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Impact of sTAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián sánchez-Ramírez mónica G mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-gonzález miriam Rodríguez-sosa juan Josémontesinos-montesinos mauricio salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico Department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico Department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio nacional en salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer *** displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better *** reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor *** are directly involved in tumorigenesis through different ***,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(sTATs)in mediating CAF activity in CRC remains *** the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating sTAT signaling ***,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using sTAT ***,we analyze the impact of different sTATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

The potential of starch-chitosan blends with poloxamer for the preparation of microparticles by spray-drying

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Particuology 2024年第6期89卷 1-10页

作者： juan Enrique Barranco-García Carolina Caicedo Enrique Javier Jiménez-Regalado Carlos Espinoza-gonzález Graciela morales Rocio Yaneli Aguirre-Loredo Abril Fonseca-García Tecnológico nacional de méxico/Instituto Tecnológico de Oaxaca Departamento de Química y BioquímicaAvenida Ing.Víctor Bravo Ahuja No.125Esquina Calzada Tecnológico68030OaxacaMexico Faculty of Engineering Unidad Central del Valle del Cauca(UCEVA)Carrera 17a 48-144763022TuluáColombia Centro de Investigación en Química Aplicada(CIQA) Blvd.Enrique Reyna Hermosillo 14025294SaltilloCoahuilaMexico Investigadoras por méxico COnAHCYT-CIQA Av.Insurgentes Sur 1562Col.Crédito Constructor03940Alcaldía Benito JuárezCDMXMexico

Using biopolymers as wall materials in spray drying poses challenges,particularly in attaining flowability and thermal stability among their physicochemical *** paper addresses these challenges by preparing microparticles using a blend of starch–chitosan and a poloxamer,commercially named Pluronic®*** aimed to elucidate the effects of varying poloxamer concentrations on the resulting particles through the spray drying *** with a poloxamer concentration of 3%(w/v)demonstrated a notably higher yield,especially when compared to those with 0%and 1%*** with 3%and 5%(w/v)poloxamer displayed a narrower particle size distribution,with the 3%blend showing a superior yield attributed to arrangements of blend components that improve flowability.X-ray diffraction analysis showcased the characteristic peaks of A-type starch form,with shifts suggesting enhanced interactions between *** with increased poloxamer content showed elevated thermal degradation temperatures,with the 3%blend registering a significant rise,opening avenues for encapsulating heat-sensitive *** study primarily focuses on the preparation and basic characterization of *** underscores the potential of blends with optimal poloxamer concentrations in microencapsulation,emphasizing further research to harness their capabilities thoroughly.

关键词： Biopolymer starch Chitosan Pluronic®F127 microparticles spray drying

soil organic carbon stocks in native forest of Argentina:a useful surrogate for mitigation and conservation planning under climate variability

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Ecological Processes 2024年第1期13卷 3-24页

作者： Pablo L.Peri juan Gaitán matías mastrangelo marcelo nosetto Pablo E.Villagra Ezequiel Balducci martín Pinazo Roxana P.Eclesia Alejandra Von Wallis sebastián Villarino Francisco Alaggia marina gonzález Polo silvina manrique Pablo A.meglioli Julián Rodríguez-souilla martín mónaco Jimena E.Chaves Ariel medina Ignacio Gasparri Eugenio Alvarez Arnesi maría Paula Barral Axel von müller norberto m.Pahr Josefina Uribe Echevarria Pedro Fernández marina morsucci Dardo López juan manuel Cellini Leandro Alvarez Ignacio Barberis Hernán Colomb Ludmila La manna sebastián Barbaro Cecilia Blundo Ximena sirimarco Laura Cavallero Gualberto Zalazar Guillermo martínez Pastur Instituto nacional de Tecnología Agropecuaria (InTA) Universidad nacional de la Patagonia Austral (UnPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad nacional de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) CCT san Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigaciones en Biodiversidad y medioambiente (InIBIOmA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigaciones en Energía no Convencional CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Recursos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Dirección nacional de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ecología Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad nacional de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroecosistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigaciones en maderas (LImAD) Universidad Nacional de La Plata (UNLP) Administración de Parques nacionales (APn) Parque Nacional Los Alerces Centro de Estudios Ambientales Integrados (CEAI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Background The nationally determined contribution（nDC） presented by Argentina within the framework of the Paris Agreement is aligned with the decisions made in the context of the United nations Framework Conven-tion on Climate Change（UnFCCC） on the reduction of emissions derived from deforestation and forest degradation, as well as forest carbon conservation（REDD+）. In addition, climate change constitutes one of the greatest threats to forest biodiversity and ecosystem services. However, the soil organic carbon（sOC） stocks of native forests have not been incorporated into the Forest Reference Emission Levels calculations and for conservation planning under cli-mate variability due to a lack of information. The objectives of this study were:（i） to model sOC stocks to 30 cm of native forests at a national scale using climatic, topographic and vegetation as predictor variables, and（ii） to relate sOC stocks with spatial–temporal remotely sensed indices to determine biodiversity conservation concerns due to threats from high inter-annual climate *** We used 1040 forest soil samples（0–30 cm） to generate spatially explicit estimates of sOC native forests in Argentina at a spatial resolution of approximately 200 m. We selected 52 potential predictive environmental covari-ates, which represent key factors for the spatial distribution of sOC. All covariate maps were uploaded to the Google Earth Engine cloud-based computing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual climate variability, we employed the spatial–temporal satellite-derived indices based on Enhanced Vegetation Index（EVI） and land surface temperature（LsT） images from Landsat *** sOC model（0–30 cm depth） prediction accounted for 69% of the variation of this soil property across the whole native forest coverage in Argentina. Total mean sOC stock reached 2.81 Pg C（2.71–2.84 Pg C with a probability of 90%） for a total area of 460,790 km2,

