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High prevalence of hepatic steatosis and vascular thrombosis in COVID-19:A systematic review and meta-analysis of autopsy data

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World Journal of Gastroenterology 2020年第48期26卷 7693-7706页

作者： luis Antonio Díaz Francisco Idalsoaga Macarena Cannistra Roberto Candia Daniel Cabrera Francisco Barrera Alejandro Soza Rondell Graham Arnoldo Riquelme Marco Arrese Michael D Leise juan Pablo Arab Department of Gastroenterology Escuela de MedicinaPontificia Universidad Católica de ChileSantiago 8320000Chile Department of Internal Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile School of Medicine Pontificia Universidad Católica de ChileSantiago 8320000Chile Facultad de Ciencias Médicas Universidad Bernardo O'HigginsSantiago 8320000Chile Department of Laboratory Medicine and Pathology Mayo Clinic RochesterMinnesotaMN 55902United States Católica de Chile Santiago 8320000Chile Division of Gastroenterology and Hepatology Mayo Clinic RochesterMinnesotaMN 55905United States

BACKGROUND Coronavirus disease 2019(COVID-19)disease can frequently affect the *** on hepatic histopathological findings in COVID-19 is *** To characterize hepatic pathological findings in patients with *** We conducted a systematic review with meta-analysis registered on PROSPERO(CRD42020192813),following PRISMA *** trials were those including patients of any age and COVID-19 diagnosis based on a molecular *** reports from deceased COVID-19 patients undergoing autopsy or liver biopsy were *** including less than ten patients were *** were pooled using random-effects models.Q statistic and I2 were used to assess heterogeneity and levels of evidence,*** We identified 18 studies from 7 countries;all were case reports and case series from *** the patients were over 15 years old,and 67.2%were *** performed a meta-analysis of 5 studies,including 116 *** prevalence estimates of liver histopathological findings were hepatic steatosis 55.1%[95%confidence interval(CI):46.2-63.8],congestion of hepatic sinuses 34.7%(95%CI:7.9-68.4),vascular thrombosis 29.4%(95%CI:0.4-87.2),fibrosis 20.5%(95%CI:0.6-57.9),Kupffer cell hyperplasia 13.5%(95%CI:0.6-54.3),portal inflammation 13.2%(95%CI:0.1-48.8),and lobular inflammation 11.6%(95%CI:0.3-35.7).We also identified the presence of venous outflow obstruction,phlebosclerosis of the portal vein,herniated portal vein,periportal abnormal vessels,hemophagocytosis,and *** We found a high prevalence of hepatic steatosis and vascular thrombosis as major histological liver *** frequent findings included portal and lobular inflammation and Kupffer cell hyperplasia or *** studies are needed to establish the mechanisms and implications of these findings.

关键词： Pathology SARS-CoV-2 COVID-19 Autopsies Liver Liver biopsies

Evaluation of an educational telephone intervention strategy to improve non-screening colonoscopy attendance:A randomized controlled trial

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World Journal of Gastroenterology 2020年第47期26卷 7568-7583页

作者： Agustin Seoane Xenia Font juan C Perez Rocio Perez Carlos F Enriquez Miriam Parrilla Faust Riu Josep M Dedeu luis E Barranco Xavier Duran Ines A Ibanez Marco A Alvarez Digestive Department Endoscopy UnitHospital del MarParc de Salut MarBarcelona 08003Spain Colorectal Cancer Research Group IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain Department of Medicine Autonomous University of BarcelonaBarcelona 08003Spain Consulting Service on Methodology for Biomedical Research IMIM(Hospital del Mar Medical Research Institute)Barcelona 08003Spain

