检索结果-南通市图书馆

KRT4 suppresses oral squamous cell carcinoma development by reducing ATG4B-mediated autophagy

在线全文

学校读者我要写书评

暂无评论

BIOCELL 2022年第2期46卷 441-451页

作者： XIAOXU LI YUn WAnG juan FAnG ZHI WAnG XIAOAn TAO juan XIA BIn CHEnG Guangdong provincial Key Laboratory of stomatology Guanghua School of StomatologyHospital of StomatologySun Yat-Sen UniversityGuangzhou510055China

Head and neck squamous cell carcinoma is the sixth most common tumor worldwide,and half of head and neck squamous cell carcinoma patients are with oral squamous cell carcinoma(OsCC).300,000 new cases of OsCC were reported *** with multi-modality treatment,the prognosis of OsCC remains ***,it is urgent to discover novel therapeutic targets for *** microarray studies have revealed that Keratin 4(KRT4)is downregulated in OsCC,whereas its role in OsCC development remains *** present study revealed that KRT4 suppressed OsCC progression by inducing cell apoptosis and inhibiting cell *** addition,KRT4 over-expression inhibited autophagy by blocking the interaction of autophagy-related 4B cysteine peptidase(ATG4B)and microtubule-associated protein 1A/1B light chain 3(LC3)to regulate apoptosis and invasion of *** conclusion,KRT4 played an important role in OsCC development through regulating ATG4B-mediated autophagy and may be a novel therapeutic drug target of OsCC.

关键词： Oral squamous cell carcinoma KRT4 Cancer-suppressive role ATG4B Autophagy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

蓬莪术挥发油中治疗痛经的活性成分研究

中国中药杂志 2024年第7期49卷 1872-1881页

作者：米福新倪红彭成刘菲戴鸥周勤梅刘娟熊亮成都中医药大学药学院、西南特色中药资源国家重点实验室四川成都611137 成都中医药大学医学技术学院四川成都611137 成都中医药大学西南特色药材创新药物成分研究所四川成都611137 成都中医药大学中医药创新研究院四川成都611137

研究蓬莪术Curcuma phaeocaulis根茎挥发油中治疗痛经的活性成分,采用分子蒸馏、硅胶和葡聚糖凝胶sephadex LH-20柱色谱、制备薄层色谱及半制备高效液相色谱等方法对蓬莪术挥发油进行分离纯化,运用质谱、核磁共振等波谱学手段鉴定化合... 详细信息

研究蓬莪术Curcuma phaeocaulis根茎挥发油中治疗痛经的活性成分,采用分子蒸馏、硅胶和葡聚糖凝胶sephadex LH-20柱色谱、制备薄层色谱及半制备高效液相色谱等方法对蓬莪术挥发油进行分离纯化,运用质谱、核磁共振等波谱学手段鉴定化合物的结构。利用原发性痛经动物模型和大鼠离体子宫平滑肌收缩模型研究蓬莪术挥发油治疗痛经的活性组分及成分。从蓬莪术挥发油高沸点组分中分离得到6个倍半萜类化合物,分别鉴定为dehydrocommiterpene A(1)、comosoneⅡ(2)、5α(H)-eudesma-3(4),7(11)-dien-9β-ol-6-one(3)、guaia-6(7)-en-11-ol(4)、莪术烯醇(5)、异莪术烯醇(6),其中化合物1为新化合物。整体动物实验表明,蓬莪术挥发油可显著降低原发性痛经动物模型大鼠子宫平滑肌中前列腺素F_(2α)(pGF_(2α))含量。离体动物实验表明,蓬莪术挥发油高沸点组分舒张子宫活性优于低沸点组分,从高沸点组分中分离出的化合物1、2、5、6具有舒张子宫平滑肌活性,其中,化合物5和6可通过抑制离体子宫外钙内流和内钙释放,从而发挥舒张子宫平滑肌活性。综上,高沸点部位是莪术油治疗痛经的活性组分,倍半萜类是莪术油治疗痛经的有效成分群。

关键词：蓬莪术挥发油分子蒸馏倍半萜分离鉴定痛经

severe bleeding after operation of preauricular fistula:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第29期9卷 8932-8937页

