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Evaluation of vaccine rollout strategies for emerging infectious diseases:A model-based approach including protection attitudes

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Infectious Disease modelling 2023年第4期8卷 1032-1049页

作者： mauricio Paton juan m.acuna Jorge Rodríguez Department of Chemical Engineering College of EngineeringKhalifa UniversitySAN Campus PO Box 127788Abu DhabiUnited Arab Emirates Department of Epidemiology and Public Health College of Medicine.Khalifa UniversityPO Box 127788Abu DhabiUnited Arab Emirates

Vaccine allocation strategies become crucial during vaccine shortages,especially in the face of potential outbreaks of new infectious diseases,as witnessed during the COVID-19 *** address this,a specialized compartmental model is created,which simulates an emerging infectious disease similar to *** model divides the population into different age groups and is used to compare various vaccine prioritisation approaches,aiming to minimize the total number of *** model is an improvement upon previous ones as it incorporates essential behavioural factors and is adapted to account for the protective effects of vaccination against both disease infection and *** takes into account human behaviors such as mask-wearing and social distancing by utilizing specific parameters related to self-protection,awareness levels,and the frequency of daily person-to-person interactions within each age ***,a novel method for dynamic vaccine prioritisation was introduced in this *** approach is model-independent and relies on the dynamic R *** is the first time such a method has been developed,offering a decision-making approach that is not tied to any specific *** innovation provides a flexible and adaptable strategy for determining vaccine priorities based on real-time data and the current state of the *** findings reveal crucial insights into vaccine allocation *** the daily rollout rates are fast(0.75%or higher)and children are eligible for vaccination,prioritising groups with high daily person-to-person interactions can lead to substantial reductions in total fatalities(up to approximately 40%lower).On the other hand,if rollout rates are slower and overall vaccination coverage is high,focusing on vaccinating elders emerges as the most effective strategy,resulting in up to approximately 10%fewer ***,the scenario changes significantly when children are not eligible for vaccination

关键词： behaviour slower utilizing

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model-based evaluation of the COVID-19 epidemiological impact on international visitors during Expo 2020

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Infectious Disease modelling 2022年第3期7卷 571-579页

作者： mauricio Paton Farida Al-Hosani Anderson E.Stanciole Bashir Aden Andrey Timoshkin Amrit Sadani Omar Najim Cybill A.Cherian juan m.acuna Jorge Rodríguez Department of Epidemiology and Public Health College of MedicineKhalifa UniversityPO Box 127788Abu DhabiUnited Arab Emirates Department of Chemical Engineering College of EngineeringKhalifa UniversitySAN CampusPO Box 127788Abu DhabiUnited Arab Emirates Research and Data Intelligence Support Center(RDISC) Khalifa UniversityPO Box 127788Abu DhabiUnited Arab Emirates Abu Dhabi Public Health Center Abu DhabiUnited Arab Emirates Department of Health Abu DhabiUnited Arab Emirates Abu Dhabi Health Services Company e SEHA PO Box 109090Abu DhabiUnited Arab Emirates

The impact of the COVID-19 pandemic on large events has been *** this work,an evaluation of the potential impact of international arrivals due to Expo 2020 in terms of potential COVID-19 infections from October 1st,2021,until the end of April 2022 in the United Arab Emirates is *** simulation results indicate that:(i)the vaccination status of the visitors appears to have a small impact on cases,this is expected as the small numbers of temporary visitors with respect to the total population contribute little to the herd immunity status;and(ii)the number of infected arrivals is the major factor of impact potentially causing a surge in cases countrywide with the subsequent hospitalisations and *** results indicate that the prevention of infected arrivals should take all precedence priority to mitigate the impact of international visitors with their vaccination status being of less relevance.