BACKGROUND Colonoscopy attendance is a key quality parameter in colorectal cancer population screening *** these programmes,educative interventions with bidirectional contact carried out by trained personnel have been proved to be an important tool for colonoscopy attendance improvement,and because of its huge clinical and economic impact,they have been widely ***,outside of this population programmes,educative measures to improve colonoscopy attendance have been poorly studied and no navigation interventions are usually *** To investigate the clinical and economic impacts of an educational telephone intervention on colonoscopy attendance outside colorectal cancer screening *** This randomized controlled trial included consecutive patients referred to colonoscopy from primary care centres from November 2017 to May *** intervention group(IG)received a telephone intervention,while the control group(CG)did *** assigned to the IG received an educational telephone call 7 d before the colonoscopy *** intervention was carried out by two nurses with deep endoscopic knowledge who were previously trained for a telephone educational intervention for *** impact on patient compliance with preparedness protocols related to bowel cleansing,antithrombotic management,and sedation scheduling was also evaluated.A second call was conducted to assess patient ***-to-treat(ITT)and perprotocol(PP)analyses were *** A total of 738 and 746 patients were finally included in the IG and CG *** hundred thirteen(83%)patients were contacted in the *** non-attendance rate was lower in the IG,both in the ITT analysis(IG 8.4%vs CG 14.3%,P<0.001)and in the PP analysis(4.4%vs 14.3%,P<0.001).In a multivariable analysis,belonging to the control group increased the risk of nonattendance in both,the ITT analysis(OR 1.81,95%CI:1.27 to 2.58,P=0.001)and the PP analysis(O

关键词： Colonoscopy Quality improvement No-show patients Nursing education Patient compliance Telephone intervention

Stress,Burnout,and Resilience:Are Teachers at Risk?

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International Journal of Mental Health Promotion 2023年第2期25卷 207-222页

作者： Joséluis Moreno-Lucas juan Pedro Martínez-Ramón Francisco Manuel Morales-Rodríguez Cecilia Ruiz-Esteban e Inmaculada Méndez Department of Developmental and Educational Psychology Campus of Excellence Mare NostrumUniversity of MurciaEspinardoMurcia30100Spain Department of Developmental and Educational Psychology University Campus of CartujaUniversity of GranadaGranada18071Spain

It is increasingly common to find alarming news related to tragic events occurring in schools around the *** able to deal with these situations without getting hurt is a task not suitable for *** general,teachers are the ones who must deal with this type of situation in addition to other daily problems that appear in any classroom that make the level of stress to which they are subjected can become *** research aims to know the current situation of teachers in a region of southeastern Spain in terms of their level of work stress,resilience,and other associated variables,for which an ex post facto quantitative approach study was *** this purpose,an ad hoc sociodemographic questionnaire,and questions based on the Teaching and Learning International Survey of the Organization for Economic Co-Operation and Development,the Maslach Burnout Inventory,and the Brief Resilient Coping Scale were *** participating sample consisted of 470 *** main findings were that 6%of teachers had burnout(high emotional exhaustion,high cynicism,and low professional effectiveness simultaneously).Resilience correlated inversely with stress,emotional exhaustion,cynicism,excessive teaching,and difficulty maintaining classroom *** conclusion,knowing the needs of teachers allows us to reflect on what kind of prevention and intervention programs are necessary to improve the well-being of teachers and thus improve the quality of education.

关键词： Burnout coping resilience stress teacher

Influence of Two Different Methods of Activation Treatment on the Photovoltaic Parameters of CdSICdTe Solar Cells

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材料科学与工程（中英文B版） 2012年第10期2卷 513-516页

作者： Araceli Rios Flores Oscar Ares juan M. Camacho Victor Rejon juan luis Pena Applied Physics Department CINVESTAV-IPN Merida C.P. 97310 Merida Yucatan Mexico

Evaluation of activity of triclabendazole against Taenia solium metacestode in naturally infected pigs

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Asian Pacific Journal of Tropical Medicine 2016年第1期9卷 20-23页

作者： Ana Vargas-Calla luis A.Gomez-Puerta juan Calcina Omar Gonzales-Viera Cesar Gavidia Maria T.Lopez-Urbina Hector H.Garcia Armando E.Gonzalez School of Veterinary Medicine Universidad Nacional Mayor de San Marcos Cysticercosis Elimination Program and Center for Global Heath Tumbes Universidad Peruana Cayetano Heredia Department of Microbiology School of SciencesUniversidad Peruana Cayetano Heredia

Objective:To assess the efficacy of triclabendazole(TCBZ) in porcine ***:Eighteen naturally infected cysticercotic pigs were divided into 3 groups of 6 individuals *** first group was treated orally with TCBZ at a single dose of 30 mg/kg of body weight,the second group was treated orally with oxfendazole at a single dose of 30 mg/kg of body weight and the third group received a placebo(control group).All animals were kept under the same management *** pigs were euthanized 17 wk post-treatment and the number of surviving cysts in muscles was assessed and compared between ***:All pigs treated with oxfendazole had only degenerated cysts in their *** contrast,TCBZ had very little effect against the parasitic *** from pigs in the TCBZ group looked apparently normal after ***,histological evaluation showed a mild to moderate degree of ***:TCBZ is not an efficacious drug against Taenia solium cysticercosis in swine using a single dose.

