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The USLE soil erodibility nomograph revisited

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International Soil and Water Conservation Research 2023年第1期11卷 1-13页

作者： Eva Corral-Pazos-de-Provens ígor Rapp-Arraras juan m.Domingo-Santos School of Engineering University of HuelvaE-21007 HuelvaSpain

The nomograph by Wischmeier et al.(1971)for calculating the K-factor in the USLE was extremely useful when there was low access to ***,the generalised calculation of this factor requires the development of analytic *** paper presents a detailed analysis of the nomograph and its underlying equation,which is applicable only when the silt plus very find sand fraction does not exceed 70%.We also examined the quality of fit on the nomograph of the adaptations to the equation that have been proposed,as a means of dealing with those areas where the original equation is not *** models are shown to have areas where the fit is deficient or even ***,the family of curves on the nomograph for the various values taken by the organic matter are not coincident with the mathematical function from which they presumably *** study also identifies those areas of the textural triangle in which the soils originally used in developing the USLE are located,with a view to according a lower predictive value to the contrasting areas in which calculations of the K-factor will necessarily be ***,a new equation for calculating the K-factor is presented,which accurately reproduces the different sections of the nomograph,and allows the poorly functioning graph to be dispensed *** paper ends with a link to a tool in R for simplifying the procedure for calculating the K-factor,taking into account varying situations of data availability.

关键词： K-factor RUSLE Soil texture Organic matter Very find sand Soil loss prediction

Diversity of plants and mammals as indicators of the effects of land management types in woodlands

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Forest Ecosystems 2021年第4期8卷 991-1005页

作者： Carolina R.Szymanski Solana Tabeni juan A.Alvarez Claudia m.Campos Instituto Argentino de Nivologia Glaciologia y Ciencias AmbientalesCCT CONICET MendozaAv.Ruiz Leal s/nParque General San Martin5000 MendozaArgentina Facultad de Ciencias Agrarias Universidad Nacional de CuyoAlte.Brown s/nChacras de Coria5505 MendozaArgentina Instituto Argentino de Investigaciones de las Zona Aridas(UNCuyo-Gobierno de mendoza-CONICET) CCT CONICET MendozaAv.Ruiz Leal s/nParque General San Martin5000 MendozaArgentina

Background:The ecological indicators are useful tools to determine the effects of human disturbances on woodland ***,ecological indicators not always responded in the same way to disturbances,and the responses can differ among *** arid and semiarid woodlands,the use of deadwood associated with cattle raising can affect biodiversity and Nature’s contributions to ***:Our study aimed to assess changes in taxonomic and functional diversity of two assemblages,plants and mammals,in Prosopis woodlands under different land management types:grazed woodlands and a protected *** plants,changes in structural diversity were also *** trees under different land management types were selected and their deadwood characteristics were *** live traps and camera traps,we obtained data on the presence-absence of mammals per tree to estimate diversity *** plants,we measured the abundance of vegetation by species and by cover type through the Line-Intercept method to estimated ***,we built generalized linear models to assess the responses of diversity of each assemblage to covariables concerning deadwood and different land management ***:We found that all diversity indeces for plants were either negatively affected by the presence of deadwood on the ground,or favored by its *** mammals,removal of deadwood increased taxonomic diversity,while functional diversity increased with deadwood on the *** structural diversity of plants and functional diversity of mammals were greater in grazed ***:The sustainable use of woodland resources is essential for the activities of rural *** study results indicated that land management of grazed woodlands promoted the structural diversity of plant assemblages and the functional diversity of *** presence of deadwood negatively affected plant diversity but it increased mammal functional *** is a

关键词： Central monte Cattle raising Deadwood extraction Taxonomic diversity Functional traits

基于生物信息学的胃癌关键糖酵解相关差异表达基因的鉴定及预后模型的构建

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医学分子生物学杂志 2025年第1期22卷 76-83页

作者：许娟胡琬琪仙桃市第一人民医院肿瘤科湖北省仙桃市433000 仙桃市第一人民医院胃肠外科湖北省仙桃市433000

目的应用生物信息学工具探索糖酵解相关基因(glycolysis-related genes,GRGs)在胃癌中的表达及基于其所构建的风险评分模型与胃癌患者预后的关系。方法从癌症基因组图谱(the cancer genome atlas,TC-GA)数据库下载胃癌组织转录组和临床... 详细信息