关键词： International travel COVID-19 infections Infectious diseases

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Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy

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Neural Regeneration Research 2025年第3期20卷 887-899页

作者： Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang juan Wang Zongjian Liu Xuechai Chen Beijing International Science and Technology Cooperation Base for Antiviral Drugs College of Chemistry and LifeBeijing University of TechnologyBeijingChina Department of Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environmental toxin that causes Parkinson's ***,the mechanism by which Sal mediates dopaminergic neuronal death remains *** this study,we found that Sal significantly enhanced the global level of N~6-methyladenosine(m~6A)RNA methylation in PC12 cells,mainly by inducing the downregulation of the expression of m~6A demethylases fat mass and obesity-associated protein(FTO)and alk B homolog 5(ALKBH5).RNA sequencing analysis showed that Sal downregulated the Hippo signaling *** m~6A reader YTH domain-containing family protein 2(YTHDF2)promoted the degradation of m~6A-containing Yes-associated protein 1(YAP1)mRNA,which is a downstream key effector in the Hippo signaling ***,downregulation of YAP1 promoted autophagy,indicating that the mutual regulation between YAP1 and autophagy can lead to *** findings reveal the role of Sal on m~6A RNA methylation and suggest that Sal may act as an RNA methylation inducer mediating dopaminergic neuronal death through YAP1 and *** results provide greater insights into the neurotoxic effects of catechol isoquinolines compared with other studies and may be a reference for assessing the involvement of RNA methylation in the pathogenesis of Parkinson's disease.

关键词： ALKBH5 autophagy FTO Hippo pathway m~6A Parkinson's disease RNA methylation salsolinol YAP1 YTHDF2

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A surface engineering strategy for the stabilization of zinc metal anodes with montmorillonite layers toward long-life rechargeable aqueous zinc ion batteries

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Journal of Energy Chemistry 2025年第1期100卷 94-105页

作者： Wenbo Wang Ruifeng Xu Xu Zhang Peiyu Wang Bao Yang Bingjun Yang juan Yang Kailimai Su Pengjun ma Yanan Deng Xianfeng Fan Wanjun Chen Key Laboratory for Electronic materials College of Electrical Engineering Northwest Minzu University Resource Chemistry and Energy materials Research Center State Key Laboratory of Solid Lubrication Lanzhou Institute of Chemical Physics Chinese Academy of Sciences University of Chinese Academy of Sciences Institute for materials and Processes School of Engineering University of Edinburgh

Rechargeable aqueous zinc-ion batteries （AZIBs） exhibit appreciable potential in the domain of electrochemical energy ***,there are serious challenges for AZIBs,for instance zinc dendrite growth,hydrogen evolution reaction （HER）,and corrosion side ***,we propose a surface engineering modification strategy for coating the montmorillonite （mmT） layer onto the surface of the Zn anode to tackle these issues,thereby achieving high cycling stability for rechargeable *** results reveal that the mmT layer on the surface of the Zn anode is able to provide ordered zincophilic channels for zinc ions migration,facilitating the reaction kinetics of zinc *** functional theory（DFT） calculations and water contact angle （CA） tests prove that mmT@Zn anode exhibits superior adsorption capacity for Zn2+and better hydrophobicity than the bare Zn anode,thereby achieving excellent cycling ***,the mmT@Zn||mmT@Zn symmetric cell holds the stable cycling over 5600 h at 0.5 mA cm-2and 0.125 m A h cm-2,even exceeding 1800 h long cycling under harsh conditions of 5 m A cm-2and 1.25 m A h *** mmT@Zn||V2O5full cell reaches over 3000 cycles at 2 A g-1with excellent rate ***,this surface engineering modification strategy for enhancing the electrochemical performance of AZIBs represents a promising application.

关键词： Surface engineering strategy montmorillonite layer Protection mechanism of Zn anode Cycling stability Aqueous zinc ion batteries

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Enhancing output performance of triboelectric nanogenerator by increasing charge storage capacity of electrodes

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Nano Research 2025年第1期18卷 395-403页

作者： Congcong Hao Zekun Wang mingzhe Cai Shuaining Cheng Zhongxin Wang Cong Zhai juan Cui Yongqiu Zheng Chenyang Xue Key Laboratory of Instrumentation Science and Dynamic measurement ministry of Education North University of ChinaTaiyuan 030051China