关键词： Taenia solium Cysticercosis Triclabendazole Oxfendazole Treatment

Lung cancer screening, what has changed after the latest evidence?

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World Journal of Radiology 2020年第7期12卷 130-136页

作者： juan Carlos Trujillo-Reyes luis Seijo Elisabeth Martinez-Tellez Felipe Counago Department of Thoracic Surgery Hospital de la Santa Creu I Sant PauBarcelona 08029Spain Department of Surgery Universitat Autonoma de BarcelonaBarcelona 08029Spain Department of Pneumology Clinica Universitaria de NavarraMadrid 28029Spain Department of Radiation Oncology Hospital Universitario Quirónsalud MadridMadrid 28223Spain Universidad Europea de Madrid Madrid 28223Spain

Lung cancer(LC)is still one of the most frequent cancers with a high related *** prognosis is directly proportional to the stage at the time of *** percent are currently diagnosed in advanced or locally advanced stage(higher than stage III),making a cure unlikely for the majority of *** in LC treatment are significant however they do not seem to be enough to reverse the current situation,at least,in a short period of *** recent advances in treatment,primary prevention and early diagnosis appear to be the key to reduce the incidence and mortality of this *** countries have developed LC screening programs based on the results of clinical trials published in recent *** aim of this paper is to review the latest results of the NEderlands Leuvens Longkanker Screenings Onderzoek and compare them with the findings of the National Lung Screening *** address the question whether it is necessary to continue discussing the evidence regarding LC *** both trials,there is a clear impact on LC mortality but,with a modest reduction in over all ***,the benefit of screening can be expected to grow as low-dose computed tomographys are performed over longer periods of time.

关键词： Lung cancer Epidemiology Lung cancer screening Low dose chest computed tomography scan Primary prevention Molecular biomarkers

Translational pancreatic cancer research:a comparative study on patient-derived xenograft models

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World Journal of Gastroenterology 2018年第7期24卷 794-809页

作者： Mercedes Rubio-Manzanares Dorado luis Miguel Marín Gómez Daniel Aparicio Sánchez Sheila Pereira Arenas juan Manuel Praena-Fernández juan Jose Borrero Martín Francisco Farfán López Miguel ángel Gómez Bravo Jordi Muntané Relat Javier Padillo Ruiz Department of Hepatobiliary and Pancreatic Surgery Virgen del Rocio University Hospital Oncology Surgery Cell Therapy and Organ Transplantation Group Institute of Biomedicine of Seville (IBiS) Virgen del Rocio University Hospital University of Seville Statistics Methodology and Evaluation of Research Unit Virgen del Rocio University Hospital Pathology Department Virgen del Rocio University Hospital

AIM To assess the viability of orthotopic and heterotopic patient-derived pancreatic cancer xenografts implanted into nude *** This study presents a prospective experimental analytical follow-up of the development of tumours in mice upon implantation of human pancreatic adenocarcinoma samples. Specimens were obtained surgically from patients with a pathological diagnosis of pancreatic adenocarcinoma. Tumour samples from pancreatic cancer patients were transplanted into nude mice in three different locations(intraperitoneal, subcutaneous and pancreatic). Histological analysis(haematoxylin-eosin and Masson's trichrome staining) and immunohistochemical assessment of apoptosis(TUNEL), proliferation(Ki-67), angiogenesis(CD31) and fibrogenesis(α-SMA) were performed. When a tumour xenograft reached the target size, it was reimplanted in a new nude mouse. Three sequential tumour xenograft generations were generated(F1, F2 and F3).RESULTS The overall tumour engraftment rate was 61.1%. The subcutaneous model was most effective in terms of tissue growth(69.9%), followed by intraperitoneal(57.6%) and pancreatic(55%) models. Tumour development was faster in the subcutaneous model(17.7 ± 2.6 wk) compared with the pancreatic(23.1 ± 2.3 wk) and intraperitoneal(25.0 ± 2.7 wk) models(P = 0.064). There was a progressive increase in the tumour engraftment rate over successive generations for all three models(F1 28.1% vs F2 71.4% vs F3 80.9%, P < 0.001). There were no significant differences in tumour xenograft differentiation and cell proliferation between human samples and the three experimental models among the sequential generations of tumour xenografts. However, a progressive decrease in fibrosis, fibrogenesis, tumour vascularisation and apoptosis was observed in the three experimental models compared with the human samples. All three pancreatic patient-derived xenograft models presented similar histological and immunohistochemical *** In our experie