目的应用生物信息学工具探索糖酵解相关基因(glycolysis-related genes,GRGs)在胃癌中的表达及基于其所构建的风险评分模型与胃癌患者预后的关系。方法从癌症基因组图谱(the cancer genome atlas,TC-GA)数据库下载胃癌组织转录组和临床特征数据。从基因集富集分析(gene set enrichment analysis,GSEA)数据库中获得GRGs集。使用limma包来识别胃癌组织中差异表达的GRGs。使用单因素Cox回归分析筛选预后相关的GRGs,应用LASSO回归分析构建基于GRGs的预后预测模型。根据Cox回归分析确定的独立预后危险因素构建Nomogram图。最后,分析22种浸润性免疫细胞与GRGs、风险评分模型相关性。结果鉴定出21个差异表达的GRGs,其主要富集在酒精代谢过程和酪氨酸代谢途径。利用LASSO和Cox模型筛选出5个预后相关的糖酵解基因(ADH1B、ADH4、CLDN9、VCAN及LHX90),构建预测胃癌预后风险评分模型。低风险评分的胃癌患者总生存时间明显优于高风险评分的胃癌患者,ROC曲线分析显示该模型预测胃癌患者1年、3年及5年生存期曲线下面积(area under curve,AUC)值分别为0.602、0.680和0.802,发现该模型预测患者生存期的效能优于肿瘤分期及分级。单因素和多因素Cox分析显示构建的模型、患者的年龄、性别及肿瘤分期、分级是胃癌患者独立预后因素。基于独立危险因素构建了用来预测胃癌患者生存Nomogram图。最后,发现CD8 T细胞和辅助性滤泡T细胞比例在高危组中明显降低,而m0型和m2型巨噬细胞比例在高危组中明显高于低危组。辅助性滤泡T细胞与ADH1B表达水平、VCAN表达水平和风险评分呈负相关。m2型巨噬细胞与VCAN表达水平和风险评分呈正相关。结论研究筛选出胃癌预后相关的5个GRGs构建的模型可作为评估胃癌患者预后的可靠工具,为胃癌提供潜在的糖酵解治疗靶点。

关键词：胃癌糖酵解差异表达基因 Cox回归预后指标诺莫图

Drinking water production by uitrafiltration of Songhuajiang River with PAC adsorption

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Journal of Environmental Sciences 2007年第5期19卷 536-539页

作者： XIA Sheng-ji LIU Ya-nane LI Xing YAO juan-juan State Key laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 China School of Environmental Science and Engineering Dong Hua UniversityShanghai 201620China School of Architecture and Civil Engineering Beijing University of Technology Bejing 100083 China

In recent years, membrane ultrafiltration （UF） of surface water for drinking water treatment has become a more attractive technology worldwide as a possible alternative treatment to conventional clarification. To evaluate the performance of ultrafiltration membranes for treatment of surface water in North China, a 48-m^2 low pressure hollow fiber membrane ultrafiltration pilot plant was constructed. Ultrafiltration was operated in cross-flow and with powdered activated carbon （PAC） adsorption. Turbidity was almost completely removed to less than 0.2 NTU （below Chinese standard 1 NTU）. It was found that PAC addition enhanced organic matter removal. The combined process of PAC/UF allowed to 41% removal of CODmn, 46% removal of DOC and 57% decrease in UV254 absorbance. The elimination of particles, from average 12000/ml in the raw water to approximately 15/ml in the permeated, was observed. When PAC concentration was below 30 mg/L, backwashing could recovery the membrane flux with backwash interval/backwashing duration of 1/30.