ABSTRACT:The practical application of rotating triboelectric nanogenerators is often limited by the wear of high-friction surface materials and low surface charge *** addition to the charge pump replenishment strategy,suppressing charge decay is also crucial for increasing surface charge ***,we present a high performance rotary triboelectric nanogenerator(HPR-TENG)based on a coplanar charge pumping strategy and polyvinyl chloride(PVC)*** has been demonstrated that applying PVC film to the surface of the storage electrode of the main TENG(m-TENG)significantly enhances the m-TENG’s output ***,the HPR-TENG with three layers of PVC film pasted achieved the best output performance,with a peak-topeak output voltage of 2828 V,a peak-to-peak output current of 327μA and a charge transfer of 0.81μC at 500 *** addition,the output improvement effects of different materials are *** TENG with 3 layers of PVC film pasted on it has a maximum output power of 748 mW at a load resistance of 4×10^(6)Ω.HPR-TENG’s output performance remains consistent after 100,000 cycles,which shows excellent *** excellent electrical performance of the HPR-TENG can be used as the energy supply for the tip high-voltage breakdown sensor system,which can achieve 14 breakdowns in 10 *** to its extraordinary electrical performance,HPRTENG can not only serve as an energy supply for cutting-edge high-voltage breakdown sensor systems,but also has the potential to serve as an energy supply for high-pressure sterilization,high-pressure vacuum and water electrolysis.

关键词： triboelectric nanogenerator coplanar charge pump enhancing charge density suppressing charge decay polyvinyl chloride(PVC)film

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Isolation, characterization and effect of plant-growth-promoting rhizobacteria on pine seedlings(Pinus pseudostrobus Lindl.)

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Journal of Forestry Research 2019年第5期30卷 1727-1734页

作者： Cristina Heredia-acuna juan J.Almaraz-Suarez Ramon Arteaga-Garibay Ronald Ferrera-Cerrato Deisy Y.Pineda-mendoza Area de microbiologia Postgrado de EdafologiaColegio de PostgraduadosCarretera Mexico-Texcoco km 36.5CP 56230 MontecilloEstado de MexicoMexico Laboratorio de Recursos Geneticos microbianos Centro Nacional de Recursos GeneticosINIFAPBoulevard de la Biodiversidad No.400CP 47600 Tepatitlan de MorelosJaliscoMexico

In this study,10 bacterial strains were isolated from the rhizosphere of coniferous trees on mount Tla′loc in *** strains were characterized by their capacity to produce auxins,solubilize phosphates and stimulate mycelial growth of the ectomycorrhizal fungus Suillus *** isolates were identified at the molecular ***,an experiment was established to evaluate the response of Pinus pseudostrobus seedlings to inoculation with the rhizobacteria *** isolated strains belonged to the species Cupriavidus basilensis,Rhodococcus qingshengii,***,Pseudomonas spp.,***,Stenotrophomonas rhizophila and Cohnella *** of the strains produced auxins;the best producer was *** CPT9(76.4 lg mL^-1).*** CPT6 solubilized phosphate at a significant level(443 lg mL^-1).The strain *** CPT8 significantly increased the radial growth of the ectomycorrhizal fungus Suillus *** 18.8%.Five strains increased the dry mass of the shoots;*** CPT4 and *** CPT9 increased growth the most,by more than 20%.Inoculation with plant-growth-promoting rhizobacteria can be a very useful practice in a forest nursery to produce healthy,vigorous plants.

关键词： Biofertilizers Forest species Rhizobacteria Indole acetic acid Phosphate solubilization

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mid-term results of patterned laser trabeculoplasty for uncontrolled ocular hypertension and primary open angle glaucoma

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International Journal of Ophthalmology(English edition) 2021年第8期14卷 1199-1204页

作者： Gustavo Espinoza Yuly Andrea Castellanos-Castellanos Angelica Pedraza-Concha Ignacio Rodriguez-Una maria Fernanda acuna juan Camilo Parra Centro Oftalmologico Virgilio Galvis BucaramangaSantander 681004Colombia Fundacion Oftalmologica de Santander BucaramangaSantander 681004Colombia Universidad Industrial de Santander BucaramangaSantander 680002Colombia Instituto Oftalmologico Fernandez-Vega Universidad de OviedoOviedo 33012Spain