关键词： Immunohistological analysis Pancreatic cancer Patient-derived xenograft Animal model Nude mice

Extension of Calcifying Epithelial Odontogenic Tumor to the Maxillary Sinus: A Case Report

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Open Journal of Stomatology 2014年第5期4卷 280-284页

作者： Mauricio Carrero luis Junquera juan Carlos de Vicente Florentino Fresno Department of Oral and Maxillofacial Surgery Central University Hospital Oviedo Spain Department of Pathologic Anatomy Central University Hospital Oviedo Spain

The calcifying epithelial odontogenic tumor (CEOT) is a rare and benign odontogenic epithelial neoplasm. This tumor accounts for less than 1% of all odontogenic tumors. It normally affects patients between 30 and 50 years old, and it is typically located in the posterior region of the mandible. Involvement of the maxillary sinus has previously been published only in six cases. This report presents a single case of CEOT that invades the maxillary sinus in a 69-year-old male. We performed a left partial maxillectomy and immediate reconstruction of the defect with a temporalis muscle flap. A comprehensive immunohistochemical study was reported. No recurrences have been found after 8 years of follow-up.

关键词： Pindborg Tumor Calcifying Epithelial Odontogenic Tumor Maxillary Sinus

Proline and Oxidative Metabolism in Young Pecan Trees Associated with Sulphate Accumulation

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Phyton-International Journal of Experimental Botany 2022年第6期91卷 1141-1152页

作者： Dalila Jacqueline Escudero-Almanza Oscar Cruz-Alvarez Ofelia Adriana Hernández-Rodríguez juan luis Jacobo-Cuellar Esteban Sánchez-Chávez Pablo Preciado-Rángel Dámaris Leopoldina Ojeda-Barrios Facultad de Ciencias Agrotecnológicas Universidad Autónoma de ChihuahuaChihuahua31350México Centro de Investigación en Alimentación y Desarrollo A.C.Delicias33088México InstitutoTecnologico Nacional de México-Instituto Tecnológico de Torreón Coahuila27170México

Pecan[Carya illinoinensis(Wangenh.)***.]is a deciduous tree whose fruits(nuts)are of high economic value and offer excellent nutritional ***,soils high in sulphates can limit its growth and *** with 5-year-old trees of‘Western Schley’pecan grown in soils high in sulphates,the levels of proline and oxidative metabolism were recorded in the *** showed that different levels of visible leaflet damage(‘sufficiency’,‘low’,‘moderate’or‘severe’)were associated with different levels of leaflet sulphates(mg kg^(−1)):‘sufficiency’(≤40),‘low’(41–60),‘moderate’(61–80)and‘severe’(80–100).‘Severe’sulphate damage was associated with significant reductions in chlorophyll(TChl)(17.04μg g^(−1)),relative water content(RWC)(50%)and leaf area(LA),and with increases in the concentrations of total carotenoids(TC)and proline(Prl).Increases were also observed in the activities of the oxidative metabolism enzymes:superoxide dismutase(SOD)(1.82 units min^(−1) g^(−1)),catalase(CAT)(2.86μmol H_(2)O_(2) min^(−1) g^(−1))and antioxidant capacity(AC)(87%DPPH inhibition).However,guaiacol peroxidase(GP)showed a reduction(2.97 nmol GSH min^(−1) g^(−1)).An inverse relationship was found between the sulphate concentration in the leaflets with respect to the evaluated parameters of TChl,TC,RWC,LA,AC,and *** synthesis and antioxidant enzymatic activity indicate salt stress in pecan leaflets in orchards irrigated with deep-well water high in sulphates.

关键词： Carya illinoinensis catalase guaiacol peroxidase salt stress photosynthetic pigments superoxide dismutase