关键词： surface water drinking water treatment ultrafiltration powdered activated carbon

Detecting accidental punctures and lacerations during cholecystectomy in large datasets: Two methods of analysis

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Hepatobiliary & Pancreatic Diseases International 2018年第5期17卷 430-436页

作者： Artem Shmelev Anne m Sill Gopal C Kowdley juan A Sanchez Steven C Cunningham Department of Surgery Saint Agnes Hospital and Cancer Center

Background: After the Institute of medicine(IOm) report To Err Is Human highlighted the impact of medical errors, the Agency for Healthcare Research and Quality(AHRQ) developed Patient-Safety Indicators(PSI) to improve quality by identifying potential inpatient safety problems. PSI-15 was created to study accidental punctures and lacerations(APL), but PSI-15 may underestimate APLs in populations of patients. This study compares PSI-15 with a more inclusive approach using a novel composite of secondary diagnostic and procedural codes. methods: We used Nationwide Inpatient Sample(NIS) data(20 0 0–2012) from AHRQ’s Healthcare Cost and Utilization Project(H-CUP). We analyzed PSI-15-positive and-negative cholecystectomies. Cross tabulations identified codes that were significantly more frequent among PSI-15-positive cases; these secondary diagnostic and procedural codes were selected as candidate members of a composite marker(Cm) of APL. We chose cholecystectomy patients for study because this is one of the most common general operations, and the large size of NIS allows for meaningful analysis of infrequent occurrences such as APL rates. Results: Cm identified 1.13 times more APLs than did PSI-15. Patients with Cm-detected APLs were significantly older and had worse mortality, comorbidities, lengths of stay, and charges than those detected with PSI-15. Further comparison of these two approaches revealed that time-series analysis for both APL markers revealed parallel trends, with inflections in 2007, and lowest APL rates in July. Conclusions: Although Cm may yield more false positives, it appears more inclusive, identifying more clinically significant APLs, than PSI-15. Both measures presented similar trends over time, arguing against inflation in PSI-15 reporting. While arguably less specific, Cm may increase sensitivity for detecting APL events during cholecystectomies. These results may inform the interpretation of other large population studies of APLs following abd

关键词： Cholecystectomy Patient safety Accidental lacerations AHRQ PSI-15

Incorporating extreme event attribution into climate change adaptation for civil infrastructure:methods,benefits,and research needs

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Resilient Cities and Structures 2024年第1期3卷 103-113页

作者： Yating Zhang Bilal m.Ayyub juan F.Fung Zachary m.Labe Department of Civil and Environmental Engineering University of MarylandCollege ParkMD 20742 Applied Economics Office Engineering LaboratoryNational Institute of Standards and TechnologyGaithersburgMD 20899 Program in Atmospheric and Oceanic Sciences Princeton UniversityPrincetonNJ 08540

In the last decade,the detection and attribution science that links climate change to extreme weather and climate events has emerged as a growing field of research with an increasing body of *** paper overviews the methods for extreme event attribution(EEA)and discusses the new insights that EEA provides for infrastructure *** found that EEA can inform stakeholders about current climate risk,support vulnerability-based and hazard-based adaptations,assist in the development of cost-effective adaptation strategies,and enhance justice and equity in the allocation of adaptation *** engineering practice shifts from a retrospective approach to a proactive,forward-looking risk management strategy,EEA can be used together with climate projections to enhance the comprehensiveness of decision making,including planning and preparing for un-precedented extreme ***,attribution assessment can be more useful for adaptation planning when the exposure and vulnerability of communities to past events are analyzed,and future changes in the probability of extreme events are *** large uncertainties inherent in event attribution and climate projections,future research should examine the sensitivity of engineering design to climate model uncertainties,and adapt engineering practice,including building codes,to uncertain future *** this study focuses on adaptation planning,EEA can also be a useful tool for informing and enhancing decisions related to climate mitigation.

关键词： Climate change Extreme weather and climate events Extreme event attribution Infrastructure adaptation Uncertainties

On the role of endogenous neurotoxins and neuroprotection in Parkinson's disease

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Neural Regeneration Research 2017年第6期12卷 897-901页

作者： juan Segura-Aguilar molecular and Clinical Pharmacology ICBM Faculty of Medicine University of Chile

