associated or not with an anterior cruciate ligament reconstruction(ACL-R)were *** ramp lesions,radial and root tears,associated with multiligament injuries,tibial fracture and meniscal allograft transplants were *** details and failure rate,defined as symptomatic patients who underwent a revision surgery,were *** isolated bucket handle tears(BHTs)were usually associated with higher failure rates,we compared BHTs and not BHTs associated or not with an *** 2014,the inside-out technique using cannulas and suture needles with 2-0 Tycron began to *** addition,the number of stitches per repair was *** view of differences in surgical technique,we compared two different cohorts:before and after *** recorded the RTS according to the level achieved and the time to *** and IKDC scores were *** were studied with x-rays and MRI as standard postoperative *** One hundred and nineteen patients were included with a mean follow up of 7 years(SD:4.08).Overall failure rate was 20.3%at a mean 20.1 *** statistically significant differences were found when comparing failure for medial and lateral meniscal repair(22.7%and 15.3%,P=0.36),BHTs and not BHTs(26%and 17.6%,P=0.27),isolated or associated with an ACL-R(22.9%and 18%,P=0.47),or when comparing only BHTs associated with an ACL-R(23%and 27.7%,P=0.9)or *** comparing cohorts before and after 2014,we found a significant decrease in the overall f

关键词： Meniscus repair Bucket handle tears Meniscal suture Failure rate Longitudinal meniscus tears

Has platelet-rich plasma any role in partial tears of the anterior cruciate ligament?Prospective comparative study

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World Journal of Orthopedics 2021年第6期12卷 423-432页

作者： juan pablo zicaro Ignacio Garcia-Mansilla Andres Zuain Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresBuenos Aires 1181Argentina

BACKGROUND Partial tears of the anterior cruciate ligament(ACL)are frequent,and there is still considerable controversy surrounding their diagnosis,natural history and *** To examine patient-reported outcomes,physical examination and magnetic resonance imaging(MRI)findings of partial ACL tears treated with an intraarticular injection of platelet-rich plasma(PRP)compared to a control *** From January 2015 to November 2017,consecutive patients from a single institution with partial ACL tears treated nonoperatively were prospectively *** tears were defined as a positive Lachman test with a clear endpoint,a negative pivot-shift and less than 3 mm of side-to-side difference using the KT1000 *** in group 1 were treated with one intraarticular injection of PRP and specific physical therapy *** group consisted of patients treated only with physical *** analyzed data included physical examination,Tegner activity level and Lysholm and International Knee Documentation Committee *** MRI findings and at 6 mo follow-up were *** was defined as those patients with clinical instability at follow-up that required a subsequent ACL *** A total of 40 patients where included,21 treated with PRP injection with a mean follow-up of 25 mo[standard deviation(SD):3.6]and 19 in the control group with a mean follow-up of 25 mo(SD:5.68).Overall failure rate was 32.0%(n=13).No significant differences were observed between groups regarding subjective outcomes,return to sport and failure *** findings revealed an improvement in the ACL signal in half of the patients of both ***,we did not find a significant relationship between MRI findings and clinical *** Overall,95.0%of patients returned to sports at a mean follow-up of 25 *** time to return to sports was 4 *** of these patients,almost 30.0%in each group had a new episode of instability

关键词： Anterior cruciate ligament Partial tears Platelet-rich plasma Non-operative treatment

Revision anterior cruciate ligament reconstruction:Return to sports at a minimum 5-year follow-up

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World Journal of Orthopedics 2022年第9期13卷 812-824页

作者： Ezequiel Ortiz juan pablo zicaro Ignacio Garcia Mansilla Carlos Yacuzzi Matias Costa-Paz Knee Division Hospital Italiano de Buenos AiresCiudad Autónoma 1181Buenos AiresArgentina

BACKGROUND Between 43%and 75%of patients who undergo primary anterior cruciate ligament(ACL)surgery return to sport ***,after a revision ACL reconstruction(ACLR)the rate of return to sports is variable.A few publications have reported returns to sports incidence between 56%to 100%after revision *** To determine return to sports and functional outcomes after a single-stage revision ACLR with a 5-year minimum follow-up at a single *** All patients operated between 2010 and 2016 with a minimum 5 years of followup were *** of sport,intensity,frequency,expectation,time to return to sport and failure rate were ***,Tegner and International Knee Documentation Committee forms were evaluated prior to the first ACLR surgery,at 6 mo after primary surgery and after revision ACLR at 5 years minimum of *** stability was tested with the knee arthrometer test(KT-1000 knee arthrometer,Medmetric Corp).RESULTS A total of 41 patients who underwent revision ACLR during that period of time were contacted and available for *** patient age at time of revision was 29 years old[interquartile range(IQR):24.0-36.0],and 39(95.0%)were *** median time from revision procedure to follow-up was 70 mo(IQR:58.0-81.0).Regarding return to sports,16(39.0%)were at the same level compared to preinjury period,and 25 patients(61.0%)returned at a lower ***-three percent categorized the sport as very important and 37.0%as *** patient(2.4%)failed with a recurrent ACL *** preoperative Lysholm and(SD)16]and 50(SD 11),*** follow-up,mean Lysholm and subjective International Knee Documentation Committee scores were 89(SD 8)and 82(SD 9)(P=0.0001).Mean Tegner score prior to primary ACLR was 6.7(SD 1.3),5.1(1.5 SD)prior to revision ACLR and 5.6(1.6 SD)at follow-up(P=0.0002).Overall,knee arthrometer test measurement showed an average of 6 mm(IQR:4.0-6.0)side-to-side difference of displacement pri