作者： Chun-Hui Tian Xiao-juan Chen Department of Otolaryngology—Head and neck surgery Suzhou Hospital of Anhui Medical UniversitySuzhou 235200Anhui ProvinceChina

BACKGROUnD severe eyelid edema and blood accumulation in the submandibular space after preauricular fistula surgery is rarely *** sUMMARY We report a 4-year-old girl with eyelid edema and swelling of the submandibular region after preauricular fistula resection under general *** drug treatment failed,neck computed tomography examination was performed,which confirmed severe bleeding in the submandibular ***,exploration and ligation of the superficial temporal artery were performed under general anesthesia to stop the *** child was successfully treated,and there were no abnormalities over 1 year of *** When severe bleeding occurs after preauricular fistula surgery,superficial temporal artery rupture should be considered as a cause.

关键词： preauricular lesions Bleeding Infection Excision surgical treatment Case report

Adaptive beamforming and phase bias compensation for Gnss receiver

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of systems Engineering and Electronics 2015年第1期26卷 10-18页

作者： Hongwei Zhao Baowang Lian juan Feng school of Electronics and Information Northwestern Polytechnical University shaanxi Fiber Home Communication Group Co. Ltd

Adaptive antenna arrays have been used to mitigate the interference on global navigation satellite system（Gnss） receivers. The performance of interference mitigation depends on the beamforming algorithms adopted by the antenna array. However,the adaptive beamforming will change the array pattern in realtime, which has the potential to introduce phase center biases into the antenna array. For precise applications, these phase biases must be mitigated or compensated because they will bring errors in code phase and carrier phase measurements. A novel adaptive beamforming algorithm is proposed firstly, then the phase bias induced by the proposed algorithm is estimated, and finally a compensation strategy is addressed. simulations demonstrate that the proposed beamforming algorithm suppresses effectively the strong interference and improves significantly the capturing performance of Gnss signals. simultaneously, the bias compensation method avoids the loss of the carrier phase lock and reduces the phase measurement errors for Gnss receivers.

关键词： global navigation satellite system(Gnss) space-time adaptive processing(sTAp) adaptive beamforming bias compensation

施用氯化钾对马铃薯氯含量的影响及动态氯临界值研究

在线全文

学校读者我要写书评

暂无评论

植物营养与肥料学报 2024年第9期30卷 1745-1757页

作者：聂鑫李佳琪原琳汤金融符强张娟孙磊东北农业大学资源与环境学院黑龙江哈尔滨150030 黑龙江省绥芬河市农业技术推广中心黑龙江绥芬河157300 黑龙江省农业科学院绥化分院黑龙江绥化152052

【目的】通过研究氯化钾(KCl)施用量和施用时期对马铃薯氯营养特征及产量的影响,确定以块茎产量为基础的氯敏感时期和指示器官,以及氯敏感时期指示器官的动态Cl^(−)临界值,为马铃薯生产中氯化钾等含氯肥料的安全施用提供参考。【方法】... 详细信息

【目的】通过研究氯化钾(KCl)施用量和施用时期对马铃薯氯营养特征及产量的影响,确定以块茎产量为基础的氯敏感时期和指示器官,以及氯敏感时期指示器官的动态Cl^(−)临界值,为马铃薯生产中氯化钾等含氯肥料的安全施用提供参考。【方法】以‘尤金’为供试品种进行田间试验,在K_(2)O施用时期和施用量相同的条件下,分别在基肥和追肥时施用不同比例的氯化钾,选取马铃薯关键生育期进行植株样品采集,分别测定各器官的Cl^(−)含量和生物量,并在成熟期测定马铃薯块茎产量及其构成因子。根据马铃薯不同生育时期各器官Cl^(−)含量与产量的相关性,确定马铃薯对Cl^(−)的敏感时期和指示器官;根据敏感期指示器官Cl^(−)含量与块茎相对产量,确定以马铃薯产量为评价依据的马铃薯动态Cl^(−)临界值。【结果】不同时期施用不同量的氯化钾均会显著提高马铃薯各器官的Cl^(−)含量与Cl^(−)积累量(pppp<0.05)。【结论】以马铃薯块茎产量为基础,叶片Cl^(−)含量可作为马铃薯氯营养状况的指示器官,在苗期Cl^(−)临界值为1.5%,块茎形成期的Cl^(−)临界值为2.1%。