AIm:To describe the safety and efficacy of patterned laser trabeculoplasty(PLT)as an adjunctive treatment in primary open angle glaucoma(POAG)and ocular hypertension(OHT)after 18-month follow-up in Hispanic ***:A single-center,retrospective study was *** patients with OHT or POAG undergoing PLT from June 2016 to August 2016 were included in the *** parameters were intraocular pressure(IOP),the number of IOP-lowering medications,best corrected visual acuity(BCVA),laser parameters and postoperative adverse *** efficacy outcome measures were the proportion of eyes achieving an IOP reduction≥20%at 18 mo versus baseline medicated IOP or a reduction in the number of medications while maintaining IOP ***:From 40 PLT-treated eyes(mean baseline IOP 20.3±1.7 mm Hg),24 patients were analyzed(age 63.4±7.3 y).The mean IOP reductions from baseline across visits(months 1,3,6,9,12,and 18)ranged from 14.1%to 20.8%.Success rate after 18-month follow-up was 61.7%with a mean IOP of 16±3.2 mm Hg(Pmber of glaucoma IOP-lowering medications per eye(preoperative 2.1±1.1 and postoperative 2.3±1.1,P=0.86)and the mean BCVA(preoperative 0.10±0.22 and postoperative 0.11±0.22 logmAR,P=0.42)remained *** events comprised transitory IOP spikes in 4 eyes(10%)and peripheral anterior synechiae in 7 eyes(17.5%).CONCLUSION:mid-term results of PLT show that this procedure may be an efficacious and safe technique to approach medically uncontrolled OHT or POAG patients.

关键词： glaucoma intraocular pressure ocular hypertension patterned laser trabeculoplasty

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Laser direct writing of flexible multifunctional airflow sensors on the Kevlar fabric

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Nano Research 2025年第1期18卷 443-454页

作者： Wei Wang Zi-Qing Chen Yong-Qi Li Yu-Long Wang mei-Chen Liu Yun-Bo Ruan Yang Zhang Shu-juan Liu Qiang Zhao College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023China State Key Laboratory of Organic Electronics and Information Displays and Jiangsu Key Laboratory for Biosensors Institute of Advanced Materials(IAM)Nanjing University of Posts and TelecommunicationsNanjing 210023China Zhe Jiang Topsun Logistic Control CO. LTD.Yuhuan 317600China Department of Rehabilitation medicine School of Acupuncture-Moxibustion and Tuina and School of Health Preservation and RehabilitationNanjing University of Chinese MedicineNanjing 210023China

The growing interest in flexible devices has emerged as a global trend due to their advantages in flexibility,lightweight structure,and wearability,addressing the limitations of traditional *** wearable airflow sensors have been previously reported,the development of flexible fabric-based airflow sensors capable of functioning in environments with open flames—critical for fire rescue operations—has yet to be explored,largely due to the poor fire resistance of conventional *** this work,we first present a flexible,wearable,and multifunctional airflow sensor with excellent fire-resistant properties,fabricated through a simple direct laser writing *** sensor maintains airflow detection capabilities even in the presence of open ***,the fabrication of fabric-based sensors involves complex procedures such as carbon materials doping or vapor-phase deposition,leading to lengthy preparation cycles and high ***,fabric-based devices are inherently prone to *** address these challenges,we introduce twice-vertical laser-induced graphene(TVLIG)as a sensitive and reliable component for fire-resistant airflow *** resulting TVLIG/Kevlar fabric can be integrated into various garments,particularly protective suits,to form sensitive and fire-resistant airflow sensors capable of detecting airflow velocity and direction in both two-dimensional(2D)and three-dimensional(3D)spaces during fire ***,the TVLIG patterns can be expanded to multifunctional platforms,such as glucose detection for injured individuals,offering further applications in rescue *** functional expansion reduces the burden on rescue personnel and streamlines device *** its outstanding sensing capabilities,fire resistance,and expandability,the developed flexible airflow sensor shows great potential for various real-world rescue scenarios,promising advancements in wearable sensing technology for rescue enginee

关键词： flexible airflow sensor direct laser writing twice-vertical laser-induced graphene fire accident rescue Kevlar fabric

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A cloud-based platform to predict wind pressure coefficients on buildings

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Building Simulation 2022年第8期15卷 1507-1525页