关键词： Return to sport Revision anterior cruciate ligament Arthroscopy Knee Functional outcome

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan pablo de Rivero Vaccari Jennifer C.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang J.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to Cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric Critical Care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

Asymptotic of Eigenvalues and Lattice Points

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Acta Mathematica Sinica,English Series 2006年第6期22卷 1645-1650页

作者： juan pablo PINASCO Instituto de Ciencias Universidad Nacional de General Sarmiento

dimension. elementary domains of In this work we study the spectral counting function for the p-Laplace operator in one We show the existence of a two-term Weyl-type asymptote. The method of proof is rather based on ... 详细信息

关键词： p-Laplacian eigenvalues lattice points

Risk Transfer for Populations in Precarious Urban Environments

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International Journal of Disaster Risk Science 2020年第1期11卷 74-86页

作者： juan pablo Sarmiento Ana María Torres-Munoz Extreme Events Institute/Disaster Risk and Resilience in the Americas(DRRA) Florida International UniversityMiamiFL 33199USA

This study explores risk transfer options that precarious and marginal urban communities could use to protect themselves from future damages and losses generated by socio-natural hazards and disasters at the individual and community levels. The design is framed within an evidence-based disaster risk reduction(DRR) strategy and follows the case study research approach. We analyze the2018 Neighborhood Approach for DRR programming evaluation carried out in four Latin American cities’ informal settlements and review relevant risk transfer experiences aimed at vulnerable populations. We calculate the pure risk premium for the four cases selected, using a previous catastrophe risk assessment for earthquakes and landslides. We propose three risk transfer options based on our analysis:(1) voluntary collective insurance;(2) structural reinforcement with a comprehensive housing insurance;and(3) hybrid parametric insurance. Risk transfer mechanisms conventionally focus on residual risk management. Here, due to the precariousness of the analyzed urban settings, the proposed alternatives go beyond the management of just residual risk to positively impact the beneficiaries’ quality of life and the reduction of the built environment’s physical vulnerability in the short and medium terms. Our study proposes a prospective estimation of future risk despite the limitations of data availability. This study opens a window to new approaches and proposes a systematic process to design DRR policy aimed at the poor and vulnerable strata of society.

关键词： Case study research Catastrophe risk assessment Informal settlements Risk transfer Urban precariousness Urban risk

Myelin lipid deficiency:a new key driver of Alzheimer’s disease

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Neural Regeneration Research 2023年第1期18卷 121-122页

作者： Shulan Qiu juan pablo Palavicini Xianlin Han Barshop Institute for Longevity and Aging Studies Division of DiabetesDepartment of MedicineUniversity of Texas Health Science Center at San AntonioSan AntonioTXUSA

Lipids play essential biological functions that include acting as components of biological membranes,energy storage,signaling,nutrients,transporters,enzyme activators,among *** with the multiple research methods to assess DNA,RNA,and protein content,location,and function in cells,there are relatively fewer methods to study ***,lipid-oriented mechanistic studies remain rare and challenging.

关键词： Alzheimer rare challenging

Self-powered smart patch for sweatconductivity monitoring

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Microsystems & Nanoengineering 2019年第1期5卷 672-681页

作者： Laura Ortega Anna Llorella juan pablo Esquivel Neus Sabate Instituto de Microelectronica de Barcelona IMB-CNM(CSIC)C/del Til·lers.Campus Universitat Autonoma de Barcelona(UAB)08193 BellaterraBarcelonaSpain Catalan Institution for Research and Advanced Studies(ICREA) Passeig Lluís Companys 2308010 BarcelonaSpain

A self-powered skin patch for the measurement of sweat conductivity is *** key component of the patch consists of a paper battery that is activated upon absorption of *** body fluid acts as the battery electrolyte,the conductivity of which has a direct impact on the battery-generated output power and *** particular behaviour enables the operation of a very simple and robust conductivity sensor in direct current mode without needing an external power *** device presented in this paper takes advantage of this new measurement method to develop a sweat patch for screening cystic fibrosis that operates with an extremely simple electronic circuit that minimizes its cost and environmental *** patch provides an unambiguous digital result that can be read in an electrochromic display and yields 95%sensitivity and 100%specificity when tested with artificial eccrine perspiration samples.

关键词： battery conductivity patch