关键词：马铃薯氯化钾产量氯离子含量氯临界值

2021年重庆市恶性肿瘤发病与死亡情况及2016年生存率分析

在线全文

学校读者我要写书评

暂无评论

中国肿瘤 2024年第2期33卷 134-139页

作者：丁贤彬吕晓燕焦艳陈婷高旸许杰熊娟重庆市疾病预防控制中心重庆400042 重庆市渝北区第二人民医院重庆401147

[目的]了解重庆市恶性肿瘤发病率、死亡率与5年生存率。[方法]采用spss 25.0分析重庆市新发恶性肿瘤发病、死亡和随访数据,计算2021年重庆市恶性肿瘤发病率、标化发病率、死亡率、标化死亡率。分别采用2000年第五次人口普查标准人口构成... 详细信息

[目的]了解重庆市恶性肿瘤发病率、死亡率与5年生存率。[方法]采用spss 25.0分析重庆市新发恶性肿瘤发病、死亡和随访数据,计算2021年重庆市恶性肿瘤发病率、标化发病率、死亡率、标化死亡率。分别采用2000年第五次人口普查标准人口构成和2000年世界人口构成计算中标率和世标率。采用寿命表法计算观察生存率,乘积极限法(Kaplan-Meier)计算平均生存时间,生存率的比较采用Log-rank法。[结果] 2021年重庆市恶性肿瘤粗发病率、中标发病率和世标发病率分别为310.50/10万、183.09/10万和196.13/10万,男性标化发病率(196.85/10万)高于女性(170.07/10万)。2021年重庆市恶性肿瘤粗死亡率、中标死亡率和世标死亡率分别为178.88/10万、89.89/10万和103.70/10万,恶性肿瘤标化死亡率男性高于女性、农村高于城市。共计随访74 953人,随访5年恶性肿瘤平均生存时间2.88(2.86~2.90)年。重庆市恶性肿瘤5年生存率为40.34%,女性(49.93%)高于男性(34.04%)(χ^(2)=1 920.842,pp<0.001)。肺癌、肝癌、食管癌、胃癌、女性乳腺癌、结直肠癌、宫颈癌、前列腺癌、甲状腺癌、子宫体癌5年生存率分别为32.12%、25.82%、29.26%、34.47%、78.95%、54.17%、69.46%、56.93%、93.93%、74.82%。[结论]重庆市恶性肿瘤发病率与死亡率较高,但5年生存率较低,应加强肿瘤综合防治,重点应针对男性和农村地区。

关键词：恶性肿瘤发病率死亡率生存率重庆

安装水平多孔板的鼓泡床反应器CFD-pBM数值模拟

在线全文

学校读者我要写书评

暂无评论

石油学报（石油加工） 2024年第3期40卷 727-734页

作者：霍莹付连超王娟车连发李秀明阚子建刘翊辉中海油天津化工研究设计院有限公司天津300131 中国石油大学重质油国家重点实验室北京102249

采用Euler-Euler双流体模型对安装水平多孔板的鼓泡床反应器内气-液两相流动进行数值模拟研究,探究了不同水平多孔板和表观气速条件对鼓泡床反应器内气含率及气泡直径的影响。结果表明:当表观气速从0.5 m/s增加到1.0 m/s时,安装水平多... 详细信息

采用Euler-Euler双流体模型对安装水平多孔板的鼓泡床反应器内气-液两相流动进行数值模拟研究,探究了不同水平多孔板和表观气速条件对鼓泡床反应器内气含率及气泡直径的影响。结果表明:当表观气速从0.5 m/s增加到1.0 m/s时,安装水平多孔板的反应器内整体气含率显著增加;安装多孔板后,气泡在中心区域分布范围加宽;轴向液体速度为0时,没有安装多孔板的反应器向上流动的液相径向无量纲分布范围为0~0.57,而安装了多孔板的径向无量纲分布范围为0~0.64;水平多孔板的安装能增强气泡之间的聚并与破碎,使大气泡在反应器中心区域的分散范围更宽。