作者： Facundo Bre juan m.Gimenez Centro de Investigacion de metodos Computacionales(CImEC) UNLCONICETPredio"Dr.Alberto Cassano"Colectora Ruta Nacional 168 s/n3000Santa FeArgentina

Natural ventilation(NV)is a key passive strategy to design energy-efficient buildings and improve indoor air ***,accurate modeling of the NV effects is a basic requirement to include this technique during the building design ***,there is an important lack of wind pressure coefficients(CP)data,essential input parameters for NV *** this,there are no simple but still reliable tools to predict CP data on buildings with arbitrary shapes and surrounding conditions,which means a significant limitation to NV modeling in real *** this reason,the present contribution proposes a novel cloud-based platform to predict wind pressure coefficients on *** platform comprises a set of tools for performing fully unattended computational fluid dynamics(CFD)simulations of the atmospheric boundary layer and getting reliable CP data for actual ***-expert decisions throughout the entire workflow are implemented to automatize the generation of the computational domain,the meshing procedure the solution stage,and the post-processing of the *** evaluate the performance of the platform,an exhaustive validation against wind tunnel experimental data is carried out for a wide range of case *** include buildings with openings,balconies,irregular floor-plans,and surrounding urban *** C_(P) results are in close agreement with experimental data,reducing 60%-77% the prediction error on the openings regarding the EnergyPlus *** platform introduced shows being a reliable and practical C_(P) data source for NV modeling in real building design scenarios.

关键词： natural ventilation building simulation airflow network model EnergyPlus wind pressure coefficient computational fluid dynamics

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Seasonal variation and chemical composition of particulate matter： A study by XPS, ICP-AES and sequential microanalysis using Raman with SEm/EDS

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Journal of Environmental Sciences 2018年第12期30卷 32-49页

作者： Lucy T.González Francisco E.Longoria-Rodríguez margarita Sánchez-Domínguez Cesar Leyva-Porras Karim.acuna-Askar Boris I.Kharissov Alejandro Arizpe-Zapata juan m.Alfaro-Barbosa Universidad Autónoma de Nuevo León Facultad de Ciencias Químicas Laboratorio de Química Analítica AmbientalCódigo Postal 64570MaonterreyN.L.Mexico Centro de Investigación en materiales Avanzados SC Unidad MonterreyAlianza Notre 202 Código Postal 66628 Apodaca Nueuo León Mexico Centro de Investigación en materiales Avanzados SC Miguel de Cervantes # 120 Código Postal 31109 Chihuahua Chih. Mexico Universidad Autónoma de Nuevo León Facultad de Medicina Laboratorio de Biorremediación AmbientalCódigo Postal 64460 MonterreyN.L. Mexico

During the winter period（January–march 2016）, the total suspended particles（TSP） and particulate matter smaller than 2.5 μm（Pm2.5） were characterized by the application of various analytical techniques in four zones of the metropolitan Area of monterrey in mexico. To evaluate the seasonal variation of some elements in the particulate matter, the results of this study were compared with those obtained during the summer season（July–September 2015）. The speciation of the C_（1s） signal by X-ray photoelectron spectroscopy revealed the contribution of aromatic and aliphatic hydrocarbons as the main components in both seasons. Conversely, carboxylic groups associated with biogenic emissions were detected only in winter. The percentages of SO_4^（2-） ions were lower in winter, possibly caused by the decrease in the solar radiation, and relative humidity recorded. The results of the ICP analysis revealed that Fe, Zn and Cu were the most abundant metals in both TSP and Pm2.5 in the two seasons. There were significant seasonal variations for concentrations of As, Ni and Zn in the urban area and for Fe, As, Cd, Ni and Zn in the industrial zone. This was attributed to the greater burning of fuels as well as to an increase in vehicular traffic, the effect of thermal inversion and changes in some meteorological parameters. The results of the sequential microanalysis by Raman spectroscopy and SEm/EDS allowed observation of deposits of carbonaceous material on the particles and to perform the speciation of particles rich in Fe and Pb, which helped infer their possible emission sources.

关键词： Seasonal variation Total suspended particles Pm2.5 X-ray photoelectron spectroscopy micro-Raman spectroscopy

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