关键词： soil organic carbon Biodiversity native forest Climate change mitigation modelling Resilience

Latest developments in early diagnosis and specific treatment of severe influenza infection

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Journal of Intensive medicine 2024年第2期4卷 160-174页

作者： Francisco Valenzuela-sánchez Blanca Valenzuela-méndez juan Francisco Rodríguez-Gutiérrez Ángel Estella Intensive Care Unit University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Haematology Department University Hospital of JerezRonda de Circunvalación s/nJerez de la FronteraSpain Centro de Investigación Biomédica en Red Enfermedades respiratoriasCIBERESInstituto de Salud Carlos IIIAv.de Monforte de LemosMadridSpain Department of Oncological surgery Institut du Cancer de Montpellier(ICM)Parc Euromédecine208 Av.des ApothicairesMontpellierFrance Department of medicine Faculty of MedicineUniversity of CádizCalle Doctor MarañónCádizSpain Instituto de Investigación e Innovación Biomédica de Cádiz(InIBiCA) Avenida Ana de Viya 21CádizSpain

Influenza pandemics are unpredictable recurrent events with global health,economic,and social *** objective of this review is to provide an update on the latest developments in early diagnosis and specific treatment of the disease and its complications,particularly with regard to respiratory organ *** advances in treatment,the rate of mortality in the intensive care unit remains approximately 30%.Therefore,early identification of potentially severe viral pneumonia is extremely important to optimize treatment in these *** pathogenesis of influenza virus infection depends on viral virulence and host ***,in some patients,it is associated with an excessive systemic response mediated by an authentic cytokine *** process leads to severe primary pneumonia and acute respiratory distress *** prognostication in the emergency department based on comorbidities,vital signs,and biomarkers(e.g.,procalcitonin,ferritin,human leukocyte antigen-DR,mid-regional proadrenomedullin,and lactate)is *** of these biomarkers on admission may facilitate clinical decision-making to determine early admission to the hospital or the intensive care *** decisions are reached considering pathophysiological circumstances that are associated with a poor prognosis(e.g.,bacterial co-infection,hyperinflammation,immune paralysis,severe endothelial damage,organ dysfunction,and septic shock).moreover,early implementation is important to increase treatment *** on a limited level of evidence,all current guidelines recommend using oseltamivir in this *** possibility of drug resistance should also be *** options include other antiviral drugs and combination therapies with monoclonal ***,it is not recommended to use corticosteroids in the initial treatment of these ***,the implementation of supportive measures for respiratory failure is ***

关键词： Influenza Pandemic Respiratory failure Acute respiratory distress syndrome Intensive care unit admission

Fast prediction of rain erosion in wind turbine blades using a data-based computational tool

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Journal of Hydrodynamics 2024年第3期36卷 504-518页

作者： juan m.Gimenez sergio R.Idelsohn Eugenio Oñate Centre Internacional de mètodes numèrics en Enginyeria(CImnE) Edifici C1 Campus Nord UPC C/Gran CapitàS/NBarcelonaSpain