关键词：鼓泡床反应器 CFD-pBM模型轴向液速气含率

posterior quadrant epilepsy surgery: case series of a south American hospital

在线全文

学校读者我要写书评

暂无评论

Acta Epileptologica 2022年第4期5卷 227-232页

作者： Mario Velasco Andrés Felipe Cárdenas-Cruz María paula Aguilera-pena Alejandro Vargas-Moreno Daniel nariño juan Carlos pérez Oscar Zorro pontificia Universidad Javeriana Cr16#75-32 apt 203BogotaColombia110221 neuroscience Department Hospital Universitario San IgnacioCr16#75-32 apt 203BogotaColombia110221

Background posterior quadrant epilepsy(pCE)is a type of focal epilepsy that originates in the parietal lobe,occipital lobe,and the parietal-occipital border of the temporal lobe,or in any combination of these *** has a low incidence,but it can cause a great burden in disability-adjusted life *** this retrospective cohort,patients of all ages with a diagnosis of pCE between 2006 and 2019 were evaluated in a referral center in Bogotá,Colombia.A descriptive analysis of demographic data,clinical history,imaging findings,type of surgery,histopathological diagnosis,outcome,and follow-up was performed using the Engel *** This study included refractory pCE patients of all ages who were evaluated by the epilepsy surgery group of the Hospital Universitario san Ignacio from 2006 to ***,imaging and surgical variables were obtained from the medical records and *** Thirteen patients were included in the study,including 8 males and 5 *** mean age of diagnosis was 8.8 years,while the mean age of surgery was 25 *** most frequent clinical finding was intellectual *** most common findings on magnetic resonance imaging were encephalomalacia and *** 61.5%of the patients,the lateralization of video-EEG matched with brain magnetic resonance imaging *** most frequent types of surgery performed were lobectomies,lesionectomies and cortical ***-freedom was achieved in approximately one third of the patients;however,more than half of the patients were free of disabling seizures or had significant improvement after *** pCE surgery is scarcely performed worldwide,therefore the effectiveness and outcomes are quite variable in the reported *** this study,we show that patients with pCE can obtain great benefits in terms of reduction of seizures with a low risk of surgical complications,encouraging the use of this type of procedure in carefully selected patients.

关键词： posterior cortex Epilepsy surgery posterior quadrant epilepsy

Highly dispersed ni/MgO-msiO_(2)catalysts with excellent activity and stability for dry reforming of methane

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

nano Research 2022年第6期15卷 5004-5013页

作者： Fang Zeng juan Zhang Run Xu Rongjun Zhang Jianping Ge shanghai Key Laboratory of Green Chemistry and Chemical processes School of Chemistry and Molecular EngineeringEast China Normal UniversityShanghai 200062China Department of Coal and syngas Conversion Research Institute of Petroleum ProcessingSINOPECBeijing 100083China

Highly dispersed ni catalyst and alkaline promoters supported by mesoporous siO_(2)nanospheres were synthesized and applied as an active and stable catalyst for dry reforming of methane(DRM).The as-prepared ni/MgO-msiO_(2)catalyst showed stable conversions of CH4 and CO_(2)around 82%and 85%in 120 h of DRM reaction,which was superior in performance compared to similar catalysts in *** on the transmission electron microscope(TEM)images,energy-dispersive spectroscopy(EDs),CO-pulse adsorption,temperature programmed reduction of the oxidized catalysts by hydrogen(H_(2)-TpR),X-ray photoelectron spectroscopy(Xps),temperature-programmed desorption of CO_(2)(CO_(2)-TpD),and thermal gravitational analysis(TGA),the promotion effect of MgO on the ni catalyst was systematically *** introduction of Mg^(2+)in synthesis enhanced the interaction between ni^(2+)and msiO_(2),which led to a high dispersion of active centers and a strong“metal–support”interactions to inhibit the sintering and deactivation of ni at reaction *** the other hand,ni and MgO nanoparticles formed adjacently on msiO_(2),where the“ni-MgO”interface not only improved the ni0 distribution and promoted the cracking of CH_(4)but also promoted the activation of CO_(2)and the elimination of carbon deposits.A high and stable conversion of CH4 and CO_(2)were then achieved through the synergistic effect of ni catalyst,MgO promoter,and msiO_(2)support.

关键词： ni-based catalyst dry reforming of methane mesoporous siO_(2) MgO alkaline