For 50 years ago was introduced L-3,4-dihydroxyphenylalanine（L-dopa） in Parkinson＇s disease treatment and during this significant advances has been done but what trigger the degeneration of the nigrostriatal system remain unknown. There is a general agreement in the scientific community that mitochondrial dysfunction, protein degradation dysfunction, alpha-synuclein aggregation to neurotoxic oligomers, neuroinflammation, oxidative and endoplasmic reticulum stress are involved in the loss of dopaminergic neurons containing neuromelanin in Parkinson＇s disease. The question is what triggers these mechanisms. The age of normal onset in idiopathic Parkinson＇s disease suggests that environmental factors such as metals, pollutants or genetic mutations cannot be involved because these factors are related to early onset of Parkinsonism. Therefore, we have to search for endogenous neurotoxins and neuroprotection in order to understand what trigger the loss of dopaminergic neurons. One important feature of Parkinson＇s disease is the rate of the degenerative process before the motor symptoms are evident and during the disease progression. The extremely slow rate of Parkinson＇s disease suggests that the neurotoxins and the neuroprotection have to be related to dopamine metabolism. Possible candidates for endogenous neurotoxins are alpha-synuclein neurotoxic oligomers, 4-dihydroxyphenylacetaldehyde and ortho-quinones formed during dopamine oxidation to neuromelanin. Vesicular monoamine transporter-2, DT-diaphorase and glutathione transferase m2-2 seems to be the most important neuroprotective mechanism to prevent neurotoxic mechanism during dopamine oxidation.

关键词： dopamine endogenous endoplasmic degeneration reticulum extremely glutathione Dopamine transporter metabolism

Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

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World Journal of Clinical Cases 2019年第16期7卷 2269-2286页

作者： Sonia Pascual Cayetano miralles juan m Bernabé Javier Irurzun mariana Planells Liver Unit Hospital General Universitario de AlicanteAlicante 03010Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDAlicante 03010Spain Radiology Department Hospital General Universitario de AlicanteAlicante 03010Spain

BACKGROUND Hepatocellular carcinoma (HCC) appears in most of cases in patients with advanced liver disease and is currently the primary cause of death in this *** of HCC has been proposed and recommended in clinical guidelines to obtain earlier diagnosis,but it is still controversial and is not accepted *** To review the actual evidence to support the surveillance programs in patients with cirrhosis as well as the diagnosis *** Systematic review of recent literature of surveillance (tools,interval,cost-benefit,target population) and the role of imaging diagnosis (radiological non-invasive diagnosis,optimal modality and agents) of *** The benefits of surveillance of HCC,mainly with ultrasonography,have been assessed in several prospective and retrospective analysis,although the percentage of patients diagnosed in surveillance programs is still *** of HCC permits diagnosis in early stages allows better access to curative treatment and increases life expectancy in patients with *** is a tumor with special radiological characteristics in computed tomography and magnetic resonance imaging,which allows highly accurate diagnosis without routine biopsy *** actual recommendation is to perform biopsy only in indeterminate *** The evidence supports the recommendation of performing surveillance of HCC in patients with cirrhosis susceptible of treatment,using ultrasonography every 6 *** diagnosis evaluation of HCC can be established based on noninvasive imaging criteria in patients with cirrhosis.

关键词： Surveillance Hepatocellular carcinoma Ultrasonography Cirrhosis Imaging diagnosis

Optimized high performance liquid chromatography–ultraviolet detection method using core-shell particles for the therapeutic monitoring of methotrexate

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Journal of Pharmaceutical Analysis 2016年第2期6卷 103-111页

作者： milagros montemurro maría m.de zan juan c.robles Laboratorio de Control de Calidad de medicamentos Facultad de Bioqufmica y Ciendas Biologicas Universidad Nacional del Litoral Santa Fe Argentina

methotrexate （mTX） is an antineoplastic drug, and due to its high toxicity, the therapeutic drug mon- itoring is strictly conducted in the clinical practice. The chemometric optimization and validation of a high performance liquid chromatography （HPLC） method using core-shell particles is presented for the determination of mTX in plasma during therapeutic monitoring. Experimental design and response surface methodology （RSm） were applied for the optimization of the chromatographic system and the analyte extraction step. A Poroshel1120 EC-C18 （3.0 mm × 75 mm, 2.7 μm） column was used to obtain a fast and efficient separation in a complete run time of 4 min. The optimum conditions for the chroma- tographic system resulted in a mobile phase consisting of acetic acid/sodium acetate buffer solution （85.0 mm, pH =4.00） and 11.2% of acetonitrile at a flow rate of 0.4 mL/min. Selectivity, linearity, accuracy and precision were demonstrated in a range of 0.10-6.0 μm of mTX. The application of the optimized method required only 150μL of patient plasma and a low consumption of solvent to provide rapid re- sults.

关键词： HPLC Core-shell particles methotrexate Drug monitoring