Wind turbines(WTs)face a high risk of failure due to environmental factors like erosion,particularly in high-precipitation areas and offshore *** this paper we introduce a novel computational tool for the fast prediction of rain erosion damage on WT blades that is useful in operation and maintenance decision making *** approach is as follows:Pseudo-Direct numerical simulation(P-Dns)simulations of the droplet-laden flow around the blade section profile are employed to build a high-fidelity data set of impact statistics for potential operating *** this database as training data,a machine learning-based surrogate model provides the feature of the impact pattern over the 2-D section for given wind and rain *** this information,a fatigue-based model estimates the remaining lifetime and erosion damage for both homogeneous and coating-substrate blade *** prediction is done by quantifying the accumulated droplet impact energy and evaluating operative conditions over time periods for which the weather at the installation site is *** this work,we describe the modules that compose the prediction method,namely the database creation,the training of the surrogate model and their coupling to build the prediction ***,the method is applied to predict the remaining lifetime and erosion damage to the blade sections of a reference *** evaluate the reliability of the tool,several site locations(offshore,coastal,and inland),the coating material and the coating thickness of the blade are *** few minutes we are able to estimate erosion after many years of *** results are in good agreement with field observations,showing the promise of the new rain erosion prediction approach.

关键词： Wind turbine blades leading edge erosion fatigue Pseudo-Direct numerical simulation(P-Dns) machine learning eblader

Rainfall sensitivity to microphysics and Planetary Boundary Layer Parameterizations in Convection-Permitting simulations over northwestern south America

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Journal of meteorological Research 2024年第4期38卷 805-825页

作者： K.santiago HERnAnDEZ sebastian GOmEZ-RIOs juan J.HEnAO Vanessa ROBLEDO Alvaro RAmiREZ-CARDOnA Angela m.REnDOn Geolimna Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Grupo de Ingenieria y Gestion Ambiental(GIGA) Escuela AmbientalFacultad de IngenieriaUniversidad de AntioquiaMedellin 050010Colombia Division of Atmospheric sciences Desert Research InstituteRenoNV 89512USA

Convection-permitting modeling allows us to understand mechanisms that influence rainfall in specific ***,microphysics parameterization(mP) and planetary boundary layer(PBL) schemes remain an important source of uncertainty,affecting rainfall intensity,occurrence,duration,and ***,we study the sensitivity of rainfall to three mP [Weather Research and Forecasting(WRF) single-moment 6-class(Wsm6),Thompson,and morrison] and two PBL [the Yonsei University(YsU) and mellor–Yamada nakanishi niino(mYnn)] schemes with a convection-permitting resolution(4 km) over northwestern south America(nWsA).simulations were performed by using the WRF model and the results were evaluated against soundings,rain gauges,and satellite data,considering the spatio-temporal variability of rainfall over diverse regions prone to deep convection in *** and PBL schemes largely influenced simulated rainfall,with better results for the less computationally expensive Wsm6 mP and YsU PBL *** rain gauges and satellite estimates,simulations with morrison mP overestimated rainfall,especially westward of the Andes,whereas the mYnn PBL underestimated precipitation in the Amazon–savannas *** found that the uncertainty in the rainfall representation is highly dependent on the region,with a higher influence of mP in the Colombian Pacific and PBL in the Amazon–savannas *** analyzing rainfall-related processes,the selection of both mP and PBL parameterizations exerted a large influence on the simulated lower tropospheric moisture flux and moisture *** schemes significantly influenced the downward shortwave radiation,with mYnn simulating a greater amount of low clouds,which decreased the radiation ***,latent heat fluxes were greater for YsU,favoring moist convection and *** schemes had a marked impact on vertical ***,morrison mP showed stronger convection and higher precipitation rates,which is assoc

关键词： sensitivity microphysics planetary boundary layer(PBL) Weather Research and Forecasting(WRF) processes

novel insights into D-Pinitol based therapies:a link between tau hyperphosphorylation and insulin resistance

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neural Regeneration Research 2024年第2期19卷 289-295页

作者： Dina medina-Vera Antonio Jesús López-Gambero juan Antonio navarro Carlos sanjuan Elena Baixeras juan Decara Fernando Rodríguez de Fonseca Instituto de Investigación Biomédica de málaga y Plataforma en nanomedicina-IBImA Plataforma BIOnAnD UGC Salud MentalMálagaSpain Facultad de Ciencias Universidad de MálagaMálagaSpain CIBER Enfermedades Cardiovasculares(CIBERCV) Hospital Universitario Virgen de la VictoriaUGC del CorazónMálagaSpain University of Bordeaux INSERMNeurocentre MagendieBordeauxFrance Euronutra s.L.Calle Johannes Kepler MálagaSpain Departamento de Bioquímica y Biología molecular Facultad de MedicinaUniversidad de MálagaMálagaSpain

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s *** pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau *** the multiple causes of tau hyperphosphorylation,brain insulin resistance has generated much attention,and inositols as insulin sensitizers,are currently considered candidates for drug *** present narrative review revises the interactions between these three elements:Alzheimer’s disease-tau-inositols,which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.

关键词： Alzheimer’s disease cyclin-dependent kinase 5 diabetes D-Pinitol inositols insulin resistance kinases phosphorylation PI3K/Akt tau

Accuracy of tree mapping based on hand-held laser scanning comparing leaf-on and leaf-off conditions in mixed forests

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Journal of Forestry Research 2024年第5期35卷 14-25页

作者： Frederico Tupinambá-simões Adrián Pascual juan Guerra-Hernández Cristóbal Ordóñez Tiago de Conto Felipe Bravo iuFOR Sustainable Forest Management Research InstituteUniversity of Valladolid&INIAValladolidSpain Department of Geographical sciences University of MarylandCollege ParkMD 20742USA Forest Research Centre School of AgricultureUniversity of LisbonTapada da Ajuda1349‑017 LisbonPortugal

The use of mobile laser scanning to survey forest ecosystems is a promising,scalable technology to describe forest 3D structures at high *** confirm the con-sistency in the retrieval of forest structural parameters using hand-held laser scanning(HLs),before operationalizing the method,confirming the data is *** analyzed the per-formance of tree-level mapping based on HLs under differ-ent phenology conditions on a mixed forest in western spain comprising Pinus pinaster and two deciduous species,Alnus glutinosa and Quercus *** area was surveyed twice during the growing season(July 2022)and once in the deciduous season(February 2022)using several scan-ning *** reference data(418 trees,15 snags)was used to calibrate the HLs data and to assess the influence of phenology when converting 3D data into tree-level attrib-utes(DBH,height and volume).The HLs-based workflow was robust at isolating tree positions and recognizing stems despite changes in ***-six percent of all pairs matched below 65 *** DBH,phenology barely altered *** observed a strong agreement when comparing HLs-based tree height *** values exceeded 2 m when comparing height measurements,confirming height data should be carefully used as reference in remote sensing-based inventories,especially for deciduous *** volume was more precise for pines(r=0.95,and rela-tive RmsE=21.3–23.8%)compared to deciduous species(r=0.91–0.96,and relative RmsE=27.3–30.5%).HLs data and the forest structural complexity tool performed remark-ably,especially in tree positioning considering mixed forests and mixed phenology conditions.

关键词： Precision forestry Forest monitoring mobile laser scanning Forest inventory

An Investigation into Forced Convection of a nanofluid Flowing in a Rectangular microchannel under the Influence of a magnetic Field

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Fluid Dynamics & materials Processing 2024年第2期20卷 311-323页

作者： muataz s.Alhassan Ameer A.Alameri Andrés Alexis Ramírez-Coronel I.B.sapaev Azher m.Abed David-juan Ramos-Huallpartupa Rahman s.Zabibah Division of Advanced nanomaterial Technologies Scientific Research CenterAl-Ayen UniversityThi-QarIraq Department of Chemistry College of ScienceUniversity of BabylonBabylonIraq Research Group in Educational statistics National University of EducatiosnAzoguesEcuador Department Physics and Chemistry Tashkent Institute of Irrigation and Agricultural Mechanization EngineersNational Research UniversityTashkentUzbekistan Akfa University TashkentUzbekistan new Uzbekistan University TashkentUzbekistan Department of Airconditioning and Refrigeration Engineering Al-Mustaqbal University CollegeHilla51001Iraq Academic Department of Agro-Industrial Engineering and Technology Universidad Nacional JoséMaría ArguedasApurimacPerú The Islamic University NajafIraq

In line with recent studies,where it has been shown that nanoﬂuids containing graphene have a stronger capacity to boost the heat transfer coefﬁcient with respect to ordinary nanoﬂuids,experiments have been conducted using water with cobalt ferrite/graphene *** particular,a circular channel made of copper subjected to a constant heatﬂux has been *** nanoparticles are sensitive to the presence of a magneticﬁeld,different conditions have been examined,allowing both the strength and the frequency of such aﬁeld to span relatively wide ranges and assuming different concentrations of *** to theﬁndings,the addition of nanoparticles to theﬂuid causes its rotation speed to increase by a factor of two,whereas ultraviolet radiation plays a negligible *** amount of time required to attain the maximum rotation speed of the nanoﬂuid and the nusselt number have been measured under both constant and alternating magneticﬁelds for a ferroﬂuid with a concentration of 0.5%and atﬂow Reynolds number of 550 and 1750.

关键词： nano fluid rectengular tube magnetic field